LOCUS       NM_002544               1775 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens oligodendrocyte myelin glycoprotein (OMG), mRNA.
ACCESSION   NM_002544
VERSION     NM_002544.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1775)
  AUTHORS   Park,G.H., Lee,S.J., Yim,H., Han,J.H., Kim,H.J., Sohn,Y.B., Ko,J.M.
            and Jeong,S.Y.
  TITLE     TAGLN expression is upregulated in NF1-associated malignant
            peripheral nerve sheath tumors by hypomethylation in its promoter
            and subpromoter regions
  JOURNAL   Oncol Rep 32 (4), 1347-1354 (2014)
   PUBMED   25109740
REFERENCE   2  (bases 1 to 1775)
  AUTHORS   Terzi,Y.K., Oguzkan-Balci,S., Anlar,B., Erdogan-Bakar,E. and
            Ayter,S.
  TITLE     Learning disability and oligodendrocyte myelin glycoprotein (OMGP)
            gene in neurofibromatosis type 1
  JOURNAL   Turk J Pediatr 53 (1), 75-78 (2011)
   PUBMED   21534343
  REMARK    GeneRIF: The results do not support a relationship between the OMGP
            gene and the learning disability phenotype observed in
            neurofibromatosis type 1.
REFERENCE   3  (bases 1 to 1775)
  AUTHORS   Martins-de-Souza,D., Gattaz,W.F., Schmitt,A., Rewerts,C.,
            Marangoni,S., Novello,J.C., Maccarrone,G., Turck,C.W. and
            Dias-Neto,E.
  TITLE     Alterations in oligodendrocyte proteins, calcium homeostasis and
            new potential markers in schizophrenia anterior temporal lobe are
            revealed by shotgun proteome analysis
  JOURNAL   J Neural Transm (Vienna) 116 (3), 275-289 (2009)
   PUBMED   19034380
  REMARK    GeneRIF: Data show that oligodendrocyte-myelin glycoprotein is
            downregulated in schizophrenia anterior temporal lobe revealed by
            shotgun proteome analysis.
REFERENCE   4  (bases 1 to 1775)
  AUTHORS   Douglas,J., Cilliers,D., Coleman,K., Tatton-Brown,K., Barker,K.,
            Bernhard,B., Burn,J., Huson,S., Josifova,D., Lacombe,D., Malik,M.,
            Mansour,S., Reid,E., Cormier-Daire,V., Cole,T. and Rahman,N.
  CONSRTM   Childhood Overgrowth Collaboration
  TITLE     Mutations in RNF135, a gene within the NF1 microdeletion region,
            cause phenotypic abnormalities including overgrowth
  JOURNAL   Nat Genet 39 (8), 963-965 (2007)
   PUBMED   17632510
REFERENCE   5  (bases 1 to 1775)
  AUTHORS   Zhou,X.F. and Li,H.Y.
  TITLE     Roles of glial p75NTR in axonal regeneration
  JOURNAL   J Neurosci Res 85 (8), 1601-1605 (2007)
   PUBMED   17335080
  REMARK    Review article
REFERENCE   6  (bases 1 to 1775)
  AUTHORS   Mikol,D.D., Rongnoparut,P., Allwardt,B.A., Marton,L.S. and
            Stefansson,K.
  TITLE     The oligodendrocyte-myelin glycoprotein of mouse: primary structure
            and gene structure
  JOURNAL   Genomics 17 (3), 604-610 (1993)
   PUBMED   8244377
REFERENCE   7  (bases 1 to 1775)
  AUTHORS   Viskochil,D., Cawthon,R., O'Connell,P., Xu,G.F., Stevens,J.,
            Culver,M., Carey,J. and White,R.
  TITLE     The gene encoding the oligodendrocyte-myelin glycoprotein is
            embedded within the neurofibromatosis type 1 gene
  JOURNAL   Mol Cell Biol 11 (2), 906-912 (1991)
   PUBMED   1899288
REFERENCE   8  (bases 1 to 1775)
  AUTHORS   Mikol,D.D., Alexakos,M.J., Bayley,C.A., Lemons,R.S., Le Beau,M.M.
            and Stefansson,K.
  TITLE     Structure and chromosomal localization of the gene for the
            oligodendrocyte-myelin glycoprotein
  JOURNAL   J Cell Biol 111 (6 Pt 1), 2673-2679 (1990)
   PUBMED   2277079
REFERENCE   9  (bases 1 to 1775)
  AUTHORS   Mikol,D.D., Gulcher,J.R. and Stefansson,K.
  TITLE     The oligodendrocyte-myelin glycoprotein belongs to a distinct
            family of proteins and contains the HNK-1 carbohydrate
  JOURNAL   J Cell Biol 110 (2), 471-479 (1990)
   PUBMED   1688857
REFERENCE   10 (bases 1 to 1775)
  AUTHORS   Mikol,D.D. and Stefansson,K.
  TITLE     A phosphatidylinositol-linked peanut agglutinin-binding
            glycoprotein in central nervous system myelin and on
            oligodendrocytes
  JOURNAL   J Cell Biol 106 (4), 1273-1279 (1988)
   PUBMED   3283151
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA206834.1, BC018050.1 and AC134669.4.
            
            On Nov 22, 2018 this sequence version replaced NM_002544.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK222663.1, SRR1660805.165268.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000247271.5/ ENSP00000247271.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 DA206834.1         124-129
            7-1772              BC018050.1         1-1766
            1773-1775           AC134669.4         33687-33689         c
FEATURES             Location/Qualifiers
     source          1..1775
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q11.2"
     gene            1..1775
                     /gene="OMG"
                     /gene_synonym="OMGP"
                     /note="oligodendrocyte myelin glycoprotein"
                     /db_xref="GeneID:4974"
                     /db_xref="HGNC:HGNC:8135"
                     /db_xref="MIM:164345"
     exon            1..84
                     /gene="OMG"
                     /gene_synonym="OMGP"
                     /inference="alignment:Splign:2.1.0"
     exon            85..1775
                     /gene="OMG"
                     /gene_synonym="OMGP"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..1413
                     /gene="OMG"
                     /gene_synonym="OMGP"
                     /codon_start=1
                     /product="oligodendrocyte-myelin glycoprotein precursor"
                     /protein_id="NP_002535.3"
                     /db_xref="CCDS:CCDS11265.1"
                     /db_xref="GeneID:4974"
                     /db_xref="HGNC:HGNC:8135"
                     /db_xref="MIM:164345"
                     /translation="MEYQILKMSLCLFILLFLTPGILCICPLQCICTERHRHVDCSGR
                     NLSTLPSGLQENIIHLNLSYNHFTDLHNQLTQYTNLRTLDISNNRLESLPAHLPRSLW
                     NMSAANNNIKLLDKSDTAYQWNLKYLDVSKNMLEKVVLIKNTLRSLEVLNLSSNKLWT
                     VPTNMPSKLHIVDLSNNSLTQILPGTLINLTNLTHLYLHNNKFTFIPDQSFDQLFQLQ
                     EITLYNNRWSCDHKQNITYLLKWMMETKAHVIGTPCSTQISSLKEHNMYPTPSGFTSS
                     LFTVSGMQTVDTINSLSVVTQPKVTKIPKQYRTKETTFGATLSKDTTFTSTDKAFVPY
                     PEDTSTETINSHEAAAATLTIHLQDGMVTNTSLTSSTKSSPTPMTLSITSGMPNNFSE
                     MPQQSTTLNLWREETTTNVKTPLPSVANAWKVNASFLLLLNVVVMLAV"
     regulatory      1754..1759
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OMG"
                     /gene_synonym="OMGP"
                     /note="hexamer: AATAAA"
     polyA_site      1775
                     /gene="OMG"
                     /gene_synonym="OMGP"
                     /note="major polyA site"
ORIGIN      
        1 agaaacagtt ccgactctac agaacaagac gacctttaag tttcccagag aaaatgagat
       61 gctgatgttg aagacgacac cacggctttg atggaatatc agatattgaa aatgtctctc
      121 tgcctgttca tccttctgtt tctcacacct ggtattttat gcatttgtcc tctccaatgt
      181 atatgcacag agaggcacag gcatgtggac tgttcaggca gaaacttgtc tacattacca
      241 tctggactgc aagagaatat tatacattta aacctgtctt ataaccactt tactgatctg
      301 cataaccagt taacccaata taccaatctg aggaccctgg acatttcaaa caacaggctt
      361 gaaagcctgc ctgctcactt acctcggtct ctgtggaaca tgtctgctgc taacaacaac
      421 attaaacttc ttgacaaatc tgatactgct tatcagtgga atcttaaata tctggatgtt
      481 tctaagaaca tgctggaaaa ggttgtcctc attaaaaata cactaagaag tctcgaggtt
      541 ctcaacctca gtagtaacaa actttggaca gttccaacca acatgccctc caaactacat
      601 atcgtggacc tgtctaataa ttctttgaca caaattcttc caggtacatt aataaacctg
      661 acaaatctca cacatcttta cctgcacaac aataagttca cattcattcc agaccaatct
      721 tttgaccaac tctttcagtt gcaagagata accctttaca ataacaggtg gtcatgtgac
      781 cacaaacaaa acattactta cttactgaag tggatgatgg aaacaaaagc ccatgtgata
      841 gggactccat gttctaccca aatatcatct ttaaaggaac ataacatgta tcccacacct
      901 tctggattta cctcaagctt attcactgta agtgggatgc agacagtgga caccattaac
      961 tctctgagtg tggtaactca acccaaagtg accaaaatac ccaaacaata tcgaacaaag
     1021 gaaacaacgt ttggtgccac tctaagcaaa gacaccacct ttactagcac tgataaggct
     1081 tttgtgccct atccagaaga tacatccaca gagactatca attcacatga agcagcagct
     1141 gcaactctaa ctattcatct ccaagatgga atggtcacaa acacaagcct cactagctca
     1201 acaaaatcat ccccaacacc catgacccta agtatcacta gtggcatgcc aaataatttc
     1261 tctgaaatgc ctcaacaaag cacaaccctt aacttatgga gggaagagac aaccacaaat
     1321 gtaaagactc cattaccttc tgtggcaaat gcttggaaag taaatgcttc atttctctta
     1381 ttgctcaatg ttgtggtcat gctggctgtc tgagggtctg cattttctga aactaatgaa
     1441 agcactcctc cctgatgtac agttgggaaa atatgtccat atctaaccag tgattcgagc
     1501 tatatttaag tattcaagaa agccagtctt aacatttcta actctgatgt aaatgaagta
     1561 acttgtctta aataaaagaa atgcacaatg tcttggtact tgctgctatt ttactgtctt
     1621 aattaagtaa actaatgagt ttcttttata aaaaaaatga aatgttttaa ggcttcaatt
     1681 tattgcacaa aatataaagc atctaaactt taatatgtat tttatgtatg tttacactgt
     1741 caaacatctg gaaaataaaa ggtctatgct cataa
//
