LOCUS       NM_182487               6567 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens olfactomedin like 2A (OLFML2A), transcript variant 1,
            mRNA.
ACCESSION   NM_182487
VERSION     NM_182487.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6567)
  AUTHORS   Perez-Ibave,D.C., Gonzalez-Alvarez,R., de La Luz
            Martinez-Fierro,M., Ruiz-Ayma,G., Luna-Munoz,M.,
            Martinez-De-Villarreal,L.E., De Lourdes Garza-Rodriguez,M.,
            Resendez-Perez,D., Mohamed-Noriega,J., Garza-Guajardo,R.,
            Bautista-De-Lucio,V.M., Mohamed-Noriega,K., Barboza-Quintana,O.,
            Aramburo-De-La-Hoz,C., Barrera-Saldana,H.A. and
            Rodriguez-Sanchez,I.P.
  TITLE     Olfactomedin-like 2 A and B (OLFML2A and OLFML2B) expression
            profile in primates (human and baboon)
  JOURNAL   Biol Res 49 (1), 44 (2016)
   PUBMED   27821182
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6567)
  AUTHORS   Greliche,N., Germain,M., Lambert,J.C., Cohen,W., Bertrand,M.,
            Dupuis,A.M., Letenneur,L., Lathrop,M., Amouyel,P., Morange,P.E. and
            Tregouet,D.A.
  TITLE     A genome-wide search for common SNP x SNP interactions on the risk
            of venous thrombosis
  JOURNAL   BMC Med Genet 14, 36 (2013)
   PUBMED   23509962
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6567)
  AUTHORS   Sistani,L., Rodriguez,P.Q., Hultenby,K., Uhlen,M., Betsholtz,C.,
            Jalanko,H., Tryggvason,K., Wernerson,A. and Patrakka,J.
  TITLE     Neuronal proteins are novel components of podocyte major processes
            and their expression in glomerular crescents supports their role in
            crescent formation
  JOURNAL   Kidney Int 83 (1), 63-71 (2013)
   PUBMED   22913984
  REMARK    GeneRIF: Three neuronal proteins (Huntingtin interacting protein 1,
            neurofascin, and olfactomedin-like 2a) are novel components of
            podocyte major processes and their expression in glomerular
            crescents supports their role in crescent formation.
REFERENCE   4  (bases 1 to 6567)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL354928.9, DA727926.1 and AB119055.1.
            
            On Nov 22, 2018 this sequence version replaced NM_182487.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358185.1, AB119055.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373580.8/ ENSP00000362682.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                AL354928.9         37001-37025
            26-138              DA727926.1         1-113
            139-2097            AB119055.1         1-1959
            2098-6567           AL354928.9         70281-74750
FEATURES             Location/Qualifiers
     source          1..6567
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q33.3"
     gene            1..6567
                     /gene="OLFML2A"
                     /gene_synonym="PRO34319"
                     /note="olfactomedin like 2A"
                     /db_xref="GeneID:169611"
                     /db_xref="HGNC:HGNC:27270"
                     /db_xref="MIM:615899"
     exon            1..228
                     /gene="OLFML2A"
                     /gene_synonym="PRO34319"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..2097
                     /gene="OLFML2A"
                     /gene_synonym="PRO34319"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; olfactomedin-like protein 2A; photomedin-1"
                     /codon_start=1
                     /product="olfactomedin-like protein 2A isoform 1
                     precursor"
                     /protein_id="NP_872293.2"
                     /db_xref="CCDS:CCDS6857.2"
                     /db_xref="GeneID:169611"
                     /db_xref="HGNC:HGNC:27270"
                     /db_xref="MIM:615899"
                     /translation="MAAAALPPRPLLLLPLVLLLSGRPTRADSKVFGDLDQVRMTSEG
                     SDCRCKCIMRPLSKDACSRVRSGRARVEDFYTVETVSSGTDCRCSCTAPPSSLNPCEN
                     EWKMEKLKKQAPELLKLQSMVDLLEGTLYSMDLMKVHAYVHKVASQMNTLEESIKANL
                     SRENEVVKDSVRHLSEQLRHYENHSAIMLGIKKELSRLGLQLLQKDAAAAPATPATGT
                     GSKAQDTARGKGKDISKYGSVQKSFADRGLPKPPKEKLLQVEKLRKESGKGSFLQPTA
                     KPRALAQQQAVIRGFTYYKAGKQEVTEAVADNTLQGTSWLEQLPPKVEGRSNSAEPNS
                     AEQDEAEPRSSERVDLASGTPTSIPATTTTATTTPTPTTSLLPTEPPSGPEVSSQGRE
                     ASCEGTLRAVDPPVRHHSYGRHEGAWMKDPAARDDRIYVTNYYYGNSLVEFRNLENFK
                     QGRWSNMYKLPYNWIGTGHVVYQGAFYYNRAFTKNIIKYDLRQRFVASWALLPDVVYE
                     DTTPWKWRGHSDIDFAVDESGLWVIYPAVDDRDEAQPEVIVLSRLDPGDLSVHRETTW
                     KTRLRRNSYGNCFLVCGILYAVDTYNQQEGQVAYAFDTHTGTDARPQLPFLNEHAYTT
                     QIDYNPKERVLYAWDNGHQLTYTLHFVV"
     exon            229..492
                     /gene="OLFML2A"
                     /gene_synonym="PRO34319"
                     /inference="alignment:Splign:2.1.0"
     exon            493..600
                     /gene="OLFML2A"
                     /gene_synonym="PRO34319"
                     /inference="alignment:Splign:2.1.0"
     exon            601..807
                     /gene="OLFML2A"
                     /gene_synonym="PRO34319"
                     /inference="alignment:Splign:2.1.0"
     exon            808..1057
                     /gene="OLFML2A"
                     /gene_synonym="PRO34319"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1306
                     /gene="OLFML2A"
                     /gene_synonym="PRO34319"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1492
                     /gene="OLFML2A"
                     /gene_synonym="PRO34319"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..6567
                     /gene="OLFML2A"
                     /gene_synonym="PRO34319"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6536..6541
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OLFML2A"
                     /gene_synonym="PRO34319"
                     /note="hexamer: AATAAA"
     polyA_site      6567
                     /gene="OLFML2A"
                     /gene_synonym="PRO34319"
                     /note="major polyA site"
ORIGIN      
        1 agacccgcgg ggctggcagc agggtgcagg cgcggggcgc ggggcaggca gagcgggcga
       61 aggcgcggag ctcgcagtgc agcccgcgct tcccagcgtc cgtgcccggc cgcctgtgcc
      121 taccgtgccc gtggcgccat ggccgctgcc gccctcccgc cccggccgct gctccttctg
      181 ccgctagtgc tgctgctgag cggccgcccc acgcgcgccg acagtaaggt gtttggggac
      241 ctggaccagg tgaggatgac ctcggagggc tccgactgcc gttgcaagtg catcatgcgg
      301 cccctgagca aggacgcgtg tagccgagtg cgcagtgggc gggcacgcgt ggaggacttc
      361 tacacggtgg agactgtgag ctcgggcact gactgccgct gctcctgtac cgcacctccc
      421 tcctctctca acccctgtga gaacgagtgg aagatggaga aactcaaaaa gcaggcgccc
      481 gagctcctca agctgcagtc catggtggat ctcctggagg gcaccctgta cagcatggac
      541 ttgatgaagg tgcacgccta cgtccacaag gtggcctccc agatgaacac actggaagag
      601 agcatcaagg ccaacctgag ccgggagaat gaggtggtga aggacagcgt gcgccacctc
      661 agtgagcagt tgaggcacta tgagaatcac tctgccatca tgctgggcat caagaaggag
      721 ctgtcccgcc tgggcctcca gctgctgcag aaggatgccg ccgccgcccc tgccacccct
      781 gccacgggca ctggtagcaa ggcccaggac acagctagag gaaaaggcaa ggacatcagc
      841 aagtatggca gtgtgcagaa aagctttgca gacagaggcc tcccaaaacc tcccaaggag
      901 aagctgcttc aggtggagaa gctgagaaag gagagcggca agggcagttt cctccagccc
      961 acagccaagc cccgcgccct ggcccagcag caggctgtga tccggggctt cacctactac
     1021 aaggcaggca agcaggaggt gaccgaggcg gtggcagaca acaccctcca gggcacttcc
     1081 tggctggagc aactgccgcc caaggtggag ggcaggtcca actccgcaga gcccaactcc
     1141 gcagagcagg atgaggctga gcccaggtcc tccgagcgag tggacctggc ttctggcacc
     1201 cccacttcaa tccctgccac caccaccacc gccaccacca ccccaacccc caccaccagt
     1261 ctcctgccca ccgagccacc ttcaggtcca gaagtctcca gccaaggcag agaggcgagc
     1321 tgtgagggca ccctccgggc tgtggacccc cctgtgaggc accacagcta tgggcgccac
     1381 gagggagcct ggatgaagga ccctgcagct cgagacgaca ggatctatgt caccaactac
     1441 tactatggaa acagcctggt ggagttccgc aacctggaaa acttcaagca aggccgctgg
     1501 agtaacatgt acaagctacc ctacaactgg atcggcacag gccacgtggt gtaccagggc
     1561 gccttctact acaaccgcgc cttcaccaag aacatcatca agtacgacct acggcagcgc
     1621 ttcgtggcct cctgggcgct gctgcccgac gtggtatatg aggacaccac accttggaag
     1681 tggcgcggac actcggacat tgactttgcc gtggacgaga gcggcctgtg ggtcatctac
     1741 cccgccgtgg acgaccgcga tgaggcccag cccgaggtga tcgtcctgag tcgcttggac
     1801 cccggcgatc tctccgtgca ccgggagacc acgtggaaga cacggctgcg gcggaactcc
     1861 tacgggaact gcttcctggt gtgcggcatc ctgtatgccg tggacacgta caaccagcag
     1921 gaaggccagg tcgcctacgc tttcgacacg cacacgggca ccgacgcacg cccccagctg
     1981 ccgttcctca acgagcacgc ctacaccacc cagatcgact acaaccccaa ggagcgggtg
     2041 ctgtacgcct gggacaatgg ccaccagctc acctacaccc tccacttcgt ggtctgagtg
     2101 gagacctgtg ctccccggag aggggcagca gtgcgggagg ggctttgcac agcagctcct
     2161 gcaactgacc cagtccgcaa atatttattg ggggccagcc cagggctggg actgggcatg
     2221 aggtggtcac caggattgag cttcctcagc acccagtggg taatacttgc ttccacttgc
     2281 agagcaccgt gccaagcact tcccacacac ttacccgttt gattctccta gcacctccct
     2341 tggaggtaga gatcatgaac ccatttaaca gacgaggaga caggctcaga gaggcaccgt
     2401 cccttgccta acacctcagt tgtgatcagg caggctgtgc tctcaggaca gccccatttt
     2461 agggatgagg agacttcacc acgccctccc ctccctgccc tcccccatct ccccggtctc
     2521 ccttgttctc tcaacccagt ctcccttccc agggccactc agaaccagag gtctttaggg
     2581 ccagtgtact ggtgtggggt ggaggccctg gctctgcctg ccatcctagg gccctgttct
     2641 ggctgagctg ttggtggccc tgggctttgg gccccttagc caatgtcctt gtctcttgtc
     2701 tttggccagc cccctcagcc cagcccaccc cacccgctgt ccggccacat tccaaacctc
     2761 taccgtcacc tagctgctga gcagaaaccg caccccgaga gaaaatccca tcctctgttc
     2821 caaggcccct gtctgctcta tgctcatttt tattttctct tattcttcat cagtgccgtc
     2881 atttgtttct gcagcagcag ctgagaaggc agccggcagc tctgccaggg tggggagctg
     2941 agctgaggct ccctctccac ccagaagcac tggcgttgtt cacatagtca ggccttgggt
     3001 cccctccctg gttcatccca gagcctttgg gcctggagtc cgccttgtcc tttttctctg
     3061 ggctttcaaa cccacaacct ttacacactc agggatacct ccgggtctgc catgaataag
     3121 accctaggcc caagtctggt gtggtgccag gatggcacag tttccctctt ccttgccagc
     3181 cctgacctgg tcactgggca ggctggccca gcagcctggg ggctgcagaa gacatggtgt
     3241 gagtagttgg gtccagggga ggcatcaggc cttcttctgg ttgcaggaga gaaccagagg
     3301 gtgggaacgg ggagggaaga actgagggtc tgcagactgg acttttcctg gctcgaccca
     3361 ggacttgggt tgaggatgca cgggggccac cttgcccggg gccactggtg gctccccaga
     3421 gcctcagacc cacacagccc agaggacgag gccttcaagc ctgcccctct tctgcttttt
     3481 tagacagtat ttttagagct ggaaagaaat tttctagccc aactccctgt ttcatgaaag
     3541 agaaaagagg ctcagaaaag tttagagagc agctcagtgt cacactggga gctgggcaca
     3601 gccgatctcc ttccagaagg gttctgtctg tatcctttat tctccgcaca tggaggctgc
     3661 cctacctggg aaggcacccc agcacctgtg aaggacattt actgctcatc ctcacctgcc
     3721 ccctggccct tgctgccttc attctgtccc aatgccagct ccctggatgt ctgtatgttt
     3781 gaataccagt tgccatgtta ggaaggtcag ctgcacagcc aagagtgtaa gagtgtaaag
     3841 aaatgccttt tttttttttt ttgagttgga gttttgctct tgtcgcccag gctggagtgc
     3901 agtggcgcga tctcggctca ctgcaacctc tgccccctgg gttcaagcga ttctcctgcc
     3961 tcagcctccc tagtagctgg gactacagca cccaccacca cacccagcta atttttgtat
     4021 ttttagtaga gacaggggtt tcaccacgtt ggccaggctg gtctcgaact cctgacctta
     4081 ggtgatccgc ccgcctcagc ctcccaaagt gttgggatta caggcatgag ccactgcgcc
     4141 tggccagcaa atgctttttg tgcagaatac acttctttca ggcattgtca ggtgctgttt
     4201 tgtttaagct ctaactcacc cctggaatac aggggaatga tgacaaccag cccagccagg
     4261 cctgactcat catggtcaca tccagccccc acccccggcc aactaaccac tgcaggctcc
     4321 tcttccagac tcaccagggg gcctcgaggc cccggcatct cccttggccc tgggtgtggg
     4381 ttttacaaga ctgtgtcttt catgacatca tagcccaacc atgtgagaag aaggagaagg
     4441 cccccctttc ttcattaatc tgaaaaaaag gaaagtgaga ataggctgat ttttaaaagt
     4501 taaggggcaa gcagcattgc attctggggg aacgatcctg gccacagccg ccaaacaaac
     4561 attcactagg cctcttctgt tttcataccc ttgtaagtgg gttatgtggt gggtatggtc
     4621 agttttttct tttttctttt cttttctttt ttttgagaca gagtttcgct tttgttgccc
     4681 gggctggaat gcaatggcgc gattcagctc actgcaatct ccgcctcccg ggttcaagtg
     4741 attctcctgc cttagcctcc tgaaaagctg ggattacagg gccctgccac caagcccagc
     4801 taattgtatt tttagtagag acaggatttc accatgttgg ccaggccagt ctcaaactcc
     4861 tgacctcagg tgatccacct gcctcagcct cccagactgt tgggattaca ggcatgagcc
     4921 accacgcctg gccagtttct tcattttaca tatggtcaca ttggcgccta gaacagttag
     4981 gtcgctcgtc acataggcag ttaagtggag aaccaggttt caaaatcagg taagaaaacc
     5041 atcatcatta actgagcacc agctgtgcta agcctgccac gggcgtatcc ttgcagcctc
     5101 acaacagtgg gaggtctgta tcctgaatgt cctcatttta cagatgagga cattgaggag
     5161 aagagactta cccaggctca cacagcagct cagcctgttc caggcgctgg tcagtgcgtg
     5221 ttctttgcca ccagcctgtc actccagtgg cagctccaga aacggaggct gttgctttta
     5281 tccctaaact gcatccacag agaagcccca agaaggaggt tggggccagc tcataaaaag
     5341 cctgaatgcc aagccaagga gtggatgcct ccagtcatat ttagaacaaa gtcaagtata
     5401 aatttacaga gaaaaaattc taagacagtt ggatgttgtc ctgttggtga ggaagggaaa
     5461 ggtttttctt gtagggaact ggaaccagcc cacaactgca cacttgtgag ctgtcatgga
     5521 aacctgatcc ccaacagctt ttgaggttgt ttgtttgttt gtttgtttac ctgtcttggg
     5581 ctttgttgct tttggcaaaa ggtacttcaa acaagggagg gcctggactg agggggacca
     5641 ggtcttcttg ctgacctcgt ctacaaaggc aaaggaaggc aaaggaagct gtctcgggtg
     5701 tttctgaaca acgtgactca tgaggggctt tggctacctc ttgcgttccc cctagagatg
     5761 tccaggcctt acatttaatc ggctttctct gcggtggggt agagaatgga gctcccgcct
     5821 tgcgggcagt gctaaaggtg gagctggggg attttcctgg gaatgatttg agggctcttg
     5881 aaagcccatg tgttccaaag cgtctttaac tctgggatag cattggaagc cgctgtcatg
     5941 acaggacatg gcactggatg gctggcagag agccctggct gggagttagg gagccctggg
     6001 ttggaatcca gccccacctc ttttatgcca caggtttggt caagttctct cccgctcagg
     6061 gtagggctgt gaactccctc ttacagctaa gaacatgcag cttagtgagg acaagaccct
     6121 tctagagctt tacccctaat ccccccccag gagccccgag gccggcatta ttcctcccca
     6181 ttacaggtga tgagcctcaa attcagagag cttaagcaac ctgctcaggg tcacgtctcc
     6241 aacaggcagt agagtcaagg tataaaccag gtctgttttt gtaccagagt cccagactaa
     6301 ctgttggtag gaatcttgta accagtcatg ttttcttcct tgttttggcc gctgggaagc
     6361 tcaaagtcaa attcgagacc cttttttttc caattgtgct gagtctccta ctagactcgc
     6421 ttcattctag ctttctgctt ttacctttac cctaatcttt ttatttttat gctattgtac
     6481 tttatttttg taagttgctg agatatctgt tttgcaacaa gatgggctat atctaaataa
     6541 agacatgatc aaaggtttga tttaaaa
//
