LOCUS       NM_005014               4324 bp    mRNA    linear   PRI 10-JUN-2024
DEFINITION  Homo sapiens osteomodulin (OMD), mRNA.
ACCESSION   NM_005014
VERSION     NM_005014.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4324)
  AUTHORS   Li,Q., Chen,H., Liu,Y. and Bi,J.
  TITLE     Osteomodulin contributes to keloid development by regulating p38
            MAPK signaling
  JOURNAL   J Dermatol 50 (7), 895-905 (2023)
   PUBMED   37017425
  REMARK    GeneRIF: Osteomodulin contributes to keloid development by
            regulating p38 MAPK signaling.
REFERENCE   2  (bases 1 to 4324)
  AUTHORS   Goncalves,I., Oduor,L., Matthes,F., Rakem,N., Meryn,J.,
            Skenteris,N.T., Aspberg,A., Orho-Melander,M., Nilsson,J., Matic,L.,
            Edsfeldt,A., Sun,J. and Bengtsson,E.
  TITLE     Osteomodulin Gene Expression Is Associated With Plaque
            Calcification, Stability, and Fewer Cardiovascular Events in the
            CPIP Cohort
  JOURNAL   Stroke 53 (3), e79-e84 (2022)
   PUBMED   35135320
  REMARK    GeneRIF: Osteomodulin Gene Expression Is Associated With Plaque
            Calcification, Stability, and Fewer Cardiovascular Events in the
            CPIP Cohort.
REFERENCE   3  (bases 1 to 4324)
  AUTHORS   Guo,W., Feng,W., Fan,X., Huang,J., Ou,C. and Chen,M.
  TITLE     Osteomodulin is a Potential Genetic Target for Hypertrophic
            Cardiomyopathy
  JOURNAL   Biochem Genet 59 (5), 1185-1202 (2021)
   PUBMED   33715137
  REMARK    GeneRIF: Osteomodulin is a Potential Genetic Target for
            Hypertrophic Cardiomyopathy.
REFERENCE   4  (bases 1 to 4324)
  AUTHORS   Tashima,T., Nagatoishi,S., Sagara,H., Ohnuma,S. and Tsumoto,K.
  TITLE     Osteomodulin regulates diameter and alters shape of collagen
            fibrils
  JOURNAL   Biochem Biophys Res Commun 463 (3), 292-296 (2015)
   PUBMED   26003732
  REMARK    GeneRIF: Osteomodulin (OMD) directly binds to type 1 collagen. OMD
            suppresses formation of collagen fibrils.
REFERENCE   5  (bases 1 to 4324)
  AUTHORS   Juchtmans,N., Dhollander,A.A., Coudenys,J., Audenaert,E.A.,
            Pattyn,C., Lambrecht,S. and Elewaut,D.
  TITLE     Distinct dysregulation of the small leucine-rich repeat protein
            family in osteoarthritic acetabular labrum compared to articular
            cartilage
  JOURNAL   Arthritis Rheumatol 67 (2), 435-441 (2015)
   PUBMED   25371314
  REMARK    GeneRIF: Osteomodulin, osteoglycin, and asporin appear to be
            distinctly regulated in osteoarthritis labrum compared to OA
            cartilage.
REFERENCE   6  (bases 1 to 4324)
  AUTHORS   Couble,M.L., Bleicher,F., Farges,J.C., Peyrol,S., Lucchini,M.,
            Magloire,H. and Staquet,M.J.
  TITLE     Immunodetection of osteoadherin in murine tooth extracellular
            matrices
  JOURNAL   Histochem Cell Biol 121 (1), 47-53 (2004)
   PUBMED   14673660
REFERENCE   7  (bases 1 to 4324)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   8  (bases 1 to 4324)
  AUTHORS   Lucchini,M., Romeas,A., Couble,M.L., Bleicher,F., Magloire,H. and
            Farges,J.C.
  TITLE     TGF beta 1 signaling and stimulation of osteoadherin in human
            odontoblasts in vitro
  JOURNAL   Connect Tissue Res 43 (2-3), 345-353 (2002)
   PUBMED   12489179
  REMARK    GeneRIF: TGF beta 1 signaling and stimulation of osteoadherin in
            human pulpal fibroblasts and in early secretory and mature
            odontoblasts
REFERENCE   9  (bases 1 to 4324)
  AUTHORS   Buchaille,R., Couble,M.L., Magloire,H. and Bleicher,F.
  TITLE     Expression of the small leucine-rich proteoglycan
            osteoadherin/osteomodulin in human dental pulp and developing rat
            teeth
  JOURNAL   Bone 27 (2), 265-270 (2000)
   PUBMED   10913920
REFERENCE   10 (bases 1 to 4324)
  AUTHORS   Wendel,M., Sommarin,Y. and Heinegard,D.
  TITLE     Bone matrix proteins: isolation and characterization of a novel
            cell-binding keratan sulfate proteoglycan (osteoadherin) from
            bovine bone
  JOURNAL   J Cell Biol 141 (3), 839-847 (1998)
   PUBMED   9566981
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL137848.5.
            
            On Aug 11, 2020 this sequence version replaced NM_005014.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.236018.1,
                                           SRR1803613.31912.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467144, SAMEA2467148
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375550.5/ ENSP00000364700.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-270               AL137848.5         67528-67797         c
            271-1226            AL137848.5         59945-60900         c
            1227-2459           AL137848.5         57571-58803         c
            2460-4324           AL137848.5         55706-57570         c
FEATURES             Location/Qualifiers
     source          1..4324
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q22.31"
     gene            1..4324
                     /gene="OMD"
                     /gene_synonym="OSAD; SLRR2C"
                     /note="osteomodulin"
                     /db_xref="GeneID:4958"
                     /db_xref="HGNC:HGNC:8134"
                     /db_xref="MIM:618926"
     exon            1..270
                     /gene="OMD"
                     /gene_synonym="OSAD; SLRR2C"
                     /inference="alignment:Splign:2.1.0"
     exon            271..1226
                     /gene="OMD"
                     /gene_synonym="OSAD; SLRR2C"
                     /inference="alignment:Splign:2.1.0"
     CDS             287..1552
                     /gene="OMD"
                     /gene_synonym="OSAD; SLRR2C"
                     /note="osteoadherin proteoglycan; KSPG osteomodulin;
                     keratan sulfate proteoglycan osteomodulin"
                     /codon_start=1
                     /product="osteomodulin precursor"
                     /protein_id="NP_005005.1"
                     /db_xref="CCDS:CCDS6696.1"
                     /db_xref="GeneID:4958"
                     /db_xref="HGNC:HGNC:8134"
                     /db_xref="MIM:618926"
                     /translation="MGFLSPIYVIFFFFGVKVHCQYETYQWDEDYDQEPDDDYQTGFP
                     FRQNVDYGVPFHQYTLGCVSECFCPTNFPSSMYCDNRKLKTIPNIPMHIQQLYLQFNE
                     IEAVTANSFINATHLKEINLSHNKIKSQKIDYGVFAKLPNLLQLHLEHNNLEEFPFPL
                     PKSLERLLLGYNEISKLQTNAMDGLVNLTMLDLCYNYLHDSLLKDKIFAKMEKLMQLN
                     LCSNRLESMPPGLPSSLMYLSLENNSISSIPEKYFDKLPKLHTLRMSHNKLQDIPYNI
                     FNLPNIVELSVGHNKLKQAFYIPRNLEHLYLQNNEIEKMNLTVMCPSIDPLHYHHLTY
                     IRVDQNKLKEPISSYIFFCFPHIHTIYYGEQRSTNGQTIQLKTQVFRRFPDDDDESED
                     HDDPDNAHESPEQEGAEGHFDLHYYENQE"
     exon            1227..4324
                     /gene="OMD"
                     /gene_synonym="OSAD; SLRR2C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1818..1823
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OMD"
                     /gene_synonym="OSAD; SLRR2C"
                     /note="hexamer: AATATA"
     polyA_site      1843
                     /gene="OMD"
                     /gene_synonym="OSAD; SLRR2C"
     regulatory      2432..2437
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OMD"
                     /gene_synonym="OSAD; SLRR2C"
                     /note="hexamer: AATAAA"
     polyA_site      2457
                     /gene="OMD"
                     /gene_synonym="OSAD; SLRR2C"
                     /note="major polyA site"
     regulatory      4300..4305
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OMD"
                     /gene_synonym="OSAD; SLRR2C"
                     /note="hexamer: ATTAAA"
     polyA_site      4324
                     /gene="OMD"
                     /gene_synonym="OSAD; SLRR2C"
                     /note="major polyA site"
ORIGIN      
        1 acataaatct gaccaagaac acaagcatct taatttgaat ccacaaagtt tcatgtaatg
       61 aaaagaaata cataatttta attcaacccg agtgttttcc aagaagattg tatttgctta
      121 aattgctaca gtaattcaag agacagccct gtctggacac agagttactg tggattttta
      181 agagactcag ttaaagaatt taggaatttc tgattcattt aaaggattta caaattcatc
      241 aacccctgaa aactaaagca aattgaacag gaaaaaaaaa aagaagatgg gttttttaag
      301 tccaatatat gttattttct tcttttttgg agtcaaagta cattgccaat atgaaactta
      361 tcagtgggat gaagactatg accaagagcc agatgatgat taccaaacag gattcccatt
      421 tcgtcaaaat gtagactacg gagttccttt tcatcagtat actttaggct gtgtcagtga
      481 atgcttctgt ccaactaact ttccatcatc aatgtactgt gataatcgca aactcaagac
      541 tatcccaaat attccgatgc acattcagca actctacctt cagttcaatg aaattgaggc
      601 tgtgactgca aattcattca tcaatgcaac tcatcttaaa gaaattaacc tcagccacaa
      661 caaaattaaa tctcaaaaga ttgattatgg tgtgtttgct aagcttccaa atctactaca
      721 acttcatcta gagcataata atttagaaga atttccattt cctcttccta aatctctgga
      781 aagactcctt cttggttaca atgaaatctc caaactgcag acaaatgcta tggatgggct
      841 agtaaacttg accatgcttg atctctgtta taattatctt catgattctc tgctaaaaga
      901 caaaatcttt gccaaaatgg aaaaactaat gcagctcaac ctctgcagta acagattaga
      961 atcaatgcct cctggtttgc cttcttcact tatgtatctg tctttagaaa ataattcaat
     1021 ttcttctata cccgaaaaat acttcgacaa acttccaaaa cttcatactc taagaatgtc
     1081 acacaacaaa ctacaagaca tcccatataa tatttttaat cttcccaaca ttgtagaact
     1141 cagtgttgga cacaacaaat tgaagcaagc attctatatt ccaagaaatt tggaacacct
     1201 atacctacaa aataatgaaa tagaaaagat gaatcttaca gtgatgtgtc cttctattga
     1261 cccactacat taccaccatt taacatacat tcgtgtggac caaaataaac taaaagaacc
     1321 aataagctca tacatcttct tctgcttccc tcatatacac actatttatt atggtgaaca
     1381 acgaagcact aatggtcaaa caatacaact aaagacacaa gttttcagga gatttccaga
     1441 tgatgatgat gaaagtgaag atcacgatga tcctgacaat gctcatgaga gcccagaaca
     1501 agaaggagca gaagggcact ttgaccttca ttattatgaa aatcaagaat agcaagaaac
     1561 tatataggta tacacttacg acttcacaaa acctatactt aatatagtaa atctaagtaa
     1621 acatgtatta ctcaaagtaa tatatttaga attatgtatt agtataagat cagaattgaa
     1681 tttaagttgt tggtgacatc tgcatcattt cataggatta gaacttactc aaaataatgt
     1741 aaatctttaa aaatataaat tagaatgaca agtgggaatc ataaattaaa cgttaatggt
     1801 ttcttatgct ctttttaaat atagaaatat catgttaaag aaagtgagtg tatcatttct
     1861 attaacagta atttttctaa aaatgaggaa ggaagtagca ttagcagtaa agacccacag
     1921 gccatgacct ttttgatcac tctgaggaca atatttaaat gacaggaagg tatattaatg
     1981 taacaagcat tcatttaagg aatagaccat tttctctgac ctcttcttca ggaaagcttt
     2041 cacactggta tttgtgatct caccattatg acatccatcc ccctagctca ccacatagca
     2101 catagaatga tatttttgat ttgtaagagg ccatccaggt actaaggacc caaggcatac
     2161 agattcacaa aattaactaa tctttttgcc tcagaatacc aaaacaacaa aattataaag
     2221 ctgtatttgg acaactaaaa aacaccaaac tatctcattg caatttgtat tttagcagat
     2281 ttcagcaact atcctaaaca atgttattgt gttccatttt aactgggata aatgtttttg
     2341 taaaaataca accatagaaa ggcctctttg ttacaaaatg atttgcaaag aaataactgc
     2401 tttgtttgca agattaaatt agtgttggca aaataaagtt ctaaagataa tactaaacac
     2461 tttatgctta tcagccaata tctacataag ctaaaattga atacagttcc tttataattt
     2521 gaatgacagg ttttaacatc ttctttaaaa ccttaaaaat cactttttcg ttaatgtatt
     2581 atttttaagt attgtaagtg tgccttacaa tgatgattat ctaactgctg tgatgaactc
     2641 tcttgatata ccatgctaat gtttcataga atttctcaga taagggacaa ataccaatct
     2701 agggctgcct atacaaatga taacaattct gacaatatgc aacagacaga caagtcaaac
     2761 tatacttcag aaatagtttt caagcttgca agtctttttt tctggaaata ccagtttaaa
     2821 gtgaagtctt taatgctctt tacatctttg aggaattatt agcattatca gaaccagaac
     2881 gcccacctgt tcccagggac aacctcaaga atccaggatg aatatgaaga aaactccatt
     2941 cattcgtcta atcaacattc atcaagtcct ttcttatata gggcttggca ataagggatc
     3001 aataaacaaa gtacaatgtg caactatgat gccacaatat gggcaaagca cattttcaac
     3061 agaggttaaa aaaaaaatct taaggcccac ctcccttttc ttgcaatttt taaatacagg
     3121 atataaattc aaacattaag agttaatacg tggaaaatac tataggtgtt ttagaaaaca
     3181 aagataagac aattcctaac ctagagcaat ttaaaattta tgagccatta gggaaatgca
     3241 aataaatgag atattactat gtgctcacta ggatagctga aatcaaaagg cagacaaata
     3301 acaagtgttg gcaagatgtg gaaaaattgg agccttcata cacctttgga aggagtgtaa
     3361 atactgcagc tgcttagaaa agcagtatgg aagttcctta aaaagttagt tacatatagt
     3421 cgggcgcatt agctcacacc tgtaatccca gcactttgga aggccgagtt aggtggatca
     3481 cctggggtcg ggagtttgag accagcctga ccaacatgga gaaaccccat ctctactaaa
     3541 aatacaaaat aattagccag gcatggtggc acatgcctgt aatcccggct acttgcgagg
     3601 ctgaggcagg agaattgcct aaacccaaga ggcagaagtt gcggtgagcc aagaccatgc
     3661 cattgcactc cagcctgggc aacaagagca aaagtccata tcaaaaaaaa aaaaaaaaaa
     3721 aaaaaaaagc ttagttacat ataacccagc gattccattc ctaactatat acccaataga
     3781 actgaacaca catgttcaca ccaaaatttg catataaatg tccacagcag cattatccac
     3841 aaggtagaaa tcacccacat gtccatcaat ggataaacaa aatgtggtat atccatttca
     3901 tggaatatta ttcagccata tccaaaggta gaaaccacgc aaatgtccat caatggatac
     3961 acaaaatgtg atatatccat acagtggaat attattcagc aataaaaagt aacgaagcac
     4021 tgacatatgc tacaacatgg ataaccttga aaacattatg ctcagtgaaa gaagtcagtc
     4081 gtaaaaagac acaaattgta tgattccatc tttatgaaat gtccagaact gggaaatcta
     4141 tggagacaaa gactattggt tgcctagagc tggggatcat gggaatgggg aaagtgagaa
     4201 gtaactgcta atgggtatat ggtttctttt ttggagtaat gaaaatgttc caaaattgac
     4261 tgtggtgatg gttgtacaaa tgcaaaaaca ctaagtacta ttaaattgta tactttaggc
     4321 tggg
//
