LOCUS       NM_002543               2456 bp    mRNA    linear   PRI 09-JUL-2024
DEFINITION  Homo sapiens oxidized low density lipoprotein receptor 1 (OLR1),
            transcript variant 1, mRNA.
ACCESSION   NM_002543
VERSION     NM_002543.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2456)
  AUTHORS   Lin,C.H., Chiang,C.C., Shih,Y.C., Tung,S.L. and Huang,W.C.
  TITLE     Elucidating the Role of Let-7d-5p and OLR1 in the Progression and
            Prognosis of Oral Squamous Cell Carcinoma via FAK/P53 Signaling
            Axis
  JOURNAL   Anticancer Res 44 (6), 2517-2531 (2024)
   PUBMED   38821588
  REMARK    GeneRIF: Elucidating the Role of Let-7d-5p and OLR1 in the
            Progression and Prognosis of Oral Squamous Cell Carcinoma via
            FAK/P53 Signaling Axis.
REFERENCE   2  (bases 1 to 2456)
  AUTHORS   Arkelius,K., Wendt,T.S., Andersson,H., Arnou,A., Gottschalk,M.,
            Gonzales,R.J. and Ansar,S.
  TITLE     LOX-1 and MMP-9 Inhibition Attenuates the Detrimental Effects of
            Delayed rt-PA Therapy and Improves Outcomes After Acute Ischemic
            Stroke
  JOURNAL   Circ Res 134 (8), 954-969 (2024)
   PUBMED   38501247
  REMARK    GeneRIF: LOX-1 and MMP-9 Inhibition Attenuates the Detrimental
            Effects of Delayed rt-PA Therapy and Improves Outcomes After Acute
            Ischemic Stroke.
REFERENCE   3  (bases 1 to 2456)
  AUTHORS   Xiong,J., Zhang,L., Chen,G., Dong,P., Tong,J., Hua,L., Li,N.,
            Wen,L., Zhu,L., Chang,W. and Jin,Y.
  TITLE     Associations of CKIP-1 and LOX-1 polymorphisms with the risk of
            type 2 diabetes mellitus with hypertension among Chinese adults
  JOURNAL   Acta Diabetol 61 (1), 43-52 (2024)
   PUBMED   37668684
  REMARK    GeneRIF: Associations of CKIP-1 and LOX-1 polymorphisms with the
            risk of type 2 diabetes mellitus with hypertension among Chinese
            adults.
REFERENCE   4  (bases 1 to 2456)
  AUTHORS   Sawamura,T.
  TITLE     [LOX-1: the oxidized LDL receptor expressed in vascular endothelial
            cells]
  JOURNAL   Seikagaku 74 (5), 365-376 (2002)
   PUBMED   12073608
  REMARK    GeneRIF: oxidized LDL receptor expressed in vascular endothelial
            cells
            Review article
REFERENCE   5  (bases 1 to 2456)
  AUTHORS   Nagase,M., Abe,J., Takahashi,K., Ando,J., Hirose,S. and Fujita,T.
  TITLE     Genomic organization and regulation of expression of the
            lectin-like oxidized low-density lipoprotein receptor (LOX-1) gene
  JOURNAL   J Biol Chem 273 (50), 33702-33707 (1998)
   PUBMED   9837956
REFERENCE   6  (bases 1 to 2456)
  AUTHORS   Yamanaka,S., Zhang,X.Y., Miura,K., Kim,S. and Iwao,H.
  TITLE     The human gene encoding the lectin-type oxidized LDL receptor
            (OLR1) is a novel member of the natural killer gene complex with a
            unique expression profile
  JOURNAL   Genomics 54 (2), 191-199 (1998)
   PUBMED   9828121
REFERENCE   7  (bases 1 to 2456)
  AUTHORS   Yoshida,H., Kondratenko,N., Green,S., Steinberg,D. and
            Quehenberger,O.
  TITLE     Identification of the lectin-like receptor for oxidized low-density
            lipoprotein in human macrophages and its potential role as a
            scavenger receptor
  JOURNAL   Biochem J 334 (Pt 1) (Pt 1), 9-13 (1998)
   PUBMED   9693095
REFERENCE   8  (bases 1 to 2456)
  AUTHORS   Mehta,J.L. and Li,D.Y.
  TITLE     Identification and autoregulation of receptor for OX-LDL in
            cultured human coronary artery endothelial cells
  JOURNAL   Biochem Biophys Res Commun 248 (3), 511-514 (1998)
   PUBMED   9703956
REFERENCE   9  (bases 1 to 2456)
  AUTHORS   Li,X., Bouzyk,M.M. and Wang,X.
  TITLE     Assignment of the human oxidized low-density lipoprotein receptor
            gene (OLR1) to chromosome 12p13.1-->p12.3, and identification of a
            polymorphic CA-repeat marker in the OLR1 gene
  JOURNAL   Cytogenet Cell Genet 82 (1-2), 34-36 (1998)
   PUBMED   9763655
REFERENCE   10 (bases 1 to 2456)
  AUTHORS   Sawamura,T., Kume,N., Aoyama,T., Moriwaki,H., Hoshikawa,H.,
            Aiba,Y., Tanaka,T., Miwa,S., Katsura,Y., Kita,T. and Masaki,T.
  TITLE     An endothelial receptor for oxidized low-density lipoprotein
  JOURNAL   Nature 386 (6620), 73-77 (1997)
   PUBMED   9052782
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC024224.33.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_002543.3.
            
            Summary: This gene encodes a low density lipoprotein receptor that
            belongs to the C-type lectin superfamily. This gene is regulated
            through the cyclic AMP signaling pathway. The encoded protein
            binds, internalizes and degrades oxidized low-density lipoprotein.
            This protein may be involved in the regulation of Fas-induced
            apoptosis. This protein may play a role as a scavenger receptor.
            Mutations of this gene have been associated with atherosclerosis,
            risk of myocardial infarction, and may modify the risk of
            Alzheimer's disease. Alternate splicing results in multiple
            transcript variants.[provided by RefSeq, Feb 2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022295.1, AK292124.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000309539.8/ ENSP00000309124.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-131               AC024224.33        162579-162709       c
            132-233             AC024224.33        159651-159752       c
            234-479             AC024224.33        157289-157534       c
            480-619             AC024224.33        151363-151502       c
            620-735             AC024224.33        150924-151039       c
            736-2456            AC024224.33        148878-150598       c
FEATURES             Location/Qualifiers
     source          1..2456
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.2"
     gene            1..2456
                     /gene="OLR1"
                     /gene_synonym="CLEC8A; LOX1; LOXIN; SCARE1; SLOX1"
                     /note="oxidized low density lipoprotein receptor 1"
                     /db_xref="GeneID:4973"
                     /db_xref="HGNC:HGNC:8133"
                     /db_xref="MIM:602601"
     exon            1..131
                     /gene="OLR1"
                     /gene_synonym="CLEC8A; LOX1; LOXIN; SCARE1; SLOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            132..233
                     /gene="OLR1"
                     /gene_synonym="CLEC8A; LOX1; LOXIN; SCARE1; SLOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            234..479
                     /gene="OLR1"
                     /gene_synonym="CLEC8A; LOX1; LOXIN; SCARE1; SLOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            480..619
                     /gene="OLR1"
                     /gene_synonym="CLEC8A; LOX1; LOXIN; SCARE1; SLOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            620..735
                     /gene="OLR1"
                     /gene_synonym="CLEC8A; LOX1; LOXIN; SCARE1; SLOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            736..2456
                     /gene="OLR1"
                     /gene_synonym="CLEC8A; LOX1; LOXIN; SCARE1; SLOX1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2427..2432
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OLR1"
                     /gene_synonym="CLEC8A; LOX1; LOXIN; SCARE1; SLOX1"
                     /note="hexamer: AATAAA"
     polyA_site      2456
                     /gene="OLR1"
                     /gene_synonym="CLEC8A; LOX1; LOXIN; SCARE1; SLOX1"
                     /note="major polyA site"
ORIGIN      
        1 agtttgttga agttcgtgac tgcttcactc tctcattctt agcttgaatt tggaaatgac
       61 ttttgatgac ctaaagatcc agactgtgaa ggaccagcct gatgagaagt caaatggaaa
      121 aaaagctaaa ggtcttcagt ttctttactc tccatggtgg tgcctggctg ctgcgactct
      181 aggggtcctt tgcctgggat tagtagtgac cattatggtg ctgggcatgc aattatccca
      241 ggtgtctgac ctcctaacac aagagcaagc aaacctaact caccagaaaa agaaactgga
      301 gggacagatc tcagcccggc aacaagcaga agaagcttca caggagtcag aaaacgaact
      361 caaggaaatg atagaaaccc ttgctcggaa gctgaatgag aaatccaaag agcaaatgga
      421 acttcaccac cagaatctga atctccaaga aacactgaag agagtagcaa attgttcagc
      481 tccttgtccg caagactgga tctggcatgg agaaaactgt tacctatttt cctcgggctc
      541 atttaactgg gaaaagagcc aagagaagtg cttgtctttg gatgccaagt tgctgaaaat
      601 taatagcaca gctgatctgg acttcatcca gcaagcaatt tcctattcca gttttccatt
      661 ctggatgggg ctgtctcgga ggaaccccag ctacccatgg ctctgggagg acggttctcc
      721 tttgatgccc cacttattta gagtccgagg cgctgtctcc cagacatacc cttcaggtac
      781 ctgtgcatat atacaacgag gagctgttta tgcggaaaac tgcattttag ctgccttcag
      841 tatatgtcag aagaaggcaa acctaagagc acagtgaatt tgaaggctct ggaagaaaag
      901 aaaaaagtct ttgagtttta ttctggaatt taagctattc tttgtcactt gggtgccaaa
      961 catgagagcc cagaaaactg tcatttagct ggctgcagaa ctcctttgca gaaactgggg
     1021 ttccaggagc ctggcacctt tatgtcaaca tttttgattc tagctacctg tattatttca
     1081 cctagcttgt cccaagcttc cctgccagcc tgaagtccat tttccccttt ttattttaaa
     1141 atttgactcc tcttcaagct tgaaaaccct ctgaactcag tcttctttac ctcattatca
     1201 ccttcccctc acactcctaa aattgcatga aagacagaac atggagaact tgctcaagtg
     1261 caggcagaga gcaaaaaggg gaaatatgtc tgggaaaaag tgcacgtgaa gaaacaaaga
     1321 aggacagagg ccattccgaa atcaagaaac tcatgttctt aactttaaaa aaggtatcaa
     1381 tccttggttt ttaaactgtg gtccatctcc agactctacc acttacggac agacagacag
     1441 acagacacac acacacacac acacacacat tttgggacaa gtggggagcc caagaaagta
     1501 attagtaagt gagtggtctt ttctgtaagc taatccacaa cctgttacca cttcctgaat
     1561 cagttattat ttcttcattt ttttttctac cagaggacag attaatagat ttaacccttc
     1621 acaacagttc ttgttagaat catgggatgt gtggcccaga ggtaagaata gaatttcttt
     1681 ccctaaagaa catacctttt gtagatgaac tcttctcaac tctgttttgc tatgctataa
     1741 ttccgaaaca tacaagacaa aaaaaatgaa gacactcaat ctagaacaaa ctaagccagg
     1801 tatgcaaata tcgctgaata gaaacagatg gaattagaaa tatatcttct atttttaggc
     1861 ttctatttcc tttccaccca ctcttcacag gctattctac tttaaaggaa gcctttttat
     1921 tttgctgcac acaatctagc aggaatcttt tttttttttt aagagctgtg tcatccttat
     1981 gtaggcaaga gatgtttgct tttgttaaaa gctttattga gatataatta acataaaata
     2041 aactgaacat atttaaagtg tactatttga taagttttca caccttgtgg agaacatgca
     2101 tactacaatt aagagagtga acatatccat catccctcaa agtgtcacaa tgctcctcct
     2161 gatgactcct ccccagaaaa ccaccaatcg gctttcattt tgcattttgt agttttatgt
     2221 gaatggaatc atatagtatg tctttttttt ttgtctggct tctttcactt tgcataatta
     2281 ttttgagatt catatgtctc catcttgatg ctcgtatgaa ttcattcttt taaatgttga
     2341 atattccctt gtatggatat accacaattc atttacccat ttacttgttg atgacatttg
     2401 ggttgtttta gttttgggat attacaaata aagctgctgt gaacatttgt gtacaa
//
