LOCUS       NM_181672               5435 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens O-linked N-acetylglucosamine (GlcNAc) transferase
            (OGT), transcript variant 1, mRNA.
ACCESSION   NM_181672
VERSION     NM_181672.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5435)
  AUTHORS   Ben Ahmed,A., Scache,J., Mortuaire,M., Lefebvre,T. and
            Vercoutter-Edouart,A.S.
  TITLE     Downregulation of O-GlcNAc transferase activity impairs basal
            autophagy and late endosome positioning under nutrient-rich
            conditions in human colon cells
  JOURNAL   Biochem Biophys Res Commun 724, 150198 (2024)
   PUBMED   38852504
  REMARK    GeneRIF: Downregulation of O-GlcNAc transferase activity impairs
            basal autophagy and late endosome positioning under nutrient-rich
            conditions in human colon cells.
REFERENCE   2  (bases 1 to 5435)
  AUTHORS   Zhao,F.Y., Chen,X., Wang,J.M., Yuan,Y., Li,C., Sun,J. and Wang,H.Q.
  TITLE     O-GlcNAcylation of TRIM29 and OGT translation forms a feedback loop
            to promote adaptive response of PDAC cells to glucose deficiency
  JOURNAL   Cell Oncol (Dordr) 47 (3), 1025-1041 (2024)
   PUBMED   38345749
  REMARK    GeneRIF: O-GlcNAcylation of TRIM29 and OGT translation forms a
            feedback loop to promote adaptive response of PDAC cells to glucose
            deficiency.
REFERENCE   3  (bases 1 to 5435)
  AUTHORS   Vang,S., Helton,E.S., Guo,Y., Burpee,B., Rose,E., Easter,M.,
            Bollenbecker,S., Hirsch,M.J., Matthews,E.L., Jones,L.I., Howze,P.H.
            4th, Rajasekaran,V., Denson,R., Cochran,P., Attah,I.K., Olson,H.,
            Clair,G., Melkani,G., Krick,S. and Barnes,J.W.
  TITLE     O-GlcNAc transferase regulates collagen deposition and fibrosis
            resolution in idiopathic pulmonary fibrosis
  JOURNAL   Front Immunol 15, 1387197 (2024)
   PUBMED   38665916
  REMARK    GeneRIF: O-GlcNAc transferase regulates collagen deposition and
            fibrosis resolution in idiopathic pulmonary fibrosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5435)
  AUTHORS   Yu,F., Zhang,Z., Leng,Y. and Chen,A.F.
  TITLE     O-GlcNAc modification of GSDMD attenuates LPS-induced endothelial
            cells pyroptosis
  JOURNAL   Inflamm Res 73 (1), 5-17 (2024)
   PUBMED   37962578
REFERENCE   5  (bases 1 to 5435)
  AUTHORS   Lu,P., Liu,Y., He,M., Cao,T., Yang,M., Qi,S., Yu,H. and Gao,H.
  TITLE     Cryo-EM structure of human O-GlcNAcylation enzyme pair OGT-OGA
            complex
  JOURNAL   Nat Commun 14 (1), 6952 (2023)
   PUBMED   37907462
  REMARK    GeneRIF: Cryo-EM structure of human O-GlcNAcylation enzyme pair
            OGT-OGA complex.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5435)
  AUTHORS   Hanover,J.A., Yu,S., Lubas,W.B., Shin,S.H., Ragano-Caracciola,M.,
            Kochran,J. and Love,D.C.
  TITLE     Mitochondrial and nucleocytoplasmic isoforms of O-linked GlcNAc
            transferase encoded by a single mammalian gene
  JOURNAL   Arch Biochem Biophys 409 (2), 287-297 (2003)
   PUBMED   12504895
REFERENCE   7  (bases 1 to 5435)
  AUTHORS   Chou,T.Y., Hart,G.W. and Dang,C.V.
  TITLE     c-Myc is glycosylated at threonine 58, a known phosphorylation site
            and a mutational hot spot in lymphomas
  JOURNAL   J Biol Chem 270 (32), 18961-18965 (1995)
   PUBMED   7642555
REFERENCE   8  (bases 1 to 5435)
  AUTHORS   Reason,A.J., Morris,H.R., Panico,M., Marais,R., Treisman,R.H.,
            Haltiwanger,R.S., Hart,G.W., Kelly,W.G. and Dell,A.
  TITLE     Localization of O-GlcNAc modification on the serum response
            transcription factor
  JOURNAL   J Biol Chem 267 (24), 16911-16921 (1992)
   PUBMED   1512232
REFERENCE   9  (bases 1 to 5435)
  AUTHORS   Haltiwanger,R.S., Blomberg,M.A. and Hart,G.W.
  TITLE     Glycosylation of nuclear and cytoplasmic proteins. Purification and
            characterization of a uridine
            diphospho-N-acetylglucosamine:polypeptide
            beta-N-acetylglucosaminyltransferase
  JOURNAL   J Biol Chem 267 (13), 9005-9013 (1992)
   PUBMED   1533623
REFERENCE   10 (bases 1 to 5435)
  AUTHORS   Roquemore,E.P., Dell,A., Morris,H.R., Panico,M., Reason,A.J.,
            Savoy,L.A., Wistow,G.J., Zigler,J.S. Jr., Earles,B.J. and Hart,G.W.
  TITLE     Vertebrate lens alpha-crystallins are modified by O-linked
            N-acetylglucosamine
  JOURNAL   J Biol Chem 267 (1), 555-563 (1992)
   PUBMED   1730617
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA460761.1, BC038180.1,
            AF070560.1 and BX537844.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_181672.2.
            
            Summary: This gene encodes a glycosyltransferase that catalyzes the
            addition of a single N-acetylglucosamine in O-glycosidic linkage to
            serine or threonine residues. Since both phosphorylation and
            glycosylation compete for similar serine or threonine residues, the
            two processes may compete for sites, or they may alter the
            substrate specificity of nearby sites by steric or electrostatic
            effects. The protein contains multiple tetratricopeptide repeats
            that are required for optimal recognition of substrates.
            Alternatively spliced transcript variants encoding distinct
            isoforms have been found for this gene. [provided by RefSeq, Oct
            2009].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX537844.1, AL833085.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373719.8/ ENSP00000362824.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                DA460761.1         43-67
            26-3895             BC038180.1         1-3870
            3896-5387           AF070560.1         128-1619
            5388-5435           BX537844.1         5389-5436
FEATURES             Location/Qualifiers
     source          1..5435
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq13.1"
     gene            1..5435
                     /gene="OGT"
                     /gene_synonym="HINCUT-1; HRNT1; MRX106; O-GLCNAC; OGT1;
                     XLID106"
                     /note="O-linked N-acetylglucosamine (GlcNAc) transferase"
                     /db_xref="GeneID:8473"
                     /db_xref="HGNC:HGNC:8127"
                     /db_xref="MIM:300255"
     exon            1..233
                     /gene="OGT"
                     /gene_synonym="HINCUT-1; HRNT1; MRX106; O-GLCNAC; OGT1;
                     XLID106"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..3337
                     /gene="OGT"
                     /gene_synonym="HINCUT-1; HRNT1; MRX106; O-GLCNAC; OGT1;
                     XLID106"
                     /EC_number="2.4.1.255"
                     /note="isoform 1 is encoded by transcript variant 1;
                     O-GlcNAc transferase p110 subunit;
                     uridinediphospho-N-acetylglucosamine:polypeptide
                     beta-N-acetylglucosaminyl transferase;
                     UDP-N-acetylglucosamine--peptide
                     N-acetylglucosaminyltransferase 110 kDa subunit; O-GlcNAc
                     transferase subunit p110; O-linked N-acetylglucosamine
                     transferase 110 kDa subunit; O-linked N-acetylglucosamine
                     (GlcNAc) transferase
                     (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl
                     transferase)"
                     /codon_start=1
                     /product="UDP-N-acetylglucosamine--peptide
                     N-acetylglucosaminyltransferase 110 kDa subunit isoform 1"
                     /protein_id="NP_858058.1"
                     /db_xref="CCDS:CCDS14414.1"
                     /db_xref="GeneID:8473"
                     /db_xref="HGNC:HGNC:8127"
                     /db_xref="MIM:300255"
                     /translation="MASSVGNVADSTEPTKRMLSFQGLAELAHREYQAGDFEAAERHC
                     MQLWRQEPDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKER
                     GQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLYCVR
                     SDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAV
                     TLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLID
                     LAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLA
                     NIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISP
                     TFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIA
                     SYRTALKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLVSIVADQLEKNRLPSVHPH
                     HSMLYPLSHGFRKAIAERHGNLCLDKINVLHKPPYEHPKDLKLSDGRLRVGYVSSDFG
                     NHPTSHLMQSIPGMHNPDKFEVFCYALSPDDGTNFRVKVMAEANHFIDLSQIPCNGKA
                     ADRIHQDGIHILVNMNGYTKGARNELFALRPAPIQAMWLGYPGTSGALFMDYIITDQE
                     TSPAEVAEQYSEKLAYMPHTFFIGDHANMFPHLKKKAVIDFKSNGHIYDNRIVLNGID
                     LKAFLDSLPDVKIVKMKCPDGGDNADSSNTALNMPVIPMNTIAEAVIEMINRGQIQIT
                     INGFSISNGLATTQINNKAATGEEVPRTIIVTTRSQYGLPEDAIVYCNFNQLYKIDPS
                     TLQMWANILKRVPNSVLWLLRFPAVGEPNIQQYAQNMGLPQNRIIFSPVAPKEEHVRR
                     GQLADVCLDTPLCNGHTTGMDVLWAGTPMVTMPGETLASRVAASQLTCLGCLELIAKN
                     RQEYEDIAVKLGTDLEYLKKVRGKVWKQRISSPLFNTKQYTMELERLYLQMWEHYAAG
                     NKPDHMIKPVEVTESA"
     exon            234..414
                     /gene="OGT"
                     /gene_synonym="HINCUT-1; HRNT1; MRX106; O-GLCNAC; OGT1;
                     XLID106"
                     /inference="alignment:Splign:2.1.0"
     exon            415..658
                     /gene="OGT"
                     /gene_synonym="HINCUT-1; HRNT1; MRX106; O-GLCNAC; OGT1;
                     XLID106"
                     /inference="alignment:Splign:2.1.0"
     exon            659..727
                     /gene="OGT"
                     /gene_synonym="HINCUT-1; HRNT1; MRX106; O-GLCNAC; OGT1;
                     XLID106"
                     /inference="alignment:Splign:2.1.0"
     exon            728..844
                     /gene="OGT"
                     /gene_synonym="HINCUT-1; HRNT1; MRX106; O-GLCNAC; OGT1;
                     XLID106"
                     /inference="alignment:Splign:2.1.0"
     exon            845..924
                     /gene="OGT"
                     /gene_synonym="HINCUT-1; HRNT1; MRX106; O-GLCNAC; OGT1;
                     XLID106"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1120
                     /gene="OGT"
                     /gene_synonym="HINCUT-1; HRNT1; MRX106; O-GLCNAC; OGT1;
                     XLID106"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1261
                     /gene="OGT"
                     /gene_synonym="HINCUT-1; HRNT1; MRX106; O-GLCNAC; OGT1;
                     XLID106"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1362
                     /gene="OGT"
                     /gene_synonym="HINCUT-1; HRNT1; MRX106; O-GLCNAC; OGT1;
                     XLID106"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1516
                     /gene="OGT"
                     /gene_synonym="HINCUT-1; HRNT1; MRX106; O-GLCNAC; OGT1;
                     XLID106"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1618
                     /gene="OGT"
                     /gene_synonym="HINCUT-1; HRNT1; MRX106; O-GLCNAC; OGT1;
                     XLID106"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1798
                     /gene="OGT"
                     /gene_synonym="HINCUT-1; HRNT1; MRX106; O-GLCNAC; OGT1;
                     XLID106"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..1957
                     /gene="OGT"
                     /gene_synonym="HINCUT-1; HRNT1; MRX106; O-GLCNAC; OGT1;
                     XLID106"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..2047
                     /gene="OGT"
                     /gene_synonym="HINCUT-1; HRNT1; MRX106; O-GLCNAC; OGT1;
                     XLID106"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2173
                     /gene="OGT"
                     /gene_synonym="HINCUT-1; HRNT1; MRX106; O-GLCNAC; OGT1;
                     XLID106"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2344
                     /gene="OGT"
                     /gene_synonym="HINCUT-1; HRNT1; MRX106; O-GLCNAC; OGT1;
                     XLID106"
                     /inference="alignment:Splign:2.1.0"
     exon            2345..2461
                     /gene="OGT"
                     /gene_synonym="HINCUT-1; HRNT1; MRX106; O-GLCNAC; OGT1;
                     XLID106"
                     /inference="alignment:Splign:2.1.0"
     exon            2462..2632
                     /gene="OGT"
                     /gene_synonym="HINCUT-1; HRNT1; MRX106; O-GLCNAC; OGT1;
                     XLID106"
                     /inference="alignment:Splign:2.1.0"
     exon            2633..2785
                     /gene="OGT"
                     /gene_synonym="HINCUT-1; HRNT1; MRX106; O-GLCNAC; OGT1;
                     XLID106"
                     /inference="alignment:Splign:2.1.0"
     exon            2786..3038
                     /gene="OGT"
                     /gene_synonym="HINCUT-1; HRNT1; MRX106; O-GLCNAC; OGT1;
                     XLID106"
                     /inference="alignment:Splign:2.1.0"
     exon            3039..3162
                     /gene="OGT"
                     /gene_synonym="HINCUT-1; HRNT1; MRX106; O-GLCNAC; OGT1;
                     XLID106"
                     /inference="alignment:Splign:2.1.0"
     exon            3163..5435
                     /gene="OGT"
                     /gene_synonym="HINCUT-1; HRNT1; MRX106; O-GLCNAC; OGT1;
                     XLID106"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3877..3882
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OGT"
                     /gene_synonym="HINCUT-1; HRNT1; MRX106; O-GLCNAC; OGT1;
                     XLID106"
                     /note="hexamer: TATAAA"
     polyA_site      3895
                     /gene="OGT"
                     /gene_synonym="HINCUT-1; HRNT1; MRX106; O-GLCNAC; OGT1;
                     XLID106"
                     /note="major polyA site"
     regulatory      5416..5421
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OGT"
                     /gene_synonym="HINCUT-1; HRNT1; MRX106; O-GLCNAC; OGT1;
                     XLID106"
                     /note="hexamer: AATGAA"
     polyA_site      5435
                     /gene="OGT"
                     /gene_synonym="HINCUT-1; HRNT1; MRX106; O-GLCNAC; OGT1;
                     XLID106"
                     /note="major polyA site"
ORIGIN      
        1 atttcaagac cgtactaggt agatggtcaa ttagagttcc cagggtttga agcctgtaac
       61 tgctgccgcc gctcaagccc tccagagcat tgctacggct gctgcccttg tactactacc
      121 tccaaatacg ttcttgctgg tagtggcggc agcaggacca attacctctt ttttgctctc
      181 cctcgagaag ctccagatgg cgtcttccgt gggcaacgtg gccgacagca cagaaccaac
      241 gaaacgtatg ctttccttcc aagggttagc tgagttggca catcgagaat atcaggcagg
      301 agattttgag gcagctgaga gacactgcat gcagctctgg agacaagagc cagacaatac
      361 tggtgtgctt ttattacttt catctataca cttccagtgt cgaaggctgg acagatctgc
      421 tcactttagc actctggcaa ttaaacagaa cccccttctg gcagaagctt attcgaattt
      481 ggggaatgtg tacaaggaaa gagggcagtt gcaggaggca attgagcatt atcgacatgc
      541 attgcgtctc aaacctgatt tcatcgatgg ttatattaac ctggcagccg ccttggtagc
      601 agcgggtgac atggaagggg cagtacaagc ttacgtctct gctcttcagt acaatcctga
      661 tttgtactgt gttcgcagtg acctggggaa cctgctcaaa gccctgggtc gcttggaaga
      721 agccaaggca tgttatttga aagcaattga gacgcaaccg aactttgcag tagcttggag
      781 taatcttggc tgtgttttca atgcacaagg ggaaatttgg cttgcaattc atcactttga
      841 aaaggctgtc acccttgacc caaactttct ggatgcttat atcaatttag gaaatgtctt
      901 gaaagaggca cgcatttttg acagagctgt ggcagcttat cttcgtgccc taagtttgag
      961 tccaaatcac gcagtggtgc acggcaacct ggcttgtgta tactatgagc aaggcctgat
     1021 agatctggca atagacacct acaggcgggc tatcgaacta caaccacatt tccctgatgc
     1081 ttactgcaac ctagccaatg ctctcaaaga gaagggcagt gttgctgaag cagaagattg
     1141 ttataataca gctctccgtc tgtgtcccac ccatgcagac tctctgaata acctagccaa
     1201 tatcaaacga gaacagggaa acattgaaga ggcagttcgc ttgtatcgta aagcattaga
     1261 agtcttccca gagtttgctg ctgcccattc aaatttagca agtgtactgc agcagcaggg
     1321 aaaactgcag gaagctctga tgcattataa ggaggctatt cgaatcagtc ctacctttgc
     1381 tgatgcctac tctaatatgg gaaacactct aaaggagatg caggatgttc agggagcctt
     1441 gcagtgttat acgcgtgcca tccaaattaa tcctgcattt gcagatgcac atagcaatct
     1501 ggcttccatt cataaggatt cagggaatat tccagaagcc atagcttctt accgcacggc
     1561 tctgaaactt aagcctgatt ttcctgatgc ttattgtaac ttggctcatt gcctgcagat
     1621 tgtctgtgat tggacagact atgatgagcg aatgaagaag ttggtcagta ttgtggctga
     1681 ccagttagag aagaataggt tgccttctgt gcatcctcat catagtatgc tatatcctct
     1741 ttctcatggc ttcaggaagg ctattgctga gaggcacggc aacctgtgct tagataagat
     1801 taatgttctt cataaaccac catatgaaca tccaaaagac ttgaagctca gtgatggtcg
     1861 gctgcgtgta ggatatgtga gttccgactt tgggaatcat cctacttctc accttatgca
     1921 gtctattcca ggcatgcaca atcctgataa atttgaggtg ttctgttatg ccctgagccc
     1981 agacgatggc acaaacttcc gagtgaaggt gatggcagaa gccaatcatt tcattgatct
     2041 ttctcagatt ccatgcaatg gaaaagcagc tgatcgcatc catcaggatg gaattcatat
     2101 ccttgtaaat atgaatggct atactaaggg cgctcgaaat gagctttttg ctctcaggcc
     2161 agctcctatt caggcaatgt ggctgggata ccctgggacg agtggtgcgc ttttcatgga
     2221 ttatattatc actgatcagg aaacttcgcc agctgaagtt gctgagcagt attccgagaa
     2281 attggcttat atgccccaca ctttttttat tggtgatcat gctaatatgt tccctcacct
     2341 gaagaaaaaa gcagtcatcg attttaagtc caatgggcac atttatgaca atcggatagt
     2401 tctgaatggc atcgacctca aagcatttct tgatagtcta ccagatgtga aaattgtcaa
     2461 gatgaagtgt cctgatggag gagacaatgc agatagcagt aacacagctc ttaatatgcc
     2521 tgttattcct atgaatacta ttgcagaagc agttattgaa atgattaacc gaggacagat
     2581 tcaaataaca attaatggat tcagtattag caatggactg gcaactactc agatcaacaa
     2641 taaggctgca actggagagg aggttccccg taccattatt gtaaccaccc gttctcagta
     2701 cgggttacca gaagatgcca tcgtatactg taactttaat cagttgtata aaattgaccc
     2761 ttctactttg cagatgtggg caaacattct gaagcgtgtt cccaatagtg tactctggct
     2821 gttgcgtttt ccagcagtag gagaacctaa tattcaacag tatgcacaaa acatgggcct
     2881 gccccagaac cgtatcattt tttcacctgt tgctcctaaa gaggaacacg tcaggagagg
     2941 ccagctggct gatgtctgct tggacactcc actctgtaat gggcacacca cagggatgga
     3001 tgtcctctgg gcagggaccc ccatggtgac tatgccagga gagactcttg cttctcgagt
     3061 tgcagcatcc cagctcactt gcttaggttg tcttgagctt attgctaaaa acagacaaga
     3121 atatgaagac atagctgtga agctgggaac tgatctagaa tacctgaaga aagttcgtgg
     3181 caaagtctgg aagcaaagaa tatctagccc tctgttcaac accaaacaat acacaatgga
     3241 actagagcgg ctctatctac agatgtggga gcattatgca gctggcaaca aacctgacca
     3301 catgattaag cctgttgaag tcactgagtc agcataaata aagactgcac aggagaatta
     3361 cccctatacc tgagcctcaa ccttctgggg gaaagggaac tagataacat acttcttact
     3421 tgtctgtaca gtaccttgtt gcagatgggt gatatataat ggtaatagaa tagcacagcc
     3481 agacttgctt cctgcatggt agggagagac acaaaagatg ggaaactgct tttccacaag
     3541 gaatctccgt agaattttgc ggcgaccaga tggtgcatag gtctggaagg tctgatctcc
     3601 cttggtcttc catgggatgg ttagtgtgga ggggagatat agattgtccg gccgctttgt
     3661 gattccatgg attgattcag tcttctggat ttttttttct ttatattttg ggtactggag
     3721 cttttaaaaa tgtttggttt caggtatttt tattcatgtg aagtgtatat gattctcttg
     3781 agataaggtt ttaagctaaa atgttactcc ctgttttagt ttctgaactc tgacagattg
     3841 acagggactt tgctggtgta gtctttttat aggttttata aaccacttga gcctatatca
     3901 gtcgttttag tgtctgacct aatatttgga gctatcagtg ctttgttgat ttagatgatg
     3961 actcaagatt ttttctggtc catttcccat ttccttttct tccctgaccc ccataccctc
     4021 acccttaaaa ttctcctgta actcaactaa caaaatcaag cctgattcaa aacatcctag
     4081 ggtgttttaa acacaccatc tggtgccaaa tgaagatttt taggagtgat tactaattat
     4141 caagggcaca gttgtggtac tgtcattgat aataatatag tttttttttt tttcctaatt
     4201 ttgacctgtt tcaccagtgt tttacccttg actgcccctt ctatgctgct tccaaaagtg
     4261 atagtgtgtg taagattttt accttccttt ctaaagtttt tttttttttt ttttaagtga
     4321 gtcctgttct tcctatttct ttcagcagaa atgaaatccc aggtaagtat aagtattcaa
     4381 gtatttgatc agtaagtcac agttatctcc agtgcattaa ataaccttca tcaagaaata
     4441 ggttataggt aaaatctctg aaggatcatc tatgtattca agtaattatt ttttagataa
     4501 taactgtctt ctggacttgg tcttgaagtc tgtacagatt cagcctcagt agtagcgaac
     4561 tgcactgctg tttggtttgg agtacaaatt agacttatag tcctcctgga acttgagtta
     4621 ttaaaatcat aggaataaaa ttatgggatc tcaacaaagg gtcgagggtt tgaggcttaa
     4681 acaagccaac atatgaatat atgttttgtc tcgctatact gcacttacgc tatccagttg
     4741 caggtaattt tttgtctgct agtagtgttc tagattatgt ctttccaaag cgctgaggct
     4801 gtgcacctat tctgtagttg cagctgatgc ctgaatgtat cctagctgac aaattattga
     4861 ttaataagaa cttgaatttc tggaagattc ttactgttaa ccaaattttg agcaaggagt
     4921 ctcaaaggta attctgaacc agaattacat gttaatgaac agtgtacctt ttaacagtgt
     4981 aaatcacgga atatccgtga agggatttct taatttattt tttaccggtt gattgaaata
     5041 tcagttaaag gttgccagca tggttgcaga taaactgatg tttgaaattc gctgaaatac
     5101 ttaatgtgga ataggataat atacttccaa tgccctcaag gctgtgacct tacagccatt
     5161 ttacatagca catcattcct cctataggga tgaacttttt cctggcacga aaagtagccg
     5221 ctctggttga agctttgctt attgtaacag gcttttattt ccaggtaata tgtcttggaa
     5281 gacttaattc tgattagaga tatagatatt actggaaact aattgttttt tttctattgt
     5341 actctgcttt atcaaagaag taaaacattt aaatcgtact acagaaatta agatgttgtc
     5401 ttgcgatcct taataaatga atgatttccc tttaa
//
