LOCUS       NM_145243               1861 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens OMA1 zinc metallopeptidase (OMA1), mRNA; nuclear gene
            for mitochondrial product.
ACCESSION   NM_145243
VERSION     NM_145243.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1861)
  AUTHORS   Wei,Y.Y., Ye,J.J., Zhang,D.W., Hu,L., Wu,H.M. and Fei,G.H.
  TITLE     Melatonin Rescues Influenza A Virus-Induced Cellular Energy
            Exhaustion via OMA1-OPA1-S in Acute Exacerbation of COPD
  JOURNAL   J Pineal Res 76 (5), e12991 (2024)
   PUBMED   39039850
  REMARK    GeneRIF: Melatonin Rescues Influenza A Virus-Induced Cellular
            Energy Exhaustion via OMA1-OPA1-S in Acute Exacerbation of COPD.
REFERENCE   2  (bases 1 to 1861)
  AUTHORS   Krakowczyk,M., Lenkiewicz,A.M., Sitarz,T., Malinska,D., Borrero,M.,
            Mussulini,B.H.M., Linke,V., Szczepankiewicz,A.A., Biazik,J.M.,
            Wydrych,A., Nieznanska,H., Serwa,R.A., Chacinska,A. and
            Bragoszewski,P.
  TITLE     OMA1 protease eliminates arrested protein import intermediates upon
            mitochondrial depolarization
  JOURNAL   J Cell Biol 223 (5) (2024)
   PUBMED   38530280
  REMARK    GeneRIF: OMA1 protease eliminates arrested protein import
            intermediates upon mitochondrial depolarization.
REFERENCE   3  (bases 1 to 1861)
  AUTHORS   Zhu,W., Rao,J., Zhang,L.H., Xue,K.M., Li,L., Li,J.J., Chen,Q.Z. and
            Fu,R.
  TITLE     OMA1 competitively binds to HSPA9 to promote mitophagy and activate
            the cGAS-STING pathway to mediate GBM immune escape
  JOURNAL   J Immunother Cancer 12 (4), e008718 (2024)
   PUBMED   38604814
  REMARK    GeneRIF: OMA1 competitively binds to HSPA9 to promote mitophagy and
            activate the cGAS-STING pathway to mediate GBM immune escape.
            Erratum:[J Immunother Cancer. 2024 Nov 20;12(11):e008718corr1. doi:
            10.1136/jitc-2023-008718corr1.. PMID: 39572161]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1861)
  AUTHORS   Purohit,G., Ghosh,P. and Khalimonchuk,O.
  TITLE     Mitochondrial metallopeptidase OMA1 in cancer
  JOURNAL   Adv Cancer Res 162, 75-97 (2024)
   PUBMED   39069370
  REMARK    GeneRIF: Mitochondrial metallopeptidase OMA1 in cancer.
            Review article
REFERENCE   5  (bases 1 to 1861)
  AUTHORS   Rivera-Mejias,P., Narbona-Perez,A.J., Hasberg,L., Kroczek,L.,
            Bahat,A., Lawo,S., Folz-Donahue,K., Schumacher,A.L., Ahola,S.,
            Mayer,F.C., Giavalisco,P., Nolte,H., Lavandero,S. and Langer,T.
  TITLE     The mitochondrial protease OMA1 acts as a metabolic safeguard upon
            nuclear DNA damage
  JOURNAL   Cell Rep 42 (4), 112332 (2023)
   PUBMED   37002921
  REMARK    GeneRIF: The mitochondrial protease OMA1 acts as a metabolic
            safeguard upon nuclear DNA damage.
REFERENCE   6  (bases 1 to 1861)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1861)
  AUTHORS   Head,B., Griparic,L., Amiri,M., Gandre-Babbe,S. and van der
            Bliek,A.M.
  TITLE     Inducible proteolytic inactivation of OPA1 mediated by the OMA1
            protease in mammalian cells
  JOURNAL   J Cell Biol 187 (7), 959-966 (2009)
   PUBMED   20038677
  REMARK    GeneRIF: OMA1 controls OPA1 cleavage and function.
REFERENCE   8  (bases 1 to 1861)
  AUTHORS   Duvezin-Caubet,S., Koppen,M., Wagener,J., Zick,M., Israel,L.,
            Bernacchia,A., Jagasia,R., Rugarli,E.I., Imhof,A., Neupert,W.,
            Langer,T. and Reichert,A.S.
  TITLE     OPA1 processing reconstituted in yeast depends on the subunit
            composition of the m-AAA protease in mitochondria
  JOURNAL   Mol Biol Cell 18 (9), 3582-3590 (2007)
   PUBMED   17615298
  REMARK    GeneRIF: These results provide evidence for different substrate
            specificities of m-AAA proteases composed of different subunits and
            reveal a striking evolutionary switch of proteases involved in the
            proteolytic processing of dynamin-like GTPases in mitochondria.
REFERENCE   9  (bases 1 to 1861)
  AUTHORS   Kaser,M., Kambacheld,M., Kisters-Woike,B. and Langer,T.
  TITLE     Oma1, a novel membrane-bound metallopeptidase in mitochondria with
            activities overlapping with the m-AAA protease
  JOURNAL   J Biol Chem 278 (47), 46414-46423 (2003)
   PUBMED   12963738
REFERENCE   10 (bases 1 to 1861)
  AUTHORS   Bao,Y.C., Tsuruga,H., Hirai,M., Yasuda,K., Yokoi,N., Kitamura,T.
            and Kumagai,H.
  TITLE     Identification of a human cDNA sequence which encodes a novel
            membrane-associated protein containing a zinc metalloprotease motif
  JOURNAL   DNA Res 10 (3), 123-128 (2003)
   PUBMED   12886954
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL365187.19 and AL109845.8.
            
            On Nov 23, 2018 this sequence version replaced NM_145243.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012915.1, AB048348.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371226.8/ ENSP00000360270.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AL365187.19        44485-44508         c
            25-540              AL365187.19        36577-37092         c
            541-769             AL365187.19        34295-34523         c
            770-943             AL365187.19        31940-32113         c
            944-1051            AL365187.19        31735-31842         c
            1052-1180           AL365187.19        28383-28511         c
            1181-1255           AL365187.19        25043-25117         c
            1256-1405           AL365187.19        3842-3991           c
            1406-1861           AL109845.8         101920-102375       c
FEATURES             Location/Qualifiers
     source          1..1861
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p32.2-p32.1"
     gene            1..1861
                     /gene="OMA1"
                     /gene_synonym="2010001O09Rik; DAB1; MPRP-1; MPRP1;
                     peptidase; YKR087C; ZMPOMA1"
                     /note="OMA1 zinc metallopeptidase"
                     /db_xref="GeneID:115209"
                     /db_xref="HGNC:HGNC:29661"
                     /db_xref="MIM:617081"
     exon            1..24
                     /gene="OMA1"
                     /gene_synonym="2010001O09Rik; DAB1; MPRP-1; MPRP1;
                     peptidase; YKR087C; ZMPOMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            25..540
                     /gene="OMA1"
                     /gene_synonym="2010001O09Rik; DAB1; MPRP-1; MPRP1;
                     peptidase; YKR087C; ZMPOMA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..1615
                     /gene="OMA1"
                     /gene_synonym="2010001O09Rik; DAB1; MPRP-1; MPRP1;
                     peptidase; YKR087C; ZMPOMA1"
                     /note="overlapping activity with M-AAA protease;
                     metalloendopeptidase OMA1, mitochondrial;
                     metalloprotease-related protein 1; OMA1 homolog, zinc
                     metallopeptidase; overlapping with the m-AAA protease 1
                     homolog; zinc metallopeptidase OMA1; OMA1 zinc
                     metallopeptidase homolog"
                     /codon_start=1
                     /product="metalloendopeptidase OMA1, mitochondrial
                     precursor"
                     /protein_id="NP_660286.1"
                     /db_xref="CCDS:CCDS608.1"
                     /db_xref="GeneID:115209"
                     /db_xref="HGNC:HGNC:29661"
                     /db_xref="MIM:617081"
                     /translation="MSFICGLQSAARNHVFFRFNSLSNWRKCNTLASTSRGCHQVQVN
                     HIVNKYQGLGVNQCDRWSFLPGNFHFYSTFNNKRTGGLSSTKSKEIWRITSKCTVWND
                     AFSRQLLIKEVTAVPSLSVLHPLSPASIRAIRNFHTSPRFQAAPVPLLLMILKPVQKL
                     FAIIVGRGIRKWWQALPPNKKEVVKENIRKNKWKLFLGLSSFGLLFVVFYFTHLEVSP
                     ITGRSKLLLLGKEQFRLLSELEYEAWMEEFKNDMLTEKDARYLAVKEVLCHLIECNKD
                     VPGISQINWVIHVVDSPIINAFVLPNGQMFVFTGFLNSVTDIHQLSFLLGHEIAHAVL
                     GHAAEKAGMVHLLDFLGMIFLTMIWAICPRDSLALLCQWIQSKLQEYMFNRPYSRKLE
                     AEADKIGLLLAAKACADIRASSVFWQQMEFVDSLHGQPKMPEWLSTHPSHGNRVEYLD
                     RLIPQALKIREMCNCPPLSNPDPRLLFKLSTKHFLEESEKEDLNITKKQKMDTLPIQK
                     QEQIPLTYIVEKRTGS"
     exon            541..769
                     /gene="OMA1"
                     /gene_synonym="2010001O09Rik; DAB1; MPRP-1; MPRP1;
                     peptidase; YKR087C; ZMPOMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            770..943
                     /gene="OMA1"
                     /gene_synonym="2010001O09Rik; DAB1; MPRP-1; MPRP1;
                     peptidase; YKR087C; ZMPOMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1051
                     /gene="OMA1"
                     /gene_synonym="2010001O09Rik; DAB1; MPRP-1; MPRP1;
                     peptidase; YKR087C; ZMPOMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1180
                     /gene="OMA1"
                     /gene_synonym="2010001O09Rik; DAB1; MPRP-1; MPRP1;
                     peptidase; YKR087C; ZMPOMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1255
                     /gene="OMA1"
                     /gene_synonym="2010001O09Rik; DAB1; MPRP-1; MPRP1;
                     peptidase; YKR087C; ZMPOMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1405
                     /gene="OMA1"
                     /gene_synonym="2010001O09Rik; DAB1; MPRP-1; MPRP1;
                     peptidase; YKR087C; ZMPOMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1861
                     /gene="OMA1"
                     /gene_synonym="2010001O09Rik; DAB1; MPRP-1; MPRP1;
                     peptidase; YKR087C; ZMPOMA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1838..1843
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OMA1"
                     /gene_synonym="2010001O09Rik; DAB1; MPRP-1; MPRP1;
                     peptidase; YKR087C; ZMPOMA1"
                     /note="hexamer: AATAAA"
     polyA_site      1861
                     /gene="OMA1"
                     /gene_synonym="2010001O09Rik; DAB1; MPRP-1; MPRP1;
                     peptidase; YKR087C; ZMPOMA1"
                     /note="major polyA site"
ORIGIN      
        1 gtcaccgctt tcgcttctgc ttgagtagtc aagtgaaaaa atgagcttca tctgtggatt
       61 gcagtctgct gctagaaacc atgttttctt ccgatttaat tcactgtcta actggagaaa
      121 atgtaacaca ttagcatcca cctcacgggg ctgtcatcaa gtacaagtta accatatagt
      181 aaataagtat cagggactgg gagtaaatca gtgtgacagg tggagttttc tgcctggaaa
      241 ctttcatttt tatagtactt ttaacaacaa aagaacagga ggcctctcaa gtaccaaaag
      301 taaggaaatt tggaggatta ccagcaaatg tactgtatgg aatgatgctt tttcaagaca
      361 gctgctaata aaagaagtta cagcagtccc tagtctgtca gtattgcatc ctctaagccc
      421 tgcttccata agagctatta ggaatttcca tacttctcca cggtttcaag ctgctccggt
      481 tcctctcttg ttgatgattc ttaaaccagt acagaagtta tttgcaatca ttgtaggcag
      541 gggcataagg aaatggtggc aggcacttcc tcctaacaag aaggaagtag ttaaagaaaa
      601 tataaggaag aataaatgga agctattcct tggtttgagt agttttggat tgctctttgt
      661 ggtgttttat tttactcacc tggaagtaag tccaatcaca ggaaggagca agctactatt
      721 attggggaaa gaacagttca gacttttatc ggaactggaa tatgaagcat ggatggaaga
      781 atttaaaaat gatatgctaa ctgagaaaga tgcccgatac ctggctgtta aagaagtgct
      841 ttgtcatcta attgaatgca ataaagatgt tccagggatc tctcagatca attgggttat
      901 tcatgtggtt gattccccaa ttattaatgc cttcgtgctt ccaaatggac aaatgtttgt
      961 tttcactgga tttttaaata gtgtaaccga tattcatcaa ctttctttcc ttctgggcca
     1021 tgaaatagca catgcagtac ttgggcatgc tgcagaaaag gctggcatgg ttcatttgtt
     1081 ggatttccta ggtatgattt tcctcacaat gatttgggcc atttgtcctc gagatagctt
     1141 ggcacttttg tgccagtgga tacagtctaa attgcaggag tatatgttta atagaccata
     1201 cagcagaaaa ttggaggccg aagctgacaa aattggacta ctgcttgctg caaaggcttg
     1261 tgcagacata agagccagtt cagtgttttg gcagcaaatg gagttcgttg atagcctgca
     1321 tggccaaccc aagatgccag aatggttatc tacacaccct tctcatggca atcgagttga
     1381 gtacttggat agacttatac ctcaggctct caaaattaga gagatgtgta attgtccacc
     1441 actgtctaat ccagaccctc gattactatt caaactcagc acgaagcatt ttcttgaaga
     1501 atcagagaaa gaagacctaa atatcacgaa gaaacagaaa atggatactc ttcctattca
     1561 aaaacaggag caaataccat taacatacat agttgagaaa agaacgggca gttgaattaa
     1621 aatttatgag acacaagata tatgaagaat gttgcagtcc ttatcatttt atgttacttt
     1681 ttaaaaaatg atgtttgaag tgaaaaaaaa aaggatattc agggtcaaat catgtacatt
     1741 acagatatta tctaaattct tctagaattt atttttcatg aaatattgat gtattttaat
     1801 ctatgttaaa atatcttcaa tgaggaaaat gtcacagaat aaatttatat tacacatttt
     1861 a
//
