LOCUS       NM_033207               3252 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens oligodendrocytic myelin paranodal and inner loop
            protein (OPALIN), transcript variant 1, mRNA.
ACCESSION   NM_033207
VERSION     NM_033207.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3252)
  AUTHORS   de Faria,O. Jr., Dhaunchak,A.S., Kamen,Y., Roth,A.D., Kuhlmann,T.,
            Colman,D.R. and Kennedy,T.E.
  TITLE     TMEM10 Promotes Oligodendrocyte Differentiation and is Expressed by
            Oligodendrocytes in Human Remyelinating Multiple Sclerosis Plaques
  JOURNAL   Sci Rep 9 (1), 3606 (2019)
   PUBMED   30837646
  REMARK    GeneRIF: TMEM10 Promotes Oligodendrocyte Differentiation and is
            Expressed by Oligodendrocytes in Human Remyelinating Multiple
            Sclerosis Plaques.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3252)
  AUTHORS   Yoshikawa,F., Sato,Y., Tohyama,K., Akagi,T., Hashikawa,T.,
            Nagakura-Takagi,Y., Sekine,Y., Morita,N., Baba,H., Suzuki,Y.,
            Sugano,S., Sato,A. and Furuichi,T.
  TITLE     Opalin, a transmembrane sialylglycoprotein located in the central
            nervous system myelin paranodal loop membrane
  JOURNAL   J Biol Chem 283 (30), 20830-20840 (2008)
   PUBMED   18490449
  REMARK    GeneRIF: highly sialylglycosylated Opalin has a role in an
            intermembranous function of the myelin paranodal loops in the
            central nervous system
REFERENCE   3  (bases 1 to 3252)
  AUTHORS   Aruga,J., Yoshikawa,F., Nozaki,Y., Sakaki,Y., Toyoda,A. and
            Furuichi,T.
  TITLE     An oligodendrocyte enhancer in a phylogenetically conserved intron
            region of the mammalian myelin gene Opalin
  JOURNAL   J Neurochem 102 (5), 1533-1547 (2007)
   PUBMED   17442045
REFERENCE   4  (bases 1 to 3252)
  AUTHORS   Nobile,C., Hinzmann,B., Scannapieco,P., Siebert,R., Zimbello,R.,
            Perez-Tur,J., Sarafidou,T., Moschonas,N.K., French,L., Deloukas,P.,
            Ciccodicola,A., Gesk,S., Poza,J.J., Lo Nigro,C., Seri,M.,
            Schlegelberger,B., Rosenthal,A., Valle,G., Lopez de Munain,A.,
            Tassinari,C.A. and Michelucci,R.
  TITLE     Identification and characterization of a novel human brain-specific
            gene, homologous to S. scrofa tmp83.5, in the chromosome 10q24
            critical region for temporal lobe epilepsy and spastic paraplegia
  JOURNAL   Gene 282 (1-2), 87-94 (2002)
   PUBMED   11814680
REFERENCE   5  (bases 1 to 3252)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA314221.1, AF367761.2, BC033737.1 and AL834229.1.
            
            On Nov 23, 2018 this sequence version replaced NM_033207.4.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC033737.1, AF367761.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371172.8/ ENSP00000360214.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 DA314221.1         364-367
            5-1278              AF367761.2         308-1581
            1279-2005           BC033737.1         1259-1985
            2006-3252           AL834229.1         1987-3233
FEATURES             Location/Qualifiers
     source          1..3252
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.1"
     gene            1..3252
                     /gene="OPALIN"
                     /gene_synonym="HTMP10; TMEM10; TMP10"
                     /note="oligodendrocytic myelin paranodal and inner loop
                     protein"
                     /db_xref="GeneID:93377"
                     /db_xref="HGNC:HGNC:20707"
                     /db_xref="MIM:617200"
     exon            1..109
                     /gene="OPALIN"
                     /gene_synonym="HTMP10; TMEM10; TMP10"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..532
                     /gene="OPALIN"
                     /gene_synonym="HTMP10; TMEM10; TMP10"
                     /note="isoform a is encoded by transcript variant 1;
                     transmembrane protein 10; transmembrane protein TMP10"
                     /codon_start=1
                     /product="opalin isoform a"
                     /protein_id="NP_149984.1"
                     /db_xref="CCDS:CCDS7448.1"
                     /db_xref="GeneID:93377"
                     /db_xref="HGNC:HGNC:20707"
                     /db_xref="MIM:617200"
                     /translation="MSFSLNFTLPANTTSSPVTGGKETDCGPSLGLAAGIPLLVATAL
                     LVALLFTLIHRRRSSIEAMEESDRPCEISEIDDNPKISENPRRSPTHEKNTMGAQEAH
                     IYVKTVAGSEEPVHDRYRPTIEMERRRGLWWLVPRLSLE"
     exon            110..145
                     /gene="OPALIN"
                     /gene_synonym="HTMP10; TMEM10; TMP10"
                     /inference="alignment:Splign:2.1.0"
     exon            146..178
                     /gene="OPALIN"
                     /gene_synonym="HTMP10; TMEM10; TMP10"
                     /inference="alignment:Splign:2.1.0"
     exon            179..298
                     /gene="OPALIN"
                     /gene_synonym="HTMP10; TMEM10; TMP10"
                     /inference="alignment:Splign:2.1.0"
     exon            299..355
                     /gene="OPALIN"
                     /gene_synonym="HTMP10; TMEM10; TMP10"
                     /inference="alignment:Splign:2.1.0"
     exon            356..3252
                     /gene="OPALIN"
                     /gene_synonym="HTMP10; TMEM10; TMP10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1228..1233
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OPALIN"
                     /gene_synonym="HTMP10; TMEM10; TMP10"
                     /note="hexamer: AATAAA"
     polyA_site      1248
                     /gene="OPALIN"
                     /gene_synonym="HTMP10; TMEM10; TMP10"
     regulatory      1603..1608
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OPALIN"
                     /gene_synonym="HTMP10; TMEM10; TMP10"
                     /note="hexamer: ATTAAA"
     polyA_site      1633
                     /gene="OPALIN"
                     /gene_synonym="HTMP10; TMEM10; TMP10"
     regulatory      3226..3231
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OPALIN"
                     /gene_synonym="HTMP10; TMEM10; TMP10"
                     /note="hexamer: AGTAAA"
     polyA_site      3252
                     /gene="OPALIN"
                     /gene_synonym="HTMP10; TMEM10; TMP10"
                     /note="major polyA site"
ORIGIN      
        1 gtcagttaac tgttcctaca aatgaaagac acaagccaat aaagccagtg agaaaggagc
       61 ttaccaaagg cagtgtacga agaaggttcc tgggagactg tcagaaatga gtttttcact
      121 gaacttcacc ctgccggcga acacaacgtc ctctcctgtc acaggtggga aagaaacgga
      181 ctgtgggccc tctcttggat tagcggcggg cataccattg ctggtggcca cagccctgct
      241 ggtggcttta ctatttactt tgattcaccg aagaagaagc agcattgagg ccatggagga
      301 aagtgacaga ccatgtgaaa tttcagaaat tgatgacaat cccaagatat ctgagaatcc
      361 taggagatca cccacacatg agaagaatac gatgggagca caagaggccc acatatatgt
      421 gaagactgta gcaggaagcg aggaacctgt gcatgaccgt taccgtccta ctatagaaat
      481 ggaaagaagg aggggattgt ggtggcttgt gcccagactg agcctggaat gatgcagctc
      541 agtcaaggag cagcagacct ggcactggaa cagggttgaa aacccagggt tttgtacttg
      601 gagaggaaag atgccaagct gcttcttaat caatccaaat ttcatttaca gctctggaac
      661 actttggggc tgatttgtct ctttagggga catccccaac atggttaatt ccaactctca
      721 gatcttgtgc tttagttagt acatgtgact caccagatgg ggtccttaga tcctattcct
      781 gctcccagtg ggaatttgct tttctttgtc attttgggaa aggggcttgg tttctgagtg
      841 tcttgccttc tcatcttttt ttttcatatc ctttttctca aaaaagccat cagatctgac
      901 tttcatggaa gtgttgctga ggtcagcctg gtgcaagttg ggatacaaat gaaacttatg
      961 caggatgtgt gagaggaagc agttaattgt ttctgaatat ctcagggtag gaaccatgtg
     1021 gagccacaca ttccctgacc acagggaagc acctggctca atcatgtcac acagcagtgg
     1081 aaagaatacg gactcttaag tcacacctac cactgagcag ctgtacgact ttggagaagt
     1141 tgtttaacat tttcaagcct cagtttttgc ttttttaaag gaggggaaat atttgcctca
     1201 tgtcataatt gaaaagatta aataagaaat aaagggaagt gtctgctact tagttgccag
     1261 tcaaaatgtt agttctctct ctctaccacc ttcttcctac ctcttcccat attgcttgcc
     1321 tgataaaaca gctaatcacc agcatttgtt ccccatagtc acagggccac acaagggaac
     1381 atttaggaca aactttctcc atggcctatg atccaaattg ttatctaaag atgattctag
     1441 gtgttgctgg tagtatgtga atcttccaat ctaggtgtga tcgtgtcctc atatgaatca
     1501 ggaaaaggca gtttcttaca agttccgaat tccaaataca gagactggtg gtgttacatt
     1561 taaccttaaa gatgttaatg ttgatggaaa ttcatgtttc atattaaaac aacactttgt
     1621 ctttacaatg aaacattttg cttaattttt aaagtaagac attatgatac ctctgatggc
     1681 agttcctcaa ataactttaa cttttgtgct ttagggatag ttgttaaagt tacaacttct
     1741 tttattttat tttttaaagg cttcagatta aacaagagcc cttaagccca cgcatagcat
     1801 tgccgcttca gcttgctgag gactgtctcc aaggaggcca aatggaaaag gagaggctac
     1861 ttcaagtggt gttggcccat tgagcctatt gggcaaacta taaccaggtt gccttatttt
     1921 gggtggatta ctccaggaga ggccaccctc cagctttctc ttatcccagt aactcctctt
     1981 cccattttcc aatccatccc cagccttttt tttttttctt ctgtactctt cttttgcctt
     2041 caatatgagt ttcatttcct ctgtgtcttt gggcagactt ccttctaaca tgtgtcagct
     2101 accctaccac acacctggcc taggagacac atcattcatt gctcctactt gtgtctgtaa
     2161 tcagagagta tttaaggagg gcagttctgc gacggactgt gtgtgtgttg aaagtaaaga
     2221 tggggggccg cggggaaggc aagagttttt ccaaaagatt attagaaatg agggctgtat
     2281 ctactctgtg gagtagaacc aagtctactt ggagaaaaga accaagtcct tggatatcta
     2341 ggggaaagct gtttggcaga aagaaaaatc aagaggaccc aaggggatgg agacaggacc
     2401 acaggaatgg gccaaggagc aacgtgcctg ccattcagcc agcttgggac aggctttcac
     2461 tttcactccc atgaggaggc ttccaggcag cctggttccc ccatgtatag ccattgccct
     2521 ctagcaggcc aggcctccca gtgggaaggc ctgggtccag ggcatcttaa gttcatccag
     2581 cagctccatg agccacacag atatcctaga aaatattcct ttctcacaca gggcttctga
     2641 ttactcagaa acatgcccct cttccctgaa taaccaagaa catgttctat gaacccaatc
     2701 tctgccacat gtcaatacct gctcttcaaa gccccttttg aaactcagtt ttgtgccaag
     2761 tcctctggat ctaattacct taaacaagca gatttagcca tttttaaaca gacattccca
     2821 gtcatcctgg tgcttgtact tctcctacat gtcatgaagg accttggatt tactgagaac
     2881 tcagccgtgg ccttggcttt gatacttata ggtgtcagcc cttgggccga ttgttgatca
     2941 tccagagcct cagttctgta cttgtaaagt ggagacagca gttctcatcc tccatccttt
     3001 tagcccatgg ggtggttgta aggctggatt gaaatatgca tgtgactaag ccatgtagct
     3061 ataaagtgag ggatgacttg tgttttggat cacttatttt aattctactt ataatccacg
     3121 gcttagaata tttaaacatt gtttctatta aactagaaag gttcagcatt tctgtcattt
     3181 acttctgcta tgatacacaa gaacttatgt tggaatgaag tgaaaagtaa aatggccatt
     3241 cttatgaacc ta
//
