LOCUS       NM_001080488            7185 bp    mRNA    linear   PRI 07-MAY-2024
DEFINITION  Homo sapiens one cut homeobox 3 (ONECUT3), mRNA.
ACCESSION   NM_001080488 XM_372702
VERSION     NM_001080488.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7185)
  AUTHORS   Luo,Y., Feng,X., Lang,W., Xu,W., Wang,W., Mei,C., Ye,L., Zhu,S.,
            Wang,L., Zhou,X., Zeng,H., Ma,L., Ren,Y., Jin,J., Xu,R., Huang,G.
            and Tong,H.
  TITLE     Ectopic expression of the transcription factor ONECUT3 drives a
            complex karyotype in myelodysplastic syndromes
  JOURNAL   J Clin Invest 134 (8), e172468 (2024)
   PUBMED   38386414
  REMARK    GeneRIF: Ectopic expression of the transcription factor ONECUT3
            drives a complex karyotype in myelodysplastic syndromes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7185)
  AUTHORS   Shi,H., Tsang,Y., Yang,Y. and Chin,H.L.
  TITLE     Identification of ONECUT3 as a stemness-related transcription
            factor regulating NK cell-mediated immune evasion in pancreatic
            cancer
  JOURNAL   Sci Rep 13 (1), 18133 (2023)
   PUBMED   37875589
  REMARK    GeneRIF: Identification of ONECUT3 as a stemness-related
            transcription factor regulating NK cell-mediated immune evasion in
            pancreatic cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7185)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 7185)
  AUTHORS   van der Raadt,J., van Gestel,S.H.C., Nadif Kasri,N. and Albers,C.A.
  TITLE     ONECUT transcription factors induce neuronal characteristics and
            remodel chromatin accessibility
  JOURNAL   Nucleic Acids Res 47 (11), 5587-5602 (2019)
   PUBMED   31049588
  REMARK    GeneRIF: Data show that chromatin regions that contain the ONECUT
            motif were in- or lowly accessible in fibroblasts and became
            accessible after the overexpression of ONECUT1, ONECUT2 or ONECUT3.
REFERENCE   5  (bases 1 to 7185)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   6  (bases 1 to 7185)
  AUTHORS   Lee,C.C., Kuo,W.H., Lin,C.K., Gao,H.W. and Tsai,W.C.
  TITLE     Discrimination of CD44 and Oct3/4 Expression in Pancreatic
            Adenocarcinoma from Benign Pancreatic Ducts in Small Biopsy
            Specimens
  JOURNAL   Chin J Physiol 60 (2), 81-88 (2017)
   PUBMED   28464601
  REMARK    GeneRIF: In conclusion, CD44 and Oct3/4 overexpression may imply
            malignant transformation of pancreatic ducts and could help
            pathologists make a more accurate diagnosis and decision on clear
            surgical margins.
REFERENCE   7  (bases 1 to 7185)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   8  (bases 1 to 7185)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
REFERENCE   9  (bases 1 to 7185)
  AUTHORS   Vanhorenbeeck,V., Jacquemin,P., Lemaigre,F.P. and Rousseau,G.G.
  TITLE     OC-3, a novel mammalian member of the ONECUT class of transcription
            factors
  JOURNAL   Biochem Biophys Res Commun 292 (4), 848-854 (2002)
   PUBMED   11944891
REFERENCE   10 (bases 1 to 7185)
  AUTHORS   Jacquemin,P., Lannoy,V.J., Rousseau,G.G. and Lemaigre,F.P.
  TITLE     OC-2, a novel mammalian member of the ONECUT class of homeodomain
            transcription factors whose function in liver partially overlaps
            with that of hepatocyte nuclear factor-6
  JOURNAL   J Biol Chem 274 (5), 2665-2671 (1999)
   PUBMED   9915796
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005256.2 and AC004755.2.
            
            On May 17, 2019 this sequence version replaced NM_001080488.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2142586,
                              SAMEA2146982 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000382349.5/ ENSP00000371786.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1349              AC005256.2         25508-26856
            1350-7185           AC004755.2         8235-14070
FEATURES             Location/Qualifiers
     source          1..7185
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..7185
                     /gene="ONECUT3"
                     /gene_synonym="OC3"
                     /note="one cut homeobox 3"
                     /db_xref="GeneID:390874"
                     /db_xref="HGNC:HGNC:13399"
                     /db_xref="MIM:611294"
     exon            1..1349
                     /gene="ONECUT3"
                     /gene_synonym="OC3"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..1642
                     /gene="ONECUT3"
                     /gene_synonym="OC3"
                     /note="OC-3; transcription factor ONECUT-3"
                     /codon_start=1
                     /product="one cut domain family member 3"
                     /protein_id="NP_001073957.1"
                     /db_xref="CCDS:CCDS45900.1"
                     /db_xref="GeneID:390874"
                     /db_xref="HGNC:HGNC:13399"
                     /db_xref="MIM:611294"
                     /translation="MELSLESLGGLHSVAHAQAGELLSPGHARSAAAQHRGLVAPGRP
                     GLVAGMASLLDGGGGGGGGGAGGAGGAGSAGGGADFRGELAGPLHPAMGMACEAPGLG
                     GTYTTLTPLQHLPPLAAVADKFHQHAAAAAVAGAHGGHPHAHPHPAAAPPPPPPPQRL
                     AASVSGSFTLMRDERAALASVGHLYGPYGKELPAMGSPLSPLPNALPPALHGAPQPPP
                     PPPPPPLAAYGPPGHLAGDKLLPPAAFEPHAALLGRAEDALARGLPGGGGGTGSGGAG
                     SGSAAGLLAPLGGLAAAGAHGPHGGGGGPGGSGGGPSAGAAAEEINTKEVAQRITAEL
                     KRYSIPQAIFAQRILCRSQGTLSDLLRNPKPWSKLKSGRETFRRMWKWLQEPEFQRMS
                     ALRLAACKRKEQEQQKERALQPKKQRLVFTDLQRRTLIAIFKENKRPSKEMQVTISQQ
                     LGLELNTVSNFFMNARRRCMNRWAEEPSTAPGGPAGATATFSKA"
     exon            1350..7185
                     /gene="ONECUT3"
                     /gene_synonym="OC3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5348..5353
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ONECUT3"
                     /gene_synonym="OC3"
                     /note="hexamer: ATTAAA"
     polyA_site      5369
                     /gene="ONECUT3"
                     /gene_synonym="OC3"
                     /note="major polyA site"
ORIGIN      
        1 acatcctggt ggccgcgctc gcagccgggc cgggccgtgc gccgcgcagc ctggcagcct
       61 cgcgcgcagc caccggggag cgggcgggag tcatgcagcg gccttgagca ctaggggccg
      121 gcgctgagga gcgcgcgcgg cgggagggca gccgagcatg gagctgagcc tggagagcct
      181 ggggggcctg cacagcgtgg cccacgcgca ggcgggcgag ctgctgagcc cgggccacgc
      241 gcgctcggcg gcggcgcagc accgcggcct ggtggcgccc gggcgcccgg gcctggtggc
      301 cggcatggcg agcctgctgg acggcggcgg cggcggcggc ggtgggggcg ccgggggcgc
      361 gggcggcgcg ggcagcgcgg gcggcggcgc ggacttccgc ggggaactgg cgggcccgct
      421 gcacccggca atgggcatgg cctgcgaggc gccgggcctg ggcggcacct acacgacgct
      481 cacgcccctg cagcacctgc cgccgctcgc ggccgtggcc gacaagttcc accagcacgc
      541 ggcggccgcg gccgtggccg gggcgcacgg cggccatccc cacgcgcacc cgcacccggc
      601 ggccgcgccg cccccgccac ccccgccgca gcgtctggcg gccagcgtga gcggcagctt
      661 caccctcatg cgcgacgagc gggcggcgct cgcctccgtg ggccacctct acggacccta
      721 cggcaaggag ctgcccgcca tggggtcgcc gctgtcgccg ctgcccaacg cgctgccgcc
      781 cgcgctgcac ggcgccccgc agcccccgcc gccgccacca cccccgccgc tggccgccta
      841 cggcccgcca ggccacctgg ctggggacaa gctgctgccg cccgccgcct tcgagccgca
      901 cgccgcgctg ctgggacgcg cggaggacgc actggcccgc gggctgcccg gaggcggcgg
      961 cggcacaggc agcggcggag cgggcagcgg gagcgccgcg gggctgctgg cgccgctggg
     1021 cgggctggcg gcggccgggg cgcacgggcc gcacggggga ggcggcggcc ccggcgggag
     1081 cggcggcggc cccagcgcgg gcgcagcggc cgaggagatc aacaccaagg aggtggcgca
     1141 gcgcatcacg gcggagctga agcgctacag catcccgcag gcaatcttcg cgcagcggat
     1201 cctgtgtcgc tctcagggca cgctctccga cctgctgcgc aaccccaagc cgtggagcaa
     1261 gctcaaatcc ggccgcgaga ccttccgcag gatgtggaag tggctgcagg agccagagtt
     1321 ccagcgcatg tcggcgctgc gcttggcagc ctgcaagcgc aaggaacagg agcagcagaa
     1381 ggagcgcgcc ctgcagccca agaagcagcg cctggtgttc accgacctgc agcgacgcac
     1441 gctgatcgcc atcttcaagg agaacaagcg gccgtccaag gagatgcagg tcaccatctc
     1501 gcagcagctc ggcttggagc tcaacaccgt cagcaacttc ttcatgaacg cgcggcgccg
     1561 ctgcatgaac cgctgggctg aggagcccag cacggccccc gggggccccg ccggcgccac
     1621 ggccactttc tccaaggcct gaggcgcccc ggccccgcgc cctccctgcc tccacggcct
     1681 gggcgctgtg cccccacgtc acctccccac atcctgccgg cccggagacc cgcccccagg
     1741 gggcacctgg agggggtgct atccgggccc cccacacccg gggaggggga agcagcacac
     1801 cccccagccc aagtgcacaa aaagggcccc ccttcctccc tccatgccca ctccctccag
     1861 gccaaaggaa gccctccacc cccccccgga ggggagggag tgacagaaag gggtttccca
     1921 gccccctctc cattcaggac gcccagaggg cctcgagaaa aaccagggct cactgtgttg
     1981 tcccctaaag cgggtcaaga agcacatact agaaatataa accgggtatt taaaaatgga
     2041 attttaaaga ataacccctc ctccgtcaga tcccctgccc caccgaggga ggtagtagaa
     2101 aacttccttc ctccccaccc gccccggccc cctccccagg gacctcagcc ctttccaaag
     2161 tcgccaaaaa cccacatcaa gccggatcct tacggtcccc caccctctcc aaaaccaacc
     2221 ccacccgctg gcaggacggc ccctgcggcc gagaactgag ctgcccctct ctgcggccag
     2281 gattcctcgt gccaagaatc gcctgcctta aagtctgggg aggggcctgc ggcgggcgcc
     2341 cagcacctac gggcgagcac ccttcccacc ccatcccagg ccgcagggga cggggggctc
     2401 ccacgtgcgg gtaaattcca gacgcccccg ccccgccccg tctgttgagt tcactttacc
     2461 tttaggcacc ttcgtggagc gcaaggaagg acgcagctcc ggacacggga gaccacgccc
     2521 aggctcccag gagaagggga cccggccgga gaaggcgccg ctggggccgc ccggaggagc
     2581 ccctctgcac gggcccgtgg agacgcttcc tgcgtggaac cttctggaat ccaccgcccc
     2641 cctttccgcc cgcgtcaggg tctgaactgg gcttgcaggg gggcagcggg gttgaacgtg
     2701 gtgttggttt ccactctcgc caaagagaga agacgccgag gaaggtggat tccgcttgct
     2761 ccattttttg ccaaaaatat ttacaaatgg gaagggtcgg aaatgaagat gagcgccccc
     2821 ctcccacccc gcgctctccc ccgctcctct catctggtct gggtgacctc cgagactggc
     2881 cggccgcggg atcccaggag cccgcctcct ccgggggttc aagatccgag tctagaagga
     2941 acctcctccc tgaaatcccc ccactcatcg gctgcctccc agggaggagg cggcccccct
     3001 accccccttg aaaatgcaaa agacatttct agtgaaatgc ccctcccctc ccccaggtaa
     3061 aggctacctc actcaagctc atgtctgtga ttggaaaatc acgcctgata ccaaagattt
     3121 ctcccaagga tttgtgctgg atgacaggat tccctggcct gggacccggc tcggggcccc
     3181 gcctgccgag tgccacccct tcccgaacct gagagcgaaa gagagagaga gagagaggga
     3241 gagagaggga gagaaaggga gagagggagg gagaggatcg tgaggtcgaa gagtgccttc
     3301 ttcttgaacc aaagacgtgt atggagtgtt ctcttgtcct tatcgacttg ctctgctccc
     3361 agctttccaa gcgaccggat ctgagtgatg cttctagaac atttgggtgt tggggggttc
     3421 ccaatagtag aaagggtccc cattcctgct cagcaccgca cctctctacc cccccacaga
     3481 cacacatgca gacacacaca tgcagacaac acgcagacac acacatgcag gcactcacat
     3541 gcaggcccat gcacacacac gtgcacacac atgcagagac atgcagacac gcaggcacac
     3601 atgcacacat gcaaagacac gcatgcaggc acacgcagac gcacacagag acacacatgc
     3661 agatacacat gcacacacac atacacacac tggcccctgt ttttctgtgg tgtcactggg
     3721 tgccagcaac tcggtatctc ccacctccca ctaaaacctg ggccttaatt tctctcccgt
     3781 ccccacccct aaattcctga tggatgaacc tagagctgtc ctgtccactc caggccggac
     3841 tgacgtagcc tatgggccca gcaggtccag ggcccacgtt ttaatttctt tttaaaaagc
     3901 tttaggtctt gccgggcgcg gtggttcacg cctggaatcc cagcattttg ggaggccgag
     3961 gcgggtggat cacaaggtca gcagttcaag accagcctga ccaacatggt gaaaccctgt
     4021 ctctactaaa aatacaaaaa aattagctgg gcgaggtggc aggcacctgt aatcccagcc
     4081 acctgggagg ctgaggcagg agaatctctt gaaactggaa ggcagaggtt gcagtgagcc
     4141 gagattgcgc cactacactc tagcctgggc aacgagagca aaactccctc tcaaaaaaaa
     4201 aaaaaaaaaa aaaaacttta ggtccaagaa gatgcacccc attcaacata ccatattatt
     4261 tgtctttata ccaaggtagc ctatagatat acaatgtttt aaatttcttt tttagaaaca
     4321 gggttttgct ctgttaccca ggctggagtg cagtggtgca atcgtagctc actgcagcct
     4381 cgaccacctg ggctcaagtg atcctcctgc ctcagcctcc cagtagctgg ggccacaagc
     4441 acaccccacc atgcccattt aattttttaa gggatttctt gtagatatgg ggtctcacta
     4501 tgctgcccag gctggtcttg aactcctggc cccaaggggg tcctcctgcc tcggcctcca
     4561 aaagtgctag gattacaggt agatagacat ttagtggagg aagaggctct caaaggcaat
     4621 aaaatgcttc tgatccaaga gaatcacgct gcagccctgg cccagtgagc ttcttagaaa
     4681 atcgatgcct gggcttcagg cactggccgg agcacgggcc tggcggggtg ctgggtctcc
     4741 tagatgccct ctgcttggcc ttcaaggccc caagggtaac acgctagggg gcctccagtt
     4801 ttgtcccctg ctggaaattt aggacttggc ttgggatcgt tctggttgtg gaatgtttta
     4861 gctatgctga actgtggtca gatcaggtca agcctcttgg tcacagaagt ggcccagcag
     4921 cactttggga ggccgagaca ggaggatcgc ttgaggccag gagtttgaga ccagcctggg
     4981 caacacagca agaccccact tctacaaaaa aaaataaata aagtggccca ggactcctgg
     5041 atccttttca gatatcttcg tatcacacac acacacacac acacacacac acacacacac
     5101 acacacacac ccctacctgt ttccggaccc caccccaaac ttggccagac ccccacagaa
     5161 ggctctatcc ccgacctgcc cgccggcccc tcaggccctc tcctgcctcc ccgcatgccc
     5221 acttggctgt cacataccaa agagcatgcg ttctccatgc agggatcaac acctccagca
     5281 caattccttc gagcctttga caattttctc tgaaatacct caaaatattt aatgtatagt
     5341 ttatgtgatt aaaaaaaaat ccttagctag tttttggaat acgtgacttg aagctttata
     5401 ccgttaaatt ataattttgc agacgatggc atgtcgtttc tttgacgagt tccgtgggag
     5461 acgcattgaa tgtcagggct ggagaccaga gggaaagtta gagggagcgt gatcgcgaga
     5521 gagactgcgg cagaaaggac cagtggcgtt tacagatttc ttatttaaat gagtccttta
     5581 ggaaagaaag gaagagagag agagagcgag cgcaagagag agagagaggg agagagaggg
     5641 agagggagag agagaggcag aggtatacct ttctgttctc tggcttgttc tgtttcttgt
     5701 tttctggagt catgtcttat aagagtattt attattctct gtgttctgtg ttcaaatgta
     5761 atttaagaaa aaaaaaggaa gaaaaatgca aaaaaaaaag acaaaatgga atttgagttg
     5821 gtgcatgact aatgtactct ttcttgacgc taattgtaat aaagtggtca gggtgggggg
     5881 cggggggcgt ggcccggttc cgtgtcgcat ctgtgtgtct ggtgcctgat cggtgctgtt
     5941 cagtggtttt tcgttactgt ttctttcctc ctttctaagg aactgtgtcc agccgggaca
     6001 ggtggacggg gccccaggta gagggggcgg gaacagagcc tcagtagccg ggtctcctcc
     6061 acctgcctgt ccatctccac ccgagatgcc acctgcctgc cccagccagg cgggagccac
     6121 cgagcgtccc cccctcagtt cctggttctt gggggcactc tggtgtcatc gatatcttag
     6181 acccccccaa ccccccatca cccggttgct ttcactctag catgaattcc caagtgtctt
     6241 gttcagagga gacagacaat cagcctattc ttgtcttgtt gcccagggtg gtgggggacg
     6301 ggagtgtgcc ccaacttcct gagatctgaa ggaccctcct gagggcccca acagcaggca
     6361 ccagcacccc ctcccccccc acctccaccc agacagcctc ggcctccctc cctgggctgg
     6421 gcatgagtcc gcctttctgt ccagcccggg aggcaggggg tgtacgcctg cagagacccc
     6481 tccctcccag cccactttcg gagcctacag aacagaggac tccccaaaat catcaaaggg
     6541 ggctctggga caatgtcctc tgcctctgac tcctcttgtg ccatgaggcc acgtccctga
     6601 gccatcccca gatagtccct ggaggtggaa aggggcacag atgtgccagc ttgggaacag
     6661 aggctggagg agagggcggc aggggagaga tgagaggggc cgcttttggg acaggcccca
     6721 gtaggggggg gcggggtagc taaacggggt gcttctcacc ccataaagca gcaagccctg
     6781 gtctggaggg ctgggcctgg ggctgagggc tcagctgacc tcaaatctga aatgatgccg
     6841 gggccaggat gctccttgca ccagcaggag cttgggccat ttcacattct ctgccccaag
     6901 cggtttaagc aaaatcaggc cagtagactc ctggggctcc tcctcgtggc cctgtcagac
     6961 cacgcagggg ctggttttgg tggaatgagc tcagccgggg gtgacggaag agccaggagg
     7021 ccctgcggcc ttgagtgttt tgaatagact ggaactgagg gctgctttca ggggagacac
     7081 cacttggacc ctccaaagtc ccctcccctc cagggacagg ggagagaagc ccttttccac
     7141 cttcaccctt gggcgacagg cttaaaagct aaaaaaaaaa aaaaa
//
