LOCUS       NM_006418               2843 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens olfactomedin 4 (OLFM4), mRNA.
ACCESSION   NM_006418
VERSION     NM_006418.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2843)
  AUTHORS   He,H., Chen,S., Yu,Y., Fan,Z., Qian,Y., Dong,Y., Song,Y., Zhong,C.,
            Sun,X., Cao,Q., Li,S., Huang,W., Li,W., Zhuang,M., Yang,J.,
            Wang,X., Wang,J., Wu,D., Wang,H. and Wen,W.
  TITLE     Comprehensive single-cell analysis deciphered microenvironmental
            dynamics and immune regulator olfactomedin 4 in pathogenesis of
            gallbladder cancer
  JOURNAL   Gut 73 (9), 1529-1542 (2024)
   PUBMED   38719336
  REMARK    GeneRIF: Comprehensive single-cell analysis deciphered
            microenvironmental dynamics and immune regulator olfactomedin 4 in
            pathogenesis of gallbladder cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2843)
  AUTHORS   Xing,Z., Li,X., He,J., Chen,Y., Zhu,L., Zhang,X., Huang,Z.,
            Tang,J., Guo,Y. and He,Y.
  TITLE     OLFM4 modulates intestinal inflammation by promoting IL-22+ILC3 in
            the gut
  JOURNAL   Commun Biol 7 (1), 914 (2024)
   PUBMED   39075283
  REMARK    GeneRIF: OLFM4 modulates intestinal inflammation by promoting
            IL-22[+]ILC3 in the gut.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2843)
  AUTHORS   Lv,S., Chen,M., Li,Z., Huang,Z., Wan,S., Kuang,S., Peng,L., Ye,J.,
            Yang,M., Li,J. and He,Y.
  TITLE     Blocking OLFM4/galectin-3 axis in placental polymorphonuclear
            myeloid-derived suppressor cells triggers intestinal inflammation
            in newborns
  JOURNAL   Int Immunopharmacol 133, 112058 (2024)
   PUBMED   38613883
  REMARK    GeneRIF: Blocking OLFM4/galectin-3 axis in placental
            polymorphonuclear myeloid-derived suppressor cells triggers
            intestinal inflammation in newborns.
REFERENCE   4  (bases 1 to 2843)
  AUTHORS   Xu,K., Zheng,P., Zhao,S., Wang,J., Feng,J., Ren,Y., Zhong,Q.,
            Zhang,H., Chen,X., Chen,J. and Xie,P.
  TITLE     LRFN5 and OLFM4 as novel potential biomarkers for major depressive
            disorder: a pilot study
  JOURNAL   Transl Psychiatry 13 (1), 188 (2023)
   PUBMED   37280213
  REMARK    GeneRIF: LRFN5 and OLFM4 as novel potential biomarkers for major
            depressive disorder: a pilot study.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2843)
  AUTHORS   Ma,H.W., Kim,J.M., Kim,D.H., Park,I.S., Kim,J.H., Park,K.C.,
            Seo,D.H., Kim,J.H., Che,X., Kim,T.I., Cheon,J.H. and Kim,S.W.
  TITLE     Olfactomedin 4 produces dysplasia but suppresses metastasis of
            colon cancer
  JOURNAL   Cancer Gene Ther 30 (5), 694-703 (2023)
   PUBMED   36577836
  REMARK    GeneRIF: Olfactomedin 4 produces dysplasia but suppresses
            metastasis of colon cancer.
REFERENCE   6  (bases 1 to 2843)
  AUTHORS   Palmer,D.J., Kelly,V.C., Smit,A.M., Kuy,S., Knight,C.G. and
            Cooper,G.J.
  TITLE     Human colostrum: identification of minor proteins in the aqueous
            phase by proteomics
  JOURNAL   Proteomics 6 (7), 2208-2216 (2006)
   PUBMED   16502470
REFERENCE   7  (bases 1 to 2843)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   8  (bases 1 to 2843)
  AUTHORS   Zhang,J., Liu,W.L., Tang,D.C., Chen,L., Wang,M., Pack,S.D.,
            Zhuang,Z. and Rodgers,G.P.
  TITLE     Identification and characterization of a novel member of
            olfactomedin-related protein family, hGC-1, expressed during
            myeloid lineage development
  JOURNAL   Gene 283 (1-2), 83-93 (2002)
   PUBMED   11867215
REFERENCE   9  (bases 1 to 2843)
  AUTHORS   Shinozaki,S., Nakamura,T., Iimura,M., Kato,Y., Iizuka,B.,
            Kobayashi,M. and Hayashi,N.
  TITLE     Upregulation of Reg 1alpha and GW112 in the epithelium of inflamed
            colonic mucosa
  JOURNAL   Gut 48 (5), 623-629 (2001)
   PUBMED   11302958
REFERENCE   10 (bases 1 to 2843)
  AUTHORS   McNearney,T.A., Odell,C., Holers,V.M., Spear,P.G. and Atkinson,J.P.
  TITLE     Herpes simplex virus glycoproteins gC-1 and gC-2 bind to the third
            component of complement and provide protection against
            complement-mediated neutralization of viral infectivity
  JOURNAL   J Exp Med 166 (5), 1525-1535 (1987)
   PUBMED   2824652
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA928098.1, AY358567.1 and
            AI560739.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006418.4.
            
            Summary: This gene was originally cloned from human myeloblasts and
            found to be selectively expressed in inflammed colonic epithelium.
            This gene encodes a member of the olfactomedin family. The encoded
            protein is an antiapoptotic factor that promotes tumor growth and
            is an extracellular matrix glycoprotein that facilitates cell
            adhesion. [provided by RefSeq, Mar 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358567.1, BC117329.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000219022.3/ ENSP00000219022.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-378               DA928098.1         78-455
            379-2431            AY358567.1         368-2420
            2432-2843           AI560739.1         21-432              c
FEATURES             Location/Qualifiers
     source          1..2843
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q14.3"
     gene            1..2843
                     /gene="OLFM4"
                     /gene_synonym="bA209J19.1; GC1; GW112; hGC-1; hOLfD; OlfD;
                     OLM4; pDP4; UNQ362"
                     /note="olfactomedin 4"
                     /db_xref="GeneID:10562"
                     /db_xref="HGNC:HGNC:17190"
                     /db_xref="MIM:614061"
     exon            1..228
                     /gene="OLFM4"
                     /gene_synonym="bA209J19.1; GC1; GW112; hGC-1; hOLfD; OlfD;
                     OLM4; pDP4; UNQ362"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..1557
                     /gene="OLFM4"
                     /gene_synonym="bA209J19.1; GC1; GW112; hGC-1; hOLfD; OlfD;
                     OLM4; pDP4; UNQ362"
                     /note="antiapoptotic protein GW112; G-CSF-stimulated clone
                     1 protein; olfactoimedin; tiarin"
                     /codon_start=1
                     /product="olfactomedin-4 precursor"
                     /protein_id="NP_006409.3"
                     /db_xref="CCDS:CCDS9440.1"
                     /db_xref="GeneID:10562"
                     /db_xref="HGNC:HGNC:17190"
                     /db_xref="MIM:614061"
                     /translation="MRPGLSFLLALLFFLGQAAGDLGDVGPPIPSPGFSSFPGVDSSS
                     SFSSSSRSGSSSSRSLGSGGSVSQLFSNFTGSVDDRGTCQCSVSLPDTTFPVDRVERL
                     EFTAHVLSQKFEKELSKVREYVQLISVYEKKLLNLTVRIDIMEKDTISYTELDFELIK
                     VEVKEMEKLVIQLKESFGGSSEIVDQLEVEIRNMTLLVEKLETLDKNNVLAIRREIVA
                     LKTKLKECEASKDQNTPVVHPPPTPGSCGHGGVVNISKPSVVQLNWRGFSYLYGAWGR
                     DYSPQHPNKGLYWVAPLNTDGRLLEYYRLYNTLDDLLLYINARELRITYGQGSGTAVY
                     NNNMYVNMYNTGNIARVNLTTNTIAVTQTLPNAAYNNRFSYANVAWQDIDFAVDENGL
                     WVIYSTEASTGNMVISKLNDTTLQVLNTWYTKQYKPSASNAFMVCGVLYATRTMNTRT
                     EEIFYYYDTNTGKEGKLDIVMHKMQEKVQSINYNPFDQKLYVYNDGYLLNYDLSVLQK
                     PQ"
     exon            229..381
                     /gene="OLFM4"
                     /gene_synonym="bA209J19.1; GC1; GW112; hGC-1; hOLfD; OlfD;
                     OLM4; pDP4; UNQ362"
                     /inference="alignment:Splign:2.1.0"
     exon            382..594
                     /gene="OLFM4"
                     /gene_synonym="bA209J19.1; GC1; GW112; hGC-1; hOLfD; OlfD;
                     OLM4; pDP4; UNQ362"
                     /inference="alignment:Splign:2.1.0"
     exon            595..754
                     /gene="OLFM4"
                     /gene_synonym="bA209J19.1; GC1; GW112; hGC-1; hOLfD; OlfD;
                     OLM4; pDP4; UNQ362"
                     /inference="alignment:Splign:2.1.0"
     exon            755..2843
                     /gene="OLFM4"
                     /gene_synonym="bA209J19.1; GC1; GW112; hGC-1; hOLfD; OlfD;
                     OLM4; pDP4; UNQ362"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2822..2827
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OLFM4"
                     /gene_synonym="bA209J19.1; GC1; GW112; hGC-1; hOLfD; OlfD;
                     OLM4; pDP4; UNQ362"
                     /note="hexamer: ATTAAA"
     polyA_site      2843
                     /gene="OLFM4"
                     /gene_synonym="bA209J19.1; GC1; GW112; hGC-1; hOLfD; OlfD;
                     OLM4; pDP4; UNQ362"
                     /note="major polyA site"
ORIGIN      
        1 agcggctcca gctaagagga caagatgagg cccggcctct catttctcct agcccttctg
       61 ttcttccttg gccaagctgc aggggatttg ggggatgtgg gacctccaat tcccagcccc
      121 ggcttcagct ctttcccagg tgttgactcc agctccagct tcagctccag ctccaggtcg
      181 ggctccagct ccagccgcag cttaggcagc ggaggttctg tgtcccagtt gttttccaat
      241 ttcaccggct ccgtggatga ccgtgggacc tgccagtgct ctgtttccct gccagacacc
      301 acctttcccg tggacagagt ggaacgcttg gaattcacag ctcatgttct ttctcagaag
      361 tttgagaaag aactttccaa agtgagggaa tatgtccaat taattagtgt gtatgaaaag
      421 aaactgttaa acctaactgt ccgaattgac atcatggaga aggataccat ttcttacact
      481 gaactggact tcgagctgat caaggtagaa gtgaaggaga tggaaaaact ggtcatacag
      541 ctgaaggaga gttttggtgg aagctcagaa attgttgacc agctggaggt ggagataaga
      601 aatatgactc tcttggtaga gaagcttgag acactagaca aaaacaatgt ccttgccatt
      661 cgccgagaaa tcgtggctct gaagaccaag ctgaaagagt gtgaggcctc taaagatcaa
      721 aacacccctg tcgtccaccc tcctcccact ccagggagct gtggtcatgg tggtgtggtg
      781 aacatcagca aaccgtctgt ggttcagctc aactggagag ggttttctta tctatatggt
      841 gcttggggta gggattactc tccccagcat ccaaacaaag gactgtattg ggtggcgcca
      901 ttgaatacag atgggagact gttggagtat tatagactgt acaacacact ggatgatttg
      961 ctattgtata taaatgctcg agagttgcgg atcacctatg gccaaggtag tggtacagca
     1021 gtttacaaca acaacatgta cgtcaacatg tacaacaccg ggaatattgc cagagttaac
     1081 ctgaccacca acacgattgc tgtgactcaa actctcccta atgctgccta taataaccgc
     1141 ttttcatatg ctaatgttgc ttggcaagat attgactttg ctgtggatga gaatggattg
     1201 tgggttattt attcaactga agccagcact ggtaacatgg tgattagtaa actcaatgac
     1261 accacacttc aggtgctaaa cacttggtat accaagcagt ataaaccatc tgcttctaac
     1321 gccttcatgg tatgtggggt tctgtatgcc acccgtacta tgaacaccag aacagaagag
     1381 attttttact attatgacac aaacacaggg aaagagggca aactagacat tgtaatgcat
     1441 aagatgcagg aaaaagtgca gagcattaac tataaccctt ttgaccagaa actttatgtc
     1501 tataacgatg gttaccttct gaattatgat ctttctgtct tgcagaagcc ccagtaagct
     1561 gtttaggagt tagggtgaaa gagaaaatgt ttgttgaaaa aatagtcttc tccacttact
     1621 tagatatctg caggggtgtc taaaagtgtg ttcattttgc agcaatgttt aggtgcatag
     1681 ttctaccaca ctagagatct aggacatttg tcttgatttg gtgagttctc ttgggaatca
     1741 tctgcctctt caggcgcatt ttgcaataaa gtctgtctag ggtgggattg tcagaggtct
     1801 aggggcactg tgggcctagt gaagcctact gtgaggaggc ttcactagaa gccttaaatt
     1861 aggaattaag gaacttaaaa ctcagtatgg cgtctaggga ttctttgtac aggaaatatt
     1921 gcccaatgac tagtcctcat ccatgtagca ccactaattc ttccatgcct ggaagaaacc
     1981 tggggactta gttaggtaga ttaatatctg gagctcctcg agggaccaaa tctccaactt
     2041 ttttttcccc tcactagcac ctggaatgat gctttgtatg tggcagataa gtaaatttgg
     2101 catgcttata tattctacat ctgtaaagtg ctgagtttta tggagagagg cctttttatg
     2161 cattaaattg tacatggcaa ataaatccca gaaggatctg tagatgaggc acctgctttt
     2221 tcttttctct cattgtccac cttactaaaa gtcagtagaa tcttctacct cataacttcc
     2281 ttccaaaggc agctcagaag attagaacca gacttactaa ccaattccac cccccaccaa
     2341 cccccttcta ctgcctactt taaaaaaatt aatagttttc tatggaactg atctaagatt
     2401 agaaaaatta attttcttta atttcattat gaacttttat ttacatgact ctaagactat
     2461 aagaaaatct gatggcagtg acaaagtgct agcatttatt gttatctaat aaagaccttg
     2521 gagcatatgt gcaacttatg agtgtatcag ttgttgcatg taatttttgc ctttgtttaa
     2581 gcctggaact tgtaagaaaa tgaaaattta attttttttt ctaggacgag ctatagaaaa
     2641 gctattgaga gtatctagtt aatcagtgca gtagttggaa accttgctgg tgtatgtgat
     2701 gtgcttctgt gcttttgaat gactttatca tctagtcttt gtctattttt cctttgatgt
     2761 tcaagtccta gtctatagga ttggcagttt aaatgcttta ctcccccttt taaaataaat
     2821 gattaaaatg tgctttgaaa aaa
//
