LOCUS       NM_001282611            2782 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens olfactomedin 1 (OLFM1), transcript variant 4, mRNA.
ACCESSION   NM_001282611 XM_005263393
VERSION     NM_001282611.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2782)
  AUTHORS   Zhang,B., Liu,T., Gu,Y., Ren,L., Wang,J., Feng,C. and Song,Z.
  TITLE     Long Non-Coding RNA LPP-AS2 Plays an Anti-Tumor Role in Thyroid
            Carcinoma by Regulating the miR-132-3p/OLFM1 Axis
  JOURNAL   Crit Rev Eukaryot Gene Expr 33 (5), 73-86 (2023)
   PUBMED   37199315
  REMARK    GeneRIF: Long Non-Coding RNA LPP-AS2 Plays an Anti-Tumor Role in
            Thyroid Carcinoma by Regulating the miR-132-3p/OLFM1 Axis.
REFERENCE   2  (bases 1 to 2782)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2782)
  AUTHORS   Sugis,E., Dauvillier,J., Leontjeva,A., Adler,P., Hindie,V.,
            Moncion,T., Collura,V., Daudin,R., Loe-Mie,Y., Herault,Y.,
            Lambert,J.C., Hermjakob,H., Pupko,T., Rain,J.C., Xenarios,I.,
            Vilo,J., Simonneau,M. and Peterson,H.
  TITLE     HENA, heterogeneous network-based data set for Alzheimer's disease
  JOURNAL   Sci Data 6 (1), 151 (2019)
   PUBMED   31413325
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2782)
  AUTHORS   Shi,W., Ye,Z., Zhuang,L., Li,Y., Shuai,W., Zuo,Z., Mao,X., Liu,R.,
            Wu,J., Chen,S. and Huang,W.
  TITLE     Olfactomedin 1 negatively regulates NF-kappaB signalling and
            suppresses the growth and metastasis of colorectal cancer cells
  JOURNAL   J Pathol 240 (3), 352-365 (2016)
   PUBMED   27555280
  REMARK    GeneRIF: OLFM1 is a negative regulator of non-canonical NF-kappaB
            signalling by interacting with and inhibiting NIK. Thus, OLFM1 may
            serve as a valuable biomarker and therapeutic target for colorectal
            cancer (CRC) patients.
REFERENCE   5  (bases 1 to 2782)
  AUTHORS   Kottawatta,K.S., So,K.H., Kodithuwakku,S.P., Ng,E.H., Yeung,W.S.
            and Lee,K.F.
  TITLE     MicroRNA-212 Regulates the Expression of Olfactomedin 1 and
            C-Terminal Binding Protein 1 in Human Endometrial Epithelial Cells
            to Enhance Spheroid Attachment In Vitro
  JOURNAL   Biol Reprod 93 (5), 109 (2015)
   PUBMED   26377223
  REMARK    GeneRIF: human chorionic gonadotropin stimulated miR-212, which
            down-regulated OLFM1 and CTBP1 expression in fallopian and
            endometrial epithelial cells to favor spheroid attachment
REFERENCE   6  (bases 1 to 2782)
  AUTHORS   Kodithuwakku,S.P., Pang,R.T., Ng,E.H., Cheung,A.N., Horne,A.W.,
            Ho,P.C., Yeung,W.S. and Lee,K.F.
  TITLE     Wnt activation downregulates olfactomedin-1 in Fallopian tubal
            epithelial cells: a microenvironment predisposed to tubal ectopic
            pregnancy
  JOURNAL   Lab Invest 92 (2), 256-264 (2012)
   PUBMED   21968811
  REMARK    GeneRIF: Wnt activation suppresses Olfm-1 expression, and this may
            predispose a favorable microenvironment of the retained embryo in
            the Fallopian tube, leading to ectopic pregnancy in humans
REFERENCE   7  (bases 1 to 2782)
  AUTHORS   Camargo,L.M., Collura,V., Rain,J.C., Mizuguchi,K., Hermjakob,H.,
            Kerrien,S., Bonnert,T.P., Whiting,P.J. and Brandon,N.J.
  TITLE     Disrupted in Schizophrenia 1 Interactome: evidence for the close
            connectivity of risk genes and a potential synaptic basis for
            schizophrenia
  JOURNAL   Mol Psychiatry 12 (1), 74-86 (2007)
   PUBMED   17043677
REFERENCE   8  (bases 1 to 2782)
  AUTHORS   Wang,L., Gao,X., Gao,P., Deng,W., Yu,P., Ma,J., Guo,J., Wang,X.,
            Cheng,H., Zhang,C., Yu,C., Ma,X., Lv,B., Lu,Y., Shi,T. and Ma,D.
  TITLE     Cell-based screening and validation of human novel genes associated
            with cell viability
  JOURNAL   J Biomol Screen 11 (4), 369-376 (2006)
   PUBMED   16751333
REFERENCE   9  (bases 1 to 2782)
  AUTHORS   Liu,T., Qian,W.J., Gritsenko,M.A., Camp,D.G. 2nd, Monroe,M.E.,
            Moore,R.J. and Smith,R.D.
  TITLE     Human plasma N-glycoproteome analysis by immunoaffinity
            subtraction, hydrazide chemistry, and mass spectrometry
  JOURNAL   J Proteome Res 4 (6), 2070-2080 (2005)
   PUBMED   16335952
REFERENCE   10 (bases 1 to 2782)
  AUTHORS   Yokoyama,M., Nishi,Y., Yoshii,J., Okubo,K. and Matsubara,K.
  TITLE     Identification and cloning of neuroblastoma-specific and nerve
            tissue-specific genes through compiled expression profiles
  JOURNAL   DNA Res 3 (5), 311-320 (1996)
   PUBMED   9039501
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL390778.32, AK290478.1 and
            BU078731.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001282611.1.
            
            Summary: This gene product shares extensive sequence similarity
            with the rat neuronal olfactomedin-related ER localized protein.
            While the exact function of the encoded protein is not known, its
            abundant expression in brain suggests that it may have an essential
            role in nerve tissue. Several alternatively spliced transcripts
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (4) differs in the 5' UTR and 5'
            coding region which results in the use of an alternate start codon,
            compared to variant 1. The encoded isoform (4) has distinct
            N-terminus, compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.172898.1,
                                           SRR1803611.163013.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371793.8/ ENSP00000360858.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-303               AL390778.32        7266-7568
            304-558             AK290478.1         92-346
            559-559             AL390778.32        9879-9879
            560-1973            AK290478.1         348-1761
            1974-2779           AL390778.32        39970-40775
            2780-2782           BU078731.1         10-12               c
FEATURES             Location/Qualifiers
     source          1..2782
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..2782
                     /gene="OLFM1"
                     /gene_synonym="AMY; NOE1; NOELIN1; OlfA"
                     /note="olfactomedin 1"
                     /db_xref="GeneID:10439"
                     /db_xref="HGNC:HGNC:17187"
                     /db_xref="MIM:605366"
     exon            1..472
                     /gene="OLFM1"
                     /gene_synonym="AMY; NOE1; NOELIN1; OlfA"
                     /inference="alignment:Splign:2.1.0"
     CDS             323..1780
                     /gene="OLFM1"
                     /gene_synonym="AMY; NOE1; NOELIN1; OlfA"
                     /note="isoform 4 precursor is encoded by transcript
                     variant 4; olfactomedin related ER localized protein;
                     neuroblastoma protein; noelin; pancortin 1; neuronal
                     olfactomedin-related ER localized protein"
                     /codon_start=1
                     /product="noelin isoform 4 precursor"
                     /protein_id="NP_001269540.1"
                     /db_xref="CCDS:CCDS65184.1"
                     /db_xref="GeneID:10439"
                     /db_xref="HGNC:HGNC:17187"
                     /db_xref="MIM:605366"
                     /translation="MSVPLLKIGVVLSTMAMITNWMSQTLPSLVGLNTTKLSAAGGGT
                     LDRSTGVLPTNPEESWQVYSSAQDSEGRCICTVVAPQQTMCSRDARTKQLRQLLEKVQ
                     NMSQSIEVLDRRTQRDLQYVEKMENQMKGLESKFKQVEESHKQHLARQFKAIKAKMDE
                     LRPLIPVLEEYKADAKLVLQFKEEVQNLTSVLNELQEEIGAYDYDELQSRVSNLEERL
                     RACMQKLACGKLTGISDPVTVKTSGSRFGSWMTDPLAPEGDNRVWYMDGYHNNRFVRE
                     YKSMVDFMNTDNFTSHRLPHPWSGTGQVVYNGSIYFNKFQSHIIIRFDLKTETILKTR
                     SLDYAGYNNMYHYAWGGHSDIDLMVDESGLWAVYATNQNAGNIVVSRLDPVSLQTLQT
                     WNTSYPKRSAGEAFIICGTLYVTNGYSGGTKVHYAYQTNASTYEYIDIPFQNKYSHIS
                     MLDYNPKDRALYAWNNGHQILYNVTLFHVIRSDEL"
     exon            473..622
                     /gene="OLFM1"
                     /gene_synonym="AMY; NOE1; NOELIN1; OlfA"
                     /inference="alignment:Splign:2.1.0"
     exon            623..778
                     /gene="OLFM1"
                     /gene_synonym="AMY; NOE1; NOELIN1; OlfA"
                     /inference="alignment:Splign:2.1.0"
     exon            779..998
                     /gene="OLFM1"
                     /gene_synonym="AMY; NOE1; NOELIN1; OlfA"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1105
                     /gene="OLFM1"
                     /gene_synonym="AMY; NOE1; NOELIN1; OlfA"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..2782
                     /gene="OLFM1"
                     /gene_synonym="AMY; NOE1; NOELIN1; OlfA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2763..2768
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OLFM1"
                     /gene_synonym="AMY; NOE1; NOELIN1; OlfA"
                     /note="hexamer: AATAAA"
     polyA_site      2782
                     /gene="OLFM1"
                     /gene_synonym="AMY; NOE1; NOELIN1; OlfA"
                     /note="major polyA site"
ORIGIN      
        1 agagccggac ggcgcttccc ggtggcggcg gaggagcccg gagggacgca gccgggcaag
       61 gcagggcgca gggcgggcgg cgcgaggcgc agggcgcggc gggcagaggc cacctggcca
      121 ccttccctgg cgcccgggga aggcgcggcg atggccgggg cgcgcggggc ggcggcggcg
      181 gcgggcgggc ggcggcgggc cgagggggcg cggggacaca gccaggcgcc cctgcccgcc
      241 gcggtgcccg ccgcctgaag gccgcctggg cgcgggagcc ggtgccagct cggagcgggc
      301 gctggaggca gctcgaggcg cgatgtcggt gccgctgctc aagatcgggg tcgtgctgag
      361 caccatggcc atgatcacta actggatgtc ccagacgctg ccctcgctgg tgggcctcaa
      421 caccaccaag ctctcggcgg ccggcggcgg gacgctggac cgcagcaccg gcgtgctgcc
      481 caccaaccct gaggagagct ggcaggtgta cagctctgcc caggacagcg agggcaggtg
      541 tatctgcaca gtggtcgctc cacagcagac catgtgttca cgggatgccc gcacaaaaca
      601 gctgaggcag ctactggaga aggtgcagaa catgtctcaa tccatagagg tcttggacag
      661 gcggacccag agagacttgc agtacgtgga gaagatggag aaccaaatga aaggactgga
      721 gtccaagttc aaacaggtgg aggagagtca taagcaacac ctggccaggc agtttaaggc
      781 gataaaagcg aaaatggatg aacttaggcc tttgatacct gtgttggaag agtacaaggc
      841 cgatgccaaa ttggtattgc agtttaaaga ggaggtccag aatctgacgt cagtgcttaa
      901 cgagctgcaa gaggaaattg gcgcctatga ctacgatgaa cttcagagca gagtgtccaa
      961 tcttgaagaa aggctccgtg catgcatgca aaaactagct tgcgggaagt tgacgggcat
     1021 cagtgacccc gtgactgtca agacctccgg ctcgaggttc ggatcctgga tgacagaccc
     1081 tctcgcccct gaaggcgata accgggtgtg gtacatggac ggctatcaca acaaccgctt
     1141 cgtacgtgag tacaagtcca tggttgactt catgaacacg gacaatttca cctcccaccg
     1201 tctcccccac ccctggtcgg gcacggggca ggtggtctac aacggttcta tctacttcaa
     1261 caagttccag agccacatca tcatcaggtt tgacctgaag acagagacca tcctcaagac
     1321 ccgcagcctg gactatgccg gttacaacaa catgtaccac tacgcctggg gtggccactc
     1381 ggacatcgac ctcatggtgg acgagagcgg gctgtgggcc gtgtacgcca ccaaccagaa
     1441 cgctggcaac atcgtggtca gtaggctgga ccccgtgtcc ctgcagaccc tgcagacctg
     1501 gaacacgagc taccccaagc gcagcgccgg ggaggccttc atcatctgcg gcacgctgta
     1561 cgtcaccaac ggctactcag ggggtaccaa ggtccactat gcataccaga ccaatgcctc
     1621 cacctatgaa tacatcgaca tcccattcca gaacaaatac tcccacatct ccatgctgga
     1681 ctacaacccc aaggaccggg ccctgtatgc ctggaacaac ggccaccaga tcctctacaa
     1741 cgtgaccctc ttccacgtca tccgctccga cgagttgtag ctccctcctc ctggaagcca
     1801 agggcccacg tcctcaccac aaagggactc ctgtgaaact gctgccaaaa agataccaat
     1861 aacactaaca ataccgatct tgaaaaatca tcagcagtgc ggattctgac atcgagggat
     1921 ggcattacct ccgtgtttct ccctttcgag ccggcgggcc acagacgtcg gaagaaactc
     1981 ccgtatttgc agctggaact gcagcccacg gcgccccggt tttcctcccc gccctgtccc
     2041 tctctggtca aacaacatac taaagaggcg aggcaatgac tgttggccag ttctcaccgg
     2101 ggaaaaaccc actgttagga tggcatgaac atttccttag atcgtggtca gctccgagga
     2161 atgtggcgtc caggctcttt gagagccatg ggctgcaccc ggccgtaggc tagtgtaact
     2221 cgcatcccat tgcagtgccg tttcttgact gtgttgctgt ctcttagatt aaccgtgctg
     2281 aggctccaca tagctcctgg acctgtgtct agtacatact gaagcgatgg tcagagtgtg
     2341 tagagtgaag ttgctgtgcc cacattgttt gaactcgcgt accccgtaga tacattgtgc
     2401 aacgttcttc tgttattccc ttgaggtggt aacttcgtat gttcagttta tgcgatgatt
     2461 gttgtaaatg caatgccgta gtttggatta ataagtggat ggtttttgtt tctaaaaaga
     2521 aaaaaaaaat cagtgttcac ccttatagag acatagtcaa gttcatgttg ataataatca
     2581 aaggaattac tctcttcttg ttaaattagc taaatcatgt aaccgcagat aggaagggct
     2641 cgcctgggga aactctggtt tccgatggga caggaaagtc atacgggcaa cagtatgcgg
     2701 aaagtacgtt ttttaagtaa aaaacaaagg caaactttgt actatccagt tatctaagga
     2761 acaataaaaa cattaggaga tc
//
