LOCUS       NM_004498               4352 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens one cut homeobox 1 (ONECUT1), transcript variant 1,
            mRNA.
ACCESSION   NM_004498
VERSION     NM_004498.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4352)
  AUTHORS   Prudente,S., Andreozzi,F., Mercuri,L., Alberico,F., Di
            Giamberardino,A., Mannino,G.C., Ludovico,O., Piscitelli,P., Di
            Paola,R., Morano,S., Penno,G., Carella,M., De Cosmo,S.,
            Trischitta,V. and Barbetti,F.
  TITLE     Contribution of ONECUT1 variants to different forms of
            non-autoimmune diabetes mellitus in Italian patients
  JOURNAL   Acta Diabetol 59 (8), 1113-1116 (2022)
   PUBMED   35482136
  REMARK    GeneRIF: Contribution of ONECUT1 variants to different forms of
            non-autoimmune diabetes mellitus in Italian patients.
REFERENCE   2  (bases 1 to 4352)
  AUTHORS   Heller,S., Li,Z., Lin,Q., Geusz,R., Breunig,M., Hohwieler,M.,
            Zhang,X., Nair,G.G., Seufferlein,T., Hebrok,M., Sander,M.,
            Julier,C., Kleger,A. and Costa,I.G.
  TITLE     Transcriptional changes and the role of ONECUT1 in hPSC pancreatic
            differentiation
  JOURNAL   Commun Biol 4 (1), 1298 (2021)
   PUBMED   34789845
  REMARK    GeneRIF: Transcriptional changes and the role of ONECUT1 in hPSC
            pancreatic differentiation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4352)
  AUTHORS   Philippi,A., Heller,S., Costa,I.G., Senee,V., Breunig,M., Li,Z.,
            Kwon,G., Russell,R., Illing,A., Lin,Q., Hohwieler,M., Degavre,A.,
            Zalloua,P., Liebau,S., Schuster,M., Krumm,J., Zhang,X., Geusz,R.,
            Benthuysen,J.R., Wang,A., Chiou,J., Gaulton,K., Neubauer,H.,
            Simon,E., Klein,T., Wagner,M., Nair,G., Besse,C.,
            Dandine-Roulland,C., Olaso,R., Deleuze,J.F., Kuster,B., Hebrok,M.,
            Seufferlein,T., Sander,M., Boehm,B.O., Oswald,F., Nicolino,M.,
            Julier,C. and Kleger,A.
  TITLE     Mutations and variants of ONECUT1 in diabetes
  JOURNAL   Nat Med 27 (11), 1928-1940 (2021)
   PUBMED   34663987
  REMARK    GeneRIF: Mutations and variants of ONECUT1 in diabetes.
REFERENCE   4  (bases 1 to 4352)
  AUTHORS   van der Raadt,J., van Gestel,S.H.C., Nadif Kasri,N. and Albers,C.A.
  TITLE     ONECUT transcription factors induce neuronal characteristics and
            remodel chromatin accessibility
  JOURNAL   Nucleic Acids Res 47 (11), 5587-5602 (2019)
   PUBMED   31049588
  REMARK    GeneRIF: Data show that chromatin regions that contain the ONECUT
            motif were in- or lowly accessible in fibroblasts and became
            accessible after the overexpression of ONECUT1, ONECUT2 or ONECUT3.
REFERENCE   5  (bases 1 to 4352)
  AUTHORS   Burglin,T.R. and Affolter,M.
  TITLE     Homeodomain proteins: an update
  JOURNAL   Chromosoma 125 (3), 497-521 (2016)
   PUBMED   26464018
  REMARK    Review article
REFERENCE   6  (bases 1 to 4352)
  AUTHORS   Pierreux,C.E., Stafford,J., Demonte,D., Scott,D.K., Vandenhaute,J.,
            O'Brien,R.M., Granner,D.K., Rousseau,G.G. and Lemaigre,F.P.
  TITLE     Antiglucocorticoid activity of hepatocyte nuclear factor-6
  JOURNAL   Proc Natl Acad Sci U S A 96 (16), 8961-8966 (1999)
   PUBMED   10430878
REFERENCE   7  (bases 1 to 4352)
  AUTHORS   Jacquemin,P., Lannoy,V.J., Rousseau,G.G. and Lemaigre,F.P.
  TITLE     OC-2, a novel mammalian member of the ONECUT class of homeodomain
            transcription factors whose function in liver partially overlaps
            with that of hepatocyte nuclear factor-6
  JOURNAL   J Biol Chem 274 (5), 2665-2671 (1999)
   PUBMED   9915796
REFERENCE   8  (bases 1 to 4352)
  AUTHORS   Vaisse,C., Kim,J., Espinosa,R. 3rd, Le Beau,M.M. and Stoffel,M.
  TITLE     Pancreatic islet expression studies and polymorphic DNA markers in
            the genes encoding hepatocyte nuclear factor-3alpha, -3beta,
            -3gamma, -4gamma, and -6
  JOURNAL   Diabetes 46 (8), 1364-1367 (1997)
   PUBMED   9231664
REFERENCE   9  (bases 1 to 4352)
  AUTHORS   Samadani,U. and Costa,R.H.
  TITLE     The transcriptional activator hepatocyte nuclear factor 6 regulates
            liver gene expression
  JOURNAL   Mol Cell Biol 16 (11), 6273-6284 (1996)
   PUBMED   8887657
REFERENCE   10 (bases 1 to 4352)
  AUTHORS   Lemaigre,F.P., Durviaux,S.M., Truong,O., Lannoy,V.J., Hsuan,J.J.
            and Rousseau,G.G.
  TITLE     Hepatocyte nuclear factor 6, a transcription factor that contains a
            novel type of homeodomain and a single cut domain
  JOURNAL   Proc Natl Acad Sci U S A 93 (18), 9460-9464 (1996)
   PUBMED   8790352
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC016044.11, U96173.1,
            AA699732.1 and BM679470.1.
            
            On May 17, 2019 this sequence version replaced NM_004498.3.
            
            Summary: This gene encodes a member of the Cut homeobox family of
            transcription factors. Expression of the encoded protein is
            enriched in the liver, where it stimulates transcription of
            liver-expressed genes, and antagonizes glucocorticoid-stimulated
            gene transcription. This gene may influence a variety of cellular
            processes including glucose metabolism, cell cycle regulation, and
            it may also be associated with cancer. Alternative splicing results
            in multiple transcript variants. [provided by RefSeq, Dec 2012].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the functional protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U96173.1, BC140830.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145122
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000305901.7/ ENSP00000302630.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-324               AC016044.11        64152-64475         c
            325-2249            U96173.1           1-1925
            2250-2442           AA699732.1         1-193               c
            2443-4351           AC016044.11        29193-31101         c
            4352-4352           BM679470.1         15-15               c
FEATURES             Location/Qualifiers
     source          1..4352
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q21.3"
     gene            1..4352
                     /gene="ONECUT1"
                     /gene_synonym="HNF-6; HNF6; HNF6A"
                     /note="one cut homeobox 1"
                     /db_xref="GeneID:3175"
                     /db_xref="HGNC:HGNC:8138"
                     /db_xref="MIM:604164"
     exon            1..1557
                     /gene="ONECUT1"
                     /gene_synonym="HNF-6; HNF6; HNF6A"
                     /inference="alignment:Splign:2.1.0"
     CDS             453..1850
                     /gene="ONECUT1"
                     /gene_synonym="HNF-6; HNF6; HNF6A"
                     /note="hepatocyte nuclear factor 6, alpha; one cut domain
                     family member 1"
                     /codon_start=1
                     /product="hepatocyte nuclear factor 6"
                     /protein_id="NP_004489.1"
                     /db_xref="CCDS:CCDS10150.1"
                     /db_xref="GeneID:3175"
                     /db_xref="HGNC:HGNC:8138"
                     /db_xref="MIM:604164"
                     /translation="MNAQLTMEAIGELHGVSHEPVPAPADLLGGSPHARSSVAHRGSH
                     LPPAHPRSMGMASLLDGGSGGGDYHHHHRAPEHSLAGPLHPTMTMACETPPGMSMPTT
                     YTTLTPLQPLPPISTVSDKFPHHHHHHHHHHHPHHHQRLAGNVSGSFTLMRDERGLAS
                     MNNLYTPYHKDVAGMGQSLSPLSSSGLGSIHNSQQGLPHYAHPGAAMPTDKMLTPNGF
                     EAHHPAMLGRHGEQHLTPTSAGMVPINGLPPHHPHAHLNAQGHGQLLGTAREPNPSVT
                     GAQVSNGSNSGQMEEINTKEVAQRITTELKRYSIPQAIFAQRVLCRSQGTLSDLLRNP
                     KPWSKLKSGRETFRRMWKWLQEPEFQRMSALRLAACKRKEQEHGKDRGNTPKKPRLVF
                     TDVQRRTLHAIFKENKRPSKELQITISQQLGLELSTVSNFFMNARRRSLDKWQDEGSS
                     NSGNSSSSSSTCTKA"
     exon            1558..4352
                     /gene="ONECUT1"
                     /gene_synonym="HNF-6; HNF6; HNF6A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3683..3688
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ONECUT1"
                     /gene_synonym="HNF-6; HNF6; HNF6A"
                     /note="hexamer: ATTAAA"
     polyA_site      3705
                     /gene="ONECUT1"
                     /gene_synonym="HNF-6; HNF6; HNF6A"
                     /note="major polyA site"
     regulatory      3724..3729
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ONECUT1"
                     /gene_synonym="HNF-6; HNF6; HNF6A"
                     /note="hexamer: ATTAAA"
     polyA_site      3746
                     /gene="ONECUT1"
                     /gene_synonym="HNF-6; HNF6; HNF6A"
ORIGIN      
        1 aacagtaaca gagccatggc tcaagctggc cagcggggcg ggcaggcagc agacgcggca
       61 ggcgcgcggg ccgcggcagg ggagccggag acctcagaat tttaagaaag agaggggcga
      121 gaggtggccg aggcgggcgg gctggggcac tgcgctctcc caacggcgcg gatcctcttt
      181 ggaaattaat attaaaaaaa aaaaagccga ggacgcagag gggaaggtgg ggggtaagag
      241 ggaaggcgag acacacacac acacacacac gcacacgcac acacggacac acacacacgg
      301 agagagagag agagagagac agagccccac agtgagagga aggaaggcaa cagtcgccag
      361 cagccgatgt gaagaccgga ctccgtgcgc ccctcgccgc ctctgcctgg ccacatcgat
      421 gttgtgtccg ccgcctgctc gcccggatca cgatgaacgc gcagctgacc atggaagcga
      481 tcggcgagct gcacggggtg agccatgagc cggtgcccgc ccctgccgac ctgctgggcg
      541 gcagccccca cgcgcgcagc tccgtggcgc accgcggcag ccacctgccc cccgcgcacc
      601 cgcgctccat gggcatggcg tccctgctgg acggcggcag cggcggcgga gattaccacc
      661 accaccaccg ggcccctgag cacagcctgg ccggccccct gcatcccacc atgaccatgg
      721 cctgcgagac tcccccaggt atgagcatgc ccaccaccta caccaccttg acccctctgc
      781 agccgctgcc tcccatctcc acagtctcgg acaagttccc ccaccatcac caccaccacc
      841 atcaccacca ccacccgcac caccaccagc gcctggcggg caacgtgagc ggtagcttca
      901 cgctcatgcg ggatgagcgc gggctggcct ccatgaataa cctctatacc ccctaccaca
      961 aggacgtggc cggcatgggc cagagcctct cgcccctctc cagctccggt ctgggcagca
     1021 tccacaactc ccagcaaggg ctcccccact atgcccaccc gggggccgcc atgcccaccg
     1081 acaagatgct cacccccaac ggcttcgaag cccaccaccc ggccatgctc ggccgccacg
     1141 gggagcagca cctcacgccc acctcggccg gcatggtgcc catcaacggc cttcctccgc
     1201 accatcccca cgcccacctg aacgcccagg gccacgggca actcctgggc acagcccggg
     1261 agcccaaccc ttcggtgacc ggcgcgcagg tcagcaatgg aagtaattca gggcagatgg
     1321 aagagatcaa taccaaagag gtggcgcagc gtatcaccac cgagctcaag cgctacagca
     1381 tcccacaggc catcttcgcg cagagggtgc tctgccgctc ccaggggacc ctctcggacc
     1441 tgctgcgcaa ccccaaaccc tggagcaaac tcaaatccgg ccgggagacc ttccggagga
     1501 tgtggaagtg gctgcaggag ccggagttcc agcgcatgtc cgcgctccgc ttagcagcat
     1561 gcaaaaggaa agaacaagaa catgggaagg atagaggcaa cacacccaaa aagcccaggt
     1621 tggtcttcac agatgtccag cgtcgaactc tacatgcaat attcaaggaa aataagcgtc
     1681 catccaaaga attgcaaatc accatttccc agcagctggg gttggagctg agcactgtca
     1741 gcaacttctt catgaacgca agaaggagga gtctggacaa gtggcaggac gagggcagct
     1801 ccaattcagg caactcatct tcttcatcaa gcacttgtac caaagcatga aggaagaacc
     1861 acaaactaaa acctcggtgg aaaagcttta aattaaaaaa aatttttaaa agaccaggac
     1921 ctcaagatag caggtttata cttagaaata tttgaagaaa aaaaagcgtt atttatagtc
     1981 caaagaaacc aaagacttag ctcacctgca ttctgacttt gtttggagac acacacttca
     2041 gcagggcggc gacttggcaa gacaaatgat gagcaggaaa acaccactgg atctcacacc
     2101 ttcaatccat gaccatcctc gctgtgcttg gctgtttagt ggtttggagc atagtgattt
     2161 tgagccattg agcggacatc ttttaagatc gaactttctc atctgttcta ccatgccacg
     2221 aaggtgtatg gtgtctcagt actaccacca ccagtggtta cagacttagg cagagctggt
     2281 cttcagaaat ggttgttcta taggagtgca accaacatgg tatggggttg tctgagttca
     2341 ttggattagg agtgtgattt tgctcgtcta gcctaacgtt tgaacctgcc aggcccgcaa
     2401 cctaaatgca gattcaaacc cagcaaagaa aatttgaatg acacctaaac cagtgcattc
     2461 tctttgtttg ttaaggaatg ttcagatatt ttttaagaaa tgaaacatga gtccatccat
     2521 taaaaaaatc acctaggtac caaagaacac acttaatatt atagtgcagg tattttattg
     2581 caatgatttt aataaccaaa gctattttta cacaagatac tatgaaaagt tatacgtatg
     2641 aactgatcta gctgtaatac acatgccaca tagaatcatg actattattt atgactcttg
     2701 aagcatttga aatatgagtt ttcagaactg gcaagaaaga atgtagcttc agggaagcaa
     2761 ttaatatcat ggcagagagg tcgatgcagt acacgtgtac atccagatgg cacactcctt
     2821 ttcaggatcc ataaatgtca cttaagtaga gagatagaca tggttccata atctgttcct
     2881 agctgagaaa acctgaggat ctttccaaag tagtacccca tttttacact agaaaactaa
     2941 atttaacagg gagggtaact aaattagaaa atttgttcaa agtaatgctt tttagtaaaa
     3001 ggtcactaaa taaagaacta tccttagatt aattgactta tatttgcttt atgcatctgg
     3061 caccaaaaac ctcttttaaa tactttacaa atacaaataa agtttaaaaa aacaacatta
     3121 ttattcaaat gagctattca gtacttataa ctatcctaaa aagttatcaa attaacttat
     3181 tgccaatccc agaaatttta tgacttggac gtcaacaaaa cagcaggtgc aactgagaaa
     3241 tggtggaatt ggtggaactg tatagaaaaa agccagtgtt ctggtggacg acaagacttt
     3301 tgatctattg gtattaatca atttatggaa ctaagaatag cctccaaagc attctgcctt
     3361 ctttcttgct actgcattta gctggaaatt ttataatata gattttgctc tctaacaggg
     3421 acagattaaa aactagacct gagcttacaa atacaaaatt ttaaatttct atttgtccaa
     3481 atcacttaac cagagctgta gaagtcaaag tcaaaaaaaa aatgaagtcg tattagtggt
     3541 accccagtga atcacttgat tcccagaaaa attctctctg aattcagttg gactgtaact
     3601 tatctaagtg gatgcccctt atgccattag gtaaagaatt ggatactgta agttaattac
     3661 cacccctact tagaactatg aaattaaatg ttatcctaat gataagttgt tttattgaga
     3721 ttcattaaaa atgccaaaga acaaaactga accatcttga cacaaaacat aactccttag
     3781 catcaaatct cagcaccttg tctaggtctg taacaggcag gcaactagag aggtaaagca
     3841 aaaccaacaa gccatctatc tgtgtctcct tcatgtctgc tgtcgaatga gaagaggaaa
     3901 ccaacatata cttctctttt gatgaaatac ttcatttgcc ttgacatgtt ttgttttttg
     3961 tttttaattt cacccacaac tccagcttaa aaatttccct tctaaatatg gcacaattat
     4021 agttcagcta ttgaaagaga ccatttaaat ggccaccctt caagatttac taaaaaatag
     4081 aatcttgtca atgacataaa caaaaaggaa aaaactgatt aacattttct ctctctccag
     4141 ggatggaggg agccggggat acagctacat aatgtattta taatttagga gggaggaaag
     4201 ccttatttat ttaaaacgtg ataattctaa atgcagggaa attcaagctg tgtctacaca
     4261 caatcttacc aaattcaata ccccaagaaa agaatagcag aattcagaca accatgtttt
     4321 ttatttgttg ctagtatata ttacccccaa aa
//
