LOCUS       NM_152635               2210 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens oncoprotein induced transcript 3 (OIT3), transcript
            variant 1, mRNA.
ACCESSION   NM_152635
VERSION     NM_152635.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2210)
  AUTHORS   Wen,J., Yang,S., Yan,G., Lei,J., Liu,X., Zhang,N., Zhang,J.,
            Deng,H., Wu,L. and Li,Y.
  TITLE     Increased OIT3 in macrophages promotes PD-L1 expression and
            hepatocellular carcinogenesis via NF-kappaB signaling
  JOURNAL   Exp Cell Res 428 (2), 113651 (2023)
   PUBMED   37201744
  REMARK    GeneRIF: Increased OIT3 in macrophages promotes PD-L1 expression
            and hepatocellular carcinogenesis via NF-kappaB signaling.
REFERENCE   2  (bases 1 to 2210)
  AUTHORS   Yang,S., Zhang,J., Xu,Y., Wang,J., Zhao,H., Lei,J., Zhou,Y.,
            Chen,Y., Wu,L., Zhou,M., Zheng,L., Ji,X. and Li,Y.
  TITLE     OIT3 mediates macrophage polarization and facilitates
            hepatocellular carcinoma progression
  JOURNAL   Cancer Immunol Immunother 71 (11), 2677-2689 (2022)
   PUBMED   35353239
  REMARK    GeneRIF: OIT3 mediates macrophage polarization and facilitates
            hepatocellular carcinoma progression.
REFERENCE   3  (bases 1 to 2210)
  AUTHORS   Yang,P., Pi,X., Marion,T.N., Wang,J., Wang,G., Xie,Y., Xie,D. and
            Liu,Y.
  TITLE     Gout inheritance in an extended Chinese family analyzed by
            whole-exome sequencing: A case-report
  JOURNAL   Medicine (Baltimore) 99 (25), e20057 (2020)
   PUBMED   32569156
  REMARK    GeneRIF: rs554643826 (T439S) may have contributed to inheritance of
            gout in a Chinese family
REFERENCE   4  (bases 1 to 2210)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2210)
  AUTHORS   Long,J., Zhang,Z.B., Liu,Z., Xu,Y.H. and Ge,C.L.
  TITLE     Loss of heterozygosity at the calcium regulation gene locus on
            chromosome 10q in human pancreatic cancer
  JOURNAL   Asian Pac J Cancer Prev 16 (6), 2489-2493 (2015)
   PUBMED   25824785
  REMARK    GeneRIF: Loss of heterozygosity of OIT3 gene on chromosome 10q is
            associated with pancreatic cancer.
REFERENCE   6  (bases 1 to 2210)
  AUTHORS   Shen,H.L., Xu,Z.G., Huang,L.Y., Liu,D., Lin,D.H., Cao,J.B.,
            Zhang,X., Wang,Z.Q., Wang,W.H., Yang,P.Y. and Han,Z.G.
  TITLE     Liver-specific ZP domain-containing protein (LZP) as a new partner
            of Tamm-Horsfall protein harbors on renal tubules
  JOURNAL   Mol Cell Biochem 321 (1-2), 73-83 (2009)
   PUBMED   18830570
  REMARK    GeneRIF: The finding that LZP might act as a new partner of THP
            would provide novel insights into renal functions related to THP
            and LZP, such as the urothelial permeability barrier and the host
            defense against the adhesion of pathogens.
REFERENCE   7  (bases 1 to 2210)
  AUTHORS   Yang,H., Wu,C., Zhao,S. and Guo,J.
  TITLE     Identification and characterization of D8C, a novel domain present
            in liver-specific LZP, uromodulin and glycoprotein 2, mutated in
            familial juvenile hyperuricaemic nephropathy
  JOURNAL   FEBS Lett 578 (3), 236-238 (2004)
   PUBMED   15589826
  REMARK    GeneRIF: D8C, a novel domain present in LZP, mutates in familial
            juvenile hyperuricemia.
REFERENCE   8  (bases 1 to 2210)
  AUTHORS   Xu,Z.G., Du,J.J., Zhang,X., Cheng,Z.H., Ma,Z.Z., Xiao,H.S., Yu,L.,
            Wang,Z.Q., Li,Y.Y., Huo,K.K. and Han,Z.G.
  TITLE     A novel liver-specific zona pellucida domain containing protein
            that is expressed rarely in hepatocellular carcinoma
  JOURNAL   Hepatology 38 (3), 735-744 (2003)
   PUBMED   12939600
  REMARK    GeneRIF: Liver-specific ZP domain-containing protein (LZP) is a
            liver-specific protein involved possibly in hepatocellular function
            and development. (liver-specific ZP domain-containing protein)
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY358339.1 and AC069548.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_152635.2.
            
            Summary: This gene was identified due to its downregulation in
            hepatocarcinomas. The encoded protein may be involved in liver
            development and function. [provided by RefSeq, Sep 2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY013707.2, SRR5189664.166699.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145122, SAMEA2145313
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334011.10/ ENSP00000333900.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2203              AY358339.1         137-2339
            2204-2210           AC069548.6         44235-44241         c
FEATURES             Location/Qualifiers
     source          1..2210
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.1"
     gene            1..2210
                     /gene="OIT3"
                     /gene_synonym="LZP"
                     /note="oncoprotein induced transcript 3"
                     /db_xref="GeneID:170392"
                     /db_xref="HGNC:HGNC:29953"
                     /db_xref="MIM:609330"
     exon            1..121
                     /gene="OIT3"
                     /gene_synonym="LZP"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..1698
                     /gene="OIT3"
                     /gene_synonym="LZP"
                     /note="liver-specific ZP domain-containing protein;
                     liver-specific zona pellucida domain-containing protein"
                     /codon_start=1
                     /product="oncoprotein-induced transcript 3 protein
                     precursor"
                     /protein_id="NP_689848.1"
                     /db_xref="CCDS:CCDS7318.1"
                     /db_xref="GeneID:170392"
                     /db_xref="HGNC:HGNC:29953"
                     /db_xref="MIM:609330"
                     /translation="MPPFLLLTCLFITGTSVSPVALDPCSAYISLNEPWRNTDHQLDE
                     SQGPPLCDNHVNGEWYHFTGMAGDAMPTFCIPENHCGTHAPVWLNGSHPLEGDGIVQR
                     QACASFNGNCCLWNTTVEVKACPGGYYVYRLTKPSVCFHVYCGHFYDICDEDCHGSCS
                     DTSECTCAPGTVLGPDRQTCFDENECEQNNGGCSEICVNLKNSYRCECGVGRVLRSDG
                     KTCEDVEGCHNNNGGCSHSCLGSEKGYQCECPRGLVLSEDNHTCQVPVLCKSNAIEVN
                     IPRELVGGLELFLTNTSCRGVSNGTHVNILFSLKTCGTVVDVVNDKIVASNLVTGLPK
                     QTPGSSGDFIIRTSKLLIPVTCEFPRLYTISEGYVPNLRNSPLEIMSRNHGIFPFTLE
                     IFKDNEFEEPYREALPTLKLRDSLYFGIEPVVHVSGLESLVESCFATPTSKIDEVLKY
                     YLIRDGCVSDDSVKQYTSRDHLAKHFQVPVFKFVGKDHKEVFLHCRVLVCGVLDERSR
                     CAQGCHRRMRRGAGGEDSAGLQGQTLTGGPIRIDWED"
     exon            122..496
                     /gene="OIT3"
                     /gene_synonym="LZP"
                     /inference="alignment:Splign:2.1.0"
     exon            497..604
                     /gene="OIT3"
                     /gene_synonym="LZP"
                     /inference="alignment:Splign:2.1.0"
     exon            605..727
                     /gene="OIT3"
                     /gene_synonym="LZP"
                     /inference="alignment:Splign:2.1.0"
     exon            728..850
                     /gene="OIT3"
                     /gene_synonym="LZP"
                     /inference="alignment:Splign:2.1.0"
     exon            851..1011
                     /gene="OIT3"
                     /gene_synonym="LZP"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1427
                     /gene="OIT3"
                     /gene_synonym="LZP"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1527
                     /gene="OIT3"
                     /gene_synonym="LZP"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..2210
                     /gene="OIT3"
                     /gene_synonym="LZP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2183..2188
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OIT3"
                     /gene_synonym="LZP"
                     /note="hexamer: AATAAA"
     polyA_site      2210
                     /gene="OIT3"
                     /gene_synonym="LZP"
                     /note="major polyA site"
ORIGIN      
        1 gacaaaggaa caccagtatt aagaggattt tccagtgttt ctggcagttg gtccagaagg
       61 atgcctccat tcctgcttct cacctgcctc ttcatcacag gcacctccgt gtcacccgtg
      121 gccctagatc cttgttctgc ttacatcagc ctgaatgagc cctggaggaa cactgaccac
      181 cagttggatg agtctcaagg tcctcctcta tgtgacaacc atgtgaatgg ggagtggtac
      241 cacttcacgg gcatggcggg agatgccatg cctaccttct gcataccaga aaaccactgt
      301 ggaacccacg cacctgtctg gctcaatggc agccaccccc tagaaggcga cggcattgtg
      361 caacgccagg cttgtgccag cttcaatggg aactgctgtc tctggaacac cacggtggaa
      421 gtcaaggctt gccctggagg ctactatgtg tatcgtctga ccaagcccag cgtctgcttc
      481 cacgtctact gtggtcattt ttatgacatc tgcgacgagg actgccatgg cagctgctca
      541 gataccagcg agtgcacatg cgctccagga actgtgctag gccctgacag gcagacatgc
      601 tttgatgaaa atgaatgtga gcaaaacaac ggtggctgca gtgagatctg tgtgaacctc
      661 aaaaactcct accgctgtga gtgtggggtt ggccgtgtgc taagaagtga tggcaagact
      721 tgtgaagacg ttgaaggatg ccacaataac aatggtggct gcagccactc ttgccttgga
      781 tctgagaaag gctaccagtg tgaatgtccc cggggcctgg tgctgtctga ggataaccac
      841 acttgccaag tccctgtgtt gtgcaaatca aatgccattg aagtgaacat ccccagggag
      901 ctggttggtg gcctggagct cttcctgacc aacacctcct gccgaggagt gtccaacggc
      961 acccatgtca acatcctctt ctctctcaag acatgtggta cagtggtcga tgtggtgaat
     1021 gacaagattg tggccagcaa cctcgtgaca ggtctaccca agcagacccc ggggagcagc
     1081 ggggacttca tcatccgaac cagcaagctg ctgatcccgg tgacctgcga gtttccacgc
     1141 ctgtacacca tttctgaagg atacgttccc aaccttcgaa actccccact ggaaatcatg
     1201 agccgaaatc atgggatctt cccattcact ctggagatct tcaaggacaa tgagtttgaa
     1261 gagccttacc gggaagctct gcccaccctc aagcttcgtg actccctcta ctttggcatt
     1321 gagcccgtgg tgcacgtgag cggcttggaa agcttggtgg agagctgctt tgccaccccc
     1381 acctccaaga tcgacgaggt cctgaaatac tacctcatcc gggatggctg tgtttcagat
     1441 gactcggtaa agcagtacac atcccgggat cacctagcaa agcacttcca ggtccctgtc
     1501 ttcaagtttg tgggcaaaga ccacaaggaa gtgtttctgc actgccgggt tcttgtctgt
     1561 ggagtgttgg acgagcgttc ccgctgtgcc cagggttgcc accggcgaat gcgtcgtggg
     1621 gcaggaggag aggactcagc cggtctacag ggccagacgc taacaggcgg cccgatccgc
     1681 atcgactggg aggactagtt cgtagccata cctcgagtcc ctgcattgga cggctctgct
     1741 ctttggagct tctcccccca ccgccctcta agaacatctg ccaacagctg ggttcagact
     1801 tcacactgtg agttcagact cccagcacca actcactctg attctggtcc attcagtggg
     1861 cacaggtcac agcactgctg aacaatgtgg cctgggtggg gtttcatctt tctagggttg
     1921 aaaactaaac tgtccaccca gaaagacact caccccattt ccctcatttc tttcctacac
     1981 ttaaatacct cgtgtatggt gcaatcagac cacaaaatca gaagctgggt ataatatttc
     2041 aagttacaaa ccctagaaaa attaaacagt tactgaaatt atgacttaaa tacccaatga
     2101 ctccttaaat atgtaaatta tagttatacc ttgaaatttc aattcaaatg cagactaatt
     2161 atagggaatt tggaagtgta tcaataaaac agtatataat tttaaaagta
//
