LOCUS       NM_001012393            6406 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens opioid binding protein/cell adhesion molecule like
            (OPCML), transcript variant 2, mRNA.
ACCESSION   NM_001012393 XR_110538
VERSION     NM_001012393.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6406)
  AUTHORS   Khamko,R., Wasenang,W., Daduang,J., Settasatian,C. and
            Limpaiboon,T.
  TITLE     Combined OPCML and AXL Expression as a Prognostic Marker and OPCML
            Enhances AXL Inhibitor in Cholangiocarcinoma
  JOURNAL   In Vivo 36 (3), 1168-1177 (2022)
   PUBMED   35478117
  REMARK    GeneRIF: Combined OPCML and AXL Expression as a Prognostic Marker
            and OPCML Enhances AXL Inhibitor in Cholangiocarcinoma.
REFERENCE   2  (bases 1 to 6406)
  AUTHORS   Khamko,R., Daduang,J., Settasatian,C. and Limpaiboon,T.
  TITLE     OPCML Exerts Antitumor Effects in Cholangiocarcinoma via AXL/STAT3
            Inactivation and Rho GTPase Down-regulation
  JOURNAL   Cancer Genomics Proteomics 18 (6), 771-780 (2021)
   PUBMED   34697068
  REMARK    GeneRIF: OPCML Exerts Antitumor Effects in Cholangiocarcinoma via
            AXL/STAT3 Inactivation and Rho GTPase Down-regulation.
REFERENCE   3  (bases 1 to 6406)
  AUTHORS   Lian,B., Li,H., Liu,Y., Chai,D., Gao,Y., Zhang,Y., Zhou,J. and
            Li,J.
  TITLE     Expression and promoter methylation status of OPCML and its
            functions in the inhibition of cell proliferation, migration, and
            invasion in breast cancer
  JOURNAL   Breast Cancer 28 (2), 448-458 (2021)
   PUBMED   33108608
  REMARK    GeneRIF: Expression and promoter methylation status of OPCML and
            its functions in the inhibition of cell proliferation, migration,
            and invasion in breast cancer.
REFERENCE   4  (bases 1 to 6406)
  AUTHORS   Antony,J., Zanini,E., Birtley,J.R., Gabra,H. and Recchi,C.
  TITLE     Emerging roles for the GPI-anchored tumor suppressor OPCML in
            cancers
  JOURNAL   Cancer Gene Ther 28 (1-2), 18-26 (2021)
   PUBMED   32595215
  REMARK    GeneRIF: Emerging roles for the GPI-anchored tumor suppressor OPCML
            in cancers.
            Review article
REFERENCE   5  (bases 1 to 6406)
  AUTHORS   Fang,X., Dong,Y., Yang,R. and Wei,L.
  TITLE     LINC00619 restricts gastric cancer progression by preventing
            microRNA-224-5p-mediated inhibition of OPCML
  JOURNAL   Arch Biochem Biophys 689, 108390 (2020)
   PUBMED   32359894
  REMARK    GeneRIF: LINC00619 restricts gastric cancer progression by
            preventing microRNA-224-5p-mediated inhibition of OPCML.
REFERENCE   6  (bases 1 to 6406)
  AUTHORS   Li,C., Tang,L., Zhao,L., Li,L., Xiao,Q., Luo,X., Peng,W., Ren,G.,
            Tao,Q. and Xiang,T.
  TITLE     OPCML is frequently methylated in human colorectal cancer and its
            restored expression reverses EMT via downregulation of smad
            signaling
  JOURNAL   Am J Cancer Res 5 (5), 1635-1648 (2015)
   PUBMED   26175934
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 6406)
  AUTHORS   Shark,K.B. and Lee,N.M.
  TITLE     Cloning, sequencing and localization to chromosome 11 of a cDNA
            encoding a human opioid-binding cell adhesion molecule (OBCAM)
  JOURNAL   Gene 155 (2), 213-217 (1995)
   PUBMED   7721093
REFERENCE   8  (bases 1 to 6406)
  AUTHORS   Struyk,A.F., Canoll,P.D., Wolfgang,M.J., Rosen,C.L., D'Eustachio,P.
            and Salzer,J.L.
  TITLE     Cloning of neurotrimin defines a new subfamily of differentially
            expressed neural cell adhesion molecules
  JOURNAL   J Neurosci 15 (3 Pt 2), 2141-2156 (1995)
   PUBMED   7891157
REFERENCE   9  (bases 1 to 6406)
  AUTHORS   Smith,M.W., Clark,S.P., Hutchinson,J.S., Wei,Y.H., Churukian,A.C.,
            Daniels,L.B., Diggle,K.L., Gen,M.W., Romo,A.J., Lin,Y. et al.
  TITLE     A sequence-tagged site map of human chromosome 11
  JOURNAL   Genomics 17 (3), 699-725 (1993)
   PUBMED   8244387
REFERENCE   10 (bases 1 to 6406)
  AUTHORS   Lane,C.M., Elde,R., Loh,H.H. and Lee,N.M.
  TITLE     Regulation of an opioid-binding protein in NG108-15 cells parallels
            regulation of delta-opioid receptors
  JOURNAL   Proc Natl Acad Sci U S A 89 (23), 11234-11238 (1992)
   PUBMED   1333602
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP004606.4, AP005122.2,
            AP000863.4 and AP000843.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Sep 16, 2020 this sequence version replaced NM_001012393.4.
            
            Summary: This gene encodes a member of the IgLON subfamily in the
            immunoglobulin protein superfamily of proteins. The encoded
            preprotein is proteolytically processed to generate the mature
            protein. This protein is localized in the plasma membrane and may
            have an accessory role in opioid receptor function. This gene has
            an ortholog in rat and bovine. The opioid binding-cell adhesion
            molecule encoded by the rat gene binds opioid alkaloids in the
            presence of acidic lipids, exhibits selectivity for mu ligands and
            acts as a GPI-anchored protein. Since the encoded protein is highly
            conserved in species during evolution, it may have a fundamental
            role in mammalian systems. Alternative splicing results in multiple
            transcript variants, at least one of which encodes an isoform that
            is proteolytically processed. [provided by RefSeq, Jan 2016].
            
            Transcript Variant: This variant (2) represents use of an alternate
            promoter and therefore differs in the 5' UTR and 5' coding region,
            and lacks an alternate in-frame exon in the 3' coding region
            compared to variant 3. The encoded isoform (b) is shorter and has a
            distinct N-terminus compared to isoform c. The encoded isoform (b)
            may undergo proteolytic processing similar to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX537377.1, SRR14038194.4499803.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000524381.6/ ENSP00000434750.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-238               AP004606.4         57858-58095         c
            239-323             AP005122.2         96607-96691         c
            324-556             AP000863.4         52944-53176         c
            557-682             AP000843.5         188793-188918       c
            683-820             AP000843.5         96954-97091         c
            821-941             AP000843.5         96391-96511         c
            942-1093            AP000843.5         95818-95969         c
            1094-6406           AP000843.5         74713-80025         c
FEATURES             Location/Qualifiers
     source          1..6406
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q25"
     gene            1..6406
                     /gene="OPCML"
                     /gene_synonym="IGLON1; OBCAM; OPCM"
                     /note="opioid binding protein/cell adhesion molecule like"
                     /db_xref="GeneID:4978"
                     /db_xref="HGNC:HGNC:8143"
                     /db_xref="MIM:600632"
     exon            1..238
                     /gene="OPCML"
                     /gene_synonym="IGLON1; OBCAM; OPCM"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..1194
                     /gene="OPCML"
                     /gene_synonym="IGLON1; OBCAM; OPCM"
                     /note="isoform b precursor is encoded by transcript
                     variant 2; IgLON family member 1; opioid binding
                     protein/cell adhesion molecule-like preprotein"
                     /codon_start=1
                     /product="opioid-binding protein/cell adhesion molecule
                     isoform b precursor"
                     /protein_id="NP_001012393.1"
                     /db_xref="CCDS:CCDS31722.1"
                     /db_xref="GeneID:4978"
                     /db_xref="HGNC:HGNC:8143"
                     /db_xref="MIM:600632"
                     /translation="MYHPAYWVVFSATTALLFIPGVPVRSGDATFPKAMDNVTVRQGE
                     SATLRCTIDDRVTRVAWLNRSTILYAGNDKWSIDPRVIILVNTPTQYSIMIQNVDVYD
                     EGPYTCSVQTDNHPKTSRVHLIVQVPPQIMNISSDITVNEGSSVTLLCLAIGRPEPTV
                     TWRHLSVKEGQGFVSEDEYLEISDIKRDQSGEYECSALNDVAAPDVRKVKITVNYPPY
                     ISKAKNTGVSVGQKGILSCEASAVPMAEFQWFKEETRLATGLDGMRIENKGRMSTLTF
                     FNVSEKDYGNYTCVATNKLGNTNASITLYGPGAVIDGVNSASRALACLWLSGTLLAHF
                     FIKF"
     exon            239..323
                     /gene="OPCML"
                     /gene_synonym="IGLON1; OBCAM; OPCM"
                     /inference="alignment:Splign:2.1.0"
     exon            324..556
                     /gene="OPCML"
                     /gene_synonym="IGLON1; OBCAM; OPCM"
                     /inference="alignment:Splign:2.1.0"
     exon            557..682
                     /gene="OPCML"
                     /gene_synonym="IGLON1; OBCAM; OPCM"
                     /inference="alignment:Splign:2.1.0"
     exon            683..820
                     /gene="OPCML"
                     /gene_synonym="IGLON1; OBCAM; OPCM"
                     /inference="alignment:Splign:2.1.0"
     exon            821..941
                     /gene="OPCML"
                     /gene_synonym="IGLON1; OBCAM; OPCM"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1093
                     /gene="OPCML"
                     /gene_synonym="IGLON1; OBCAM; OPCM"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..6406
                     /gene="OPCML"
                     /gene_synonym="IGLON1; OBCAM; OPCM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6384..6389
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OPCML"
                     /gene_synonym="IGLON1; OBCAM; OPCM"
                     /note="hexamer: AATAAA"
     polyA_site      6406
                     /gene="OPCML"
                     /gene_synonym="IGLON1; OBCAM; OPCM"
                     /note="major polyA site"
ORIGIN      
        1 agagacgctg cctgcctgct cccatctctc gcgcgctctc tctctcttct gctctctccc
       61 tccctttgca aacattggat ttaaacctgc tcagaattca gcacagagga aggcagcagc
      121 ggtagcagca gcagaagcag tagcaagccc ggcagctgag agcaccgcag cgtcgagatg
      181 taccatcctg cctactgggt cgtcttctcg gcgacaactg ccctgctctt catcccagga
      241 gtgcccgtgc gcagcggaga tgccaccttc cccaaagcta tggacaacgt gacggtccgg
      301 cagggggaga gcgccaccct caggtgtacc atagatgacc gggtaacccg ggtggcctgg
      361 ctaaaccgca gcaccatcct ctacgctggg aatgacaagt ggtccataga ccctcgtgtg
      421 atcatcctgg tcaatacacc aacccagtac agcatcatga tccaaaatgt ggatgtgtat
      481 gacgaaggtc cgtacacctg ctctgtgcag acagacaatc atcccaaaac gtcccgggtt
      541 cacctaatag tgcaagttcc tcctcagatc atgaatatct cctcagacat cactgtgaat
      601 gagggaagca gtgtgaccct gctgtgtctt gctattggca gaccagagcc aactgtgaca
      661 tggagacacc tgtcagtcaa ggaaggccag ggctttgtaa gtgaggatga gtacctggag
      721 atctctgaca tcaagcgaga ccagtccggg gagtacgaat gcagcgcgtt gaacgatgtc
      781 gctgcgcccg atgtgcggaa agtaaaaatc actgtaaact atcctcccta tatctcaaaa
      841 gccaagaaca ctggtgtttc agtcggtcag aagggcatcc tgagctgtga agcctctgca
      901 gtccccatgg ctgaattcca gtggttcaag gaagaaacca ggttagccac tggtctggat
      961 ggaatgagga ttgaaaacaa aggccgcatg tccactctga ctttcttcaa tgtttcagaa
     1021 aaggattatg ggaactatac ttgtgtggcc acgaacaagc ttgggaacac caatgccagc
     1081 atcacattgt atgggcctgg agcagtcatt gatggtgtaa actcggcctc cagagcactg
     1141 gcttgtctct ggctatcagg gaccctctta gcccacttct tcatcaagtt ttgataagaa
     1201 atcctaggtc ctctgagcaa cgcctgcttc tccatatcac agactttaat ctacactgcg
     1261 gagagcaaac cagcttgggc ttctttttgt ttttttctgt tattctagat ttgttttctt
     1321 tttgtttttg tttatttgtt tgtttgcttt tatttccagc ttgaatgagt ggggttgggg
     1381 gcggggtggg cagggttcta ccacgtgtag gataatcatt cattggtgtg tccaaaaatg
     1441 gggtctgctc ctgctacctt gacccttccc tttcctctgc ttctctcctc atcatcattc
     1501 ccaacaacat cctctgccac acacaacaaa acgtaagttt catttgggca aaaattgagc
     1561 ctcacaataa acaccctgaa gacacaactt gacttataac atagtgcaca gcaagagcta
     1621 catccaagtg tcctattatc tgtgattatt ttcttaatga caatgtacat atgcccccat
     1681 ccatgttaat tattatctaa ttccattagg gttcacgtct tttctttctg ggacactatc
     1741 ctactatatc catatctata gatttcaata tagatgattg tgccatcttc tgtagcccct
     1801 ccgctctact cattccttcc accatctgca gagatttgaa gtttggggct atgcatgaaa
     1861 cccaacacta aattttgcaa gtcaagtaac caaaaaaggg ggaggcattt tgaagataga
     1921 acctctattt taaaaagaga agttcaactc ataaacgtga ttgataggtg gctgatttat
     1981 ttaggttttg tcaagctatc tatcaaagta atggtacagt tacccatcta ctcaaatatc
     2041 tgatttatct caccatccaa ttatctaccc acctgtcttc ctctctagca atctatttac
     2101 tgtttatcaa tctatcaatg taattgtcta acactccttt ctattctctc cctactactc
     2161 actatcaatt catccccata tgaatctcta accatattgt atctctccca ctgtattcat
     2221 ttatacacca tcagcagaca ttggcatctt caaaattatc tttcaacttc tgtgaaagcc
     2281 aacgatctca caggttaaca aaatacaaaa gcaataccct gtgttgtgga ctctttaaaa
     2341 tctggtatcc tatccaccca agggagacac taacagatag gccaaagtag caagctaatg
     2401 atcagtcact cactattccc agaagagcct gtgttttcta aaacactttc ttgggaagca
     2461 gatcagccta gaaaagtttt gattagcact gtggttttcc ttttgcactt gaaggacaaa
     2521 ggtgccagcc tttatgcttc tctcaaccct tcaagaaagt acatgtcagg aacctatggc
     2581 tggctttcct tagcagcaag aacttgagag aaaaacacat ctgtctctgc aatgcaaagt
     2641 gaagagtcca cccgcctgag tgggatgact tcagctagag tctcctttct gctccagttc
     2701 tggtttaatc tgtttgaaaa ctatccagta aaaagctgat ggaggccaat tacatggcgg
     2761 gtgtattgac aactctggta tttgtttcag gaagctcttc taagctgagg gcacttgagc
     2821 aactgactta attttcaagc acttgattaa cacaacactg caaacagaag ggagaaagtg
     2881 tcagtgacac agtttcctct gatgcagctg cttctccaat ggctttgggg aagaacttca
     2941 ccagctcttc aggttcaaag cagacccagc atacaaacaa gagctgagcc acctttgctg
     3001 tcttgtctcc tgggacgaga aggactcatc cagcaaagtt gcctgggatt caaaataaag
     3061 gcattgcaga ccgcacaggt gtgctgcagg gactgatcca cagagaggat gagaatgcag
     3121 catcaatcgc agacctgccc tgcctcagtt ggaaaacctt ttcaggccct cagtctaaaa
     3181 aataaaaaat atgagcacca ttgaattctg tgcccttaat gcttaactgg tcttcttcct
     3241 ctggtatcag tgtcctcttt gtttttgtcc atcaaggcac atgagtgtga cctctgccat
     3301 ggggaaacac acacagagat atctatacat atatacatac atacaaacat aggctatctt
     3361 ggcacactaa atgctaagca ctgtcttaag aggtagagct ggtgtgagtg aaattaatgt
     3421 tacattttcc agctgtaaac agacatctgc atttcctagt gagctgccag gagccagatt
     3481 cgggaaccgt aactgatgtg ccaggaatgg tgcattgatt cccagttcca gggatgatca
     3541 tgagcaggcg caaaatcaga attaaaggtc gcacatagac gtttcagatc tgtcaccacc
     3601 ttcagcatct ggagttgagt tggtgtcaga tagtgtatga gaattaaatg tgtcatctga
     3661 gcatgctact gatgataaat ttgttacttt ggagttgaat aaatgtgaag gctgtgaaga
     3721 gtggacagtc ttggagaaca cagtgcttga aatggacaag ctggacctat tcctcactcc
     3781 aagacttgtt ctacaggaaa gggtccatgc tcctttggcc aagatcatca gaacctctca
     3841 acccaacaag gctggcttca gggccactat ggaaccctgc tgttccccct tccaaaggat
     3901 actaagatgc ccctctggtg ggtacctatc ccagccacgt ttcagaggga gagaaatgct
     3961 acagttgatc ctcatctgtc tggggtaaag acaacaaagt aaatacaacc caaggcaact
     4021 ggggtactca ctgggagtga aaatgacttc ttcacaacag acatatttct gcttctgtgt
     4081 ttttgtgttt ctttggtggg gatggcttca tgggagagtg gctgtcaccc atcattttga
     4141 agcatataga acaacaaatg cttacacaag acaatatcca cacttttcca acttcacaca
     4201 cggagagtac atggagaatg cctacaggct agatttgttc agggtgccag tagtgggcat
     4261 ggggtggggg caaggcagga caaaacatac aagtctgagc aagtacatct cttgcaggtt
     4321 ttccacatga aaaggaagcc aaataagtcc tgttaggaga ttaggtgaga ggaattagca
     4381 atgtagggac tctgaaaccc ttccccttcc caaaacagag ttcatatgca cttccaccaa
     4441 agtaatgcca atgaaagtgc tcgtgttaag gctgcagcca agcttgtttt tcagtagttt
     4501 aatgtcaagt gcctgataca gtcgactgca agtctaaaca agcatgttta gtttttctca
     4561 ttcttgcttt aattcaggga gggggagatg tagagaagtg gttgtgaaaa catgtacagg
     4621 ctttatgcag agcactgcgc atggctgttc tgctgcaact gtgctccacg aaacagaaga
     4681 aaaggtaagg tgttgtgtca caaagaggcc ccagtctctt tcttcttaca tccatgcctc
     4741 ttactagatg atacatttac agattgggca gtttgttctc aaaacctggg tgagaagact
     4801 attcctggac tctagcaact tcaaaactga ggctgggttt cagaatcttt ttctgcatca
     4861 attcagtcaa tttgccttca acaaagagaa gtcagcaagt tctatttatg ctgaaagaac
     4921 tattccatga gaaaagcaga gaaccccaaa gtgggcaggc aaccccgacg agagcttatc
     4981 cctgtggcgg catcaggagt ggctgtacat tgaattttca agtgctggtt ggctgtcgcc
     5041 agcccatggt aggaggggag gaatggctta agatgaggta agatctggtg gtggggcatc
     5101 tttcctcaat tccatactga ctttgatctt gagaaagaaa aactggctat gcattaccta
     5161 aaaccagtcc aaaatgaaac agaccaacac acacacaaaa gcaaattgtc aatccctttg
     5221 gaattaaggg aagcagcata aggtttttct ttttggaaaa aatgcattta ttttcttttt
     5281 ctccaacagc aagaatcttt tgttttcatt ttgcacgtga ccttatcttg gaaactctta
     5341 tacccaattg cctcccctcc tattattcag agcttccctg tctttttact tgaagacaaa
     5401 taagtttgag cacttgagta aaacttcaca ggtgtgtaag taggaaggca acattttcaa
     5461 aaagagacca tatgatgaga acgcctaatg atcaccacat gcaaacaaac aaaactgcca
     5521 gtctcatttc ccacatttct tacttaagag aagagaagta aatgaaagga agaagaaata
     5581 gatttgtaat taaagatgtg gcaaaaaaga tagggctgag ccagttcaat ttagccttca
     5641 ggtgcagaat acttagagtc caaagaaatg tggagtggac ttaattagat gcagttgtct
     5701 ttatcctgaa agtagtgagc taagcctaat ttccagcatt ttgaaagaga ttcctttttg
     5761 tttctttcca tggtgccctc tttaaggcac agagttgctc cacaccactg ggtggagaaa
     5821 gaaagattgc gaaccctcga ccatcctttt gaggctacat tctatgttat ttggcagatt
     5881 tataaagcta tcagtaataa caatgctatg tactgcaagc tgcccttgtg ttagttaaag
     5941 ggagcatttt taatcgttcg gaaattttcg tgacatgtca agtgcagttg tgaggactgt
     6001 gtgggtgaac gaaaatgtgt ctgtcaagtt cagagtcctt tagatttaaa aaaaaattat
     6061 gacttatcaa tggtgccgtt atagctgtgt cagacaatgg gtgtgcccat tctcacaatt
     6121 atccttcaaa aaaaatctat gttcaaatgc tttaaaaatt tatcacacga tacaagagta
     6181 tgactttgtc agccttctag agttcttttt ttcttttatt ttctttcgta ttttttcctt
     6241 caaaaaatca atgaagactt gatttctgtc aataattgta tcaagggtga atatactacc
     6301 tgaattttgt gcatgttaca ttgtagttgt aaccttttct aattcaggat gaatacgaga
     6361 tggttgtgat tgtgcagtgt accaataaag ttcgagaaat ttgtaa
//
