LOCUS       NM_025136               7811 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens outer mitochondrial membrane lipid metabolism
            regulator OPA3 (OPA3), transcript variant 2, mRNA.
ACCESSION   NM_025136
VERSION     NM_025136.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7811)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 7811)
  AUTHORS   Gaier,E.D., Sahai,I., Wiggs,J.L., McGeeney,B., Hoffman,J. and
            Peeler,C.E.
  TITLE     Novel homozygous OPA3 mutation in an Afghani family with
            3-methylglutaconic aciduria type III and optic atrophy
  JOURNAL   Ophthalmic Genet 40 (6), 570-573 (2019)
   PUBMED   31928268
  REMARK    GeneRIF: Homozygous OPA3 mutation is associated with
            3-methylglutaconic aciduria type III and optic atrophy.
REFERENCE   3  (bases 1 to 7811)
  AUTHORS   Yang,Z., Zhang,Y., Wang,X., Huang,J., Guo,W., Wei,P., Li,G.,
            Wang,Z., Huang,Z. and Zhang,L.
  TITLE     Putative biomarkers of malignant transformation of sinonasal
            inverted papilloma into squamous cell carcinoma
  JOURNAL   J Int Med Res 47 (6), 2371-2380 (2019)
   PUBMED   30991875
  REMARK    GeneRIF: Low OPA3 expression is associated with squamous cell
            carcinoma in Paranasal Sinus Neoplasms.
REFERENCE   4  (bases 1 to 7811)
  AUTHORS   Chen,J., Xu,K., Zhang,X., Jiang,F., Liu,L., Dong,B., Ren,Y. and
            Li,Y.
  TITLE     Mutation screening of mitochondrial DNA as well as OPA1 and OPA3 in
            a Chinese cohort with suspected hereditary optic atrophy
  JOURNAL   Invest Ophthalmol Vis Sci 55 (10), 6987-6995 (2014)
   PUBMED   25205859
  REMARK    GeneRIF: Mutations of the OPA3 gene can cause either autosomal
            dominant or autosomal recessive optic atrophy.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7811)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
  REMARK    GeneRIF: The mouse ortholog of OPA3 purifies with mitochondrial
            inner membranes.
REFERENCE   6  (bases 1 to 7811)
  AUTHORS   Kleta,R., Skovby,F., Christensen,E., Rosenberg,T., Gahl,W.A. and
            Anikster,Y.
  TITLE     3-Methylglutaconic aciduria type III in a non-Iraqi-Jewish kindred:
            clinical and molecular findings
  JOURNAL   Mol Genet Metab 76 (3), 201-206 (2002)
   PUBMED   12126933
REFERENCE   7  (bases 1 to 7811)
  AUTHORS   Anikster,Y., Kleta,R., Shaag,A., Gahl,W.A. and Elpeleg,O.
  TITLE     Type III 3-methylglutaconic aciduria (optic atrophy plus syndrome,
            or Costeff optic atrophy syndrome): identification of the OPA3 gene
            and its founder mutation in Iraqi Jews
  JOURNAL   Am J Hum Genet 69 (6), 1218-1224 (2001)
   PUBMED   11668429
  REMARK    GeneRIF: type III 3-methylglutaconic aciduria (optic atrophy plus
            syndrome, or Costeff optic atrophy syndrome): identification of the
            OPA3 gene and its founder mutation in Iraqi Jews
REFERENCE   8  (bases 1 to 7811)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   9  (bases 1 to 7811)
  AUTHORS   Nystuen,A., Costeff,H., Elpeleg,O.N., Apter,N., Bonne-Tamir,B.,
            Mohrenweiser,H., Haider,N., Stone,E.M. and Sheffield,V.C.
  TITLE     Iraqi-Jewish kindreds with optic atrophy plus (3-methylglutaconic
            aciduria type 3) demonstrate linkage disequilibrium with the CTG
            repeat in the 3' untranslated region of the myotonic dystrophy
            protein kinase gene
  JOURNAL   Hum Mol Genet 6 (4), 563-569 (1997)
   PUBMED   9097959
REFERENCE   10 (bases 1 to 7811)
  AUTHORS   Anikster,Y.
  TITLE     Costeff Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301646
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB034102.1, BC005059.1,
            AC006261.1 and BU617706.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_025136.3.
            
            Summary: The mouse ortholog of this protein co-purifies with the
            mitochondrial inner membrane. Mutations in this gene have been
            shown to result in 3-methylglutaconic aciduria type III and
            autosomal dominant optic atrophy and cataract. Multiple transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Oct 2009].
            
            Transcript Variant: This variant (2) represents the longer
            transcript but encodes the shorter isoform (b).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138528.1214006.1,
                                           SRR1660805.63227.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142670, SAMEA2154405
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: PMID: 18614015, 12865426;
                                                  reported by MitoCarta
            MANE Ensembl match                 :: ENST00000263275.5/
                                                  ENSP00000263275.4
            RefSeq Select criteria             :: based on manual assertion,
                                                  conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                DB034102.1         63-79
            18-268              BC005059.1         1-251
            269-7368            AC006261.1         20905-28004         c
            7369-7811           BU617706.1         17-459              c
FEATURES             Location/Qualifiers
     source          1..7811
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.32"
     gene            1..7811
                     /gene="OPA3"
                     /gene_synonym="MGA3"
                     /note="outer mitochondrial membrane lipid metabolism
                     regulator OPA3"
                     /db_xref="GeneID:80207"
                     /db_xref="HGNC:HGNC:8142"
                     /db_xref="MIM:606580"
     exon            1..180
                     /gene="OPA3"
                     /gene_synonym="MGA3"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..578
                     /gene="OPA3"
                     /gene_synonym="MGA3"
                     /note="isoform b is encoded by transcript variant 2; optic
                     atrophy 3 protein; Optic atrophy 3 (Iraqi-Jewish 'optic
                     atrophy plus'); optic atrophy 3 (autosomal recessive, with
                     chorea and spastic paraplegia); OPA3 outer mitochondrial
                     membrane lipid metabolism regulator; 3-methylglutaconic
                     aciduria type III"
                     /codon_start=1
                     /product="optic atrophy 3 protein isoform b"
                     /protein_id="NP_079412.1"
                     /db_xref="CCDS:CCDS12668.1"
                     /db_xref="GeneID:80207"
                     /db_xref="HGNC:HGNC:8142"
                     /db_xref="MIM:606580"
                     /translation="MVVGAFPMAKLLYLGIRQVSKPLANRIKEAARRSEFFKTYICLP
                     PAQLYHWVEMRTKMRIMGFRGTVIKPLNEEAAAELGAELLGEATIFIVGGGCLVLEYW
                     RHQAQQRHKEEEQRAAWNALRDEVGHLALALEALQAQVQAAPPQGALEELRTELQEVR
                     AQLCNPGRSASHAVPASKK"
     exon            181..7811
                     /gene="OPA3"
                     /gene_synonym="MGA3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4917..4922
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OPA3"
                     /gene_synonym="MGA3"
                     /note="hexamer: AATAAA"
     regulatory      4929..4934
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OPA3"
                     /gene_synonym="MGA3"
                     /note="hexamer: AATGAA"
     polyA_site      4939
                     /gene="OPA3"
                     /gene_synonym="MGA3"
                     /note="major polyA site"
     polyA_site      4949
                     /gene="OPA3"
                     /gene_synonym="MGA3"
     regulatory      7793..7798
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OPA3"
                     /gene_synonym="MGA3"
                     /note="hexamer: ATTAAA"
     polyA_site      7811
                     /gene="OPA3"
                     /gene_synonym="MGA3"
ORIGIN      
        1 agtcagcaag gttgcgcgtg ccctgtgaga ccgccaagat ggtggtgggc gcgttcccta
       61 tggcgaagct gctatacttg ggcatccggc aggtcagcaa gccgcttgcc aaccgtatta
      121 aggaggccgc ccgccgaagc gagttcttca agacctatat ctgcctcccg ccggctcaac
      181 tgtatcactg ggtggagatg cggaccaaga tgcgcatcat gggcttccgg ggcacggtca
      241 tcaagccgct gaacgaggag gcggcagctg agctgggcgc agagctgctg ggcgaagcca
      301 ccatcttcat cgtgggcggc ggctgcctag tgctggagta ctggcgccac caggcgcagc
      361 agcgccacaa ggaggaggag cagcgtgctg cctggaacgc gctgcgggac gaggtgggcc
      421 acctggcgct ggcgctggaa gcgctgcagg cgcaggtgca ggcggcgccg ccacagggcg
      481 ccctggagga actgcgcaca gagctgcaag aggtgcgcgc ccagctctgc aatcccggcc
      541 ggtccgcttc ccacgcagtg cctgcgtcca agaaatagga gcttgctgga tggaacctga
      601 atttggacat ggcctatgta cctaacgtgg ccttcttccc gcaccaccct tgcctgcgct
      661 ggcccagtgg aaaccaccag gatcttgatg caacttggca tttggttacc cctgctgata
      721 agagcagccg ttacctgcca ctgggaccag caggtgaagc gttgcaacat agccccctcc
      781 atcatccttc acctcctatc ccccactcca aaccaggacg acctgcaagg tcccagccag
      841 caggacaccg tgggcactct ggcaaatgaa aaaatggaac ctggtcttga gctgaatcaa
      901 tgtgttattg ttacccccac ccccggttta cctgatcagt gttaaccttt actgggacac
      961 tcatctgtta cactggaaca ccttcttctt tttgtcaatc ggcacagacc actgtaagga
     1021 aatgcagtgt gttgcagtgg ccttttctcc ccctcacctt ctaaggtcag ctctagctga
     1081 gcatcagtgc tctcttaagg aggaaaaaaa cggtgcggct gggagcggtg gctcacgcct
     1141 gtaatcctag caccttggga ggccgaggcg ggcggatcac ttgaggtcag gagttccaga
     1201 ccagcctggc caacatggtg aaactccgtc tctactaaaa atacaaaaat tagccgggtg
     1261 tggtggggtg cgcttgtaat cccagctact cgggaggctg aggcaggaga attgcttgaa
     1321 cccatgaggt ggaggttgcg gtgagccaag atggcaccat tgcaccctag cctgggcaac
     1381 agagcaagac accgtcttaa aaccaaaagt taaccgggcg tggtggtggg tgcctgtaat
     1441 cctagctact tgggaggctg aggcaggaga attgcttgaa cttgggaggt ggaggccaag
     1501 attgtaccac tgtattccag cccgggtgac agagcaagac tgtgtctcaa aaaaaaaaaa
     1561 aaaatcctgg ctgggcacgg tggctcacac ctgcaatccc agcactttgg aaggtcgagg
     1621 tgggcgggtc atttgaagtc gggaggtcgg gagatcggga gctcgagacc agcctgacca
     1681 atatgatgaa accccgtctc tactaaaaat acataaatta gctgggcatg gtggcatgca
     1741 cctgtaatcc cagctacttg ggaggctgag acaggagaat tgcttgaacc cgggaggcag
     1801 aggttgcagt gagccgagat tgcgcaattg catgccagcc tgggtaacga gcaaaactcc
     1861 atcttaaaaa aacccacaaa aggtcctggc ctgcagtcaa tccctggaat cattgtacct
     1921 tcccttgaga cccgaagtgg actattccaa cagaaccccc tcatccttga gtctatggca
     1981 caacccactg gaatggcact acaggatctt ttctgtgaat gtcctccaac ccccctttcc
     2041 gtggtgggaa atttgatcct aactagggct aatccagcct gtccttcagc ctcagccccc
     2101 tattttcctg tcctcagagt ccctggagct tgtactgtgt ggcatgtcct ttcttgcctt
     2161 ccccaccttg ctcagtagca tttctcaggg acccagtcga atccaagccc atggattcaa
     2221 ttgtcacatc cttcatcttc catccgtgtc tcctaatctg tgtgctcttg ctttctttcc
     2281 tcggagctct ggactgaccc gacagcctgt cttcatgtag cagtaccctc ctgcctccat
     2341 agcccccggt cccaccccca tcctaccaat taggccagca gttggcctta actgcttgat
     2401 taatttcctt ggactgccat aacagatcac cattgggtgg tgaacttgat ggcttaagtc
     2461 caacaggaat ttaattcaca cagttctgga gtccagaagt ctgaaaccaa ggtgctgaca
     2521 gggacacgct ccctcttcca gctcctggtg attccaggcc ttccttggct ctgcctgcag
     2581 cttcacatgg ccttttccct cttctatttt gtctcttaca agaacacctg tcattgcatt
     2641 tagggcccat cttaagttca ggatgatccc acctcaagac ccttaattac atctgaaaaa
     2701 acactttttc caaataaact gtcataagca caggtcctgg gggttagtat gtggacttgt
     2761 ctgttggggg cacaccattc aagccattca gcccactatt cctcctcacc ccaagagtac
     2821 gctggcgtcc aggtgcagtg gctcacacct gtaatcccag cactttggga gaccagggca
     2881 ggagggatct ctttgagccc aggagctgaa gaccagcctg ggcaacatag tgagacccca
     2941 tctctacaaa agtaaaataa aaaattagcc aggtgcggtg atgcatgcct gtagtcccag
     3001 ctacttggga ggctgaggca ggaggatcac ctgagccctg gaggtcgagg ctgcagcgag
     3061 ccgtgatcgc gccactacac tccagcctgg atgacagagt gagacccttt ctcagaaaaa
     3121 aagtaccctg ggactcctgc caaccccgcg ggccatttgg ccttcctgct agctgagagg
     3181 aacagtctag gaaccaccct tttctactgg gtttctcttc caggatctgc cactgaagcg
     3241 ggagggggtg ggtcccagta gcctgcagtc tgtccttccg actgtagctc tctcattaga
     3301 ggagctgcaa ggtgatgaag gcatcctgag gctgtacctg aaccaccatg tggatctcca
     3361 caatgggtac agagcttatt aaaatcagga gggaaactgg gagggttctg atggggagag
     3421 gcccaagagt caccctatga gctggggaaa ctaaggccag gggtaagcaa agggacttgc
     3481 cagagatgcc acagccagtg aggggctgac tgcccagggt ggtgaagtag taggggcaga
     3541 gtgagaggct tggattaccc cagctgcaga gtgaggaggg agaggcgatg gctgagcaga
     3601 ggctgggagg gtgacgatct ctacacagag gcccagacca tcccagaggt ggcgttgata
     3661 gtgggagacc ctctctatcc cctctcagag cagccccaga tcacaccaga gatcatagca
     3721 ttgtgtaaac tgggtgacca ttccacctgg gcccgctttt gggaagctgc aggtgaaagt
     3781 gggagggccg ggctttcccc gacttccatc ctcacctccc ttctctaaag aggtaaaact
     3841 ggcctggacc aagatctgcc cagatagaaa gccaagaaac aggttctgaa acttttcttt
     3901 tcttcttttc tcttcttttt tcttttcttt tctttcggag acagtctagc tccgtcaccc
     3961 tgacggagtg cagtggtgca atctcggctc actgcaactt ctacctccca ggctcaacca
     4021 atgatcctgc ctcagcttcc gaagtagctg ggattacatg tgcccaccac ccacgcctgg
     4081 ctaatttttg tattttagtg gagacggggt ttctccaagt tgcccaggct gatcttgaac
     4141 tcctgacctc aggtaatccg cccgcctcgg cctcccaaag tgctgggatt acaggcgtga
     4201 gccaccgcgc ctggcctgaa acagcatttc agttccttct ggaagagggg gagaagctgg
     4261 agcagaggga actgaccgag tgggtcctga gtgggctgtg tttaaaactg ggagtgaccc
     4321 aggccagctc acgcctgtca tcccagcact ttgagaggcc aaggtggact gatcacatga
     4381 tgttaggaga tcgagaccag cctggccaac atggcaaaac cccgtctcta ctaaaaatac
     4441 aaaaattagc cgggcatgtt ggcacattcc tgaatcccag ctactcggga ggctgaggca
     4501 cgagaattgc ttgaacccag gaggtggagg ttgcagtgag ctgagatcgc gccactgcac
     4561 tccagcctgg gtgacagagt gagactcaac tcaaaaaaaa aaaacagagg tgggagtgtg
     4621 aacacaggca ggagctccaa ttcctgaccc cagcgctgtc ctgacccaga tggagtgctg
     4681 ctctcacatc tcagagactt cgcactcagc cctgccctgc cctgccctga caggcagcca
     4741 gtcatcgtgg gcagcagggc catctacttc ccccactgcg gcgtcagggg tggccagagt
     4801 gtgtggaagt ggaaagaacg tcctctcaaa atgcaagagg ccagaggatg gttcactgct
     4861 cgtgtgttct gctagctaga attctgtgta ccttgtaatt tggggagagg ggttagaata
     4921 aatttgtaaa tgaagctgat tatcttcaag ttgatgcatt cttttttcat atttaaaaag
     4981 tccttgggac tgggcgcagt ggctcacacc tgtaatccta gcactttggg aggccagggt
     5041 gggtggatca cctgaggtca ggagttcaag accaacctga tcaacatggt gaaacctcgt
     5101 ctctactaaa aatacaaaaa ttagctgggc atggtggttg tgcacctgta atcccaccta
     5161 ctcgggaggc tgaggcagga gaatctcttg gacccgggag gcggaggttg cagtgagccg
     5221 agatcatgcc attatactcc agcctgggtg acagagcgag acttcatctc taaataaata
     5281 aataaataaa taaataaata aggtccatgt caaccttagg aaaaatatcc tttatttatt
     5341 ctttcactca aaaaactcac tgaggtggtc ccgcaccggg acatggaccc agtgtccttg
     5401 gtagggcgtc tcccgcaaaa aaaaaaaaaa taaaaaaaat aaaacacaaa actcactgag
     5461 ttacccactc tctgccccac cctatgctgg ggtcacagtg gtgacagaga cagccccagc
     5521 cctgccgtca ccgggtctta cagatgctca cacgtacatt tcttttccag tgttccctgc
     5581 cccaccccat agttgtttag gaagcagggg ctgggctgaa tccggaatcc tccctctgga
     5641 gtgactcagg actataaacc cattcatccc agctcacaaa accctgggag gtgccctgag
     5701 ggctgtgccc ctcccatctc ctggcaggcc ctgctgtccc tcttgttggt ttctctgtag
     5761 ggcaggccat tgcctggagg gaggcaaaat ggctgagagc caccccagga gaaaatgggc
     5821 tttacataag ccccaacctg atctattggc tcacggagct actcctgggc tggtcgctgt
     5881 gttgctgagt ggcaggcttg ggtcccccag tggcaatggc ttgtagctgg agtcggtgtg
     5941 gacagagaga ggagaagcat ggcaactctg agtgtactga ggatcaactg caccaggctc
     6001 cattctagta gctgggagcc agttgggagc aagcagaggc cctcactgga gctgacattc
     6061 tagtgccaga gaccggcaat aaagaaggaa agagtggcca ggcgtggtgg ctcacacctg
     6121 taatctcagc actttgggag gccgaggcgg gccaatcccc tgaggtcggg agttcgagac
     6181 cagcctgacc gacatggaga aaccccatct ctactaaaaa tacaaaatta gcagggcatg
     6241 gtggtgcatg cctgtaatcc cagccactca ggaggctgtg gcaggagaat cgcttgaacc
     6301 cgggaggcgg aggttgcggt gagccaatat tgcaccattg cactccagcc tgggcaacaa
     6361 gaacgagact ccatctcaaa aaaaaaagga aaaagctaat ccagcatagg gtgatgagga
     6421 ctgagaggaa tggaggcagg gtaggagttc cggacttacg ggcaccgctg atctagacag
     6481 gtgggcaggg aggaggcagc gcttcagatg gagggagata ggaagagggc tgtgagtatc
     6541 tgtgaaagtc ctaggacaga tgtggccttg gcctgttcct ggaacagcaa gagtttctgg
     6601 ctgtcagaat agagcagagg ctcgctgacc aaggcctttg ggccaaatca aggggaccct
     6661 tgcttcctgt ctttgtaaat aaagacttat tggaacccag gcgctcattc gtttgcatat
     6721 tttccacagt tgcttttgca gtacagtgac agagctgagt atttgcacag agatcctagg
     6781 gctctcgtac tctctggccc tttacagaaa aagtttacca tcccctggaa tagagtaagc
     6841 gaggggagaa gttaggtgag ggggccaggc aagcaaaggc tgccccttgc cttgattggc
     6901 acaactgtgg aggtcatccc agctctggag ccccaacagg atcactcagg cctctgcttc
     6961 caccacatct ggcttcagct tccccctctg tggagtcctc cctccctccc tccttcccca
     7021 taggaaatga ccccagtgct cagcagtaac ccccactgcg cgcagatctc agaacctcca
     7081 cctcaatcta cagccacgtg ccacaataag aagcagagtt ttaggccagg cgcggtggct
     7141 cacgcctgta atctcagtac tttggaagac caaggtggga ggatcacttg aagtcaggag
     7201 ttcgagacca gcctgcccaa catggtgaag ccccgtctct aataaaaaga atacaaaaat
     7261 tagccgggtg tggtggtgca catctgtaat cccagctaca tgagaggctg acataggaga
     7321 attgcttgag cccaggaggt ggacgttgca gtgagccaag attgcactac tgcattccag
     7381 cctaggtgcc agagtgagac ttggtctcaa aacaaaacaa aacaaaaaat tagccaggca
     7441 tggtggcaca cacctgtagt cccagctact tggggggctg aggcaggagg atcgcttgaa
     7501 cccgggtgtt taaggctgca gtgaactgag atcaggccac agcacctcaa cctgggagac
     7561 aaagtgagac cctgtctcaa aaaaaaaaaa aagcagagtt tatgtaatcc atcgtgtgca
     7621 tatttataca ataatttaca attctatgta ttttaaaagt gtataattca tatattatgt
     7681 gacacaatat ataatggaat ataaaatata tattttatgt catgtgtaac ataacatcat
     7741 ctattatatg tagtgtatgt gcttatgtac atatcattgg aatgaaagtt tcattaaata
     7801 attaccctta a
//
