LOCUS       NM_058164               1982 bp    mRNA    linear   PRI 26-FEB-2024
DEFINITION  Homo sapiens olfactomedin 2 (OLFM2), transcript variant 2, mRNA.
ACCESSION   NM_058164
VERSION     NM_058164.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1982)
  AUTHORS   Tang,Y., Liu,Y., Wang,X., Guo,H., Chen,L., Hu,G., Cui,Y., Liang,S.,
            Zuo,J., Luo,Z., Chen,X. and Wang,X.
  TITLE     OLFM2 promotes epithelial-mesenchymal transition, migration, and
            invasion in colorectal cancer through the TGF-beta/Smad signaling
            pathway
  JOURNAL   BMC Cancer 24 (1), 204 (2024)
   PUBMED   38350902
  REMARK    GeneRIF: OLFM2 promotes epithelial-mesenchymal transition,
            migration, and invasion in colorectal cancer through the
            TGF-beta/Smad signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1982)
  AUTHORS   Barrientos-Riosalido,A., Bertran,L., Vilaro-Blay,M., Aguilar,C.,
            Martinez,S., Paris,M., Sabench,F., Riesco,D., Binetti,J.,
            Castillo,D.D., Richart,C. and Auguet,T.
  TITLE     The Role of Olfactomedin 2 in the Adipose Tissue-Liver Axis and Its
            Implication in Obesity-Associated Nonalcoholic Fatty Liver Disease
  JOURNAL   Int J Mol Sci 24 (6), 5221 (2023)
   PUBMED   36982296
  REMARK    GeneRIF: The Role of Olfactomedin 2 in the Adipose Tissue-Liver
            Axis and Its Implication in Obesity-Associated Nonalcoholic Fatty
            Liver Disease.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1982)
  AUTHORS   Bertran,L., Jorba-Martin,R., Barrientos-Riosalido,A.,
            Portillo-Carrasquer,M., Aguilar,C., Riesco,D., Martinez,S.,
            Vives,M., Sabench,F., Castillo,D.D., Richart,C. and Auguet,T.
  TITLE     New Insights of OLFM2 and OLFM4 in Gut-Liver Axis and Their
            Potential Involvement in Nonalcoholic Fatty Liver Disease
  JOURNAL   Int J Mol Sci 23 (13), 7442 (2022)
   PUBMED   35806447
  REMARK    GeneRIF: New Insights of OLFM2 and OLFM4 in Gut-Liver Axis and
            Their Potential Involvement in Nonalcoholic Fatty Liver Disease.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1982)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1982)
  AUTHORS   Li,H., Gui,H., Yuan,G., Zheng,X., Gao,C. and Yuan,H.
  TITLE     Increased plasma olfactomedin 2 after interventional therapy is a
            predictor for restenosis in lower extremity arteriosclerosis
            obliterans patients
  JOURNAL   Scand J Clin Lab Invest 78 (4), 269-274 (2018)
   PUBMED   29553861
  REMARK    GeneRIF: plasma OLFM2 is a potential biomarker for restenosis and
            may be a novel target for the treatment of restenosis.
REFERENCE   6  (bases 1 to 1982)
  AUTHORS   Tomarev,S.I. and Nakaya,N.
  TITLE     Olfactomedin domain-containing proteins: possible mechanisms of
            action and functions in normal development and pathology
  JOURNAL   Mol Neurobiol 40 (2), 122-138 (2009)
   PUBMED   19554483
  REMARK    Review article
REFERENCE   7  (bases 1 to 1982)
  AUTHORS   Funayama,T., Mashima,Y., Ohtake,Y., Ishikawa,K., Fuse,N.,
            Yasuda,N., Fukuchi,T., Murakami,A., Hotta,Y. and Shimada,N.
  CONSRTM   Glaucoma Gene Research Group
  TITLE     SNPs and interaction analyses of noelin 2, myocilin, and optineurin
            genes in Japanese patients with open-angle glaucoma
  JOURNAL   Invest Ophthalmol Vis Sci 47 (12), 5368-5375 (2006)
   PUBMED   17122126
  REMARK    GeneRIF: The Arg144Gln mutation in OLFM2 is a possible
            disease-causing mutation in Japanese patients with OAG. Common
            polymorphisms in OLFM2 and OPTN may interactively contribute to the
            development of OAG, indicating a polygenic etiology.
            GeneRIF: Observational study of gene-disease association and
            gene-gene interaction. (HuGE Navigator)
REFERENCE   8  (bases 1 to 1982)
  AUTHORS   Mukhopadhyay,A., Talukdar,S., Bhattacharjee,A. and Ray,K.
  TITLE     Bioinformatic approaches for identification and characterization of
            olfactomedin related genes with a potential role in pathogenesis of
            ocular disorders
  JOURNAL   Mol Vis 10, 304-314 (2004)
   PUBMED   15123989
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1982)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
REFERENCE   10 (bases 1 to 1982)
  AUTHORS   Tomarev,S.I., Wistow,G., Raymond,V., Dubois,S. and Malyukova,I.
  TITLE     Gene expression profile of the human trabecular meshwork: NEIBank
            sequence tag analysis
  JOURNAL   Invest Ophthalmol Vis Sci 44 (6), 2588-2596 (2003)
   PUBMED   12766061
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL538120.3, BC011361.1 and AC008752.6.
            
            On Jun 2, 2019 this sequence version replaced NM_058164.3.
            
            Transcript Variant: This variant (2) uses an alternate 5' terminal
            exon, lacks a portion of the 5' coding region, and initiates
            translation at an alternate start codon, compared to variant 1. The
            encoded isoform (2) has a distinct N-terminus and is shorter than
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011361.1, SRR3476690.700416.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2157437 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264833.9/ ENSP00000264833.3
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               AL538120.3         6-126
            122-1552            BC011361.1         4-1434
            1553-1553           AC008752.6         918-918
            1554-1982           BC011361.1         1436-1864
FEATURES             Location/Qualifiers
     source          1..1982
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..1982
                     /gene="OLFM2"
                     /gene_synonym="NOE2; NOELIN2; NOELIN2_V1; OlfC"
                     /note="olfactomedin 2"
                     /db_xref="GeneID:93145"
                     /db_xref="HGNC:HGNC:17189"
                     /db_xref="MIM:617492"
     exon            1..212
                     /gene="OLFM2"
                     /gene_synonym="NOE2; NOELIN2; NOELIN2_V1; OlfC"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..1514
                     /gene="OLFM2"
                     /gene_synonym="NOE2; NOELIN2; NOELIN2_V1; OlfC"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; neuronal olfactomedin related ER localized
                     protein 2; noelin-2"
                     /codon_start=1
                     /product="noelin-2 isoform 2 precursor"
                     /protein_id="NP_477512.1"
                     /db_xref="CCDS:CCDS12221.1"
                     /db_xref="GeneID:93145"
                     /db_xref="HGNC:HGNC:17189"
                     /db_xref="MIM:617492"
                     /translation="MWPLTVPPPLLLLLCSGLAGQTLFQNPEEGWQLYTSAQAPDGKC
                     ICTAVIPAQSTCSRDGRSRELRQLMEKVQNVSQSMEVLELRTYRDLQYVRGMETLMRS
                     LDARLRAADGSLSAKSFQELKDRMTELLPLSSVLEQYKADTRTIVRLREEVRNLSGSL
                     AAIQEEMGAYGYEDLQQRVMALEARLHACAQKLGCGKLTGVSNPITVRAMGSRFGSWM
                     TDTMAPSADSRVWYMDGYYKGRRVLEFRTLGDFIKGQNFIQHLLPQPWAGTGHVVYNG
                     SLFYNKYQSNVVVKYHFRSRSVLVQRSLPGAGYNNTFPYSWGGFSDMDFMVDESGLWA
                     VYTTNQNAGNIVVSRLDPHTLEVMRSWDTGYPKRSAGEAFMICGVLYVTNSHLAGAKV
                     YFAYFTNTSSYEYTDVPFHNQYSHISMLDYNPRERALYTWNNGHQVLYNVTLFHVIST
                     SGDP"
     exon            213..362
                     /gene="OLFM2"
                     /gene_synonym="NOE2; NOELIN2; NOELIN2_V1; OlfC"
                     /inference="alignment:Splign:2.1.0"
     exon            363..509
                     /gene="OLFM2"
                     /gene_synonym="NOE2; NOELIN2; NOELIN2_V1; OlfC"
                     /inference="alignment:Splign:2.1.0"
     exon            510..729
                     /gene="OLFM2"
                     /gene_synonym="NOE2; NOELIN2; NOELIN2_V1; OlfC"
                     /inference="alignment:Splign:2.1.0"
     exon            730..836
                     /gene="OLFM2"
                     /gene_synonym="NOE2; NOELIN2; NOELIN2_V1; OlfC"
                     /inference="alignment:Splign:2.1.0"
     exon            837..1982
                     /gene="OLFM2"
                     /gene_synonym="NOE2; NOELIN2; NOELIN2_V1; OlfC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1958..1963
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OLFM2"
                     /gene_synonym="NOE2; NOELIN2; NOELIN2_V1; OlfC"
                     /note="hexamer: AATAAA"
     polyA_site      1982
                     /gene="OLFM2"
                     /gene_synonym="NOE2; NOELIN2; NOELIN2_V1; OlfC"
                     /note="major polyA site"
ORIGIN      
        1 ggggcggaat cccggccgcc ggcgaggcgg gggaggcggc ggcgcagggt cgccccggcc
       61 gggcgggcgg ggtcgcgcct ggtggcggtc cccgcgccga ggcgccgcta gggcgggcgg
      121 gggtcgggac gccgggctag gggcgcgtca tgtggccgct cacggtcccg ccgccgctgc
      181 tgctgctgct gtgctcaggc ctggccggac agactctctt ccagaaccca gaagagggct
      241 ggcagctgta cacctcagcc caggcccctg acgggaaatg catctgcacg gccgtgatcc
      301 cagcgcagag tacctgctct cgagatggca ggagtcggga gctgcggcaa ctgatggaga
      361 aggtccagaa cgtctcccag tccatggagg tccttgagtt gcggacgtat cgcgacctcc
      421 agtatgtacg cggcatggag accctcatgc ggagcctgga tgcgcggctc cgggcagctg
      481 atgggtccct ctcggccaag agcttccagg agctgaagga caggatgacg gaactgttgc
      541 ccctgagctc ggtcctggag cagtacaagg cagacacgcg gaccattgta cgcttgcggg
      601 aggaggtgag gaatctctcc ggcagtctgg cggccattca ggaggagatg ggtgcctacg
      661 ggtatgagga cctgcagcaa cgggtgatgg ccctggaggc ccggctccac gcctgcgccc
      721 agaagctggg ctgtgggaag ctgaccgggg tcagtaaccc catcaccgtt cgggccatgg
      781 ggtcccgctt cggctcctgg atgactgaca cgatggcccc cagtgcggat agccgggtct
      841 ggtacatgga tggctattac aaaggccgcc gggtcctgga gttccgtacc ctgggagact
      901 tcatcaaagg ccagaacttt atccagcacc tgctgcccca gccgtgggcg ggcacgggcc
      961 acgtggtgta caacggctcc ctgttctata acaagtacca gagcaacgtg gtggtcaaat
     1021 accacttccg ctcgcgctct gtgctggtgc agaggagcct cccgggcgcc ggttacaaca
     1081 acaccttccc ctactcctgg ggcggcttct ccgacatgga cttcatggtg gacgagagcg
     1141 ggctctgggc tgtgtacacc accaaccaga acgcgggcaa catcgtggtc agccggctgg
     1201 acccgcacac cctcgaggtc atgcggtcct gggacaccgg ctaccccaag cgcagcgctg
     1261 gcgaggcctt catgatctgc ggtgtgctct acgtgaccaa ctcccacctg gctggggcca
     1321 aggtctactt cgcctatttt accaacacgt ccagttacga gtacacggac gtgcccttcc
     1381 acaaccagta ttcccacatc tcgatgctgg attacaaccc ccgggagcgc gccctctata
     1441 cctggaacaa cggccaccag gtgctctaca atgtcaccct gtttcacgtc atcagcacct
     1501 ctggggaccc ctgagccaat gctgtggctc gggctgctgc ctggggggcc tctgggggct
     1561 gggggccctt ttcattctgc ctgtgtccct caagggtgat ctctctgtct ctgtcacgcc
     1621 ctttctcccc gcctttttgc tgggcttttg ttctctgcct atgtatttct gtctattttt
     1681 tcaatttccc ctcttctcct ttattgatct ctgcttttaa tacaccactt ctttctttct
     1741 gcctttttat ggatgtcttt ttctttttat ggctctggtt ctccagttct ttccgtctct
     1801 gcctctctct gtctctctct ctctgtcctt ccacccctcc ctccttgctt cccacccatt
     1861 cctcatccct cactcccacc cccaccccca cccccaggag ttgagtgcat ggatctgttt
     1921 ctttttttat ttacactttt tctttccggt ttgccggaat aaacaggacc tttgacattt
     1981 ga
//
