LOCUS       NM_005806               2477 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens oligodendrocyte transcription factor 2 (OLIG2), mRNA.
ACCESSION   NM_005806
VERSION     NM_005806.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2477)
  AUTHORS   Hayashi,S., Seki-Omura,R., Yamada,S., Kamata,T., Sato,Y., Oe,S.,
            Koike,T., Nakano,Y., Iwashita,H., Hirahara,Y., Tanaka,S.,
            Sekijima,T., Ito,T., Yasukochi,Y., Higasa,K. and Kitada,M.
  TITLE     OLIG2 translocates to chromosomes during mitosis via a temperature
            downshift: A novel neural cold response of mitotic bookmarking
  JOURNAL   Gene 891, 147829 (2024)
   PUBMED   37748631
  REMARK    GeneRIF: OLIG2 translocates to chromosomes during mitosis via a
            temperature downshift: A novel neural cold response of mitotic
            bookmarking.
REFERENCE   2  (bases 1 to 2477)
  AUTHORS   Zhou,J., Shi,L.F., Wang,Z., Li,M., Zhang,J.S., Mao,Y. and Hua,W.
  TITLE     OLIG2 expression level could be used as an independent prognostic
            factor for patients with cerebellar Glioblastoma (cGBM)
  JOURNAL   Clinics (Sao Paulo) 78, 100120 (2023)
   PUBMED   37001387
  REMARK    GeneRIF: OLIG2 expression level could be used as an independent
            prognostic factor for patients with cerebellar Glioblastoma (cGBM).
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2477)
  AUTHORS   Fan,C., Kim,D., An,H. and Park,Y.
  TITLE     Identifying an oligodendrocyte enhancer that regulates Olig2
            expression
  JOURNAL   Hum Mol Genet 32 (5), 835-846 (2023)
   PUBMED   36193754
  REMARK    GeneRIF: Identifying an oligodendrocyte enhancer that regulates
            Olig2 expression.
REFERENCE   4  (bases 1 to 2477)
  AUTHORS   Mo,H., Magaki,S., Deisch,J.K. and Raghavan,R.
  TITLE     Isocitrate Dehydrogenase Mutations Are Associated with Different
            Expression and DNA Methylation Patterns of OLIG2 in Adult Gliomas
  JOURNAL   J Neuropathol Exp Neurol 81 (9), 707-716 (2022)
   PUBMED   35856894
  REMARK    GeneRIF: Isocitrate Dehydrogenase Mutations Are Associated with
            Different Expression and DNA Methylation Patterns of OLIG2 in Adult
            Gliomas.
REFERENCE   5  (bases 1 to 2477)
  AUTHORS   Furuta,S., Aleksic,B., Nawa,Y., Kimura,H., Kushima,I., Ishizuka,K.,
            Kato,H., Toyama,M., Arioka,Y., Mori,D., Morikawa,M., Inada,T. and
            Ozaki,N.
  TITLE     Investigation of OLIG2 as a candidate gene for schizophrenia and
            autism spectrum disorder
  JOURNAL   Nagoya J Med Sci 84 (2), 260-268 (2022)
   PUBMED   35967956
  REMARK    GeneRIF: Investigation of OLIG2 as a candidate gene for
            schizophrenia and autism spectrum disorder.
REFERENCE   6  (bases 1 to 2477)
  AUTHORS   Fukuda,S., Kondo,T., Takebayashi,H. and Taga,T.
  TITLE     Negative regulatory effect of an oligodendrocytic bHLH factor OLIG2
            on the astrocytic differentiation pathway
  JOURNAL   Cell Death Differ 11 (2), 196-202 (2004)
   PUBMED   14576772
REFERENCE   7  (bases 1 to 2477)
  AUTHORS   Sun,T., Dong,H., Wu,L., Kane,M., Rowitch,D.H. and Stiles,C.D.
  TITLE     Cross-repressive interaction of the Olig2 and Nkx2.2 transcription
            factors in developing neural tube associated with formation of a
            specific physical complex
  JOURNAL   J Neurosci 23 (29), 9547-9556 (2003)
   PUBMED   14573534
REFERENCE   8  (bases 1 to 2477)
  AUTHORS   Lu,Q.R., Park,J.K., Noll,E., Chan,J.A., Alberta,J., Yuk,D.,
            Alzamora,M.G., Louis,D.N., Stiles,C.D., Rowitch,D.H. and Black,P.M.
  TITLE     Oligodendrocyte lineage genes (OLIG) as molecular markers for human
            glial brain tumors
  JOURNAL   Proc Natl Acad Sci U S A 98 (19), 10851-10856 (2001)
   PUBMED   11526205
REFERENCE   9  (bases 1 to 2477)
  AUTHORS   Marie,Y., Sanson,M., Mokhtari,K., Leuraud,P., Kujas,M.,
            Delattre,J.Y., Poirier,J., Zalc,B. and Hoang-Xuan,K.
  TITLE     OLIG2 as a specific marker of oligodendroglial tumour cells
  JOURNAL   Lancet 358 (9278), 298-300 (2001)
   PUBMED   11498220
REFERENCE   10 (bases 1 to 2477)
  AUTHORS   Wang,J., Jani-Sait,S.N., Escalon,E.A., Carroll,A.J., de Jong,P.J.,
            Kirsch,I.R. and Aplan,P.D.
  TITLE     The t(14;21)(q11.2;q22) chromosomal translocation associated with
            T-cell acute lymphoblastic leukemia activates the BHLHB1 gene
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3497-3502 (2000)
   PUBMED   10737801
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC047511.1 and AF221520.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_005806.3.
            
            Summary: This gene encodes a basic helix-loop-helix transcription
            factor which is expressed in oligodendroglial tumors of the brain.
            The protein is an essential regulator of ventral neuroectodermal
            progenitor cell fate. The gene is involved in a chromosomal
            translocation t(14;21)(q11.2;q22) associated with T-cell acute
            lymphoblastic leukemia. Its chromosomal location is within a region
            of chromosome 21 which has been suggested to play a role in
            learning deficits associated with Down syndrome. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC047511.1, AF221520.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000382357.4/ ENSP00000371794.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-601               BC047511.1         1-601
            602-1446            AF221520.1         552-1396
            1447-2477           BC047511.1         1447-2477
FEATURES             Location/Qualifiers
     source          1..2477
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.11"
     gene            1..2477
                     /gene="OLIG2"
                     /gene_synonym="BHLHB1; bHLHe19; OLIGO2; PRKCBP2; RACK17"
                     /note="oligodendrocyte transcription factor 2"
                     /db_xref="GeneID:10215"
                     /db_xref="HGNC:HGNC:9398"
                     /db_xref="MIM:606386"
     exon            1..92
                     /gene="OLIG2"
                     /gene_synonym="BHLHB1; bHLHe19; OLIGO2; PRKCBP2; RACK17"
                     /inference="alignment:Splign:2.1.0"
     exon            93..2477
                     /gene="OLIG2"
                     /gene_synonym="BHLHB1; bHLHe19; OLIGO2; PRKCBP2; RACK17"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..1126
                     /gene="OLIG2"
                     /gene_synonym="BHLHB1; bHLHe19; OLIGO2; PRKCBP2; RACK17"
                     /note="oligodendrocyte-specific bHLH transcription factor
                     2; human protein kinase C-binding protein RACK17; basic
                     domain, helix-loop-helix protein, class B, 1; protein
                     kinase C-binding protein 2; class B basic helix-loop-helix
                     protein 1; class E basic helix-loop-helix protein 19;
                     oligodendrocyte lineage transcription factor 2"
                     /codon_start=1
                     /product="oligodendrocyte transcription factor 2"
                     /protein_id="NP_005797.1"
                     /db_xref="CCDS:CCDS13620.1"
                     /db_xref="GeneID:10215"
                     /db_xref="HGNC:HGNC:9398"
                     /db_xref="MIM:606386"
                     /translation="MDSDASLVSSRPSSPEPDDLFLPARSKGSSGSAFTGGTVSSSTP
                     SDCPPELSAELRGAMGSAGAHPGDKLGGSGFKSSSSSTSSSTSSAAASSTKKDKKQMT
                     EPELQQLRLKINSRERKRMHDLNIAMDGLREVMPYAHGPSVRKLSKIATLLLARNYIL
                     MLTNSLEEMKRLVSEIYGGHHAGFHPSACGGLAHSAPLPAATAHPAAAAHAAHHPAVH
                     HPILPPAAAAAAAAAAAAAVSSASLPGSGLPSVGSIRPPHGLLKSPSAAAAAPLGGGG
                     GGSGASGGFQHWGGMPCPCSMCQVPPPHHHVSAMGAGSLPRLTSDAK"
     regulatory      1822..1827
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OLIG2"
                     /gene_synonym="BHLHB1; bHLHe19; OLIGO2; PRKCBP2; RACK17"
                     /note="hexamer: AATAAA"
     polyA_site      1849
                     /gene="OLIG2"
                     /gene_synonym="BHLHB1; bHLHe19; OLIGO2; PRKCBP2; RACK17"
                     /note="major polyA site"
     regulatory      2444..2449
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OLIG2"
                     /gene_synonym="BHLHB1; bHLHe19; OLIGO2; PRKCBP2; RACK17"
                     /note="hexamer: AATAAA"
     polyA_site      2477
                     /gene="OLIG2"
                     /gene_synonym="BHLHB1; bHLHe19; OLIGO2; PRKCBP2; RACK17"
                     /note="major polyA site"
ORIGIN      
        1 ggatgcttat tatagatcga cgcgacacca gcgcccggtg ccaggttctc ccctgaggct
       61 tttcggagcg agctcctcaa atcgcatcca gattttcggg tccgagggaa ggaggaccct
      121 gcgaaagctg cgacgactat cttcccctgg ggccatggac tcggacgcca gcctggtgtc
      181 cagccgcccg tcgtcgccag agcccgatga cctttttctg ccggcccgga gtaagggcag
      241 cagcggcagc gccttcactg ggggcaccgt gtcctcgtcc accccgagtg actgcccgcc
      301 ggagctgagc gccgagctgc gcggcgctat gggctctgcg ggcgcgcatc ctggggacaa
      361 gctaggaggc agtggcttca agtcatcctc gtccagcacc tcgtcgtcta cgtcgtcggc
      421 ggctgcgtcg tccaccaaga aggacaagaa gcaaatgaca gagccggagc tgcagcagct
      481 gcgtctcaag atcaacagcc gcgagcgcaa gcgcatgcac gacctcaaca tcgccatgga
      541 tggcctccgc gaggtcatgc cgtacgcaca cggcccttcg gtgcgcaagc tttccaagat
      601 cgccacgctg ctgctggcgc gcaactacat cctcatgctc accaactcgc tggaggagat
      661 gaagcgactg gtgagcgaga tctacggggg ccaccacgct ggcttccacc cgtcggcctg
      721 cggcggcctg gcgcactccg cgcccctgcc cgccgccacc gcgcacccgg cagcagcagc
      781 gcacgccgca catcaccccg cggtgcacca ccccatcctg ccgcccgccg ccgcagcggc
      841 tgctgccgcc gctgcagccg cggctgtgtc cagcgcctct ctgcccggat ccgggctgcc
      901 gtcggtcggc tccatccgtc caccgcacgg cctactcaag tctccgtctg ctgccgcggc
      961 cgccccgctg gggggcgggg gcggcggcag tggggcgagc gggggcttcc agcactgggg
     1021 cggcatgccc tgcccctgca gcatgtgcca ggtgccgccg ccgcaccacc acgtgtcggc
     1081 tatgggcgcc ggcagcctgc cgcgcctcac ctccgacgcc aagtgagccg actggcgccg
     1141 gcgcgttctg gcgacagggg agccaggggc cgcggggaag cgaggactgg cctgcgctgg
     1201 gctcgggagc tctgtcgcga ggaggggcgc aggaccatgg actgggggtg gggcatggtg
     1261 gggattccag catctgcgaa cccaagcaat gggggcgccc acagagcagt ggggagtgag
     1321 gggatgttct ctccgggacc tgatcgagcg ctgtctggct ttaacctgag ctggtccagt
     1381 agacatcgtt ttatgaaaag gtaccgctgt gtgcattcct cactagaact catccgaccc
     1441 ccgaccccca cctccgggaa aagattctaa aaacttcttt ccctgagagc gtggcctgac
     1501 ttgcagactc ggcttgggca gcacttcggg gggggagggg gtgttatggg agggggacac
     1561 attggggcct tgctcctctt cctcctttct tggcgggtgg gagactccgg gtagccgcac
     1621 tgcagaagca acagcccgac cgcgccctcc agggtcgtcc ctggcccaag gccaggggcc
     1681 acaagttagt tggaagccgg cgttcggtat cagaagcgct gatggtcata tccaatctca
     1741 atatctgggt caatccacac cctcttagaa ctgtggccgt tcctccctgt ctctcgttga
     1801 tttgggagaa tatggttttc taataaatct gtggatgttc cttcttcaac agtatgagca
     1861 agtttataga cattcagagt agaaccactt gtggattgga ataacccaaa actgccgatt
     1921 tcaggggcgg gtgcattgta gttattattt taaaatagaa actaccccac cgactcatct
     1981 ttccttctct aagcacaaag tgatttggtt attttggtac ctgagaacgt aacagaatta
     2041 aaaggcagtt gctgtggaaa cagtttgggt tatttggggg ttctgttggc tttttaaaat
     2101 tttctttttt ggatgtgtaa atttatcaat gatgaggtaa gtgcgcaatg ctaagctgtt
     2161 tgctcacgtg actgccagcc ccatcggagt ctaagccggc tttcctctat tttggtttat
     2221 ttttgccacg tttaacacaa atggtaaact cctccacgtg cttcctgcgt tccgtgcaag
     2281 ccgcctcggc gctgcctgcg ttgcaaactg ggctttgtag cgtctgccgt gtaacaccct
     2341 tcctctgatc gcaccgcccc tcgcagagag tgtatcatct gttttatttt tgtaaaaaca
     2401 aagtgctaaa taatatttat tacttgtttg gttgcaaaaa cggaataaat gactgagtgt
     2461 tgagatttta aataaaa
//
