LOCUS       NM_001039702            1629 bp    mRNA    linear   PRI 06-OCT-2024
DEFINITION  Homo sapiens oleoyl-ACP hydrolase (OLAH), transcript variant 2,
            mRNA.
ACCESSION   NM_001039702
VERSION     NM_001039702.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1629)
  AUTHORS   Ritchie,M.K., Johnson,L.C., Clodfelter,J.E., Pemble,C.W. 4th,
            Fulp,B.E., Furdui,C.M., Kridel,S.J. and Lowther,W.T.
  TITLE     Crystal Structure and Substrate Specificity of Human Thioesterase
            2: INSIGHTS INTO THE MOLECULAR BASIS FOR THE MODULATION OF FATTY
            ACID SYNTHASE
  JOURNAL   J Biol Chem 291 (7), 3520-3530 (2016)
   PUBMED   26663084
REFERENCE   2  (bases 1 to 1629)
  AUTHORS   Nakamura,N., Shimaoka,Y., Tougan,T., Onda,H., Okuzaki,D., Zhao,H.,
            Fujimori,A., Yabuta,N., Nagamori,I., Tanigawa,A., Sato,J., Oda,T.,
            Hayashida,K., Suzuki,R., Yukioka,M., Nojima,H. and Ochi,T.
  TITLE     Isolation and expression profiling of genes upregulated in bone
            marrow-derived mononuclear cells of rheumatoid arthritis patients
  JOURNAL   DNA Res 13 (4), 169-183 (2006)
   PUBMED   17082220
REFERENCE   3  (bases 1 to 1629)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC050372.1, BG281536.1, AK001968.1 and AL590365.14.
            
            On Jun 2, 2019 this sequence version replaced NM_001039702.2.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the coding region, compared to variant 1. This results in a
            shorter protein (isoform 2), compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK001844.1, SRR5189667.186150.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145313
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000378228.8/ ENSP00000367473.4
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1048              BC050372.1         15-1062
            1049-1366           BG281536.1         281-598
            1367-1453           AK001968.1         1506-1592
            1454-1455           AL590365.14        35910-35911
            1456-1628           AK001968.1         1593-1765
            1629-1629           AL590365.14        36085-36085
FEATURES             Location/Qualifiers
     source          1..1629
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p13"
     gene            1..1629
                     /gene="OLAH"
                     /gene_synonym="AURA1; SAST; TE2; THEDC1"
                     /note="oleoyl-ACP hydrolase"
                     /db_xref="GeneID:55301"
                     /db_xref="HGNC:HGNC:25625"
     exon            1..44
                     /gene="OLAH"
                     /gene_synonym="AURA1; SAST; TE2; THEDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            45..239
                     /gene="OLAH"
                     /gene_synonym="AURA1; SAST; TE2; THEDC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..1005
                     /gene="OLAH"
                     /gene_synonym="AURA1; SAST; TE2; THEDC1"
                     /EC_number="3.1.2.14"
                     /note="isoform 2 is encoded by transcript variant 2;
                     thioesterase domain containing 1; S-acyl fatty acid
                     synthase thioesterase, medium chain; augmented in
                     rheumatoid arthritis 1; thioesterase II; thioesterase
                     domain-containing protein 1; oleoyl-acyl-carrier-protein
                     hydrolase; thioesterase 2; type II thioesterase"
                     /codon_start=1
                     /product="S-acyl fatty acid synthase thioesterase, medium
                     chain isoform 2"
                     /protein_id="NP_001034791.1"
                     /db_xref="CCDS:CCDS31152.1"
                     /db_xref="GeneID:55301"
                     /db_xref="HGNC:HGNC:25625"
                     /translation="MERGDQPKRTRNENIFNCLYKNPEATFKLICFPWMGGGSTHFAK
                     WGQDTHDLLEVHSLRLPGRESRVEEPLENDISQLVDEVVCALQPVIQDKPFAFFGHSM
                     GSYIAFRTALGLKENNQPEPLHLFLSSATPVHSKAWHRIPKDDELSEEQISHYLMEFG
                     GTPKHFAEAKEFVKQCSPIIRADLNIVRSCTSNVPSKAVLSCDLTCFVGSEDIAKDME
                     AWKDVTSGNAKIYQLPGGHFYLLDPANEKLIKNYIIKCLEVSSISNF"
     exon            240..370
                     /gene="OLAH"
                     /gene_synonym="AURA1; SAST; TE2; THEDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            371..509
                     /gene="OLAH"
                     /gene_synonym="AURA1; SAST; TE2; THEDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            510..609
                     /gene="OLAH"
                     /gene_synonym="AURA1; SAST; TE2; THEDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            610..779
                     /gene="OLAH"
                     /gene_synonym="AURA1; SAST; TE2; THEDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            780..862
                     /gene="OLAH"
                     /gene_synonym="AURA1; SAST; TE2; THEDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            863..1629
                     /gene="OLAH"
                     /gene_synonym="AURA1; SAST; TE2; THEDC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1607..1612
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OLAH"
                     /gene_synonym="AURA1; SAST; TE2; THEDC1"
                     /note="hexamer: AGTAAA"
     polyA_site      1629
                     /gene="OLAH"
                     /gene_synonym="AURA1; SAST; TE2; THEDC1"
                     /note="major polyA site"
ORIGIN      
        1 atctttcaga ttgtctgctc agagttcatc tcaaagcctg gcaaggattg gagaggtcaa
       61 taagagtcag cgcctttaaa aagaaatcta ctcactcttc tgtgtgcata aggccgagca
      121 gaggttcttc gtctcaagag gaactgactt ctgttgagca ctcaacacgc cacagagacc
      181 agccatcttg caacctcacc tcacagcatg gagagaggag accaacctaa gagaaccagg
      241 aatgaaaaca ttttcaactg cttatacaaa aaccctgagg caacttttaa gctgatttgc
      301 tttccctgga tgggaggtgg ctccactcat tttgccaaat ggggccaaga tactcatgat
      361 ttgctggaag tgcactcctt aaggcttcct ggaagagaaa gcagagttga agaacctctt
      421 gaaaatgaca tctcccagtt agttgatgaa gttgtttgtg ctctgcagcc agtcatccag
      481 gataaaccat ttgcattttt tggccacagt atgggatcct acattgcttt taggactgca
      541 ctaggtctaa aagaaaacaa tcaaccagaa ccattgcatt tatttttgtc aagtgcaact
      601 cctgtacatt caaaggcctg gcatcgcatt cccaaagatg atgaattgtc agaagaacaa
      661 ataagtcatt accttatgga atttggaggc acccccaagc attttgctga agccaaggaa
      721 tttgtgaaac aatgtagtcc catcataagg gcagatctga acattgttag aagttgcacc
      781 tctaacgtac catctaaggc tgttctttcc tgtgacttga catgttttgt tggatctgaa
      841 gacatagcaa aggacatgga agcctggaaa gatgtaacca gtggaaatgc taaaatttac
      901 cagcttccag ggggtcactt ttatcttctg gatcctgcga acgagaaatt aatcaagaac
      961 tacataatca agtgtctaga agtatcatcg atatccaatt tttagatatt ttccctttca
     1021 cttttaaaat aatcaaagta atatcatact cttctcagtt attcagatat agctcagttt
     1081 tattcagatt ggaaattaca cattttctac tgtcagggag attcgttaca taaatatatt
     1141 tacgtatctg gggacaaagg tcaagccagt aaagaatact tctggcagca ctttgggagg
     1201 ccaaggcggg cggatcacga ggtcaggaga tcgagaccgt cctggctaac accgtgaaac
     1261 cccatctcta ctaaaaatac acaaaattag ccgggcgtgg tggtgggcac ctgtagtccc
     1321 agctactcgg gaggctgagg caggagaatg gtgtgaacct gggaggtgga gcttgcagtg
     1381 aaccgagatc gctccactgc actccagcct gggtgacaga tccagactct gtctcaaaaa
     1441 aaaaaaaaaa aaaaatactt ctggcagagt cttttatctt cctattaaaa tctcacttga
     1501 ttctccttta tgggaagttt gtcgacaaaa ttcatgatta gtaaattatc cattttttcc
     1561 ttcagttagt ttaatggtga agatgattaa caggggaaat gcttgaagta aatgattgtt
     1621 tcaatggca
//
