LOCUS       NM_198474               2768 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens olfactomedin like 1 (OLFML1), transcript variant 1,
            mRNA.
ACCESSION   NM_198474 XM_208606
VERSION     NM_198474.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2768)
  AUTHORS   Murakami,K., Kikugawa,S., Kobayashi,Y., Uehara,S., Suzuki,T.,
            Kato,H., Udagawa,N. and Nakamura,Y.
  TITLE     Olfactomedin-like protein OLFML1 inhibits Hippo signaling and
            mineralization in osteoblasts
  JOURNAL   Biochem Biophys Res Commun 505 (2), 419-425 (2018)
   PUBMED   30266405
  REMARK    GeneRIF: mutation of OLFML1 leads to impaired osteoblast
            differentiation and abnormal development of bone tissue
REFERENCE   2  (bases 1 to 2768)
  AUTHORS   Wan,B., Zhou,Y.B., Zhang,X., Zhu,H., Huo,K. and Han,Z.G.
  TITLE     hOLFML1, a novel secreted glycoprotein, enhances the proliferation
            of human cancer cell lines in vitro
  JOURNAL   FEBS Lett 582 (21-22), 3185-3192 (2008)
   PUBMED   18708057
  REMARK    GeneRIF: These findings suggest that hOLFML1 may play a significant
            role in the regulation of cell proliferation in vitro.
REFERENCE   3  (bases 1 to 2768)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   4  (bases 1 to 2768)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC397336.1, DB257515.1, AK298137.1, AC107884.15 and BX647908.1.
            
            On Nov 23, 2018 this sequence version replaced NM_198474.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a). Variants 1 and 2
            both encode the same isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX647908.1, SRR1803617.154587.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000329293.4/ ENSP00000332511.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-261               DC397336.1         138-398
            262-566             DB257515.1         267-571
            567-1740            AK298137.1         299-1472
            1741-2727           AC107884.15        77376-78362         c
            2728-2768           BX647908.1         2753-2793
FEATURES             Location/Qualifiers
     source          1..2768
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..2768
                     /gene="OLFML1"
                     /gene_synonym="MVAL564; ONT2; UNQ564"
                     /note="olfactomedin like 1"
                     /db_xref="GeneID:283298"
                     /db_xref="HGNC:HGNC:24473"
     exon            1..499
                     /gene="OLFML1"
                     /gene_synonym="MVAL564; ONT2; UNQ564"
                     /inference="alignment:Splign:2.1.0"
     CDS             371..1579
                     /gene="OLFML1"
                     /gene_synonym="MVAL564; ONT2; UNQ564"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; olfactomedin-like protein 1"
                     /codon_start=1
                     /product="olfactomedin-like protein 1 isoform a precursor"
                     /protein_id="NP_940876.2"
                     /db_xref="CCDS:CCDS7779.1"
                     /db_xref="GeneID:283298"
                     /db_xref="HGNC:HGNC:24473"
                     /translation="MMVALRGASALLVLFLAAFLPPPQCTQDPAMVHYIYQRFRVLEQ
                     GLEKCTQATRAYIQEFQEFSKNISVMLGRCQTYTSEYKSAVGNLALRVERAQREIDYI
                     QYLREADECIESEDKTLAEMLLQEAEEEKKIRTLLNASCDNMLMGIKSLKIVKKMMDT
                     HGSWMKDAVYNSPKVYLLIGSRNNTVWEFANIRAFMEDNTKPAPRKQILTLSWQGTGQ
                     VIYKGFLFFHNQATSNEIIKYNLQKRTVEDRMLLPGGVGRALVYQHSPSTYIDLAVDE
                     HGLWAIHSGPGTHSHLVLTKIEPGTLGVEHSWDTPCRSQDAEASFLLCGVLYVVYSTG
                     GQGPHRITCIYDPLGTISEEDLPNLFFPKRPRSHSMIHYNPRDKQLYAWNEGNQIIYK
                     LQTKRKLPLK"
     exon            500..788
                     /gene="OLFML1"
                     /gene_synonym="MVAL564; ONT2; UNQ564"
                     /inference="alignment:Splign:2.1.0"
     exon            789..2768
                     /gene="OLFML1"
                     /gene_synonym="MVAL564; ONT2; UNQ564"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2272..2277
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OLFML1"
                     /gene_synonym="MVAL564; ONT2; UNQ564"
                     /note="hexamer: AATAAA"
     polyA_site      2298
                     /gene="OLFML1"
                     /gene_synonym="MVAL564; ONT2; UNQ564"
                     /note="major polyA site"
     regulatory      2703..2708
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OLFML1"
                     /gene_synonym="MVAL564; ONT2; UNQ564"
                     /note="hexamer: AATAAA"
     polyA_site      2727
                     /gene="OLFML1"
                     /gene_synonym="MVAL564; ONT2; UNQ564"
     polyA_site      2768
                     /gene="OLFML1"
                     /gene_synonym="MVAL564; ONT2; UNQ564"
                     /note="major polyA site"
ORIGIN      
        1 atcttcaccc cccaccccaa tgcacacaca attaagccag gaagcagctt gcaaccacta
       61 gcctggggag ggtccgcatg tgtcaagggt gagggcaaca gatgctggac ccagggagct
      121 ctctgccaca ggtcagtcta caaggcctca gggaccaact tgccaacagc tggacttgat
      181 cactagctgg caaactgagc tcacgtatcg ggtggaataa caagcggact ttgctctctg
      241 ctgtgcaaaa cgctgttttt agaggatttg ccacagcagc ggatagagca ggagagcacc
      301 accggagccc ttgagacatc cttgagaaga gccacagcat aagagactgc cctgcttggt
      361 gttttgcagg atgatggtgg cccttcgagg agcttctgca ttgctggttc tgttccttgc
      421 agcttttctg cccccgccgc agtgtaccca ggacccagcc atggtgcatt acatctacca
      481 gcgctttcga gtcttggagc aagggctgga aaaatgtacc caagcaacga gggcatacat
      541 tcaagaattc caagagttct caaaaaatat atctgtcatg ctgggaagat gtcagaccta
      601 cacaagtgag tacaagagtg cagtgggtaa cttggcactg agagttgaac gtgcccaacg
      661 ggagattgac tacatacaat accttcgaga ggctgacgag tgcatcgaat cagaggacaa
      721 gacactggca gaaatgttgc tccaagaagc tgaagaagag aaaaagatcc ggactctgct
      781 gaatgcaagc tgtgacaaca tgctgatggg cataaagtct ttgaaaatag tgaagaagat
      841 gatggacaca catggctctt ggatgaaaga tgctgtctat aactctccaa aggtgtactt
      901 attaattgga tccagaaaca acactgtttg ggaatttgca aacatacggg cattcatgga
      961 ggataacacc aagccagctc cccggaagca aatcctaaca ctttcctggc agggaacagg
     1021 ccaagtgatc tacaaaggtt ttctattttt tcataaccaa gcaacttcta atgagataat
     1081 caaatataac ctgcagaaga ggactgtgga agatcgaatg ctgctcccag gaggggtagg
     1141 ccgagcattg gtttaccagc actccccctc aacttacatt gacctggctg tggatgagca
     1201 tgggctctgg gccatccact ctgggccagg cacccatagc catttggttc tcacaaagat
     1261 tgagccgggc acactgggag tggagcattc atgggatacc ccatgcagaa gccaggatgc
     1321 tgaagcctca ttcctcttgt gtggggttct ctatgtggtc tacagtactg ggggccaggg
     1381 ccctcatcgc atcacctgca tctatgatcc actgggcact atcagtgagg aggacttgcc
     1441 caacttgttc ttccccaaga gaccaagaag tcactccatg atccattaca accccagaga
     1501 taagcagctc tatgcctgga atgaaggaaa ccagatcatt tacaaactcc agacaaagag
     1561 aaagctgcct ctgaagtaat gcattacagc tgtgagaaag agcactgtgg ctttggcagc
     1621 tgttctacag gacagtgagg ctatagcccc ttcacaatat agtatccctc taatcacaca
     1681 caggaagagt gtgtagaagt ggaaatacgt atgcctcctt tcccaaatgt cactgcctta
     1741 ggtatcttcc aagagcttag atgagagcat atcatcagga aagtttcaac aatgtccatt
     1801 actcccccaa acctcctggc tctcaaggat gaccacattc tgatacagcc tacttcaagc
     1861 cttttgtttt actgctcccc agcatttact gtaactctgc catcttccct cccacaatta
     1921 gagttgtatg ccagccccta atattcacca ctggcttttc tctcccctgg cctttgctga
     1981 agctcttccc tctttttcaa atgtctattg atattctccc attttcactg cccaactaaa
     2041 atactattaa tatttctttc ttttcttttc ttttttttga gacaaggtct cactatgttg
     2101 cccaggctgg tctcaaactc cagagctcaa gagatcctcc tgcctcagcc tcctaagtac
     2161 ctgggattac aggcatgtgc caccacacct ggcttaaaat actatttctt attgaggttt
     2221 aacctctatt tcccctagcc ctgtccttcc actaagcttg gtagatgtaa taataaagtg
     2281 aaaatattaa catttgaata tcgctttcca ggtgtggagt gtttgcacat catttaattc
     2341 tcgtttcacc tttgtgaaac atgcacaagt ctttacagct gtcattctag agtttaggtg
     2401 agtaacacaa ttacaaagtg aaagatacag ctagaaaata ctacaaatcc catagttttt
     2461 ccattgccca aggaagcatc aaatacgtat gtttgttcac ctactcttat agtcaatgcg
     2521 ttcatcgttt cagcctaaaa ataatagtct gtccctttag ccagttttca tgtctgcaca
     2581 agacctttca ataggccttt caaatgataa ttcctccaga aaaccagtct aagggtgagg
     2641 accccaactc tagcctcctc ttgtcttgct gtcctctgtt tctctctttc tgctttaaat
     2701 tcaataaaag tgacactgag caaataacct catcaggtta tatttgccca cataccctaa
     2761 gcacaaaa
//
