LOCUS       NM_173801               1499 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens oocyte secreted protein 2 (OOSP2), mRNA.
ACCESSION   NM_173801
VERSION     NM_173801.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1499)
  AUTHORS   Hu,W., Zeng,H., Shi,Y., Zhou,C., Huang,J., Jia,L., Xu,S., Feng,X.,
            Zeng,Y., Xiong,T., Huang,W., Sun,P., Chang,Y., Li,T., Fang,C.,
            Wu,K., Cai,L., Ni,W., Li,Y., Yang,Z., Zhang,Q.C., Chian,R.,
            Chen,Z., Liang,X. and Kee,K.
  TITLE     Single-cell transcriptome and translatome dual-omics reveals
            potential mechanisms of human oocyte maturation
  JOURNAL   Nat Commun 13 (1), 5114 (2022)
   PUBMED   36042231
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1499)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1499)
  AUTHORS   Abbasi,F., Kodani,M., Emori,C., Kiyozumi,D., Mori,M., Fujihara,Y.
            and Ikawa,M.
  TITLE     CRISPR/Cas9-Mediated Genome Editing Reveals Oosp Family Genes are
            Dispensable for Female Fertility in Mice
  JOURNAL   Cells 9 (4), 821 (2020)
   PUBMED   32231122
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1499)
  AUTHORS   Pineau,C., Hikmet,F., Zhang,C., Oksvold,P., Chen,S., Fagerberg,L.,
            Uhlen,M. and Lindskog,C.
  TITLE     Cell Type-Specific Expression of Testis Elevated Genes Based on
            Transcriptomics and Antibody-Based Proteomics
  JOURNAL   J Proteome Res 18 (12), 4215-4230 (2019)
   PUBMED   31429579
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC036256.1 and BC048121.1.
            
            On Nov 22, 2018 this sequence version replaced NM_173801.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC048121.1, SRR5189667.118184.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000278855.7/ ENSP00000278855.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1487              BC036256.1         1-1487
            1488-1499           BC048121.1         1622-1633
FEATURES             Location/Qualifiers
     source          1..1499
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.1"
     gene            1..1499
                     /gene="OOSP2"
                     /gene_synonym="OOSP2A; PLAC1L; TMEM122"
                     /note="oocyte secreted protein 2"
                     /db_xref="GeneID:219990"
                     /db_xref="HGNC:HGNC:26699"
                     /db_xref="MIM:620263"
     exon            1..115
                     /gene="OOSP2"
                     /gene_synonym="OOSP2A; PLAC1L; TMEM122"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..528
                     /gene="OOSP2"
                     /gene_synonym="OOSP2A; PLAC1L; TMEM122"
                     /note="transmembrane protein 122; placenta-specific 1-like
                     protein; testicular tissue protein Li 142"
                     /codon_start=1
                     /product="oocyte-secreted protein 2 precursor"
                     /protein_id="NP_776162.2"
                     /db_xref="CCDS:CCDS7979.1"
                     /db_xref="GeneID:219990"
                     /db_xref="HGNC:HGNC:26699"
                     /db_xref="MIM:620263"
                     /translation="MALEVLMLLAVLIWTGAENLHVKISCSLDWLMVSVIPVAESRNL
                     YIFADELHLGMGCPANRIHTYVYEFIYLVRDCGIRTRVVSEETLLFQTELYFTPRNID
                     HDPQEIHLECSTSRKSVWLTPVSTENEIKLDPSPFIADFQTTAEELGLLSSSPNLL"
     exon            116..294
                     /gene="OOSP2"
                     /gene_synonym="OOSP2A; PLAC1L; TMEM122"
                     /inference="alignment:Splign:2.1.0"
     exon            295..398
                     /gene="OOSP2"
                     /gene_synonym="OOSP2A; PLAC1L; TMEM122"
                     /inference="alignment:Splign:2.1.0"
     exon            399..1499
                     /gene="OOSP2"
                     /gene_synonym="OOSP2A; PLAC1L; TMEM122"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1239..1244
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OOSP2"
                     /gene_synonym="OOSP2A; PLAC1L; TMEM122"
                     /note="hexamer: ATTAAA"
     polyA_site      1264
                     /gene="OOSP2"
                     /gene_synonym="OOSP2A; PLAC1L; TMEM122"
                     /note="major polyA site"
     regulatory      1468..1473
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OOSP2"
                     /gene_synonym="OOSP2A; PLAC1L; TMEM122"
                     /note="hexamer: ATTAAA"
     polyA_site      1499
                     /gene="OOSP2"
                     /gene_synonym="OOSP2A; PLAC1L; TMEM122"
                     /note="major polyA site"
ORIGIN      
        1 cttgtttcct gagttgtcct gtgctggagg tctgctcaga cgaaggtctc catggcgtta
       61 gaagtcttga tgctcctcgc tgtcttgatt tggaccggtg ctgagaacct ccatgtgaaa
      121 ataagttgct ctctggactg gttgatggtc tcagttatcc cagttgcaga aagcagaaat
      181 ctgtatatat ttgcggatga attacatctg ggaatgggct gccctgcaaa tcggatacat
      241 acatatgtat atgagtttat atatcttgtt cgtgattgtg gcatcaggac aagggtagtt
      301 tctgaggaaa ctctcctttt tcaaaccgag ctgtacttta ccccaaggaa tatagatcat
      361 gaccctcagg aaatccattt ggagtgttcc acctctagga aatcagtgtg gcttacacca
      421 gtttctactg agaatgaaat aaaattggat cctagtcctt ttattgctga ctttcagaca
      481 acagcagaag agttaggatt attatcttct agtccaaact tgctctgagc taaaggagaa
      541 atggaaactt gaagctggtg ttatgtattt tgcaggaaaa cagtttcatt ttttcatagc
      601 aaaaatatag ttggtgtata tctctcctta agtctctggt ttctaaaaac cctacttcag
      661 taaaggtcct gattagttga ttagtgaatg tgtatttcta aatatttgta ttcagtaggg
      721 gtatggctga ttaatttaac attaactatt aggtaattca tattatacat ttaagttctt
      781 tctgttctgt gtagaagatt cagaaatatg tcttcaaaga caatgacttg atctaattga
      841 taagaacctc caataaatat gttctaatat ttttcaggaa gaataaagaa tagagagaga
      901 catataaatg tgcaagaggc aaaactttga gcatagtgta aaatttaaca tattaactct
      961 cacgaaaggc aaaatccttt tatgtgcaga tactttaatt catgtagatt ttcctattaa
     1021 tcagtaaagt tgaatcctaa caataatgcc atgtgacaac ctatttagat tattccagaa
     1081 ttaaattcaa tttattttct agagctcaag taaccactac cttaactgaa atttgatgtt
     1141 aggtttccct tgttcctccg aatggttctt ccacactcaa aataattgaa tggttgagtt
     1201 ggttaagcaa agagttatcc tgccacctaa gagcattcat taaatgatta tttattacca
     1261 cctactttat actatcttcc tttctttaaa catggagtct aaatatgtaa tatatcaaaa
     1321 aatacttctg atttggtaga tttcttatat caagggtgag aattgaactg tgccattggc
     1381 tattcaatag cttattgaat gtatgttttg gatgccacat cctcctggaa gcaaattttg
     1441 ccaagatact gtttattatt atttttaatt aaagtgatac tattccattt tcaattaaa
//
