LOCUS       NM_015441               3175 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens olfactomedin like 2B (OLFML2B), transcript variant 2,
            mRNA.
ACCESSION   NM_015441 XM_034000
VERSION     NM_015441.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3175)
  AUTHORS   Liu,J., Liu,Z., Zhang,X., Gong,T. and Yao,D.
  TITLE     Bioinformatic exploration of OLFML2B overexpression in gastric
            cancer base on multiple analyzing tools
  JOURNAL   BMC Cancer 19 (1), 227 (2019)
   PUBMED   30866865
  REMARK    GeneRIF: The high expression of OLFML2B was associate with a short
            overall survival in gastric cancer patients.
            Erratum:[BMC Cancer. 2019 Aug 1;19(1):759. doi:
            10.1186/s12885-019-5937-1.. PMID: 31370831]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3175)
  AUTHORS   Arking,D.E., Pulit,S.L., Crotti,L., van der Harst,P., Munroe,P.B.,
            Koopmann,T.T., Sotoodehnia,N., Rossin,E.J., Morley,M., Wang,X.,
            Johnson,A.D., Lundby,A., Gudbjartsson,D.F., Noseworthy,P.A.,
            Eijgelsheim,M., Bradford,Y., Tarasov,K.V., Dorr,M.,
            Muller-Nurasyid,M., Lahtinen,A.M., Nolte,I.M., Smith,A.V.,
            Bis,J.C., Isaacs,A., Newhouse,S.J., Evans,D.S., Post,W.S.,
            Waggott,D., Lyytikainen,L.P., Hicks,A.A., Eisele,L., Ellinghaus,D.,
            Hayward,C., Navarro,P., Ulivi,S., Tanaka,T., Tester,D.J.,
            Chatel,S., Gustafsson,S., Kumari,M., Morris,R.W., Naluai,A.T.,
            Padmanabhan,S., Kluttig,A., Strohmer,B., Panayiotou,A.G.,
            Torres,M., Knoflach,M., Hubacek,J.A., Slowikowski,K.,
            Raychaudhuri,S., Kumar,R.D., Harris,T.B., Launer,L.J.,
            Shuldiner,A.R., Alonso,A., Bader,J.S., Ehret,G., Huang,H.,
            Kao,W.H., Strait,J.B., Macfarlane,P.W., Brown,M., Caulfield,M.J.,
            Samani,N.J., Kronenberg,F., Willeit,J., Smith,J.G., Greiser,K.H.,
            Meyer Zu Schwabedissen,H., Werdan,K., Carella,M., Zelante,L.,
            Heckbert,S.R., Psaty,B.M., Rotter,J.I., Kolcic,I., Polasek,O.,
            Wright,A.F., Griffin,M., Daly,M.J., Arnar,D.O., Holm,H.,
            Thorsteinsdottir,U., Denny,J.C., Roden,D.M., Zuvich,R.L.,
            Emilsson,V., Plump,A.S., Larson,M.G., O'Donnell,C.J., Yin,X.,
            Bobbo,M., D'Adamo,A.P., Iorio,A., Sinagra,G., Carracedo,A.,
            Cummings,S.R., Nalls,M.A., Jula,A., Kontula,K.K., Marjamaa,A.,
            Oikarinen,L., Perola,M., Porthan,K., Erbel,R., Hoffmann,P.,
            Jockel,K.H., Kalsch,H., Nothen,M.M., den Hoed,M., Loos,R.J.,
            Thelle,D.S., Gieger,C., Meitinger,T., Perz,S., Peters,A.,
            Prucha,H., Sinner,M.F., Waldenberger,M., de Boer,R.A., Franke,L.,
            van der Vleuten,P.A., Beckmann,B.M., Martens,E., Bardai,A.,
            Hofman,N., Wilde,A.A., Behr,E.R., Dalageorgou,C., Giudicessi,J.R.,
            Medeiros-Domingo,A., Barc,J., Kyndt,F., Probst,V., Ghidoni,A.,
            Insolia,R., Hamilton,R.M., Scherer,S.W., Brandimarto,J.,
            Margulies,K., Moravec,C.E., del Greco,M. F, Fuchsberger,C.,
            O'Connell,J.R., Lee,W.K., Watt,G.C., Campbell,H., Wild,S.H., El
            Mokhtari,N.E., Frey,N., Asselbergs,F.W., Mateo Leach,I., Navis,G.,
            van den Berg,M.P., van Veldhuisen,D.J., Kellis,M., Krijthe,B.P.,
            Franco,O.H., Hofman,A., Kors,J.A., Uitterlinden,A.G.,
            Witteman,J.C., Kedenko,L., Lamina,C., Oostra,B.A., Abecasis,G.R.,
            Lakatta,E.G., Mulas,A., Orru,M., Schlessinger,D., Uda,M.,
            Markus,M.R., Volker,U., Snieder,H., Spector,T.D., Arnlov,J.,
            Lind,L., Sundstrom,J., Syvanen,A.C., Kivimaki,M., Kahonen,M.,
            Mononen,N., Raitakari,O.T., Viikari,J.S., Adamkova,V., Kiechl,S.,
            Brion,M., Nicolaides,A.N., Paulweber,B., Haerting,J.,
            Dominiczak,A.F., Nyberg,F., Whincup,P.H., Hingorani,A.D.,
            Schott,J.J., Bezzina,C.R., Ingelsson,E., Ferrucci,L., Gasparini,P.,
            Wilson,J.F., Rudan,I., Franke,A., Muhleisen,T.W., Pramstaller,P.P.,
            Lehtimaki,T.J., Paterson,A.D., Parsa,A., Liu,Y., van Duijn,C.M.,
            Siscovick,D.S., Gudnason,V., Jamshidi,Y., Salomaa,V., Felix,S.B.,
            Sanna,S., Ritchie,M.D., Stricker,B.H., Stefansson,K., Boyer,L.A.,
            Cappola,T.P., Olsen,J.V., Lage,K., Schwartz,P.J., Kaab,S.,
            Chakravarti,A., Ackerman,M.J., Pfeufer,A., de Bakker,P.I. and
            Newton-Cheh,C.
  CONSRTM   CARe Consortium; COGENT Consortium; DCCT/EDIC; eMERGE Consortium;
            HRGEN Consortium
  TITLE     Genetic association study of QT interval highlights role for
            calcium signaling pathways in myocardial repolarization
  JOURNAL   Nat Genet 46 (8), 826-836 (2014)
   PUBMED   24952745
REFERENCE   3  (bases 1 to 3175)
  AUTHORS   Deng,X., Sabino,E.C., Cunha-Neto,E., Ribeiro,A.L., Ianni,B.,
            Mady,C., Busch,M.P. and Seielstad,M.
  CONSRTM   REDSII Chagas Study Group from the NHLBI Retrovirus Epidemiology
            Donor Study-II Component International
  TITLE     Genome wide association study (GWAS) of Chagas cardiomyopathy in
            Trypanosoma cruzi seropositive subjects
  JOURNAL   PLoS One 8 (11), e79629 (2013)
   PUBMED   24324551
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3175)
  AUTHORS   Reiner,A.P., Beleza,S., Franceschini,N., Auer,P.L., Robinson,J.G.,
            Kooperberg,C., Peters,U. and Tang,H.
  TITLE     Genome-wide association and population genetic analysis of
            C-reactive protein in African American and Hispanic American women
  JOURNAL   Am J Hum Genet 91 (3), 502-512 (2012)
   PUBMED   22939635
REFERENCE   5  (bases 1 to 3175)
  AUTHORS   Tomarev,S.I. and Nakaya,N.
  TITLE     Olfactomedin domain-containing proteins: possible mechanisms of
            action and functions in normal development and pathology
  JOURNAL   Mol Neurobiol 40 (2), 122-138 (2009)
   PUBMED   19554483
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL590408.15, BC067274.1 and
            AL391825.15.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 11, 2020 this sequence version replaced NM_015441.2.
            
            Summary: This gene encodes an olfactomedin domain-containing
            protein. Most olfactomedin domain-containing proteins are secreted
            glycoproteins. [provided by RefSeq, Dec 2016].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site, compared to variant 3. The encoded isoform (2) is
            shorter than isoform 3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC067274.1, BX648975.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000294794.8/ ENSP00000294794.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AL590408.15        19021-19035         c
            16-1014             BC067274.1         1-999
            1015-1015           AL391825.15        211272-211272       c
            1016-3175           BC067274.1         1001-3160
FEATURES             Location/Qualifiers
     source          1..3175
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.3"
     gene            1..3175
                     /gene="OLFML2B"
                     /note="olfactomedin like 2B"
                     /db_xref="GeneID:25903"
                     /db_xref="HGNC:HGNC:24558"
     exon            1..613
                     /gene="OLFML2B"
                     /inference="alignment:Splign:2.1.0"
     CDS             440..2692
                     /gene="OLFML2B"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; olfactomedin-like protein 2B; photomedin-2"
                     /codon_start=1
                     /product="olfactomedin-like protein 2B isoform 2
                     precursor"
                     /protein_id="NP_056256.1"
                     /db_xref="CCDS:CCDS1236.1"
                     /db_xref="GeneID:25903"
                     /db_xref="HGNC:HGNC:24558"
                     /translation="MAKPRLLVLYFALIVVPAWVSSIVLTGTSEPPDAQTVAPAEDET
                     LQNEADNQENVLSQLLGDYDKVKAMSEGSDCQCKCVVRPLGRDACQRINAGASRKEDF
                     YTVETITSGSSCKCACVAPPSALNPCEGDFRLQKLREADSQDLKLSTIIDMLEGAFYG
                     LDLLKLHSVTTKLVGRVDKLEEEVSKNLTKENEQIKEDMEEIRTEMNKRGKENCSENI
                     LDSMPDIRSALQRDAAAAYAHPEYEERFLQEETVSQQINSIELLQTRPLALPEVVKSQ
                     RPLQRQVHLRGRPASQPTVIRGITYYKAKVSEEENDIEEQQDEFFSGDNGVDLLIEDQ
                     LLRHNGLMTSVTRRPAATRQGHSTAVTSDLNARTAPWSSALPQPSTSDPSIANHASVG
                     PTLQTTSVSPDPTRESVLQPSPQVPATTVAHTATQQPAAPAPPAVSPREALMEAMHTV
                     PVPPTTVRTDSLGKDAPAGWGTTPASPTLSPEEEDDIRNVIGRCKDTLSTITGPTTQN
                     TYGRNEGAWMKDPLAKDERIYVTNYYYGNTLVEFRNLENFKQGRWSNSYKLPYSWIGT
                     GHVVYNGAFYYNRAFTRNIIKYDLKQRYVAAWAMLHDVAYEEATPWRWQGHSDVDFAV
                     DENGLWLIYPALDDEGFSQEVIVLSKLNAADLSTQKETTWRTGLRRNFYGNCFVICGV
                     LYAVDSYNQRNANISYAFDTHTNTQIVPRLLFENEYSYTTQIDYNPKDRLLYAWDNGH
                     QVTYHVIFAY"
     exon            614..877
                     /gene="OLFML2B"
                     /inference="alignment:Splign:2.1.0"
     exon            878..985
                     /gene="OLFML2B"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1162
                     /gene="OLFML2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1388
                     /gene="OLFML2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1913
                     /gene="OLFML2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2090
                     /gene="OLFML2B"
                     /inference="alignment:Splign:2.1.0"
     exon            2091..3175
                     /gene="OLFML2B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3153..3158
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OLFML2B"
                     /note="hexamer: AATAAA"
     polyA_site      3175
                     /gene="OLFML2B"
                     /note="major polyA site"
ORIGIN      
        1 agccctcgcc cagcagcccg cgccgccacc gcctcttccc tccccgtgtc cggtccccgt
       61 gcgtcccgag gctccccgcc gcccgtcccg gcgcgcaccg cgggcgtctg tccgaacgcc
      121 ttccagccac ctgagccctc ctgcgggcga ctcgctcagc tagcccgtgc ccgcctccac
      181 cttctccgtc atcccctctt ccttgcgtcc ggctctccac tggggctgca cagtcgaggg
      241 ctgctcgcgt cgggaaggag atgcccagag tctctggggc gcaccctccc gtcccgctca
      301 gccgcaccca gctttagaag gtgctctcag cagccacttt cgggctctag cgaggacacc
      361 ctctcgcaga agtccttgcc gagacccccc gccccagcca ttctctgaag gggctgagga
      421 cactcttatc gcgcccctca tggccaagcc tcggctgcta gttctctact tcgctctgat
      481 tgtggttccg gcctgggtgt ccagcattgt cctcacaggg acaagcgagc ccccagatgc
      541 gcagacagtg gcgcctgcgg aggacgagac tctgcaaaac gaggcggaca accaggagaa
      601 cgttttatct cagttgctgg gggactatga caaggtcaag gctatgtctg agggctcgga
      661 ctgtcagtgc aagtgtgtgg tgagacccct gggccgggat gcctgccaga ggatcaatgc
      721 gggggcctcc aggaaggaag acttctatac cgtggaaacc atcacctcag gctcgtcgtg
      781 caagtgtgcc tgtgtagcac ccccatcggc cctcaatccc tgcgagggag acttcaggct
      841 ccagaagctg cgggaggcag acagccagga cttgaagctc tccacaatca tagacatgtt
      901 ggaaggagcg ttctatggcc tggatctcct gaagctacat tcagtcacca ccaaactggt
      961 ggggcgagtg gataaactgg aggaggaagt gtctaaaaac ctcaccaagg aaaatgaaca
     1021 aatcaaagag gacatggaag aaattcgaac cgagatgaat aagcgaggca aagaaaattg
     1081 ctctgaaaac atcctagata gcatgccaga catccgctca gccctgcaga gggatgcagc
     1141 agcagcctac gcccacccag agtatgaaga gcggtttctg caggaagaaa ccgtgtccca
     1201 gcagatcaac tccatcgaac ttctgcagac gcgacccctg gctctgcctg aggtggtgaa
     1261 gtcacagcgg cccctgcaga ggcaggtcca cctgagaggc cggccggcct cccagcccac
     1321 tgtcatccgg ggcatcacct actataaagc caaggtctct gaagaagaga atgacattga
     1381 agagcagcaa gatgagtttt tcagcggtga caatggagtg gatttgctga ttgaagatca
     1441 gctcctgaga cacaacggcc tgatgaccag tgtcacccgg aggcctgcag ccacccgtca
     1501 gggacacagc actgctgtga caagcgacct gaacgctcgg accgcaccct ggtcctcagc
     1561 actgccacag ccctcgacct cagatcccag catcgccaac catgcctcag tgggaccaac
     1621 actccaaaca acctcggtgt ctccagatcc cacaagggag tcagtcctgc agccttctcc
     1681 tcaggtacca gccaccactg tggcccacac agccacccag caaccagcag ccccagctcc
     1741 tccggcagtg tctcccaggg aggcattgat ggaagctatg cacacagtcc cagtgcctcc
     1801 caccacagtc agaacagact cgctggggaa agatgctcct gctgggtggg gaacaacccc
     1861 tgccagcccc acgctgagcc ccgaagaaga agatgacatc cggaatgtca taggaaggtg
     1921 caaggacact ctctccacaa tcacggggcc gaccacccag aacacatatg ggcggaatga
     1981 aggggcctgg atgaaggacc ccctggccaa ggatgagcgg atttacgtaa ccaactatta
     2041 ctacggcaac accctggtag agttccggaa cctggagaac ttcaaacaag gtcgctggag
     2101 caattcctac aagctcccgt acagctggat cggcacaggc cacgtggtat acaatggcgc
     2161 cttctactac aatcgcgcct tcacccgcaa catcatcaag tacgacctga agcagcgcta
     2221 cgtggctgcc tgggccatgc tgcatgacgt ggcctacgag gaggccaccc cctggcgatg
     2281 gcagggccac tcagacgtgg actttgctgt ggacgagaat ggcctatggc tcatctaccc
     2341 ggccctggac gatgagggct tcagccagga ggtcattgtc ctgagcaagc tcaatgccgc
     2401 ggacctgagc acacagaagg agaccacatg gcgcacgggg ctccggagga atttctacgg
     2461 caactgcttc gtcatctgtg gggtgctgta tgccgtggat agctacaacc agcggaatgc
     2521 caacatctcc tacgctttcg acacccacac caacacacag atcgtcccca ggctgctgtt
     2581 cgagaatgag tattcctata cgacccagat agactacaac cccaaggacc gcctgctcta
     2641 tgcctgggac aatggccacc aggtcactta ccatgtcatc tttgcctact gacacccttg
     2701 tccccacaag cagaagcaca gaggggtcac tagcaccttg tgtgtatgtg tgtgcgcgca
     2761 cgtgtgtgta ggtgggtatg tgttgtttaa aaatatatat tattttgtat aatattgcaa
     2821 atgtaaaatg acaatttggg tctatttttt tatatggatt gtagatcaat ccatacgtgt
     2881 atgtgctggt ctcatcctcc ccagtttata tttttgtgca aatgaacttc tccttttgac
     2941 cagtaaccac cttccttcaa gccttcagcc cctccagctc caagtctcag atctcgacca
     3001 ttgaaaaggt ttcttcatct gggtcttgca ggaggcaggc aacaccagga gcagaaatga
     3061 aagaggcaag aaagaagtgc tatgtggcga gaaaaaaagt tttaatgtat tggagaagtt
     3121 ttaaaaaacc cagaaaaacg cttttttttt ttaataaaga agaaatttaa aatca
//
