LOCUS       NM_020190               1748 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens olfactomedin like 3 (OLFML3), transcript variant 1,
            mRNA.
ACCESSION   NM_020190
VERSION     NM_020190.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1748)
  AUTHORS   Toedebusch,R.G., Lucchesi,C.A., Debebe,E.T., Wittenburg,L.A.,
            Chen,X. and Toedebusch,C.M.
  TITLE     Microglia-Derived Olfactomedin-like 3 Promotes Pro-Tumorigenic
            Microglial Function and Malignant Features of Glioma Cells
  JOURNAL   Int J Mol Sci 22 (23), 13052 (2021)
   PUBMED   34884869
  REMARK    GeneRIF: Microglia-Derived Olfactomedin-like 3 Promotes
            Pro-Tumorigenic Microglial Function and Malignant Features of
            Glioma Cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1748)
  AUTHORS   Mei,H., Zha,Z., Wang,W., Xie,Y., Huang,Y., Li,W., Wei,D., Zhang,X.,
            Qu,J. and Liu,J.
  TITLE     Surfaceome CRISPR screen identifies OLFML3 as a
            rhinovirus-inducible IFN antagonist
  JOURNAL   Genome Biol 22 (1), 297 (2021)
   PUBMED   34686207
  REMARK    GeneRIF: Surfaceome CRISPR screen identifies OLFML3 as a
            rhinovirus-inducible IFN antagonist.
            Erratum:[Genome Biol. 2021 Nov 15;22(1):314. doi:
            10.1186/s13059-021-02534-5.. PMID: 34782001]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1748)
  AUTHORS   Chen,P., Hsu,W.H., Chang,A., Tan,Z., Lan,Z., Zhou,A., Spring,D.J.,
            Lang,F.F., Wang,Y.A. and DePinho,R.A.
  TITLE     Circadian Regulator CLOCK Recruits Immune-Suppressive Microglia
            into the GBM Tumor Microenvironment
  JOURNAL   Cancer Discov 10 (3), 371-381 (2020)
   PUBMED   31919052
  REMARK    GeneRIF: Circadian Regulator CLOCK Recruits Immune-Suppressive
            Microglia into the GBM Tumor Microenvironment.
REFERENCE   4  (bases 1 to 1748)
  AUTHORS   Dunn,L.L., de Valence,S., Tille,J.C., Hammel,P., Walpoth,B.H.,
            Stocker,R., Imhof,B.A. and Miljkovic-Licina,M.
  TITLE     Biodegradable and plasma-treated electrospun scaffolds coated with
            recombinant Olfactomedin-like 3 for accelerating wound healing and
            tissue regeneration
  JOURNAL   Wound Repair Regen 24 (6), 1030-1035 (2016)
   PUBMED   27684720
REFERENCE   5  (bases 1 to 1748)
  AUTHORS   Anholt,R.R.
  TITLE     Olfactomedin proteins: central players in development and disease
  JOURNAL   Front Cell Dev Biol 2, 6 (2014)
   PUBMED   25364714
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1748)
  AUTHORS   Rodriguez-Sanchez,I.P., Garza-Rodriguez,M.L., Mohamed-Noriega,K.,
            Voruganti,V.S., Tejero,M.E., Delgado-Enciso,I., Perez-Ibave,D.C.,
            Schlabritz-Loutsevitch,N.E., Mohamed-Noriega,J.,
            Martinez-Fierro,M.L., Resendez-Perez,D., Cole,S.A.,
            Cavazos-Adame,H., Comuzzie,A.G., Mohamed-Hamsho,J. and
            Barrera-Saldana,H.A.
  TITLE     Olfactomedin-like 3 (OLFML3) gene expression in baboon and human
            ocular tissues: cornea, lens, uvea, and retina
  JOURNAL   J Med Primatol 42 (3), 105-111 (2013)
   PUBMED   23398349
  REMARK    GeneRIF: This paper reports OLFML3 expression in human and baboon
            eye. The full coding DNA sequence has 1221 bp, from which an open
            reading frame of 406 amino acid was obtained.
REFERENCE   7  (bases 1 to 1748)
  AUTHORS   Miljkovic-Licina,M., Hammel,P., Garrido-Urbani,S., Lee,B.P.,
            Meguenani,M., Chaabane,C., Bochaton-Piallat,M.L. and Imhof,B.A.
  TITLE     Targeting olfactomedin-like 3 inhibits tumor growth by impairing
            angiogenesis and pericyte coverage
  JOURNAL   Mol Cancer Ther 11 (12), 2588-2599 (2012)
   PUBMED   23002094
REFERENCE   8  (bases 1 to 1748)
  AUTHORS   Fautsch,M.P., Vrabel,A.M. and Johnson,D.H.
  TITLE     The identification of myocilin-associated proteins in the human
            trabecular meshwork
  JOURNAL   Exp Eye Res 82 (6), 1046-1052 (2006)
   PUBMED   16289162
REFERENCE   9  (bases 1 to 1748)
  AUTHORS   Zeng,L.C., Han,Z.G. and Ma,W.J.
  TITLE     Elucidation of subfamily segregation and intramolecular coevolution
            of the olfactomedin-like proteins by comprehensive phylogenetic
            analysis and gene expression pattern assessment
  JOURNAL   FEBS Lett 579 (25), 5443-5453 (2005)
   PUBMED   16212957
REFERENCE   10 (bases 1 to 1748)
  AUTHORS   Zeng,L.C., Liu,F., Zhang,X., Zhu,Z.D., Wang,Z.Q., Han,Z.G. and
            Ma,W.J.
  TITLE     hOLF44, a secreted glycoprotein with distinct expression pattern,
            belongs to an uncharacterized olfactomedin-like subfamily newly
            identified by phylogenetic analysis
  JOURNAL   FEBS Lett 571 (1-3), 74-80 (2004)
   PUBMED   15280020
  REMARK    GeneRIF: may have matrix-related function involved in human
            placental and embryonic development, or play a similar role in
            other physiological processes
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY464015.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_020190.4.
            
            Summary: This gene encodes a member of the olfactomedin-like gene
            family which also includes genes encoding noelin, tiarin, myocilin,
            amassin, optimedin, photomedin, and latrophilin. The encoded
            protein is a secreted extracellular matrix glycoprotein with a
            C-terminal olfactomedin domain that facilitates protein-protein
            interactions, cell adhesion, and intercellular interactions. It
            serves as both a scaffold protein that recruits bone morphogenetic
            protein 1 to its substrate chordin, and as a vascular tissue
            remodeler with pro-angiogenic properties. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Feb
            2017].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF201945.1, AY464015.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000320334.5/ ENSP00000322273.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1748              AY464015.1         49-1796
FEATURES             Location/Qualifiers
     source          1..1748
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.2"
     gene            1..1748
                     /gene="OLFML3"
                     /gene_synonym="HNOEL-iso; OLF44"
                     /note="olfactomedin like 3"
                     /db_xref="GeneID:56944"
                     /db_xref="HGNC:HGNC:24956"
                     /db_xref="MIM:610088"
     exon            1..157
                     /gene="OLFML3"
                     /gene_synonym="HNOEL-iso; OLF44"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..1264
                     /gene="OLFML3"
                     /gene_synonym="HNOEL-iso; OLF44"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; olfactomedin-like protein 3; olfactomedin,
                     44-kd"
                     /codon_start=1
                     /product="olfactomedin-like protein 3 isoform 1 precursor"
                     /protein_id="NP_064575.1"
                     /db_xref="CCDS:CCDS870.1"
                     /db_xref="GeneID:56944"
                     /db_xref="HGNC:HGNC:24956"
                     /db_xref="MIM:610088"
                     /translation="MGPSTPLLILFLLSWSGPLQGQQHHLVEYMERRLAALEERLAQC
                     QDQSSRHAAELRDFKNKMLPLLEVAEKEREALRTEADTISGRVDRLEREVDYLETQNP
                     ALPCVEFDEKVTGGPGTKGKGRRNEKYDMVTDCGYTISQVRSMKILKRFGGPAGLWTK
                     DPLGQTEKIYVLDGTQNDTAFVFPRLRDFTLAMAARKASRVRVPFPWVGTGQLVYGGF
                     LYFARRPPGRPGGGGEMENTLQLIKFHLANRTVVDSSVFPAEGLIPPYGLTADTYIDL
                     AADEEGLWAVYATREDDRHLCLAKLDPQTLDTEQQWDTPCPRENAEAAFVICGTLYVV
                     YNTRPASRARIQCSFDASGTLTPERAALPYFPRRYGAHASLRYNPRERQLYAWDDGYQ
                     IVYKLEMRKKEEEV"
     exon            158..443
                     /gene="OLFML3"
                     /gene_synonym="HNOEL-iso; OLF44"
                     /inference="alignment:Splign:2.1.0"
     exon            444..1748
                     /gene="OLFML3"
                     /gene_synonym="HNOEL-iso; OLF44"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1727..1732
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OLFML3"
                     /gene_synonym="HNOEL-iso; OLF44"
                     /note="hexamer: ATTAAA"
     polyA_site      1748
                     /gene="OLFML3"
                     /gene_synonym="HNOEL-iso; OLF44"
                     /note="major polyA site"
ORIGIN      
        1 gactgtacgt tccttctact ctggcaccac tctccaggct gccatggggc ccagcacccc
       61 tctcctcatc ttgttccttt tgtcatggtc gggacccctc caaggacagc agcaccacct
      121 tgtggagtac atggaacgcc gactagctgc tttagaggaa cggctggccc agtgccagga
      181 ccagagtagt cggcatgctg ctgagctgcg ggacttcaag aacaagatgc tgccactgct
      241 ggaggtggca gagaaggagc gggaggcact cagaactgag gccgacacca tctccgggag
      301 agtggatcgt ctggagcggg aggtagacta tctggagacc cagaacccag ctctgccctg
      361 tgtagagttt gatgagaagg tgactggagg ccctgggacc aaaggcaagg gaagaaggaa
      421 tgagaagtac gatatggtga cagactgtgg ctacacaatc tctcaagtga gatcaatgaa
      481 gattctgaag cgatttggtg gcccagctgg tctatggacc aaggatccac tggggcaaac
      541 agagaagatc tacgtgttag atgggacaca gaatgacaca gcctttgtct tcccaaggct
      601 gcgtgacttc acccttgcca tggctgcccg gaaagcttcc cgagtccggg tgcccttccc
      661 ctgggtaggc acagggcagc tggtatatgg tggctttctt tattttgctc ggaggcctcc
      721 tggaagacct ggtggaggtg gtgagatgga gaacactttg cagctaatca aattccacct
      781 ggcaaaccga acagtggtgg acagctcagt attcccagca gaggggctga tcccccccta
      841 cggcttgaca gcagacacct acatcgacct ggcagctgat gaggaaggtc tttgggctgt
      901 ctatgccacc cgggaggatg acaggcactt gtgtctggcc aagttagatc cacagacact
      961 ggacacagag cagcagtggg acacaccatg tcccagagag aatgctgagg ctgcctttgt
     1021 catctgtggg accctctatg tcgtctataa cacccgtcct gccagtcggg cccgcatcca
     1081 gtgctccttt gatgccagcg gcaccctgac ccctgaacgg gcagcactcc cttattttcc
     1141 ccgcagatat ggtgcccatg ccagcctccg ctataacccc cgagaacgcc agctctatgc
     1201 ctgggatgat ggctaccaga ttgtctataa gctggagatg aggaagaaag aggaggaggt
     1261 ttgaggagct agccttgttt tttgcatctt tctcactccc atacatttat attatatccc
     1321 cactaaattt cttgttcctc attcttcaaa tgtgggccag ttgtggctca aatcctctat
     1381 atttttagcc aatggcaatc aaattctttc agctcctttg tttcatacgg aactccagat
     1441 cctgagtaat ccttttagag cccgaagagt caaaaccctc aatgttccct cctgctctcc
     1501 tgccccatgt caacaaattt caggctaagg atgccccaga cccagggctc taaccttgta
     1561 tgcgggcagg cccagggagc aggcagcagt gttcttcccc tcagagtgac ttggggaggg
     1621 agaaatagga ggagacgtcc agctctgtcc tctcttcctc actcctccct tcagtgtcct
     1681 gaggaacagg actttctcca cattgttttg tattgcaaca ttttgcatta aaaggaaaat
     1741 ccactgct
//
