LOCUS       NM_024416               3455 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens osteoglycin (OGN), transcript variant 2, mRNA.
ACCESSION   NM_024416
VERSION     NM_024416.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3455)
  AUTHORS   Starup-Linde,J., Westberg-Rasmussen,S., Viggers,R.,
            Al-Mashhadi,Z.K., Handberg,A., Vestergaard,P. and Gregersen,S.
  TITLE     Serum osteoglycin is stable during various glycemic challenges in
            healthy men
  JOURNAL   Endocrine 85 (3), 1117-1121 (2024)
   PUBMED   38549032
  REMARK    GeneRIF: Serum osteoglycin is stable during various glycemic
            challenges in healthy men.
REFERENCE   2  (bases 1 to 3455)
  AUTHORS   Qin,W., Zhang,J., Rong,R., Zhang,L., Gao,H., Liu,C., Ren,Q.,
            Zheng,G., Wang,J., Meng,L., Qiao,S., Qian,R., Zhou,C., Wang,H. and
            Zhang,Y.
  TITLE     Osteoglycin (OGN) promotes tumorigenesis of pancreatic cancer cell
            via targeting ID4
  JOURNAL   Tissue Cell 78, 101867 (2022)
   PUBMED   35908351
  REMARK    GeneRIF: Osteoglycin (OGN) promotes tumorigenesis of pancreatic
            cancer cell via targeting ID4.
REFERENCE   3  (bases 1 to 3455)
  AUTHORS   Al-Sharify,D., Nielsen,S.H., Matthes,F., Tengryd,C., Sun,J.,
            Genovese,F., Karsdal,M.A., Nilsson,J., Goncalves,I. and Edsfeldt,A.
  TITLE     Increased proteolytic cleavage of osteoglycin is associated with a
            stable plaque phenotype and lower risk of cardiovascular events
  JOURNAL   Atherosclerosis 355, 8-14 (2022)
   PUBMED   35850021
  REMARK    GeneRIF: Increased proteolytic cleavage of osteoglycin is
            associated with a stable plaque phenotype and lower risk of
            cardiovascular events.
REFERENCE   4  (bases 1 to 3455)
  AUTHORS   Wang,J. and Lv,P.
  TITLE     Chrysophanol inhibits the osteoglycin/mTOR and activats NF2
            signaling pathways to reduce viability and proliferation of
            malignant meningioma cells
  JOURNAL   Bioengineered 12 (1), 755-762 (2021)
   PUBMED   33622177
  REMARK    GeneRIF: Chrysophanol inhibits the osteoglycin/mTOR and activats
            NF2 signaling pathways to reduce viability and proliferation of
            malignant meningioma cells.
REFERENCE   5  (bases 1 to 3455)
  AUTHORS   Pellegata,N.S., Dieguez-Lucena,J.L., Joensuu,T., Lau,S.,
            Montgomery,K.T., Krahe,R., Kivela,T., Kucherlapati,R., Forsius,H.
            and de la Chapelle,A.
  TITLE     Mutations in KERA, encoding keratocan, cause cornea plana
  JOURNAL   Nat Genet 25 (1), 91-95 (2000)
   PUBMED   10802664
REFERENCE   6  (bases 1 to 3455)
  AUTHORS   Matsushima,N., Ohyanagi,T., Tanaka,T. and Kretsinger,R.H.
  TITLE     Super-motifs and evolution of tandem leucine-rich repeats within
            the small proteoglycans--biglycan, decorin, lumican, fibromodulin,
            PRELP, keratocan, osteoadherin, epiphycan, and osteoglycin
  JOURNAL   Proteins 38 (2), 210-225 (2000)
   PUBMED   10656267
REFERENCE   7  (bases 1 to 3455)
  AUTHORS   Tasheva,E.S., Pettenati,M., Von Kap-Her,C. and Conrad,G.W.
  TITLE     Assignment of mimecan gene (OGN) to human chromosome band 9q22 by
            in situ hybridization
  JOURNAL   Cytogenet Cell Genet 88 (3-4), 326-327 (2000)
   PUBMED   10828622
REFERENCE   8  (bases 1 to 3455)
  AUTHORS   Funderburgh,J.L., Corpuz,L.M., Roth,M.R., Funderburgh,M.L.,
            Tasheva,E.S. and Conrad,G.W.
  TITLE     Mimecan, the 25-kDa corneal keratan sulfate proteoglycan, is a
            product of the gene producing osteoglycin
  JOURNAL   J Biol Chem 272 (44), 28089-28095 (1997)
   PUBMED   9346963
REFERENCE   9  (bases 1 to 3455)
  AUTHORS   Madisen,L., Neubauer,M., Plowman,G., Rosen,D., Segarini,P.,
            Dasch,J., Thompson,A., Ziman,J., Bentz,H. and Purchio,A.F.
  TITLE     Molecular cloning of a novel bone-forming compound: osteoinductive
            factor
  JOURNAL   DNA Cell Biol 9 (5), 303-309 (1990)
   PUBMED   2372374
REFERENCE   10 (bases 1 to 3455)
  AUTHORS   Kukita,A., Bonewald,L., Rosen,D., Seyedin,S., Mundy,G.R. and
            Roodman,G.D.
  TITLE     Osteoinductive factor inhibits formation of human osteoclast-like
            cells
  JOURNAL   Proc Natl Acad Sci U S A 87 (8), 3023-3026 (1990)
   PUBMED   2326263
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK295433.1, BG772245.1,
            BC095443.1, AF086912.1, AL137848.5 and BM679549.1.
            
            On Jan 23, 2016 this sequence version replaced NM_024416.3.
            
            Summary: This gene encodes a member of the small leucine-rich
            proteoglycan (SLRP) family of proteins. The encoded protein induces
            ectopic bone formation in conjunction with transforming growth
            factor beta and may regulate osteoblast differentiation. High
            expression of the encoded protein may be associated with elevated
            heart left ventricular mass. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Jan 2016].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and uses
            an alternate translation start site compared to variant 1. The
            encoded isoform (1) has a longer N-terminus and lacks a predicted
            signal peptide compared to isoform 2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK295433.1, SRR1803614.341301.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                AK295433.1         1-44
            45-376              BG772245.1         47-378
            377-2627            BC095443.1         262-2512
            2628-2748           AF086912.1         2556-2676
            2749-2854           AL137848.5         27187-27292         c
            2855-3455           BM679549.1         1-601               c
FEATURES             Location/Qualifiers
     source          1..3455
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q22.31"
     gene            1..3455
                     /gene="OGN"
                     /gene_synonym="OG; OIF; SLRR3A"
                     /note="osteoglycin"
                     /db_xref="GeneID:4969"
                     /db_xref="HGNC:HGNC:8126"
                     /db_xref="MIM:602383"
     exon            1..204
                     /gene="OGN"
                     /gene_synonym="OG; OIF; SLRR3A"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..1095
                     /gene="OGN"
                     /gene_synonym="OG; OIF; SLRR3A"
                     /note="isoform 1 is encoded by transcript variant 2;
                     mimecan proteoglycan; osteoinductive factor; corneal
                     keratan sulfate proteoglycan"
                     /codon_start=1
                     /product="mimecan isoform 1"
                     /protein_id="NP_077727.3"
                     /db_xref="GeneID:4969"
                     /db_xref="HGNC:HGNC:8126"
                     /db_xref="MIM:602383"
                     /translation="MLAKISTTWKLFLKLLGPEILLSSLKSRHSFSHSPSHLGLMHRH
                     EHLLRKTTKNFKTATTTLQSTLLLLLLVPLIKPAPPTQQDSRIIYDYGTDNFEESIFS
                     QDYEDKYLDGKNIKEKETVIIPNEKSLQLQKDEAITPLPPKKENDEMPTCLLCVCLSG
                     SVYCEEVDIDAVPPLPKESAYLYARFNKIKKLTAKDFADIPNLRRLDFTGNLIEDIED
                     GTFSKLSLLEELSLAENQLLKLPVLPPKLTLFNAKYNKIKSRGIKANAFKKLNNLTFL
                     YLDHNALESVPLNLPESLRVIHLQFNNIASITDDTFCKANDTSYIRDRIEEIRLEGNP
                     IVLGKHPNSFICLKRLPIGSYF"
     exon            205..372
                     /gene="OGN"
                     /gene_synonym="OG; OIF; SLRR3A"
                     /inference="alignment:Splign:2.1.0"
     exon            373..466
                     /gene="OGN"
                     /gene_synonym="OG; OIF; SLRR3A"
                     /inference="alignment:Splign:2.1.0"
     exon            467..625
                     /gene="OGN"
                     /gene_synonym="OG; OIF; SLRR3A"
                     /inference="alignment:Splign:2.1.0"
     exon            626..828
                     /gene="OGN"
                     /gene_synonym="OG; OIF; SLRR3A"
                     /inference="alignment:Splign:2.1.0"
     exon            829..924
                     /gene="OGN"
                     /gene_synonym="OG; OIF; SLRR3A"
                     /inference="alignment:Splign:2.1.0"
     exon            925..3444
                     /gene="OGN"
                     /gene_synonym="OG; OIF; SLRR3A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2713..2718
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OGN"
                     /gene_synonym="OG; OIF; SLRR3A"
                     /note="hexamer: AATAAA"
     regulatory      2727..2732
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OGN"
                     /gene_synonym="OG; OIF; SLRR3A"
                     /note="hexamer: AATAAA"
     polyA_site      2737
                     /gene="OGN"
                     /gene_synonym="OG; OIF; SLRR3A"
                     /note="major polyA site"
     polyA_site      2748
                     /gene="OGN"
                     /gene_synonym="OG; OIF; SLRR3A"
                     /note="major polyA site"
ORIGIN      
        1 actgcatttc accctagaga aagaatgctg gcaaagatct ctaccacatg gaaactgttc
       61 ttaaagctgc tgggccctga aattttactc agcagtttga aatcaagaca tagcttttct
      121 cattcaccct cccacttggg gctaatgcac agacatgaac atctattgag gaaaaccaca
      181 aaaaacttca aaacagctac aacgactctg cagtctacac ttctcctgtt actgcttgtg
      241 cctctgataa agccagcacc accaacccag caggactcac gcattatcta tgattatgga
      301 acagataatt ttgaagaatc catatttagc caagattatg aggataaata cctggatgga
      361 aaaaatatta aggaaaaaga aactgtgata atacccaatg agaaaagtct tcaattacaa
      421 aaagatgagg caataacacc attacctccc aagaaagaaa atgatgaaat gcccacgtgt
      481 ctgctgtgtg tttgtttaag tggctctgta tactgtgaag aagttgacat tgatgctgta
      541 ccacccttac caaaggaatc agcctatctt tacgcacgat tcaacaaaat taaaaagctg
      601 actgccaaag attttgcaga catacctaac ttaagaagac tcgattttac aggaaatttg
      661 atagaagata tagaagatgg tactttttca aaactttctc tgttagaaga actttcactt
      721 gctgaaaatc aactactaaa acttccagtt cttcctccca agctcacttt atttaatgca
      781 aaatacaaca aaatcaagag taggggaatc aaagcaaatg cattcaaaaa actgaataac
      841 ctcaccttcc tctacttgga ccataatgcc ctggaatccg tgcctcttaa tttaccagaa
      901 agtctacgtg taattcatct tcagttcaac aacatagctt caattacaga tgacacattc
      961 tgcaaggcta atgacaccag ttacatccgg gaccgcattg aagagatacg cctggagggc
     1021 aatccaatcg tcctgggaaa gcatccaaac agttttattt gcttaaaaag attaccgata
     1081 gggtcatact tttaacctct attggtacaa catataaatg aaagtacacc tacactaata
     1141 gtctgtctca acaatgagta aaggaactta agtattggtt taatattaac cttgtatctc
     1201 attttgaagg aatttaatat tttaagcaag gatgttcaaa atcttacata taataagtaa
     1261 aaagtaagac tgaatgtcta cgttcgaaac aaagtaatat gaaaatattt aaacagcatt
     1321 acaaaatcct agtttatact agactaccat ttaaaaatca tgtttttata taaatgccca
     1381 aatttgagat gcattattcc tattactaat gatgtaagta cgaggataaa tccaagaaac
     1441 tttcaactct ttgcctttcc tggcctttac tggatcccaa aagcatttaa ggtacatgtt
     1501 ccaaaaactt tgaaaagcta aatgtttccc atgatcgctc attcttcttt tatgattcat
     1561 acgttattcc ttataaagta agaactttgt tttcctccta tcaaggcagc tattttatta
     1621 aatttttcac ttagtctgag aaatagcaga tagtctcata tttaggaaaa ctttccaaat
     1681 aaaataaatg ttattctctg ataaagagct aatacagaaa tgttcaagtt attttacttt
     1741 ctggtaatgt cttcagtaaa atattttctt tatctaaata ttaacattct aagtctacca
     1801 aaaaaagttt taaactcaag caggccaaaa ccaatatgct tataagaaat aatgaaaagt
     1861 tcatccattt ctgataaagt tctctatggc aaagtctttc aaatacgaga taactgcaaa
     1921 atattttcct tttatactac agaaatgaga atctcatcaa taaattagtt caagcataag
     1981 atgaaaacag aatattctgt ggtgccagtg cacactacct tcccacccat acacatccat
     2041 gttcactgta acaaactgaa tattcacaat aaagcttctg agtaacactt tctgattact
     2101 catgataaac tgacatggct aactgcaaga attaaatctt ctatctgaga gtaataattt
     2161 atgatgactc agtggtgcca gagtaaagtt tctaaaataa cattcctctc acttgtaccc
     2221 cactaaaagt attagactac acattacatt gaagttaaac acaaaattat cagtgtttta
     2281 gaaacatgag tccggactgt gtaagtaaaa gtacaaacat tatttccacc ataaagtatg
     2341 tattgaaatc aagttgtctc tgtgtacaga atacatactt attcccattt ttaagcattt
     2401 gcttctgttt tccctaccta gaatgtcaga tgtttttcag ttatctcccc atttgtcaaa
     2461 gttgacctca agataacatt tttcattaaa gcatctgaga tctaagaaca caattattat
     2521 tctaacaatg attattagct cattcactta ttttgataac taatgatcac agctattata
     2581 ctactttctc gttattttgt gtgcatgcct catttccctg acttaaacct cactgagagc
     2641 gcaaaatgca gctttatact ttttactttc aattgcctag cacaatagtg agtacatttg
     2701 aattgaatat ataataaata ttgcaaaata aaatccatct aaatagaagg gttctgtttt
     2761 atttggaaaa attgaatctt taaactatca taatcttgaa tgactgtcat ctttctagtt
     2821 ttcagaaaaa taatgtattc ctatattatt tttatgataa aacttatgga gcaaaacacc
     2881 atcaaataac tctcaaatta agaaaaaatt caaaagtcag tagttttaga taagataatg
     2941 ataagggaga aagaacattg gtaaaaggta tgaattccag aattaaagaa ataatttggg
     3001 gatttctaga taagaggata tatatgaaca tgcatacctt acaccttcat atacacaacc
     3061 ttaaatcaca aataaaacaa aataaacaat acaaattata ccaccaagat tcagaagata
     3121 tcagacgaaa taattagaga aagtaaaaat atgctgtctc cattatattc ataatgtttc
     3181 attcttgaca ctaataatta gaggctttaa atttttaaat gatttacttt ttactaacat
     3241 tgctgaaaaa aactaaagac atacataaat ggaaagatgt cttgtgttta tggatggtaa
     3301 gatttaatgt tgttaagaca acaatactat ccaatatgat atgcagactg aacacagttg
     3361 ccatcaaaat ctcaatgatg ctttcacaca aataaaatgg aacttcaaga gacccccaaa
     3421 taaagagaag aatcttgaaa ataaaaaaaa aaaaa
//
