LOCUS       NM_007280               1201 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens Opa interacting protein 5 (OIP5), transcript variant
            1, mRNA.
ACCESSION   NM_007280
VERSION     NM_007280.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1201)
  AUTHORS   Xie,Y., She,Z., Li,R., Wu,R., Wang,R. and Liu,J.
  TITLE     [H3K27 acetylation promotes lncRNA OIP5-AS1 transcription and
            induces apoptosis of nasal epithelial cells in allergic rhinitis
            through up-regulation of TLR4]
  JOURNAL   Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 40 (5), 419-427 (2024)
   PUBMED   38790098
  REMARK    GeneRIF: [H3K27 acetylation promotes lncRNA OIP5-AS1 transcription
            and induces apoptosis of nasal epithelial cells in allergic
            rhinitis through up-regulation of TLR4].
REFERENCE   2  (bases 1 to 1201)
  AUTHORS   Sethi,S.C., Shrestha,R.L., Balachandra,V., Durairaj,G., Au,W.C.,
            Nirula,M., Karpova,T.S., Kaiser,P. and Basrai,M.A.
  TITLE     beta-TrCP-Mediated Proteolysis of Mis18beta Prevents
            Mislocalization of CENP-A and Chromosomal Instability
  JOURNAL   Mol Cell Biol 44 (10), 429-442 (2024)
   PUBMED   39135477
  REMARK    GeneRIF: beta-TrCP-Mediated Proteolysis of Mis18beta Prevents
            Mislocalization of CENP-A and Chromosomal Instability.
REFERENCE   3  (bases 1 to 1201)
  AUTHORS   Zhang,X., Gu,W., Lin,A., Duan,R., Lian,L., Huang,Y., Li,T. and
            Sun,Q.
  TITLE     The role of OIP5 in the carcinogenesis and progression of ovarian
            cancer
  JOURNAL   J Ovarian Res 16 (1), 185 (2023)
   PUBMED   37660035
  REMARK    GeneRIF: The role of OIP5 in the carcinogenesis and progression of
            ovarian cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1201)
  AUTHORS   Xu,H., Wang,J., Liu,J. and Huang,J.
  TITLE     Opa interacting protein 5 promotes proliferation and migration of
            trophoblast cells via activating STAT3 pathway
  JOURNAL   Reprod Biol 22 (2), 100639 (2022)
   PUBMED   35429809
  REMARK    GeneRIF: Opa interacting protein 5 promotes proliferation and
            migration of trophoblast cells via activating STAT3 pathway.
REFERENCE   5  (bases 1 to 1201)
  AUTHORS   Qiao,X. and Zhao,F.
  TITLE     Long non-coding RNA Opa interacting protein 5-antisense RNA 1 binds
            to micorRNA-34a to upregulate oncogenic PD-L1 in non-small cell
            lung cancer
  JOURNAL   Bioengineered 13 (4), 9264-9273 (2022)
   PUBMED   35411833
  REMARK    GeneRIF: Long non-coding RNA Opa interacting protein 5-antisense
            RNA 1 binds to micorRNA-34a to upregulate oncogenic PD-L1 in
            non-small cell lung cancer.
REFERENCE   6  (bases 1 to 1201)
  AUTHORS   Chun,H.K., Chung,K.S., Kim,H.C., Kang,J.E., Kang,M.A., Kim,J.T.,
            Choi,E.H., Jung,K.E., Kim,M.H., Song,E.Y., Kim,S.Y., Won,M. and
            Lee,H.G.
  TITLE     OIP5 is a highly expressed potential therapeutic target for
            colorectal and gastric cancers
  JOURNAL   BMB Rep 43 (5), 349-354 (2010)
   PUBMED   20510019
  REMARK    GeneRIF: These results indicate that knockdown of OIP5 may induce
            apoptosis in cancer cells.
REFERENCE   7  (bases 1 to 1201)
  AUTHORS   Naetar,N., Hutter,S., Dorner,D., Dechat,T., Korbei,B., Gotzmann,J.,
            Beug,H. and Foisner,R.
  TITLE     LAP2alpha-binding protein LINT-25 is a novel chromatin-associated
            protein involved in cell cycle exit
  JOURNAL   J Cell Sci 120 (Pt 5), 737-747 (2007)
   PUBMED   17284516
REFERENCE   8  (bases 1 to 1201)
  AUTHORS   Fujita,Y., Hayashi,T., Kiyomitsu,T., Toyoda,Y., Kokubu,A., Obuse,C.
            and Yanagida,M.
  TITLE     Priming of centromere for CENP-A recruitment by human hMis18alpha,
            hMis18beta, and M18BP1
  JOURNAL   Dev Cell 12 (1), 17-30 (2007)
   PUBMED   17199038
  REMARK    GeneRIF: Three human proteins essential for centromere/kinetochore
            structure and function, hMis18alpha, hMis18beta, and M18BP1, the
            complex of which is accumulated specifically at the telophase-G1
            centromere, are identified.[Mis18alpha, Mis18beta, M18BP1]
REFERENCE   9  (bases 1 to 1201)
  AUTHORS   Yuryev,A. and Wennogle,L.P.
  TITLE     Novel raf kinase protein-protein interactions found by an
            exhaustive yeast two-hybrid analysis
  JOURNAL   Genomics 81 (2), 112-125 (2003)
   PUBMED   12620389
REFERENCE   10 (bases 1 to 1201)
  AUTHORS   Williams,J.M., Chen,G.C., Zhu,L. and Rest,R.F.
  TITLE     Using the yeast two-hybrid system to identify human epithelial cell
            proteins that bind gonococcal Opa proteins: intracellular gonococci
            bind pyruvate kinase via their Opa proteins and require host
            pyruvate for growth
  JOURNAL   Mol Microbiol 27 (1), 171-186 (1998)
   PUBMED   9466265
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC015050.1.
            
            On Nov 24, 2018 this sequence version replaced NM_007280.1.
            
            Summary: The protein encoded by this gene localizes to centromeres,
            where it is essential for recruitment of CENP-A through the
            mediator Holliday junction recognition protein. Expression of this
            gene is upregulated in several cancers, making it a putative
            therapeutic target. Two transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Dec
            2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF025441.1, BC015050.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000220514.8/ ENSP00000220514.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1201              BC015050.1         31-1231
FEATURES             Location/Qualifiers
     source          1..1201
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.1"
     gene            1..1201
                     /gene="OIP5"
                     /gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
                     MIS18B; MIS18beta"
                     /note="Opa interacting protein 5"
                     /db_xref="GeneID:11339"
                     /db_xref="HGNC:HGNC:20300"
                     /db_xref="MIM:606020"
     exon            1..352
                     /gene="OIP5"
                     /gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
                     MIS18B; MIS18beta"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..720
                     /gene="OIP5"
                     /gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
                     MIS18B; MIS18beta"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cancer/testis antigen 86; MIS18 kinetochore protein
                     homolog B; LAP2alpha interactor-25; protein Mis18-beta;
                     opa-interacting protein 5"
                     /codon_start=1
                     /product="protein Mis18-beta isoform 1"
                     /protein_id="NP_009211.1"
                     /db_xref="CCDS:CCDS10074.1"
                     /db_xref="GeneID:11339"
                     /db_xref="HGNC:HGNC:20300"
                     /db_xref="MIM:606020"
                     /translation="MAAQPLRHRSRCATPPRGDFCGGTERAIDQASFTTSMEWDTQVV
                     KGSSPLGPAGLGAEEPAAGPQLPSWLQPERCAVFQCAQCHAVLADSVHLAWDLSRSLG
                     AVVFSRVTNNVVLEAPFLVGIEGSLKGSTYNLLFCGSCGIPVGFHLYSTHAALAALRG
                     HFCLSSDKMVCYLLKTKAIVNASEMDIQNVPLSEKIAELKEKIVLTHNRLKSLMKILS
                     EVTPDQSKPEN"
     exon            353..419
                     /gene="OIP5"
                     /gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
                     MIS18B; MIS18beta"
                     /inference="alignment:Splign:2.1.0"
     exon            420..542
                     /gene="OIP5"
                     /gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
                     MIS18B; MIS18beta"
                     /inference="alignment:Splign:2.1.0"
     exon            543..624
                     /gene="OIP5"
                     /gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
                     MIS18B; MIS18beta"
                     /inference="alignment:Splign:2.1.0"
     exon            625..1201
                     /gene="OIP5"
                     /gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
                     MIS18B; MIS18beta"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1182..1187
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OIP5"
                     /gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
                     MIS18B; MIS18beta"
                     /note="hexamer: AATAAA"
     polyA_site      1201
                     /gene="OIP5"
                     /gene_synonym="5730547N13Rik; CT86; hMIS18beta; LINT-25;
                     MIS18B; MIS18beta"
                     /note="major polyA site"
ORIGIN      
        1 attcgaaagg aaggcgccgg ctgcgggaag atggcggctc agccgctgcg gcatcgctca
       61 cgttgtgcaa cgccgccccg gggggacttt tgtggtggca ctgagagggc gattgaccaa
      121 gcttctttta cgacctccat ggagtgggat acgcaggtgg tgaaggggtc ctcgccgctc
      181 ggccccgcag ggctgggggc tgaggagcca gccgccggcc cgcagctgcc gtcttggctg
      241 cagcctgaga ggtgcgctgt gttccagtgc gcacagtgtc acgcagtgct cgccgactcg
      301 gtgcacctcg cctgggacct gtcgcggtcc ctcggggccg tggtcttctc cagagttaca
      361 aataacgtcg ttttggaagc gcccttccta gttggcattg aaggttcact caaaggcagt
      421 acttacaacc ttttattctg tggttcttgt gggattcccg ttggtttcca tctgtattct
      481 acccatgctg ccctggctgc cttgagaggt cacttctgcc tttccagtga caaaatggtg
      541 tgctatctct taaaaacaaa agccatagta aatgcatcag agatggatat tcaaaatgtt
      601 cctctatcag aaaagattgc agagctgaaa gagaagatag tgctaacgca caatcgctta
      661 aaatcactaa tgaagattct gagtgaagtg actcctgacc agtccaagcc agaaaactga
      721 tcctgtacca aagcttgagt gtcaggttca ggctttattg ctgtcttcaa caacaggtgc
      781 tgcttagtca tttcttgaaa aagattggct tcaagaatgg aggggaaatg cagtttctat
      841 ttacctttag gctgattttc caaattattt gtgaagctgt ttttagaaga tgagagacta
      901 aggattcttc tcttttatag ctatttgcct taagaactta ctttagattc ttattgaatt
      961 cataatactt atctctgaaa atgtctttga ctgtaaattt aggaattaag atgcagagtc
     1021 ccatgtgtcc tctgatctaa agttgcatgg ttggtctgaa aatagagttg ggcttaatgt
     1081 tgacttctat tactcctgca tggagcagtt gttatgaata ctaatacatc actttttaac
     1141 ttctgtaaaa tacagatcat aatattctat aggtaatgtt taataaattg cctgaataat
     1201 a
//
