LOCUS       NM_014057               3407 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens osteoglycin (OGN), transcript variant 3, mRNA.
ACCESSION   NM_014057 XM_005252032
VERSION     NM_014057.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3407)
  AUTHORS   Starup-Linde,J., Westberg-Rasmussen,S., Viggers,R.,
            Al-Mashhadi,Z.K., Handberg,A., Vestergaard,P. and Gregersen,S.
  TITLE     Serum osteoglycin is stable during various glycemic challenges in
            healthy men
  JOURNAL   Endocrine 85 (3), 1117-1121 (2024)
   PUBMED   38549032
  REMARK    GeneRIF: Serum osteoglycin is stable during various glycemic
            challenges in healthy men.
REFERENCE   2  (bases 1 to 3407)
  AUTHORS   Qin,W., Zhang,J., Rong,R., Zhang,L., Gao,H., Liu,C., Ren,Q.,
            Zheng,G., Wang,J., Meng,L., Qiao,S., Qian,R., Zhou,C., Wang,H. and
            Zhang,Y.
  TITLE     Osteoglycin (OGN) promotes tumorigenesis of pancreatic cancer cell
            via targeting ID4
  JOURNAL   Tissue Cell 78, 101867 (2022)
   PUBMED   35908351
  REMARK    GeneRIF: Osteoglycin (OGN) promotes tumorigenesis of pancreatic
            cancer cell via targeting ID4.
REFERENCE   3  (bases 1 to 3407)
  AUTHORS   Al-Sharify,D., Nielsen,S.H., Matthes,F., Tengryd,C., Sun,J.,
            Genovese,F., Karsdal,M.A., Nilsson,J., Goncalves,I. and Edsfeldt,A.
  TITLE     Increased proteolytic cleavage of osteoglycin is associated with a
            stable plaque phenotype and lower risk of cardiovascular events
  JOURNAL   Atherosclerosis 355, 8-14 (2022)
   PUBMED   35850021
  REMARK    GeneRIF: Increased proteolytic cleavage of osteoglycin is
            associated with a stable plaque phenotype and lower risk of
            cardiovascular events.
REFERENCE   4  (bases 1 to 3407)
  AUTHORS   Wang,J. and Lv,P.
  TITLE     Chrysophanol inhibits the osteoglycin/mTOR and activats NF2
            signaling pathways to reduce viability and proliferation of
            malignant meningioma cells
  JOURNAL   Bioengineered 12 (1), 755-762 (2021)
   PUBMED   33622177
  REMARK    GeneRIF: Chrysophanol inhibits the osteoglycin/mTOR and activats
            NF2 signaling pathways to reduce viability and proliferation of
            malignant meningioma cells.
REFERENCE   5  (bases 1 to 3407)
  AUTHORS   Pellegata,N.S., Dieguez-Lucena,J.L., Joensuu,T., Lau,S.,
            Montgomery,K.T., Krahe,R., Kivela,T., Kucherlapati,R., Forsius,H.
            and de la Chapelle,A.
  TITLE     Mutations in KERA, encoding keratocan, cause cornea plana
  JOURNAL   Nat Genet 25 (1), 91-95 (2000)
   PUBMED   10802664
REFERENCE   6  (bases 1 to 3407)
  AUTHORS   Matsushima,N., Ohyanagi,T., Tanaka,T. and Kretsinger,R.H.
  TITLE     Super-motifs and evolution of tandem leucine-rich repeats within
            the small proteoglycans--biglycan, decorin, lumican, fibromodulin,
            PRELP, keratocan, osteoadherin, epiphycan, and osteoglycin
  JOURNAL   Proteins 38 (2), 210-225 (2000)
   PUBMED   10656267
REFERENCE   7  (bases 1 to 3407)
  AUTHORS   Tasheva,E.S., Pettenati,M., Von Kap-Her,C. and Conrad,G.W.
  TITLE     Assignment of mimecan gene (OGN) to human chromosome band 9q22 by
            in situ hybridization
  JOURNAL   Cytogenet Cell Genet 88 (3-4), 326-327 (2000)
   PUBMED   10828622
REFERENCE   8  (bases 1 to 3407)
  AUTHORS   Funderburgh,J.L., Corpuz,L.M., Roth,M.R., Funderburgh,M.L.,
            Tasheva,E.S. and Conrad,G.W.
  TITLE     Mimecan, the 25-kDa corneal keratan sulfate proteoglycan, is a
            product of the gene producing osteoglycin
  JOURNAL   J Biol Chem 272 (44), 28089-28095 (1997)
   PUBMED   9346963
REFERENCE   9  (bases 1 to 3407)
  AUTHORS   Madisen,L., Neubauer,M., Plowman,G., Rosen,D., Segarini,P.,
            Dasch,J., Thompson,A., Ziman,J., Bentz,H. and Purchio,A.F.
  TITLE     Molecular cloning of a novel bone-forming compound: osteoinductive
            factor
  JOURNAL   DNA Cell Biol 9 (5), 303-309 (1990)
   PUBMED   2372374
REFERENCE   10 (bases 1 to 3407)
  AUTHORS   Kukita,A., Bonewald,L., Rosen,D., Seyedin,S., Mundy,G.R. and
            Roodman,G.D.
  TITLE     Osteoinductive factor inhibits formation of human osteoclast-like
            cells
  JOURNAL   Proc Natl Acad Sci U S A 87 (8), 3023-3026 (1990)
   PUBMED   2326263
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK295433.1, AF100758.1,
            AF086912.1, AL137848.5 and BM679549.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014057.4.
            
            Summary: This gene encodes a member of the small leucine-rich
            proteoglycan (SLRP) family of proteins. The encoded protein induces
            ectopic bone formation in conjunction with transforming growth
            factor beta and may regulate osteoblast differentiation. High
            expression of the encoded protein may be associated with elevated
            heart left ventricular mass. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Jan 2016].
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 3 encode the same isoform (2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.115497.1,
                                           SRR1660807.251550.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267759, SAMN03267760
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375561.10/ ENSP00000364711.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                AK295433.1         122-153
            33-1261             AF100758.1         1-1229
            1262-2708           AF086912.1         1230-2676
            2709-2814           AL137848.5         27187-27292         c
            2815-3404           BM679549.1         12-601              c
            3405-3407           AL137848.5         26594-26596         c
FEATURES             Location/Qualifiers
     source          1..3407
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q22.31"
     gene            1..3407
                     /gene="OGN"
                     /gene_synonym="OG; OIF; SLRR3A"
                     /note="osteoglycin"
                     /db_xref="GeneID:4969"
                     /db_xref="HGNC:HGNC:8126"
                     /db_xref="MIM:602383"
     exon            1..83
                     /gene="OGN"
                     /gene_synonym="OG; OIF; SLRR3A"
                     /inference="alignment:Splign:2.1.0"
     exon            84..332
                     /gene="OGN"
                     /gene_synonym="OG; OIF; SLRR3A"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..1055
                     /gene="OGN"
                     /gene_synonym="OG; OIF; SLRR3A"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 3; mimecan proteoglycan; osteoinductive factor;
                     corneal keratan sulfate proteoglycan"
                     /codon_start=1
                     /product="mimecan isoform 2 precursor"
                     /protein_id="NP_054776.1"
                     /db_xref="CCDS:CCDS6695.1"
                     /db_xref="GeneID:4969"
                     /db_xref="HGNC:HGNC:8126"
                     /db_xref="MIM:602383"
                     /translation="MKTLQSTLLLLLLVPLIKPAPPTQQDSRIIYDYGTDNFEESIFS
                     QDYEDKYLDGKNIKEKETVIIPNEKSLQLQKDEAITPLPPKKENDEMPTCLLCVCLSG
                     SVYCEEVDIDAVPPLPKESAYLYARFNKIKKLTAKDFADIPNLRRLDFTGNLIEDIED
                     GTFSKLSLLEELSLAENQLLKLPVLPPKLTLFNAKYNKIKSRGIKANAFKKLNNLTFL
                     YLDHNALESVPLNLPESLRVIHLQFNNIASITDDTFCKANDTSYIRDRIEEIRLEGNP
                     IVLGKHPNSFICLKRLPIGSYF"
     exon            333..426
                     /gene="OGN"
                     /gene_synonym="OG; OIF; SLRR3A"
                     /inference="alignment:Splign:2.1.0"
     exon            427..585
                     /gene="OGN"
                     /gene_synonym="OG; OIF; SLRR3A"
                     /inference="alignment:Splign:2.1.0"
     exon            586..788
                     /gene="OGN"
                     /gene_synonym="OG; OIF; SLRR3A"
                     /inference="alignment:Splign:2.1.0"
     exon            789..884
                     /gene="OGN"
                     /gene_synonym="OG; OIF; SLRR3A"
                     /inference="alignment:Splign:2.1.0"
     exon            885..3407
                     /gene="OGN"
                     /gene_synonym="OG; OIF; SLRR3A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2673..2678
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OGN"
                     /gene_synonym="OG; OIF; SLRR3A"
                     /note="hexamer: AATAAA"
     regulatory      2687..2692
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OGN"
                     /gene_synonym="OG; OIF; SLRR3A"
                     /note="hexamer: AATAAA"
     polyA_site      2697
                     /gene="OGN"
                     /gene_synonym="OG; OIF; SLRR3A"
                     /note="major polyA site"
     polyA_site      2708
                     /gene="OGN"
                     /gene_synonym="OG; OIF; SLRR3A"
                     /note="major polyA site"
     regulatory      3379..3384
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OGN"
                     /gene_synonym="OG; OIF; SLRR3A"
                     /note="hexamer: AATAAA"
     polyA_site      3407
                     /gene="OGN"
                     /gene_synonym="OG; OIF; SLRR3A"
ORIGIN      
        1 attcaccctc ccacttgggg ctaatgcaca gacatgaaca tctattgagg aaaaccacaa
       61 aaaacttcaa aacagctaca acgggaaaaa gagagttttg tcccacagtc agcaggccac
      121 tagtttatta acttccagtc accttgattt ttgctaaaat gaagactctg cagtctacac
      181 ttctcctgtt actgcttgtg cctctgataa agccagcacc accaacccag caggactcac
      241 gcattatcta tgattatgga acagataatt ttgaagaatc catatttagc caagattatg
      301 aggataaata cctggatgga aaaaatatta aggaaaaaga aactgtgata atacccaatg
      361 agaaaagtct tcaattacaa aaagatgagg caataacacc attacctccc aagaaagaaa
      421 atgatgaaat gcccacgtgt ctgctgtgtg tttgtttaag tggctctgta tactgtgaag
      481 aagttgacat tgatgctgta ccacccttac caaaggaatc agcctatctt tacgcacgat
      541 tcaacaaaat taaaaagctg actgccaaag attttgcaga catacctaac ttaagaagac
      601 tcgattttac aggaaatttg atagaagata tagaagatgg tactttttca aaactttctc
      661 tgttagaaga actttcactt gctgaaaatc aactactaaa acttccagtt cttcctccca
      721 agctcacttt atttaatgca aaatacaaca aaatcaagag taggggaatc aaagcaaatg
      781 cattcaaaaa actgaataac ctcaccttcc tctacttgga ccataatgcc ctggaatccg
      841 tgcctcttaa tttaccagaa agtctacgtg taattcatct tcagttcaac aacatagctt
      901 caattacaga tgacacattc tgcaaggcta atgacaccag ttacatccgg gaccgcattg
      961 aagagatacg cctggagggc aatccaatcg tcctgggaaa gcatccaaac agttttattt
     1021 gcttaaaaag attaccgata gggtcatact tttaacctct attggtacaa catataaatg
     1081 aaagtacacc tacactaata gtctgtctca acaatgagta aaggaactta agtattggtt
     1141 taatattaac cttgtatctc attttgaagg aatttaatat tttaagcaag gatgttcaaa
     1201 atcttacata taataagtaa aaagtaagac tgaatgtcta cgttcgaaac aaagtaatat
     1261 gaaaatattt aaacagcatt acaaaatcct agtttatact agactaccat ttaaaaatca
     1321 tgtttttata taaatgccca aatttgagat gcattattcc tattactaat gatgtaagta
     1381 cgaggataaa tccaagaaac tttcaactct ttgcctttcc tggcctttac tggatcccaa
     1441 aagcatttaa ggtacatgtt ccaaaaactt tgaaaagcta aatgtttccc atgatcgctc
     1501 attcttcttt tatgattcat acgttattcc ttataaagta agaactttgt tttcctccta
     1561 tcaaggcagc tattttatta aatttttcac ttagtctgag aaatagcaga tagtctcata
     1621 tttaggaaaa ctttccaaat aaaataaatg ttattctctg ataaagagct aatacagaaa
     1681 tgttcaagtt attttacttt ctggtaatgt cttcagtaaa atattttctt tatctaaata
     1741 ttaacattct aagtctacca aaaaaagttt taaactcaag caggccaaaa ccaatatgct
     1801 tataagaaat aatgaaaagt tcatccattt ctgataaagt tctctatggc aaagtctttc
     1861 aaatacgaga taactgcaaa atattttcct tttatactac agaaatgaga atctcatcaa
     1921 taaattagtt caagcataag atgaaaacag aatattctgt ggtgccagtg cacactacct
     1981 tcccacccat acacatccat gttcactgta acaaactgaa tattcacaat aaagcttctg
     2041 agtaacactt tctgattact catgataaac tgacatggct aactgcaaga attaaatctt
     2101 ctatctgaga gtaataattt atgatgactc agtggtgcca gagtaaagtt tctaaaataa
     2161 cattcctctc acttgtaccc cactaaaagt attagactac acattacatt gaagttaaac
     2221 acaaaattat cagtgtttta gaaacatgag tccggactgt gtaagtaaaa gtacaaacat
     2281 tatttccacc ataaagtatg tattgaaatc aagttgtctc tgtgtacaga atacatactt
     2341 attcccattt ttaagcattt gcttctgttt tccctaccta gaatgtcaga tgtttttcag
     2401 ttatctcccc atttgtcaaa gttgacctca agataacatt tttcattaaa gcatctgaga
     2461 tctaagaaca caattattat tctaacaatg attattagct cattcactta ttttgataac
     2521 taatgatcac agctattata ctactttctc gttattttgt gtgcatgcct catttccctg
     2581 acttaaacct cactgagagc gcaaaatgca gctttatact ttttactttc aattgcctag
     2641 cacaatagtg agtacatttg aattgaatat ataataaata ttgcaaaata aaatccatct
     2701 aaatagaagg gttctgtttt atttggaaaa attgaatctt taaactatca taatcttgaa
     2761 tgactgtcat ctttctagtt ttcagaaaaa taatgtattc ctatattatt tttatgataa
     2821 aacttatgga gcaaaacacc atcaaataac tctcaaatta agaaaaaatt caaaagtcag
     2881 tagttttaga taagataatg ataagggaga aagaacattg gtaaaaggta tgaattccag
     2941 aattaaagaa ataatttggg gatttctaga taagaggata tatatgaaca tgcatacctt
     3001 acaccttcat atacacaacc ttaaatcaca aataaaacaa aataaacaat acaaattata
     3061 ccaccaagat tcagaagata tcagacgaaa taattagaga aagtaaaaat atgctgtctc
     3121 cattatattc ataatgtttc attcttgaca ctaataatta gaggctttaa atttttaaat
     3181 gatttacttt ttactaacat tgctgaaaaa aactaaagac atacataaat ggaaagatgt
     3241 cttgtgttta tggatggtaa gatttaatgt tgttaagaca acaatactat ccaatatgat
     3301 atgcagactg aacacagttg ccatcaaaat ctcaatgatg ctttcacaca aataaaatgg
     3361 aacttcaaga gacccccaaa taaagagaag aatcttgaaa ataagaa
//
