LOCUS       NM_002542               1630 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens 8-oxoguanine DNA glycosylase (OGG1), transcript
            variant 1a, mRNA.
ACCESSION   NM_002542
VERSION     NM_002542.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1630)
  AUTHORS   Zhong,Y., Zhang,X., Feng,R., Fan,Y., Zhang,Z., Zhang,Q.W.,
            Wan,J.B., Wang,Y., Yu,H. and Li,G.
  TITLE     OGG1: An emerging multifunctional therapeutic target for the
            treatment of diseases caused by oxidative DNA damage
  JOURNAL   Med Res Rev 44 (6), 2825-2848 (2024)
   PUBMED   39119702
  REMARK    GeneRIF: OGG1: An emerging multifunctional therapeutic target for
            the treatment of diseases caused by oxidative DNA damage.
            Review article
REFERENCE   2  (bases 1 to 1630)
  AUTHORS   Ren,M., Gut,F., Fan,Y., Ma,J., Shan,X., Yikilmazsoy,A.,
            Likhodeeva,M., Hopfner,K.P. and Zhou,C.
  TITLE     Structural basis for human OGG1 processing 8-oxodGuo within
            nucleosome core particles
  JOURNAL   Nat Commun 15 (1), 9407 (2024)
   PUBMED   39477986
  REMARK    GeneRIF: Structural basis for human OGG1 processing 8-oxodGuo
            within nucleosome core particles.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1630)
  AUTHORS   Pan,L., Wang,K., Hao,W., Xue,Y., Zheng,X., Basu,R.S., Hazra,T.K.,
            Islam,A., Hosakote,Y., Tian,B., Gagnon,M.G., Ba,X. and Boldogh,I.
  TITLE     8-Oxoguanine DNA Glycosylase1 conceals oxidized guanine in
            nucleoprotein-associated RNA of respiratory syncytial virus
  JOURNAL   PLoS Pathog 20 (10), e1012616 (2024)
   PUBMED   39413143
  REMARK    GeneRIF: 8-Oxoguanine DNA Glycosylase1 conceals oxidized guanine in
            nucleoprotein-associated RNA of respiratory syncytial virus.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1630)
  AUTHORS   You,Q., Feng,X., Cai,Y., Baylin,S.B. and Li,H.
  TITLE     Human 8-oxoguanine glycosylase OGG1 binds nucleosome at the dsDNA
            ends and the super-helical locations
  JOURNAL   Commun Biol 7 (1), 1202 (2024)
   PUBMED   39341999
  REMARK    GeneRIF: Human 8-oxoguanine glycosylase OGG1 binds nucleosome at
            the dsDNA ends and the super-helical locations.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1630)
  AUTHORS   Geng,A., Sun,J., Tang,H., Yu,Y., Wang,X., Zhang,J., Wang,X.,
            Sun,X., Zhou,X., Gao,N., Tan,R., Xu,Z., Jiang,Y. and Mao,Z.
  TITLE     SIRT2 promotes base excision repair by transcriptionally activating
            OGG1 in an ATM/ATR-dependent manner
  JOURNAL   Nucleic Acids Res 52 (9), 5107-5120 (2024)
   PUBMED   38554113
  REMARK    GeneRIF: SIRT2 promotes base excision repair by transcriptionally
            activating OGG1 in an ATM/ATR-dependent manner.
REFERENCE   6  (bases 1 to 1630)
  AUTHORS   Rosenquist,T.A., Zharkov,D.O. and Grollman,A.P.
  TITLE     Cloning and characterization of a mammalian 8-oxoguanine DNA
            glycosylase
  JOURNAL   Proc Natl Acad Sci U S A 94 (14), 7429-7434 (1997)
   PUBMED   9207108
REFERENCE   7  (bases 1 to 1630)
  AUTHORS   Arai,K., Morishita,K., Shinmura,K., Kohno,T., Kim,S.R., Nohmi,T.,
            Taniwaki,M., Ohwada,S. and Yokota,J.
  TITLE     Cloning of a human homolog of the yeast OGG1 gene that is involved
            in the repair of oxidative DNA damage
  JOURNAL   Oncogene 14 (23), 2857-2861 (1997)
   PUBMED   9190902
REFERENCE   8  (bases 1 to 1630)
  AUTHORS   Lu,R., Nash,H.M. and Verdine,G.L.
  TITLE     A mammalian DNA repair enzyme that excises oxidatively damaged
            guanines maps to a locus frequently lost in lung cancer
  JOURNAL   Curr Biol 7 (6), 397-407 (1997)
   PUBMED   9197244
REFERENCE   9  (bases 1 to 1630)
  AUTHORS   Aburatani,H., Hippo,Y., Ishida,T., Takashima,R., Matsuba,C.,
            Kodama,T., Takao,M., Yasui,A., Yamamoto,K. and Asano,M.
  TITLE     Cloning and characterization of mammalian 8-hydroxyguanine-specific
            DNA glycosylase/apurinic, apyrimidinic lyase, a functional mutM
            homologue
  JOURNAL   Cancer Res 57 (11), 2151-2156 (1997)
   PUBMED   9187114
REFERENCE   10 (bases 1 to 1630)
  AUTHORS   Chung,U., Igarashi,T., Nishishita,T., Iwanari,H., Iwamatsu,A.,
            Suwa,A., Mimori,T., Hata,K., Ebisu,S., Ogata,E., Fujita,T. and
            Okazaki,T.
  TITLE     The interaction between Ku antigen and REF1 protein mediates
            negative gene regulation by extracellular calcium
  JOURNAL   J Biol Chem 271 (15), 8593-8598 (1996)
   PUBMED   8621488
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM847736.1, U88527.1 and
            Y11838.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 11, 2020 this sequence version replaced NM_002542.5.
            
            Summary: This gene encodes the enzyme responsible for the excision
            of 8-oxoguanine, a mutagenic base byproduct which occurs as a
            result of exposure to reactive oxygen. The action of this enzyme
            includes lyase activity for chain cleavage. Alternative splicing of
            the C-terminal region of this gene classifies splice variants into
            two major groups, type 1 and type 2, depending on the last exon of
            the sequence. Type 1 alternative splice variants end with exon 7
            and type 2 end with exon 8. All variants share the N-terminal
            region in common, which contains a mitochondrial targeting signal
            that is essential for mitochondrial localization. Many alternative
            splice variants for this gene have been described, but the
            full-length nature for every variant has not been determined.
            [provided by RefSeq, Aug 2008].
            
            Transcript Variant: Transcript variant 1a represents the
            predominant form of this gene.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y11838.1, BC000657.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000344629.12/
                                                  ENSP00000342851.7
            RefSeq Select criteria             :: based on manual assertion,
                                                  conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                BM847736.1         10-34
            26-1626             U88527.1           1-1601
            1627-1630           Y11838.1           1599-1602
FEATURES             Location/Qualifiers
     source          1..1630
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p25.3"
     gene            1..1630
                     /gene="OGG1"
                     /gene_synonym="HMMH; HOGG1; MUTM; OGH1"
                     /note="8-oxoguanine DNA glycosylase"
                     /db_xref="GeneID:4968"
                     /db_xref="HGNC:HGNC:8125"
                     /db_xref="MIM:601982"
     exon            1..472
                     /gene="OGG1"
                     /gene_synonym="HMMH; HOGG1; MUTM; OGH1"
                     /inference="alignment:Splign:2.1.0"
     CDS             336..1373
                     /gene="OGG1"
                     /gene_synonym="HMMH; HOGG1; MUTM; OGH1"
                     /EC_number="4.2.99.18"
                     /note="isoform 1a is encoded by transcript variant 1a;
                     8-hydroxyguanine DNA glycosylase; DNA-apurinic or
                     apyrimidinic site lyase; AP lyase; N-glycosylase/DNA
                     lyase; OGG1 type 1f"
                     /codon_start=1
                     /product="N-glycosylase/DNA lyase isoform 1a"
                     /protein_id="NP_002533.1"
                     /db_xref="CCDS:CCDS2581.1"
                     /db_xref="GeneID:4968"
                     /db_xref="HGNC:HGNC:8125"
                     /db_xref="MIM:601982"
                     /translation="MPARALLPRRMGHRTLASTPALWASIPCPRSELRLDLVLPSGQS
                     FRWREQSPAHWSGVLADQVWTLTQTEEQLHCTVYRGDKSQASRPTPDELEAVRKYFQL
                     DVTLAQLYHHWGSVDSHFQEVAQKFQGVRLLRQDPIECLFSFICSSNNNIARITGMVE
                     RLCQAFGPRLIQLDDVTYHGFPSLQALAGPEVEAHLRKLGLGYRARYVSASARAILEE
                     QGGLAWLQQLRESSYEEAHKALCILPGVGTKVADCICLMALDKPQAVPVDVHMWHIAQ
                     RDYSWHPTTSQAKGPSPQTNKELGNFFRSLWGPYAGWAQAVLFSADLRQSRHAQEPPA
                     KRRKGSKGPEG"
     exon            473..720
                     /gene="OGG1"
                     /gene_synonym="HMMH; HOGG1; MUTM; OGH1"
                     /inference="alignment:Splign:2.1.0"
     exon            721..900
                     /gene="OGG1"
                     /gene_synonym="HMMH; HOGG1; MUTM; OGH1"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1082
                     /gene="OGG1"
                     /gene_synonym="HMMH; HOGG1; MUTM; OGH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1233
                     /gene="OGG1"
                     /gene_synonym="HMMH; HOGG1; MUTM; OGH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1283
                     /gene="OGG1"
                     /gene_synonym="HMMH; HOGG1; MUTM; OGH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1630
                     /gene="OGG1"
                     /gene_synonym="HMMH; HOGG1; MUTM; OGH1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1608..1613
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OGG1"
                     /gene_synonym="HMMH; HOGG1; MUTM; OGH1"
                     /note="hexamer: AATAGA"
     polyA_site      1630
                     /gene="OGG1"
                     /gene_synonym="HMMH; HOGG1; MUTM; OGH1"
                     /note="major polyA site"
ORIGIN      
        1 ggtggtgctg tggtctgccc ctggagaacc cagaagaaca cagctgtgcg cgcccacagg
       61 ctctgggggc gggagaagat aagtcgcaag gagggggcgg gacctacacc tcaggaaagc
      121 cggagaattg gggcacgaag cggggctttg atgacccgca aagggcgagg catgcaggag
      181 gtggaggaat taagtgaaac agggaaggtt gttaaacagc accgtgtggg cgaggcctta
      241 agggtcgtgg tccttgtctg ggcggggtct ttgggcgtcg acgaggcctg gttctgggta
      301 ggcggggcta ctacggggcg gtgcctgctg tggaaatgcc tgcccgcgcg cttctgccca
      361 ggcgcatggg gcatcgtact ctagcctcca ctcctgccct gtgggcctcc atcccgtgcc
      421 ctcgctctga gctgcgcctg gacctggttc tgccttctgg acaatctttc cggtggaggg
      481 agcaaagtcc tgcacactgg agtggtgtac tagcggatca agtatggaca ctgactcaga
      541 ctgaggagca gctccactgc actgtgtacc gaggagacaa gagccaggct agcaggccca
      601 caccagacga gctggaggcc gtgcgcaagt acttccagct agatgttacc ctggctcaac
      661 tgtatcacca ctggggttcc gtggactccc acttccaaga ggtggctcag aaattccaag
      721 gtgtgcgact gctgcgacaa gaccccatcg aatgcctttt ctcttttatc tgttcctcca
      781 acaacaacat cgcccgcatc actggcatgg tggagcggct gtgccaggct tttggacctc
      841 ggctcatcca gcttgatgat gtcacctacc atggcttccc cagcctgcag gccctggctg
      901 ggccagaggt ggaggctcat ctcaggaagc tgggcctggg ctatcgtgcc cgttacgtga
      961 gtgccagtgc ccgagccatc ctggaagaac agggcgggct agcctggctg cagcagctac
     1021 gagagtcctc atatgaggag gcccacaagg ccctctgcat cctgcctgga gtgggcacca
     1081 aggtggctga ctgcatctgc ctgatggccc tagacaagcc ccaggctgtg cccgtggatg
     1141 tccatatgtg gcacattgcc caacgtgact acagctggca ccctaccacg tcccaggcga
     1201 agggaccgag cccccagacc aacaaggaac tgggaaactt tttccggagc ctgtggggac
     1261 cttatgctgg ctgggcccaa gcggtgctgt tcagtgccga cctgcgccaa tcccgccatg
     1321 ctcaggagcc accagcaaag cgcagaaagg gttccaaagg gccggaaggc tagatggggc
     1381 accctggaca aagaaattcc ccaagcacct tcccctccat tccccacttc tctctcccca
     1441 tccccaccca gtctcatgtt ggggaggggc ctccctgtga ctacctcaaa ggccaggcac
     1501 ccccaaatca agcagtcagt ttgcacaaca agatggggtg ggggatattg agggagacag
     1561 cgctaaggat ggttttatct tccctttatt acaagaagga acaataaaat agaaacattt
     1621 gtatggaaaa
//
