LOCUS       NM_001172632            2316 bp    mRNA    linear   PRI 09-JUL-2024
DEFINITION  Homo sapiens oxidized low density lipoprotein receptor 1 (OLR1),
            transcript variant 2, mRNA.
ACCESSION   NM_001172632
VERSION     NM_001172632.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2316)
  AUTHORS   Lin,C.H., Chiang,C.C., Shih,Y.C., Tung,S.L. and Huang,W.C.
  TITLE     Elucidating the Role of Let-7d-5p and OLR1 in the Progression and
            Prognosis of Oral Squamous Cell Carcinoma via FAK/P53 Signaling
            Axis
  JOURNAL   Anticancer Res 44 (6), 2517-2531 (2024)
   PUBMED   38821588
  REMARK    GeneRIF: Elucidating the Role of Let-7d-5p and OLR1 in the
            Progression and Prognosis of Oral Squamous Cell Carcinoma via
            FAK/P53 Signaling Axis.
REFERENCE   2  (bases 1 to 2316)
  AUTHORS   Arkelius,K., Wendt,T.S., Andersson,H., Arnou,A., Gottschalk,M.,
            Gonzales,R.J. and Ansar,S.
  TITLE     LOX-1 and MMP-9 Inhibition Attenuates the Detrimental Effects of
            Delayed rt-PA Therapy and Improves Outcomes After Acute Ischemic
            Stroke
  JOURNAL   Circ Res 134 (8), 954-969 (2024)
   PUBMED   38501247
  REMARK    GeneRIF: LOX-1 and MMP-9 Inhibition Attenuates the Detrimental
            Effects of Delayed rt-PA Therapy and Improves Outcomes After Acute
            Ischemic Stroke.
REFERENCE   3  (bases 1 to 2316)
  AUTHORS   Xiong,J., Zhang,L., Chen,G., Dong,P., Tong,J., Hua,L., Li,N.,
            Wen,L., Zhu,L., Chang,W. and Jin,Y.
  TITLE     Associations of CKIP-1 and LOX-1 polymorphisms with the risk of
            type 2 diabetes mellitus with hypertension among Chinese adults
  JOURNAL   Acta Diabetol 61 (1), 43-52 (2024)
   PUBMED   37668684
  REMARK    GeneRIF: Associations of CKIP-1 and LOX-1 polymorphisms with the
            risk of type 2 diabetes mellitus with hypertension among Chinese
            adults.
REFERENCE   4  (bases 1 to 2316)
  AUTHORS   Sawamura,T.
  TITLE     [LOX-1: the oxidized LDL receptor expressed in vascular endothelial
            cells]
  JOURNAL   Seikagaku 74 (5), 365-376 (2002)
   PUBMED   12073608
  REMARK    GeneRIF: oxidized LDL receptor expressed in vascular endothelial
            cells
            Review article
REFERENCE   5  (bases 1 to 2316)
  AUTHORS   Nagase,M., Abe,J., Takahashi,K., Ando,J., Hirose,S. and Fujita,T.
  TITLE     Genomic organization and regulation of expression of the
            lectin-like oxidized low-density lipoprotein receptor (LOX-1) gene
  JOURNAL   J Biol Chem 273 (50), 33702-33707 (1998)
   PUBMED   9837956
REFERENCE   6  (bases 1 to 2316)
  AUTHORS   Yamanaka,S., Zhang,X.Y., Miura,K., Kim,S. and Iwao,H.
  TITLE     The human gene encoding the lectin-type oxidized LDL receptor
            (OLR1) is a novel member of the natural killer gene complex with a
            unique expression profile
  JOURNAL   Genomics 54 (2), 191-199 (1998)
   PUBMED   9828121
REFERENCE   7  (bases 1 to 2316)
  AUTHORS   Yoshida,H., Kondratenko,N., Green,S., Steinberg,D. and
            Quehenberger,O.
  TITLE     Identification of the lectin-like receptor for oxidized low-density
            lipoprotein in human macrophages and its potential role as a
            scavenger receptor
  JOURNAL   Biochem J 334 (Pt 1) (Pt 1), 9-13 (1998)
   PUBMED   9693095
REFERENCE   8  (bases 1 to 2316)
  AUTHORS   Mehta,J.L. and Li,D.Y.
  TITLE     Identification and autoregulation of receptor for OX-LDL in
            cultured human coronary artery endothelial cells
  JOURNAL   Biochem Biophys Res Commun 248 (3), 511-514 (1998)
   PUBMED   9703956
REFERENCE   9  (bases 1 to 2316)
  AUTHORS   Li,X., Bouzyk,M.M. and Wang,X.
  TITLE     Assignment of the human oxidized low-density lipoprotein receptor
            gene (OLR1) to chromosome 12p13.1-->p12.3, and identification of a
            polymorphic CA-repeat marker in the OLR1 gene
  JOURNAL   Cytogenet Cell Genet 82 (1-2), 34-36 (1998)
   PUBMED   9763655
REFERENCE   10 (bases 1 to 2316)
  AUTHORS   Sawamura,T., Kume,N., Aoyama,T., Moriwaki,H., Hoshikawa,H.,
            Aiba,Y., Tanaka,T., Miwa,S., Katsura,Y., Kita,T. and Masaki,T.
  TITLE     An endothelial receptor for oxidized low-density lipoprotein
  JOURNAL   Nature 386 (6620), 73-77 (1997)
   PUBMED   9052782
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC024224.33.
            
            On Aug 13, 2020 this sequence version replaced NM_001172632.1.
            
            Summary: This gene encodes a low density lipoprotein receptor that
            belongs to the C-type lectin superfamily. This gene is regulated
            through the cyclic AMP signaling pathway. The encoded protein
            binds, internalizes and degrades oxidized low-density lipoprotein.
            This protein may be involved in the regulation of Fas-induced
            apoptosis. This protein may play a role as a scavenger receptor.
            Mutations of this gene have been associated with atherosclerosis,
            risk of myocardial infarction, and may modify the risk of
            Alzheimer's disease. Alternate splicing results in multiple
            transcript variants.[provided by RefSeq, Feb 2010].
            
            Transcript Variant: This variant (2) lacks an exon in the coding
            region, which results in a frameshift and an early stop codon,
            compared to variant 1. The encoded isoform (2) is shorter and has a
            distinct C-terminus, compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK295409.1, SRR1803614.30175.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-131               AC024224.33        162579-162709       c
            132-233             AC024224.33        159651-159752       c
            234-479             AC024224.33        157289-157534       c
            480-595             AC024224.33        150924-151039       c
            596-2316            AC024224.33        148878-150598       c
FEATURES             Location/Qualifiers
     source          1..2316
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.2"
     gene            1..2316
                     /gene="OLR1"
                     /gene_synonym="CLEC8A; LOX1; LOXIN; SCARE1; SLOX1"
                     /note="oxidized low density lipoprotein receptor 1"
                     /db_xref="GeneID:4973"
                     /db_xref="HGNC:HGNC:8133"
                     /db_xref="MIM:602601"
     exon            1..131
                     /gene="OLR1"
                     /gene_synonym="CLEC8A; LOX1; LOXIN; SCARE1; SLOX1"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..601
                     /gene="OLR1"
                     /gene_synonym="CLEC8A; LOX1; LOXIN; SCARE1; SLOX1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     scavenger receptor class E, member 1; lectin-type oxidized
                     LDL receptor 1; ox LDL receptor 1; C-type lectin domain
                     family 8 member A; oxidized low-density lipoprotein
                     receptor 1, soluble form; oxidized low density lipoprotein
                     (lectin-like) receptor 1; hLOX-1"
                     /codon_start=1
                     /product="oxidized low-density lipoprotein receptor 1
                     isoform 2"
                     /protein_id="NP_001166103.1"
                     /db_xref="CCDS:CCDS53745.1"
                     /db_xref="GeneID:4973"
                     /db_xref="HGNC:HGNC:8133"
                     /db_xref="MIM:602601"
                     /translation="MTFDDLKIQTVKDQPDEKSNGKKAKGLQFLYSPWWCLAAATLGV
                     LCLGLVVTIMVLGMQLSQVSDLLTQEQANLTHQKKKLEGQISARQQAEEASQESENEL
                     KEMIETLARKLNEKSKEQMELHHQNLNLQETLKRVANCSGLHPASNFLFQFSILDGAV
                     SEEPQLPMALGGRFSFDAPLI"
     exon            132..233
                     /gene="OLR1"
                     /gene_synonym="CLEC8A; LOX1; LOXIN; SCARE1; SLOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            234..479
                     /gene="OLR1"
                     /gene_synonym="CLEC8A; LOX1; LOXIN; SCARE1; SLOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            480..595
                     /gene="OLR1"
                     /gene_synonym="CLEC8A; LOX1; LOXIN; SCARE1; SLOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            596..2316
                     /gene="OLR1"
                     /gene_synonym="CLEC8A; LOX1; LOXIN; SCARE1; SLOX1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2287..2292
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OLR1"
                     /gene_synonym="CLEC8A; LOX1; LOXIN; SCARE1; SLOX1"
                     /note="hexamer: AATAAA"
     polyA_site      2316
                     /gene="OLR1"
                     /gene_synonym="CLEC8A; LOX1; LOXIN; SCARE1; SLOX1"
                     /note="major polyA site"
ORIGIN      
        1 agtttgttga agttcgtgac tgcttcactc tctcattctt agcttgaatt tggaaatgac
       61 ttttgatgac ctaaagatcc agactgtgaa ggaccagcct gatgagaagt caaatggaaa
      121 aaaagctaaa ggtcttcagt ttctttactc tccatggtgg tgcctggctg ctgcgactct
      181 aggggtcctt tgcctgggat tagtagtgac cattatggtg ctgggcatgc aattatccca
      241 ggtgtctgac ctcctaacac aagagcaagc aaacctaact caccagaaaa agaaactgga
      301 gggacagatc tcagcccggc aacaagcaga agaagcttca caggagtcag aaaacgaact
      361 caaggaaatg atagaaaccc ttgctcggaa gctgaatgag aaatccaaag agcaaatgga
      421 acttcaccac cagaatctga atctccaaga aacactgaag agagtagcaa attgttcagg
      481 acttcatcca gcaagcaatt tcctattcca gttttccatt ctggatgggg ctgtctcgga
      541 ggaaccccag ctacccatgg ctctgggagg acggttctcc tttgatgccc cacttattta
      601 gagtccgagg cgctgtctcc cagacatacc cttcaggtac ctgtgcatat atacaacgag
      661 gagctgttta tgcggaaaac tgcattttag ctgccttcag tatatgtcag aagaaggcaa
      721 acctaagagc acagtgaatt tgaaggctct ggaagaaaag aaaaaagtct ttgagtttta
      781 ttctggaatt taagctattc tttgtcactt gggtgccaaa catgagagcc cagaaaactg
      841 tcatttagct ggctgcagaa ctcctttgca gaaactgggg ttccaggagc ctggcacctt
      901 tatgtcaaca tttttgattc tagctacctg tattatttca cctagcttgt cccaagcttc
      961 cctgccagcc tgaagtccat tttccccttt ttattttaaa atttgactcc tcttcaagct
     1021 tgaaaaccct ctgaactcag tcttctttac ctcattatca ccttcccctc acactcctaa
     1081 aattgcatga aagacagaac atggagaact tgctcaagtg caggcagaga gcaaaaaggg
     1141 gaaatatgtc tgggaaaaag tgcacgtgaa gaaacaaaga aggacagagg ccattccgaa
     1201 atcaagaaac tcatgttctt aactttaaaa aaggtatcaa tccttggttt ttaaactgtg
     1261 gtccatctcc agactctacc acttacggac agacagacag acagacacac acacacacac
     1321 acacacacat tttgggacaa gtggggagcc caagaaagta attagtaagt gagtggtctt
     1381 ttctgtaagc taatccacaa cctgttacca cttcctgaat cagttattat ttcttcattt
     1441 ttttttctac cagaggacag attaatagat ttaacccttc acaacagttc ttgttagaat
     1501 catgggatgt gtggcccaga ggtaagaata gaatttcttt ccctaaagaa catacctttt
     1561 gtagatgaac tcttctcaac tctgttttgc tatgctataa ttccgaaaca tacaagacaa
     1621 aaaaaatgaa gacactcaat ctagaacaaa ctaagccagg tatgcaaata tcgctgaata
     1681 gaaacagatg gaattagaaa tatatcttct atttttaggc ttctatttcc tttccaccca
     1741 ctcttcacag gctattctac tttaaaggaa gcctttttat tttgctgcac acaatctagc
     1801 aggaatcttt tttttttttt aagagctgtg tcatccttat gtaggcaaga gatgtttgct
     1861 tttgttaaaa gctttattga gatataatta acataaaata aactgaacat atttaaagtg
     1921 tactatttga taagttttca caccttgtgg agaacatgca tactacaatt aagagagtga
     1981 acatatccat catccctcaa agtgtcacaa tgctcctcct gatgactcct ccccagaaaa
     2041 ccaccaatcg gctttcattt tgcattttgt agttttatgt gaatggaatc atatagtatg
     2101 tctttttttt ttgtctggct tctttcactt tgcataatta ttttgagatt catatgtctc
     2161 catcttgatg ctcgtatgaa ttcattcttt taaatgttga atattccctt gtatggatat
     2221 accacaattc atttacccat ttacttgttg atgacatttg ggttgtttta gttttgggat
     2281 attacaaata aagctgctgt gaacatttgt gtacaa
//
