LOCUS       NM_013341               4251 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens Obg like ATPase 1 (OLA1), transcript variant 1, mRNA.
ACCESSION   NM_013341
VERSION     NM_013341.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4251)
  AUTHORS   Sidlowski,P., Czerwinski,A., Liu,Y., Liu,P., Teng,R.J., Kumar,S.,
            Wells,C., Pritchard,K. Jr., Konduri,G.G. and Afolayan,A.J.
  TITLE     OLA1 Phosphorylation Governs the Mitochondrial Bioenergetic
            Function of Pulmonary Vascular Cells
  JOURNAL   Am J Respir Cell Mol Biol 68 (4), 395-405 (2023)
   PUBMED   36481055
  REMARK    GeneRIF: OLA1 Phosphorylation Governs the Mitochondrial
            Bioenergetic Function of Pulmonary Vascular Cells.
REFERENCE   2  (bases 1 to 4251)
  AUTHORS   Wang,J., Cao,Q. and Wang,Z.
  TITLE     Clinicopathological significance of Obg-like ATPase 1 and its
            association with Snail in gastric cancer
  JOURNAL   Pol J Pathol 74 (1), 42-50 (2023)
   PUBMED   37306352
  REMARK    GeneRIF: Clinicopathological significance of Obg-like ATPase 1 and
            its association with Snail in gastric cancer.
REFERENCE   3  (bases 1 to 4251)
  AUTHORS   Liu,Y., Kong,X.X., He,J.J., Xu,Y.B., Zhang,J.K., Zou,L.Y.,
            Ding,K.F. and Xu,D.
  TITLE     OLA1 promotes colorectal cancer tumorigenesis by activation of
            HIF1alpha/CA9 axis
  JOURNAL   BMC Cancer 22 (1), 424 (2022)
   PUBMED   35440019
  REMARK    GeneRIF: OLA1 promotes colorectal cancer tumorigenesis by
            activation of HIF1alpha/CA9 axis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4251)
  AUTHORS   Lu,S., Han,L., Hu,X., Sun,T., Xu,D., Li,Y., Chen,Q., Yao,W., He,M.,
            Wang,Z., Wu,H. and Wei,M.
  TITLE     N6-methyladenosine reader IMP2 stabilizes the ZFAS1/OLA1 axis and
            activates the Warburg effect: implication in colorectal cancer
  JOURNAL   J Hematol Oncol 14 (1), 188 (2021)
   PUBMED   34743750
  REMARK    GeneRIF: N6-methyladenosine reader IMP2 stabilizes the ZFAS1/OLA1
            axis and activates the Warburg effect: implication in colorectal
            cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4251)
  AUTHORS   Matsuzawa,A., Kanno,S., Nakayama,M., Mochiduki,H., Wei,L.,
            Shimaoka,T., Furukawa,Y., Kato,K., Shibata,S., Yasui,A., Ishioka,C.
            and Chiba,N.
  TITLE     The BRCA1/BARD1-interacting protein OLA1 functions in centrosome
            regulation
  JOURNAL   Mol Cell 53 (1), 101-114 (2014)
   PUBMED   24289923
  REMARK    GeneRIF: OLA1 plays an important role in centrosome regulation
            together with BRCA1.
REFERENCE   6  (bases 1 to 4251)
  AUTHORS   Sun,H., Luo,X., Montalbano,J., Jin,W., Shi,J., Sheikh,M.S. and
            Huang,Y.
  TITLE     DOC45, a novel DNA damage-regulated nucleocytoplasmic ATPase that
            is overexpressed in multiple human malignancies
  JOURNAL   Mol Cancer Res 8 (1), 57-66 (2010)
   PUBMED   20053727
  REMARK    GeneRIF: DOC45 is a novel ATPase that is linked to cellular stress
            response and tumorigenesis, and may also serve as a valuable tumor
            marker.
REFERENCE   7  (bases 1 to 4251)
  AUTHORS   Zhang,J.W., Rubio,V., Zheng,S. and Shi,Z.Z.
  TITLE     Knockdown of OLA1, a regulator of oxidative stress response,
            inhibits motility and invasion of breast cancer cells
  JOURNAL   J Zhejiang Univ Sci B 10 (11), 796-804 (2009)
   PUBMED   19882753
  REMARK    GeneRIF: knockdown of OLA1 inhibits breast cancer cell migration
            and invasion through a mechanism that involves the modulation of
            intracellular ROS levels
REFERENCE   8  (bases 1 to 4251)
  AUTHORS   Zhang,J., Rubio,V., Lieberman,M.W. and Shi,Z.Z.
  TITLE     OLA1, an Obg-like ATPase, suppresses antioxidant response via
            nontranscriptional mechanisms
  JOURNAL   Proc Natl Acad Sci U S A 106 (36), 15356-15361 (2009)
   PUBMED   19706404
  REMARK    GeneRIF: OLA1 suppresses the antioxidant response through
            nontranscriptional mechanisms.
REFERENCE   9  (bases 1 to 4251)
  AUTHORS   Kira,Y. and Nishikawa,M.
  TITLE     The identification and characterization of a new GTP-binding
            protein (Gbp45) involved in cell proliferation and death related to
            mitochondrial function
  JOURNAL   Cell Mol Biol Lett 13 (4), 570-584 (2008)
   PUBMED   18536999
  REMARK    GeneRIF: Results indicate that Gbp45/OLA1 plays important roles in
            cell proliferation and death related to mitochondrial function.
REFERENCE   10 (bases 1 to 4251)
  AUTHORS   Koller-Eichhorn,R., Marquardt,T., Gail,R., Wittinghofer,A.,
            Kostrewa,D., Kutay,U. and Kambach,C.
  TITLE     Human OLA1 defines an ATPase subfamily in the Obg family of
            GTP-binding proteins
  JOURNAL   J Biol Chem 282 (27), 19928-19937 (2007)
   PUBMED   17430889
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC012842.1 and AC016737.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_013341.4.
            
            Summary: This gene encodes a member of the GTPase protein family.
            The encoded protein interacts with breast cancer-associated gene 1
            (BRCA1) and BRCA1-associated RING domain protein (BARD1), and is
            involved in centrosome regulation. Overexpression of this gene has
            been observed in multiple types of cancer and may be associated
            with poor survival. Pseudogenes of this gene have been defined on
            chromosomes 17 and 22. [provided by RefSeq, Jun 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.378309.1,
                                           SRR1803616.41281.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000284719.8/ ENSP00000284719.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1444              BC012842.1         106-1549
            1445-1690           BC012842.1         1551-1796
            1691-4251           AC016737.8         136743-139303       c
FEATURES             Location/Qualifiers
     source          1..4251
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q31.1"
     gene            1..4251
                     /gene="OLA1"
                     /gene_synonym="DOC45; GBP45; GTBP9; GTPBP9; PTD004"
                     /note="Obg like ATPase 1"
                     /db_xref="GeneID:29789"
                     /db_xref="HGNC:HGNC:28833"
                     /db_xref="MIM:611175"
     exon            1..81
                     /gene="OLA1"
                     /gene_synonym="DOC45; GBP45; GTBP9; GTPBP9; PTD004"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..1272
                     /gene="OLA1"
                     /gene_synonym="DOC45; GBP45; GTBP9; GTPBP9; PTD004"
                     /note="isoform 1 is encoded by transcript variant 1;
                     GTP-binding protein 9 (putative); homologous yeast-44.2
                     protein; GTP-binding protein PTD004; DNA damage-regulated
                     overexpressed in cancer 45 protein; obg-like ATPase 1"
                     /codon_start=1
                     /product="obg-like ATPase 1 isoform 1"
                     /protein_id="NP_037473.3"
                     /db_xref="CCDS:CCDS2255.1"
                     /db_xref="GeneID:29789"
                     /db_xref="HGNC:HGNC:28833"
                     /db_xref="MIM:611175"
                     /translation="MPPKKGGDGIKPPPIIGRFGTSLKIGIVGLPNVGKSTFFNVLTN
                     SQASAENFPFCTIDPNESRVPVPDERFDFLCQYHKPASKIPAFLNVVDIAGLVKGAHN
                     GQGLGNAFLSHISACDGIFHLTRAFEDDDITHVEGSVDPIRDIEIIHEELQLKDEEMI
                     GPIIDKLEKVAVRGGDKKLKPEYDIMCKVKSWVIDQKKPVRFYHDWNDKEIEVLNKHL
                     FLTSKPMVYLVNLSEKDYIRKKNKWLIKIKEWVDKYDPGALVIPFSGALELKLQELSA
                     EERQKYLEANMTQSALPKIIKAGFAALQLEYFFTAGPDEVRAWTIRKGTKAPQAAGKI
                     HTDFEKGFIMAEVMKYEDFKEEGSENAVKAAGKYRQQGRNYIVEDGDIIFFKFNTPQQ
                     PKKK"
     exon            82..182
                     /gene="OLA1"
                     /gene_synonym="DOC45; GBP45; GTBP9; GTPBP9; PTD004"
                     /inference="alignment:Splign:2.1.0"
     exon            183..326
                     /gene="OLA1"
                     /gene_synonym="DOC45; GBP45; GTBP9; GTPBP9; PTD004"
                     /inference="alignment:Splign:2.1.0"
     exon            327..454
                     /gene="OLA1"
                     /gene_synonym="DOC45; GBP45; GTBP9; GTPBP9; PTD004"
                     /inference="alignment:Splign:2.1.0"
     exon            455..630
                     /gene="OLA1"
                     /gene_synonym="DOC45; GBP45; GTBP9; GTPBP9; PTD004"
                     /inference="alignment:Splign:2.1.0"
     exon            631..711
                     /gene="OLA1"
                     /gene_synonym="DOC45; GBP45; GTBP9; GTPBP9; PTD004"
                     /inference="alignment:Splign:2.1.0"
     exon            712..809
                     /gene="OLA1"
                     /gene_synonym="DOC45; GBP45; GTBP9; GTPBP9; PTD004"
                     /inference="alignment:Splign:2.1.0"
     exon            810..950
                     /gene="OLA1"
                     /gene_synonym="DOC45; GBP45; GTBP9; GTPBP9; PTD004"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1047
                     /gene="OLA1"
                     /gene_synonym="DOC45; GBP45; GTBP9; GTPBP9; PTD004"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1170
                     /gene="OLA1"
                     /gene_synonym="DOC45; GBP45; GTBP9; GTPBP9; PTD004"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..4251
                     /gene="OLA1"
                     /gene_synonym="DOC45; GBP45; GTBP9; GTPBP9; PTD004"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1670..1675
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OLA1"
                     /gene_synonym="DOC45; GBP45; GTBP9; GTPBP9; PTD004"
                     /note="hexamer: AATAAA"
     polyA_site      1691
                     /gene="OLA1"
                     /gene_synonym="DOC45; GBP45; GTBP9; GTPBP9; PTD004"
                     /note="major polyA site"
     regulatory      2076..2081
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OLA1"
                     /gene_synonym="DOC45; GBP45; GTBP9; GTPBP9; PTD004"
                     /note="hexamer: ATTAAA"
     polyA_site      2094
                     /gene="OLA1"
                     /gene_synonym="DOC45; GBP45; GTBP9; GTPBP9; PTD004"
     regulatory      4232..4237
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OLA1"
                     /gene_synonym="DOC45; GBP45; GTBP9; GTPBP9; PTD004"
                     /note="hexamer: AATAAA"
     polyA_site      4251
                     /gene="OLA1"
                     /gene_synonym="DOC45; GBP45; GTBP9; GTPBP9; PTD004"
ORIGIN      
        1 cttcctcccc gcctccagct gccggcagga cctttctctc gctgccgctg ggaccccgtg
       61 tcatcgccca ggccgagcac gatgccccct aaaaagggag gtgatggaat taaaccaccc
      121 ccaatcattg gaagatttgg aacctcactg aaaattggta ttgttggatt gccaaatgtt
      181 gggaaatcta ctttcttcaa tgtgttaacc aatagtcagg cttcagcaga aaacttcccg
      241 ttctgcacta ttgatcctaa tgagagcaga gtacctgtgc cagatgaaag gtttgacttt
      301 ctttgtcaat accacaaacc agcaagcaaa attcctgcct ttctaaatgt ggtggatatt
      361 gctggccttg tgaaaggagc tcacaatggg cagggcctgg ggaatgcttt tttatctcat
      421 attagtgcct gtgatggcat ctttcatcta acacgtgctt ttgaagatga tgatatcacg
      481 cacgttgaag gaagtgtaga tcctattcga gatatagaaa taatacatga agagcttcag
      541 cttaaagatg aggaaatgat tgggcccatt atagataaac tagaaaaggt ggctgtgaga
      601 ggaggagata aaaaactaaa acctgaatat gatataatgt gcaaagtaaa atcctgggtt
      661 atagatcaaa agaaacctgt tcgcttctat catgattgga atgacaaaga gattgaagtg
      721 ttgaataaac acttattttt gacttcaaaa ccaatggtct acttggttaa tctttctgaa
      781 aaagactaca ttagaaagaa aaacaaatgg ttgataaaaa ttaaagagtg ggtggacaag
      841 tatgacccag gtgctttggt cattcctttt agtggggcct tggaactcaa gttgcaagaa
      901 ttgagtgctg aggagagaca gaagtatctg gaagcgaaca tgacacaaag tgctttgcca
      961 aagatcatta aggctgggtt tgcagcactc caactagaat actttttcac tgcaggccca
     1021 gatgaagtgc gtgcatggac catcaggaaa gggactaagg ctcctcaggc tgcaggaaag
     1081 attcacacag attttgaaaa gggattcatt atggctgaag taatgaaata cgaagatttt
     1141 aaagaggaag gttctgaaaa tgcagtcaag gctgctggaa agtacagaca acaaggcaga
     1201 aattatattg ttgaagatgg agatattatc ttcttcaaat ttaacacacc tcaacaaccg
     1261 aagaagaaat aaaatttagt tattgctcag ataaacatac aacttccaaa aggcatctga
     1321 tttttaaaaa attaaaattt ctgaaaacca atgcgacaaa taaagttggg gagatgggaa
     1381 tctttgacaa acaaattatt tttatttgtt ttaaaattaa aatactgtgt accccccccc
     1441 ccccatgaaa tgcaggttca ctaaatgtga acagctttgc ttttcacgtg attaagaccc
     1501 tactccaaat tgtagaagct tttcaggaac catattactc tcatgatact tcattaatct
     1561 ccatcatgta tgccaagcct gacacatttg acagtgagga caatgtggct tgctcctttt
     1621 tgaatctaca gataatgcat gttttacagt actccagatg tctacactca ataaaacatt
     1681 tgacaaaacc agccttggtg tgtttgggga tgtctgtatt gactgactgt ggtgtgctga
     1741 atgcgatacg gcacctggtg gttgctgatt acagaatttt aaggcgtgtg tatgacacag
     1801 taactggcag tgtggggcag ctgcaattgt atcttaaaag tgagtctttc atgggaatca
     1861 gaagaatagt ataccaggga tttgtctcaa aaaagttaat taatttatag atcaacattt
     1921 attgaaagat gatagcaatg atattatgag ggatatgaga taggtgactg accacaaaga
     1981 agaaaattct gtctcaaaaa ttaaagaatt ttgtttgtta ttgttgttct gaccatattg
     2041 aaaagaggtt cacttttaat ctttcctttg aaattattaa attgtaaaaa ctgacccatt
     2101 gatgtctggt gggttatgtt ttgcttcaat tcagcaatgt gtataaaagt tcctacactg
     2161 attttgaaat actaagatca gactttgaaa attttaaaaa ttctttcatt cttacttttc
     2221 agatatttga gagcagtcga agtggtagta tgggtaagtt aagcacttct taacattgta
     2281 gcagaaaatt ccaaaagaaa gactagaaca aattggtaat ttggagaccc tttgccactt
     2341 agccttctct tgtgatgatg gcctgaaagc tctctcggcc ctgagcctcc ctttctctcc
     2401 catgtttcca ttcctgtgag acctcccttc cttgtccttg tcctctgccc ttttgtgctc
     2461 ttctgtgatc acaggaccat ttccatggaa tgcagattca tacccagcca gcctttgcct
     2521 ctactgtatc gctttgggac tttaaagatg cagaagtatt agaacacaca caaacttaaa
     2581 atggaaagtt accaaatgta gcactagagg caagaaaagg ggtgattttt taaagatttg
     2641 gctatactta agatatttaa agaggatgag gttgagtcgt gagtataatt tagaagctct
     2701 ccagtgagta tttttttagt atcaaatagt gatcttcttt tgctaacata aaaatgagta
     2761 aactacagca gagaaataag aataaaacta atgaagggtt ttttaaaaga actaaataaa
     2821 acaaataaaa ctaggctaca ggtatagctg accaagtttg ctgtgaaaaa tccttgttat
     2881 atctatttct gtattggagt aatgtgtaga ttagtggatt gttagggatt tcagcagtat
     2941 aagaaagaat caaatatctt gcttttgggt cttctccaaa gtaaattgca tggacttctt
     3001 aaagaagttt gaaatcagta aaaagacatt aggatcatgc aattttactt tgtctagctt
     3061 ctaatgtggt aaattgcaca ttgtgcaaca gaaccattaa taaaagaaag gagttagttt
     3121 tgaggtaact gcattcatta ggggctgaaa ataaatgtta aaaatgttta atttggttag
     3181 aagttctaca acattgtatg tacatataca aaatttcatt ttctctgaaa gtcgagaatt
     3241 ccaagaactg ttacatataa tcatatatat gcctatatct aaacgttttc cctcctttaa
     3301 tattgataaa gttaatatat tttaggatgt tatgtaaata tttttgcatg tatctgtagc
     3361 tccatcttaa tcaaatttat ggttaaaaga gatttgaggc caggcgtgga ggctcacacc
     3421 tataatccca acactttggg aggccgaggt gggaggatca cttgagcaca ggagtttgag
     3481 accagcctgt gcaacatcat gaaacatcat ctctacataa aaaaatacat atatacaaaa
     3541 attagctggg catcatggca cacacctgta gtcccagcta cttaggaggc tgagatggga
     3601 ggattgatcg atcgcttgag cctgggaggt ggaggctact gtgagccatg atcatgccac
     3661 tgcactccag cctgggcaac agagtgagac cctgtctcca aagagaaaga gaaacttgag
     3721 aaggcttgtg cccaaagctt gaagaaagat tgtaatagca tttagttgtg ttttatcatg
     3781 ttatcttcat aacatgcatt ttgcatatgg ctcagagcag agccggatct cccaaggaag
     3841 cacaaatagt ttttgtcgct aacttagtta tgagtgaagc ctctgttcac ttataacttg
     3901 ccagtttcat tggtggaata agtcccctta ctcatgattc atcaatattc ctatattaaa
     3961 attccagttt gatgtttgtc tctagttgtc tgtgtataat atttccaaag ctcctttgta
     4021 aaccccgtct cctttcattc agagagtcag agacggtatc tcctcctcct gcctcttcta
     4081 ttgttctgat tagtctactt aaattcactt gatgctcttt ttattttaca agagacttga
     4141 gaaatgtcgg ttgttcctaa tggcaaacta ctttagctgg gaaaattcat ttcaacttat
     4201 tttaagcttg taaaatacac tgtggtgata aaataaaaga gctgggtttg a
//
