LOCUS       NM_138983               2273 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens oligodendrocyte transcription factor 1 (OLIG1), mRNA.
ACCESSION   NM_138983 XM_001127883 XM_001131712
VERSION     NM_138983.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2273)
  AUTHORS   Sabo,J.K., Heine,V., Silbereis,J.C., Schirmer,L., Levison,S.W. and
            Rowitch,D.H.
  TITLE     Olig1 is required for noggin-induced neonatal myelin repair
  JOURNAL   Ann Neurol 81 (4), 560-571 (2017)
   PUBMED   28253550
  REMARK    GeneRIF: Olig1 has a critical function in regulation of postnatal
            neural progenitor cell production in response to Noggin.
REFERENCE   2  (bases 1 to 2273)
  AUTHORS   Rajkowska,G., Mahajan,G., Maciag,D., Sathyanesan,M., Iyo,A.H.,
            Moulana,M., Kyle,P.B., Woolverton,W.L., Miguel-Hidalgo,J.J.,
            Stockmeier,C.A. and Newton,S.S.
  TITLE     Oligodendrocyte morphometry and expression of myelin - Related mRNA
            in ventral prefrontal white matter in major depressive disorder
  JOURNAL   J Psychiatr Res 65, 53-62 (2015)
   PUBMED   25930075
  REMARK    GeneRIF: This study demonstrated that increased expression of mRNA
            of OLIG1 in ventral prefrontal white matter in major depressive
            disorder.
REFERENCE   3  (bases 1 to 2273)
  AUTHORS   Grossmann,A., Benlasfer,N., Birth,P., Hegele,A., Wachsmuth,F.,
            Apelt,L. and Stelzl,U.
  TITLE     Phospho-tyrosine dependent protein-protein interaction network
  JOURNAL   Mol Syst Biol 11 (3), 794 (2015)
   PUBMED   25814554
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2273)
  AUTHORS   Motizuki,M., Isogaya,K., Miyake,K., Ikushima,H., Kubota,T.,
            Miyazono,K., Saitoh,M. and Miyazawa,K.
  TITLE     Oligodendrocyte transcription factor 1 (Olig1) is a Smad cofactor
            involved in cell motility induced by transforming growth
            factor-beta
  JOURNAL   J Biol Chem 288 (26), 18911-18922 (2013)
   PUBMED   23720758
  REMARK    GeneRIF: Olig1 is a Smad cofactor involved in TGF-beta-induced cell
            motility
REFERENCE   5  (bases 1 to 2273)
  AUTHORS   Meijer,D.H., Kane,M.F., Mehta,S., Liu,H., Harrington,E.,
            Taylor,C.M., Stiles,C.D. and Rowitch,D.H.
  TITLE     Separated at birth? The functional and molecular divergence of
            OLIG1 and OLIG2
  JOURNAL   Nat Rev Neurosci 13 (12), 819-831 (2012)
   PUBMED   23165259
  REMARK    GeneRIF: This study review OLIG1 have developmental functions in
            patterning, neuron subtype specification and the formation of
            oligodendrocytes and play the role in the postnatal brain during
            repair processes and in neurological disease states.
            Review article
REFERENCE   6  (bases 1 to 2273)
  AUTHORS   Arnett,H.A., Fancy,S.P., Alberta,J.A., Zhao,C., Plant,S.R.,
            Kaing,S., Raine,C.S., Rowitch,D.H., Franklin,R.J. and Stiles,C.D.
  TITLE     bHLH transcription factor Olig1 is required to repair demyelinated
            lesions in the CNS
  JOURNAL   Science 306 (5704), 2111-2115 (2004)
   PUBMED   15604411
REFERENCE   7  (bases 1 to 2273)
  AUTHORS   McLellan,A.S., Langlands,K. and Kealey,T.
  TITLE     Exhaustive identification of human class II basic helix-loop-helix
            proteins by virtual library screening
  JOURNAL   Mech Dev 119 Suppl 1, S285-S291 (2002)
   PUBMED   14516699
REFERENCE   8  (bases 1 to 2273)
  AUTHORS   Lu,Q.R., Park,J.K., Noll,E., Chan,J.A., Alberta,J., Yuk,D.,
            Alzamora,M.G., Louis,D.N., Stiles,C.D., Rowitch,D.H. and Black,P.M.
  TITLE     Oligodendrocyte lineage genes (OLIG) as molecular markers for human
            glial brain tumors
  JOURNAL   Proc Natl Acad Sci U S A 98 (19), 10851-10856 (2001)
   PUBMED   11526205
REFERENCE   9  (bases 1 to 2273)
  AUTHORS   Takebayashi,H., Yoshida,S., Sugimori,M., Kosako,H., Kominami,R.,
            Nakafuku,M. and Nabeshima,Y.
  TITLE     Dynamic expression of basic helix-loop-helix Olig family members:
            implication of Olig2 in neuron and oligodendrocyte differentiation
            and identification of a new member, Olig3
  JOURNAL   Mech Dev 99 (1-2), 143-148 (2000)
   PUBMED   11091082
REFERENCE   10 (bases 1 to 2273)
  AUTHORS   Zhou,Q., Wang,S. and Anderson,D.J.
  TITLE     Identification of a novel family of oligodendrocyte
            lineage-specific basic helix-loop-helix transcription factors
  JOURNAL   Neuron 25 (2), 331-343 (2000)
   PUBMED   10719889
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP000289.1, BC033290.1, AL834450.1 and AL355743.1.
            
            On Nov 22, 2018 this sequence version replaced NM_138983.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AL834450.1, BC033290.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000382348.2/ ENSP00000371785.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AP000289.1         1734-1736
            4-929               BC033290.1         8-933
            930-1334            AL834450.1         920-1324
            1335-2273           AL355743.1         476-1414
FEATURES             Location/Qualifiers
     source          1..2273
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.11"
     gene            1..2273
                     /gene="OLIG1"
                     /gene_synonym="BHLHB6; BHLHE21"
                     /note="oligodendrocyte transcription factor 1"
                     /db_xref="GeneID:116448"
                     /db_xref="HGNC:HGNC:16983"
                     /db_xref="MIM:606385"
     exon            1..2273
                     /gene="OLIG1"
                     /gene_synonym="BHLHB6; BHLHE21"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..922
                     /gene="OLIG1"
                     /gene_synonym="BHLHB6; BHLHE21"
                     /note="oligodendrocyte-specific bHLH transcription factor
                     1; basic domain, helix-loop-helix protein, class B, 6;
                     oligodendrocyte lineage transcription factor 1; oligo1;
                     class B basic helix-loop-helix protein 6; class E basic
                     helix-loop-helix protein 21"
                     /codon_start=1
                     /product="oligodendrocyte transcription factor 1"
                     /protein_id="NP_620450.2"
                     /db_xref="CCDS:CCDS42920.2"
                     /db_xref="GeneID:116448"
                     /db_xref="HGNC:HGNC:16983"
                     /db_xref="MIM:606385"
                     /translation="MYYAVSQARVNAVPGTMLRPQRPGDLQLGASLYELVGYRQPPSS
                     SSSSTSSTSSTSSSSTTAPLLPKAAREKPEAPAEPPGPGPGSGAHPGGSARPDAKEEQ
                     QQQLRRKINSRERKRMQDLNLAMDALREVILPYSAAHCQGAPGRKLSKIATLLLARNY
                     ILLLGSSLQELRRALGEGAGPAAPRLLLAGLPLLAAAPGSVLLAPGAVGPPDALRPAK
                     YLSLALDEPPCGQFALPGGGAGGPGLCTCAVCKFPHLVPASLGLAAVQAQFSK"
     regulatory      2253..2258
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OLIG1"
                     /gene_synonym="BHLHB6; BHLHE21"
                     /note="hexamer: AATAAA"
     polyA_site      2273
                     /gene="OLIG1"
                     /gene_synonym="BHLHB6; BHLHE21"
                     /note="major polyA site"
ORIGIN      
        1 accatcgttt ccccgcgcgc aggtccgcgg ggaggggcgg cctgccgacc ggcccacccc
       61 agggcgttcc tgaagggcgt cctcggccgc ccccaccgcc tcccagatgt actatgcggt
      121 ttcccaggcg cgcgtgaacg cggtccccgg gaccatgctg cggccacagc ggcccggaga
      181 cttgcagctc ggggcctccc tctacgagct ggtgggctac aggcagccgc cctcctcctc
      241 ctcctcctcc acctcctcca cctcctccac ttcctcctcc tccacgacgg cccccctcct
      301 ccccaaggct gcgcgcgaga agccggaggc gccggccgag cctccaggcc ccgggcccgg
      361 gtcaggcgcg cacccgggcg gcagcgcccg gccggacgcc aaggaggagc agcagcagca
      421 gctgcggcgc aagatcaaca gccgcgagcg gaagcgcatg caggacctga acctggccat
      481 ggacgccctg cgcgaggtca tcctgcccta ctcagcggcg cactgccagg gcgcgcccgg
      541 ccgcaagctc tccaagatag ccacgctgct gctcgcccgc aactacatcc tactgctggg
      601 cagctcgctg caggagctgc gccgcgcgct gggcgagggc gccgggcccg ccgcgccgcg
      661 cctgctgctg gccgggctgc ccctgctcgc cgccgcgccc ggctccgtgc tgctggcgcc
      721 cggcgccgta ggaccccccg acgcgctgcg ccccgccaag tacctgtcgc tggcgctgga
      781 cgagccgccg tgcggccagt tcgctctccc cggcggcggc gcaggcggcc ccggcctctg
      841 cacctgcgcc gtgtgcaagt tcccgcacct ggtcccggcc agcctgggcc tggccgccgt
      901 gcaggcgcaa ttctccaagt gagggcgggc ctgggcctgg ggcgcgacct cggcccggcc
      961 tcccttcgct cagcttctcc gcgcccctgc tccctgcgtc tgggagagcg aggccgagca
     1021 aggaaagcat ttcgaacctt ccagtccaga ggaagggact gtcgggcacc cccttccccg
     1081 cccccacccc tgggacgtta aagtgaccag agcggatgtt cgatggcgcc tcggggcagt
     1141 ttggggttct gggtcggttc cagcggcttt aggcagaaag tgctcgctct cacccagcac
     1201 atctctctcc ttgtccctgg agttgcgcgc ttcgcggggc cgatgtagaa cttagggcgc
     1261 cttgccgtgg ttggcgcgcc ccgggtgcag cgagaggcca tccccgagcg ctacctcccc
     1321 ggagcggagc acgccggctc ccagtactag gggctgcgct cgagcagtgg cgggggcgga
     1381 ggggtggttc ttttccttct cctccgccag aggccacggg cgcccttgtt cccgccggcc
     1441 aggtcctatc aaaggaggct gccggaactc aagaggcaga aaaagaccag ttaggcggtg
     1501 cagacggtct gggacgtggc agacggacgg accctcggcg gacaggtggt cggcgtcggg
     1561 gtgcggtggg taggggcgag gacaacgcag ggtgcgctgg gttgggacgt gggtccactt
     1621 ttgtagacca gctgtttgga gagctgtatt taagactcgc gtatccagtg ttttgtcgca
     1681 gagagttttc gctcttaaat cctgggggtt tcttagaaag caacttagaa ctcgagattc
     1741 acctttcgtt tccctttccc caaaagtagc gtaaccaaca tttaagcttg cttaaaaacg
     1801 aaaaccaacc gccttgcatc cagtgttccc gatttactaa aataggtaac caggcgtctc
     1861 acagtcgccg tcctgtcaag agcgctaatg aacgttctca ttaacacgca ggagtaccgg
     1921 gagccctgaa ccgcccgctg ctcggcggat cccagctgcg gtggcgacgg cgggaaggcg
     1981 ctttccgctg ttcctcagcg ggccgggccc ttgaccagcg cggcccgcag gtcttccttc
     2041 tcgccgtctt gcagttgaag agctacatac gtagtcagtt tcgatttgtt acagacgtta
     2101 acaaattcct ttacccaagg ttatgctatg acctttccgc agtttacttt gattttctat
     2161 gtttaaggtt ttggttgttg gtagtagccg aatttaactg gcactttatt ttacttctaa
     2221 ccttgtttcc tgacggtgta cagaatcaac aaaataaaac atttaaagtc tga
//
