LOCUS       NM_175747               2196 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens oligodendrocyte transcription factor 3 (OLIG3), mRNA.
ACCESSION   NM_175747
VERSION     NM_175747.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2196)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2196)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2196)
  AUTHORS   Skarp,S., Kamarainen,O.P., Wei,G.H., Jakkula,E., Kiviranta,I.,
            Kroger,H., Auvinen,J., Lehenkari,P., Ala-Kokko,L. and Mannikko,M.
  TITLE     Whole exome sequencing in Finnish families identifies new candidate
            genes for osteoarthritis
  JOURNAL   PLoS One 13 (8), e0203313 (2018)
   PUBMED   30157244
  REMARK    GeneRIF: Two identified variants revealed novel candidate genes for
            hip and knee osteoarthritis. OLIG3 and FIP1L1 have specific roles
            in transcription and may effect expression of other genes.
            Identified variants in these genes may thus have a role in the
            regulatory events leading to osteoarthritis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2196)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   5  (bases 1 to 2196)
  AUTHORS   Plant,D., Farragher,T., Flynn,E., Martin,P., Eyre,S., Bunn,D.,
            Worthington,J., Symmons,D., Barton,A. and Thomson,W.
  TITLE     A genetic marker at the OLIG3/TNFAIP3 locus associates with
            methotrexate continuation in early inflammatory polyarthritis:
            results from the Norfolk Arthritis Register
  JOURNAL   Pharmacogenomics J 12 (2), 128-133 (2012)
   PUBMED   20921970
  REMARK    GeneRIF: SNP within the OLIG3/TNFAIP3 locus (rs6920220) was
            associated with being less likely to maintain MTX monotherapy
            GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   6  (bases 1 to 2196)
  AUTHORS   Morgan,A.W., Robinson,J.I., Conaghan,P.G., Martin,S.G.,
            Hensor,E.M., Morgan,M.D., Steiner,L., Erlich,H.A., Gooi,H.C.,
            Barton,A., Worthington,J. and Emery,P.
  CONSRTM   UKRAG Consortium; YEAR Consortium
  TITLE     Evaluation of the rheumatoid arthritis susceptibility loci
            HLA-DRB1, PTPN22, OLIG3/TNFAIP3, STAT4 and TRAF1/C5 in an inception
            cohort
  JOURNAL   Arthritis Res Ther 12 (2), R57 (2010)
   PUBMED   20353580
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 2196)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   8  (bases 1 to 2196)
  AUTHORS   Muller,T., Anlag,K., Wildner,H., Britsch,S., Treier,M. and
            Birchmeier,C.
  TITLE     The bHLH factor Olig3 coordinates the specification of dorsal
            neurons in the spinal cord
  JOURNAL   Genes Dev 19 (6), 733-743 (2005)
   PUBMED   15769945
REFERENCE   9  (bases 1 to 2196)
  AUTHORS   Takebayashi,H., Yoshida,S., Sugimori,M., Kosako,H., Kominami,R.,
            Nakafuku,M. and Nabeshima,Y.
  TITLE     Dynamic expression of basic helix-loop-helix Olig family members:
            implication of Olig2 in neuron and oligodendrocyte differentiation
            and identification of a new member, Olig3
  JOURNAL   Mech Dev 99 (1-2), 143-148 (2000)
   PUBMED   11091082
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK096362.1.
            
            On Jun 3, 2003 this sequence version replaced NM_175747.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK096362.1, BC051352.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367734.4/ ENSP00000356708.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..2196
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q23.3"
     gene            1..2196
                     /gene="OLIG3"
                     /gene_synonym="Bhlhb7; bHLHe20"
                     /note="oligodendrocyte transcription factor 3"
                     /db_xref="GeneID:167826"
                     /db_xref="HGNC:HGNC:18003"
                     /db_xref="MIM:609323"
     exon            1..2196
                     /gene="OLIG3"
                     /gene_synonym="Bhlhb7; bHLHe20"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..1043
                     /gene="OLIG3"
                     /gene_synonym="Bhlhb7; bHLHe20"
                     /note="oligo3; class B basic helix-loop-helix protein 7;
                     class E basic helix-loop-helix protein 20"
                     /codon_start=1
                     /product="oligodendrocyte transcription factor 3"
                     /protein_id="NP_786923.1"
                     /db_xref="CCDS:CCDS5186.1"
                     /db_xref="GeneID:167826"
                     /db_xref="HGNC:HGNC:18003"
                     /db_xref="MIM:609323"
                     /translation="MNSDSSSVSSRASSPDMDEMYLRDHHHRHHHHQESRLNSVSSTQ
                     GDMMQKMPGESLSRAGAKAAGESSKYKIKKQLSEQDLQQLRLKINGRERKRMHDLNLA
                     MDGLREVMPYAHGPSVRKLSKIATLLLARNYILMLTSSLEEMKRLVGEIYGGHHSAFH
                     CGTVGHSAGHPAHAANSVHPVHPILGGALSSGNASSPLSAASLPAIGTIRPPHSLLKA
                     PSTPPALQLGSGFQHWAGLPCPCTICQMPPPPHLSALSTANMARLSAESKDLLK"
     regulatory      2172..2177
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OLIG3"
                     /gene_synonym="Bhlhb7; bHLHe20"
                     /note="hexamer: AATAAA"
     polyA_site      2196
                     /gene="OLIG3"
                     /gene_synonym="Bhlhb7; bHLHe20"
                     /note="major polyA site"
ORIGIN      
        1 agttcaagca cacaccaact agctgtccag gaagcagcct aaccagagag aggggcgtgg
       61 gagggagaga ggcggggaaa agcagcgtct ccgcttttct tctcacgtct tgccgcggag
      121 aagtgggttc ctgggcagtg cagatttttt ttttttaatt caagattttc tttaatttcc
      181 cgcctaaagc ctccccacgg tagggccgca tcccctgtaa taaaatgaat tctgattcga
      241 gctctgtctc cagcagagct tcatctccgg acatggatga gatgtacctg agggaccacc
      301 accaccgcca ccaccaccac caggagagcc gtctcaactc ggtctcgtcc acgcagggcg
      361 atatgatgca gaagatgccc ggggaaagcc tctcgcgggc tggcgccaag gccgcgggag
      421 agagcagcaa gtacaaaatc aagaagcagc tgtcggagca ggacctacag cagttgaggc
      481 tgaagatcaa cggacgcgaa cgcaagcgga tgcacgacct gaacctagcc atggacgggc
      541 tgcgcgaagt catgccctac gcgcatgggc cgtcggtgcg caagctctcc aagatcgcca
      601 cactcctgct cgccagaaac tacatcctca tgctcaccag ctccctggag gagatgaaga
      661 ggctggttgg cgagatctat gggggccacc actcggcctt tcactgcggg accgtgggcc
      721 actcggccgg ccaccccgcg cacgcggcca actccgtgca cccggtgcac cccatcttgg
      781 gcggcgcgct ctcatctggc aacgcctcgt caccgctgtc cgccgcctca cttcccgcca
      841 tcggcaccat ccggcctccc cactcgctac tcaaggcgcc ctccacgccg cccgcgctgc
      901 agctgggcag cggcttccag cactgggctg gtctgccctg cccctgcacc atctgccaga
      961 tgccgccgcc gccgcacctg tccgctctct ccacagccaa catggcccgg ctgtcggccg
     1021 agtccaagga cttgctcaag tgagcagcgg gcgggcccgg ctgccaagga ggagggagag
     1081 cggcgggagg ggccgcggtg ccgggccggg agggaagagg gaggctgcac gctcggccca
     1141 cgggagggca ggctccgggg cccgcagcct cccacgctgt ctgagagatc tcagactcca
     1201 cttgaccccc ggagggaaag gaccaaaatc aaaccgcaat ttctaggtgg tagcaaaggg
     1261 ggactcgaac cagatgtcgt gtgttttgca tgcatgcttc ttttccccat gccgcgccag
     1321 tatttttcac tgccatatgc tcttgtcaaa actgcatttg ttgtataaag atgggatcgg
     1381 tgtagttaaa aacttgcgaa gggacttttg agttggcttt ctctgactct gtgttctcgc
     1441 tttggaaaaa gacggccatc ccttttgtgc aaaacaaatg taaatatttt cttgagatgg
     1501 atgcgattat gattgtctct gtccttgcca cagtttttct agagacaatg gagagagaaa
     1561 gagagagaga gcgcgagaga gatcaagacc caagttttga atctcaaccg aggtccaggg
     1621 catgacacct cctatgtggg ttttcctttc gacgcagtgt aggtcaaaag aatgcatgca
     1681 cgcttctaaa tgaatcttgt ctgaatatgt cgtgcaggct gtggtgccgt tttccttgta
     1741 acaaggattt attagtgaat tatcccaagt actccatata tctgtctgtg gttgtatgaa
     1801 atgaaaaaag gggcagagtg caaagaccca cactcacgca cacgcgcttc ttctcccacc
     1861 cccaccccct tcaaacttta ttcggaacct tcctttgctg ttctggggcc gctattgtaa
     1921 aagcctgggc tccctctagt agcttgcgcc accccccctc gctcagttat tctgcatgcg
     1981 gggttggctc tctctattat cagctttgaa aacttatcct ggttttggga ggggtgccgt
     2041 ttttattttc ctgaacattt gcttgaaata ttttgttagg gcctcaaaga cgatacctgt
     2101 ctttattttt tatatattct tgataactat gatatattta ttaataacca gtgtttctgg
     2161 atgagatttc aaataaaaaa gaacctttaa atcgtg
//
