LOCUS       NM_024576               8492 bp    mRNA    linear   PRI 21-MAR-2025
DEFINITION  Homo sapiens opioid growth factor receptor like 1 (OGFRL1),
            transcript variant 2, mRNA.
ACCESSION   NM_024576
VERSION     NM_024576.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8492)
  AUTHORS   Abd El-Aziz,M.M., Patel,R.J., El-Ashry,M.F., Barragan,I.,
            Marcos,I., Borrego,S., Antinolo,G. and Bhattacharya,S.S.
  TITLE     Exclusion of four candidate genes, KHDRBS2, PTP4A1, KIAA1411 and
            OGFRL1, as causative of autosomal recessive retinitis pigmentosa
  JOURNAL   Ophthalmic Res 38 (1), 19-23 (2006)
   PUBMED   16192744
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC018688.1, AK308623.1, AK124833.1, DA330565.1, BX488500.1,
            DA852679.1, DA151056.1, AL137346.1, CK819012.1 and AI800853.1.
            
            On Nov 22, 2018 this sequence version replaced NM_024576.4.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the central coding region, compared to variant 1,
            resulting in an isoform (b) that is 1 aa shorter than isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018688.1, SRR1803617.193672.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370435.5/ ENSP00000359464.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1311              BC018688.1         5-1315
            1312-1902           AK308623.1         762-1352
            1903-2244           AK124833.1         12-353
            2245-2488           DA330565.1         323-566
            2489-2787           AK124833.1         598-896
            2788-3311           BX488500.1         96-619
            3312-5015           AK124833.1         1421-3124
            5016-5528           DA852679.1         51-563
            5529-6030           DA151056.1         55-556
            6031-6665           AL137346.1         135-769
            6666-7211           CK819012.1         14-559
            7212-8374           AL137346.1         1315-2477
            8375-8492           AI800853.1         14-131              c
FEATURES             Location/Qualifiers
     source          1..8492
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q13"
     gene            1..8492
                     /gene="OGFRL1"
                     /gene_synonym="dJ331H24.1"
                     /note="opioid growth factor receptor like 1"
                     /db_xref="GeneID:79627"
                     /db_xref="HGNC:HGNC:21378"
                     /db_xref="MIM:621133"
     exon            1..360
                     /gene="OGFRL1"
                     /gene_synonym="dJ331H24.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..1482
                     /gene="OGFRL1"
                     /gene_synonym="dJ331H24.1"
                     /note="isoform b is encoded by transcript variant 2;
                     opioid growth factor receptor-like protein 1"
                     /codon_start=1
                     /product="opioid growth factor receptor-like protein 1
                     isoform b"
                     /protein_id="NP_078852.3"
                     /db_xref="CCDS:CCDS34482.1"
                     /db_xref="GeneID:79627"
                     /db_xref="HGNC:HGNC:21378"
                     /db_xref="MIM:621133"
                     /translation="MGNLLGGVSFREPTTVEDCDSTWQTDSEPEPEEPGPGGGSEGPG
                     QESEQPAQPPEQAGGRPGASPAPDEDAEAAGAEQGGDSTEATAKPKRSFYAARDLYKY
                     RHQYPNFKDIRYQNDLSNLRFYKNKIPFKPDGVYIEEVLSKWKGDYEKLEHNHTYIQW
                     LFPLREQGLNFYAKELTTYEIEEFKKTKEAIRRFLLAYKMMLEFFGIKLTDKTGNVAR
                     AVNWQERFQHLNESQHNYLRITRILKSLGELGYESFKSPLVKFILHEALVENTIPNIK
                     QSALEYFVYTIRDRRERRKLLRFAQKHYTPSENFIWGPPRKEQSEGSKAQKMSSPLAS
                     SHNSQTSMHKKAKDSKNSSSAVHLNSKTAEDKKVAPKEPVEETDRPSPEPSNEAAKPR
                     NTEKDSNAENMNSQPEKTVTTPTEKKESVSPENNEEGGNDNQDNENPGNTNCHDVVLV
                     Q"
     exon            361..447
                     /gene="OGFRL1"
                     /gene_synonym="dJ331H24.1"
                     /inference="alignment:Splign:2.1.0"
     exon            448..526
                     /gene="OGFRL1"
                     /gene_synonym="dJ331H24.1"
                     /inference="alignment:Splign:2.1.0"
     exon            527..605
                     /gene="OGFRL1"
                     /gene_synonym="dJ331H24.1"
                     /inference="alignment:Splign:2.1.0"
     exon            606..672
                     /gene="OGFRL1"
                     /gene_synonym="dJ331H24.1"
                     /inference="alignment:Splign:2.1.0"
     exon            673..818
                     /gene="OGFRL1"
                     /gene_synonym="dJ331H24.1"
                     /inference="alignment:Splign:2.1.0"
     exon            819..8492
                     /gene="OGFRL1"
                     /gene_synonym="dJ331H24.1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1686..1691
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OGFRL1"
                     /gene_synonym="dJ331H24.1"
                     /note="hexamer: AATGAA"
     polyA_site      1703
                     /gene="OGFRL1"
                     /gene_synonym="dJ331H24.1"
                     /note="major polyA site"
     regulatory      8354..8359
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OGFRL1"
                     /gene_synonym="dJ331H24.1"
                     /note="hexamer: ATTAAA"
     polyA_site      8383
                     /gene="OGFRL1"
                     /gene_synonym="dJ331H24.1"
                     /note="major polyA site"
     regulatory      8466..8471
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OGFRL1"
                     /gene_synonym="dJ331H24.1"
                     /note="hexamer: AATAAA"
     polyA_site      8492
                     /gene="OGFRL1"
                     /gene_synonym="dJ331H24.1"
ORIGIN      
        1 agtgcggggc gggcgcgcct aggctgccgc ccagcgccct cgccgcggcc atgcccgggc
       61 cctagagcgc ctgccgcagc ttgcgccccg cagccccgca gccccgcgcc cgccgccgcc
      121 tcttcaatgg gcaacctgct cggcggggtc agcttccgcg agcccaccac cgtggaggac
      181 tgcgactcca cctggcagac cgactcggag cccgagcccg aagaaccagg gccgggcggc
      241 ggcagcgagg gcccggggca ggagtccgag cagcccgcgc agcccccgga gcaagccggc
      301 gggcggcccg gcgccagccc cgcgccggac gaggacgccg aggcggcggg cgccgagcag
      361 ggtggtgatt ccactgaagc aactgccaaa ccaaagagaa gtttttatgc tgccagggat
      421 ttgtacaagt accgacacca gtacccaaac ttcaaagata tccgatatca aaatgacttg
      481 agcaatcttc gtttttataa gaataaaatt ccattcaagc cagatggtgt ttacattgaa
      541 gaagttctaa gtaaatggaa aggagattat gaaaaactgg agcacaacca cacttacatt
      601 caatggcttt tccccctgag agaacaaggc ttgaacttct atgccaaaga actaactaca
      661 tatgaaattg aggaattcaa aaaaacaaaa gaagcaatta gaagattcct cctggcttat
      721 aaaatgatgc tagaattttt tggaataaaa ctgactgata aaactggaaa tgttgctcgg
      781 gctgttaact ggcaggaaag atttcagcat ctgaatgagt cccagcacaa ctatttaaga
      841 atcactcgta ttcttaaaag ccttggtgag cttggatatg aaagttttaa atctcctctt
      901 gtaaaattta ttcttcatga agctcttgtg gagaatacta ttcccaatat taagcagagt
      961 gctctagagt attttgttta tacaattaga gacagaagag aaaggagaaa gctcctgcgg
     1021 ttcgcccaga aacactacac gccttcagag aactttatct ggggaccgcc tcgaaaagaa
     1081 cagtcggagg gaagcaaagc ccagaaaatg tcttcccctc tcgcctccag tcataacagt
     1141 caaacttcta tgcacaaaaa agccaaggac tccaaaaatt cctcctcagc tgttcattta
     1201 aatagcaaaa cagctgaaga caaaaaagtg gcaccaaaag agcctgtgga agagacagac
     1261 aggcccagcc cagagcccag caatgaagct gccaagccaa gaaatacaga gaaggacagt
     1321 aatgctgaga acatgaattc tcaacctgag aaaacagtta ctactcccac agaaaaaaag
     1381 gagagtgtat ctcctgagaa taacgaagaa ggtggaaatg ataaccaaga caatgaaaat
     1441 cctggaaata caaattgcca tgatgttgta ctagtacagt gaattatcag aaaacccaga
     1501 agccagttta ggctagagag gaaaaaacta ctgtatcatt tatcctaaag aacagagatg
     1561 aggtcaattt caaattttag ccatctgttt gtgatttctg tcataagcat tttgttgttt
     1621 gtttttttat tttggatgac aatgaattga atatctaata aggagattta agataagacc
     1681 caataaatga atgtattctg taatgctttt aggatgtgaa ttttcaaatt ttgtatataa
     1741 taattacttt gagaatattt tcagagtatc tagaaattac catgtagtat ttggtataca
     1801 aaatacattc ttttgagaca ttatagtcta catgaaggaa atcaagagga taatttcatt
     1861 ggattgctac acttttacct gatttatggc tttattttac tttattttat tttattatta
     1921 ttttttgaga cggagtctct gttgcccagg ctggagtgca gtggcatgat ctcggctcac
     1981 tgcaacctct gcctcctgga ctcaaacgat tctcctgcct cagcctcctg agtagctggg
     2041 attacaggcg tgtgccacca cgcctggcta atttttgtat ttttagtaga gacggggttt
     2101 caccatgttg gtcaggctgg tctcaaactc ctgacctcat gatccacccg cctcggcctc
     2161 ccaaagtgct gggattacag gcatgagcca ccatgtctgg ctgattaatt ttttttttaa
     2221 ctgtaagagt ttgatctttt caaatgtgtt cagaaactaa tttggattct ttgattctag
     2281 tatctcaacg tgtttatttt tagattctga taagtgaaat ggatgtcctt gtggagctct
     2341 ggcctcccca gcttatctat cagtcctgct gtcctcacct ccttgcctct ttccatgctt
     2401 acccttaagc caccatcttt ctcagctagc gtgtgtgttt ctagtgtagt tggccctcca
     2461 tattcagggg tccagcatct gtggattcaa ccaaccgcag attgaaaata tttgttggaa
     2521 aaaatggatg gttacatctc tactaaatat gtgcagtcct tttatttgtc attattctct
     2581 aaacaataca gtataacaac tattgacata gcatttatat tgtatgtatt aggtattgta
     2641 agtaatttag agatgattta aagtatttta cataagggac ttgagcattc ctagattttg
     2701 gtaactgcag agggtcctgg aaccaacccc ctacagatat caagggacca ctatacacat
     2761 taggatgatc tatattgaaa tctacatgga acagagtggg acttctaatt gtatgacttc
     2821 aagattttgc tttgtttaaa ttaataactg ttttcagaat taagtgctta aaaacaaatt
     2881 tgattgaaaa gttcaagaca agaattttgc tctctatggc tgttccatat aaatttgatg
     2941 gttgattctg aatgtaaatg actgaagaat taaaaaataa gaaattcctt tttaaaaggc
     3001 atgcctcttg cactgtgaac aagacagtag tcccttaaac catgaatatg tcagtgttct
     3061 atggattacg aaattagtaa tgttgcttag cccaaacgtg ttttttaaaa agtatagttt
     3121 tgtacatctc taagttatca aacttcaaaa ttgagaacaa atttaaaagt ccatatatgc
     3181 aactctagta agcacttaat aggttacata gcactggtta agaacaatta attttgtttc
     3241 tatattatta ctaattatta ttacaaatca aaaaacactg tgataagaac ttcaaagcat
     3301 atatacaaat atagttaaag caatgaatag atgaaacatg tctactttat ttcatttaga
     3361 aaggaattaa cttttttgtt aggcttttaa gaaaagttct attcatttta atcccctagg
     3421 gaatttgtaa tatgtcctac ttcatatcat cttctgttgc ctctattgat ccacattttc
     3481 tgcagtggat ttcttgaaaa gaatcacact tatagtatgc ctctagaaat atgattttac
     3541 tgctttgaag tttacatgaa acatgccagt tgcttaactc taatttttta tatgaatctc
     3601 agtagcactt ttgttgtaca ttgtgttcca ataagtatag tatggaacac tttctcattt
     3661 ttagttccca taatatgcca gtttttgctt tcctagtgtt ctgtgagtat taggatttgg
     3721 caatctgctt ttgcatttca atttctgttt tacatgcaag aaaaacatgg acactcttac
     3781 gtggtgcttg tagctgtgtc tccgtagagc tcagtaaata gttctacagg gtttagagga
     3841 tgagaagcga ttgtcaaatt aggctgaatt gtagaacaca aataatttaa ttcaaaataa
     3901 cttaccaatt ttatatacat gataaagtat tcagacaact ttctaaatgc ataatagtaa
     3961 aagattgtga ccagatatta tgatattaat aaagttacca gatactaaaa tcaatgaatg
     4021 taatttgaat tacttagaaa ttgtatatta gagcccttat gagtaaaaac atttcattta
     4081 gcaacttaac ttttagaata ttcttcctac ttagggattt tgattagatt gtaacattaa
     4141 attcgagaat atttagtctc aagagaaaca cttcctggca tccatcttaa atagtggcct
     4201 tttcccacta tggtgttttt aaatgcatat tcatatataa tagtatgttt cttacattta
     4261 atccctaaat aacttagata atcattcagt ggagaacaag taaaaggata tcattccttt
     4321 tggagataaa cattgagtgt ctagaatttt tttctattaa tgctttgtat attagttttt
     4381 taaataagat ctatagatat gtatttatgt gtgtcttata tatgaaacag tgctctgggt
     4441 ttgactccta tgttttgtaa ttttaaaaac tacgatatgc ttgcagaaat tcattgagaa
     4501 gctgttataa aaaatgcagt gaagcatgac caaatagcta aaaatattac tgaatcttta
     4561 caaatatata atctttattg ttgtactgtg gagtgcaagg atactaaata ttggctattg
     4621 ataaaatact aacttgcatt tcatggcaaa tagatgttat atcgcttgat tagtctagaa
     4681 catttctaat attttgtgct ttcatatatc aaaggagatt atgtgaaact atttttaaat
     4741 actgtaaagt gacatatagt tataagatat atttctgtac agtagagaaa gagtttataa
     4801 catgaagaat attgtaccat tatacatttt cattctcgat ctcataagaa attcaaaaga
     4861 ataatgatag aggtgaaaat atgtttactt tctctaaatc aagcctagtt gtcaactcaa
     4921 aaattatgtt gcatagtttt attttgaatt taggttttgg gactactttt ttccagcttc
     4981 aatgagaaaa taaaatctac aactcaggag ttactagaga agttctaagt atttttttgc
     5041 taagtagtaa aaatataaac atatgaaaat gccataatgc ctgtcatagt cattgtttca
     5101 tattttgtca tataaaatca cctaccctgc ttctagtttt atactttaat ctgagtgaaa
     5161 gtatgatgtg gtggaaagaa aaaacagtac agtattacat ctgagttagt ctttgaaaaa
     5221 tcatagtagt aaatgaacct caacactgag tggtcaaaaa ttgggttaac caatgggggg
     5281 agaatatttg gttaattgtt ttaatattaa attttcaagt ttataataga gttatggttg
     5341 agtagtcatc catactgagt aatcacgcat tttttaaact ataattgagg ctcttctaaa
     5401 gctttgtttt ctaatctaag atacaaagga tattcttgat cttgcttgat tgtaactaca
     5461 tctaccagtc tttaatgtct gtttggggtg agtggcgatc ctctgttgta ggaatgtttt
     5521 tgaagatttc tattttgttt tccacttagg aaattcccct ctctcatttg gggtatatgc
     5581 gttgagtata aggtaggctg tatttagaca cactagaatc attaaatgta ggtgaagttg
     5641 tagagaaaaa tggcctgggt caatgtagga tctagaaaat taggagtgta catttgctgg
     5701 cttctttttg agttttgtac tgtttattac aggaacatat ttgtgtggct aatctctagg
     5761 gtgacagtga gtactaccct gctccttctg cattctagtt atccaacaca cccagcagat
     5821 tgtgttcagg gacagaatgt gtttttagaa atcccttatt attgaaatga ataataatat
     5881 agctataaat atgaatgtct ggaggtatcc agatgtgcct taacaaatgt aaatggtttt
     5941 cattcagaag tttacatttt tattacatta taaaatctca tcattgggaa ctttctaaac
     6001 catgaatatc agttctttta atgaaattta ggtggtgctt tatcattttg gagaagttgc
     6061 tgtttgggac aatagcatca gtttatcaag aagtgtactc accatgatat tcaacaatgt
     6121 gttacatttg acaaaacgtg tttagagtaa gaaagactaa ctatactgtc tgttatattt
     6181 atttatgctt tttgtagttt agctacatac tataattttc attttaaacg ttccttagtt
     6241 actacaaata atatttatgt tttgcttctt cttagatgta ggcggatgca gaaatagaat
     6301 tatgttagag aaattattaa aagtttaatt ccagtaggca gttggagaaa tctgaaacta
     6361 atttgaaaaa cttttatgct gtagtctcat tagaatcatt ttaaaagcac tgttcttgca
     6421 tttttcctag actacagaga gtgttctttg tcattttttt tcctattctg ttgtgaagtt
     6481 tattgtttca gttatttgag ggaaataacc tcttaatatg tttattttcc tgaactaaag
     6541 ttttcatgta gagaatacaa ttaaatgttt tgtgttatga cccaaactgg ctggaagtag
     6601 agttcagaga gggagaaggg acaagaatca gtgtgggcat ctcaggaaag tggcgccagt
     6661 gctgggctcc agccttctcc actggcatga tgggtcctca gattctcctc tggataatga
     6721 gggtgttggg cactgtgagc tctgacttct ggggaggata ggccatcatg gactccatac
     6781 acaattttga tgggtatcag ttctcataaa atacctgcta caatttattt attttgtagt
     6841 tgtttagaaa actgtgagca gttgggcatt agtaaattgt agttatatct taacgatctt
     6901 gggaatcatt gaaatatgag tttttttccc tcactcctat ttatttaatt aaaaaattag
     6961 ggaagttgtt cattcacagc tgtatattaa tataaaatct ctttataaaa tgattcagag
     7021 aaaaggcagt agtggtcact tactgtgcta aaataccttt ttctctaaaa atatttaagc
     7081 tttagggttt gtcatagttt tactttttaa attatacttt gtgtaacaat ttacgttaac
     7141 tagaaaaatt agatatataa taagttttgg tactaagaaa catttacatt ctacactcat
     7201 tagtcaaatg aacttttctt tcccagtgct aacagatttt gtttcatgtg aagaaaaata
     7261 aaatacaaat gaaataaaag tctagaaaca gcaacaggaa actcaccaca gaaataaaga
     7321 cataaccctt gataagtttg tgtaagtgcc agaattattg gaagcaggtg acgaatgatt
     7381 aagaaaagct ttattgtggg gacatgcttt aagaatcagc tctgtatttg tgccaaggag
     7441 atcaggtatt ggtgtgcaaa cagatcccat taatactctg atttgaacca tgaattccac
     7501 ctactctgcg ttgaagccct ccagtagact gatagatgta atcaaatgat cagctaccaa
     7561 gtttaattcc tttgcctgtg tgtagcaaca gttggtagtt ttacaagtta agttgatggt
     7621 ctggctgcag ataagagaaa gactcagtga taggtggttt gtgagtgaag taacttccac
     7681 actgtcaaga gttgacagca tattaattgt gtggcattat aattgtgaga aacaaatgag
     7741 agcaaaatgt taggtccttt gacaagcatt ttcctcctgt ttttaaaaag ggctttaagt
     7801 tgtttcctat gtaaggtaat ctttcttttt tagtattatc taagaaggat ggtagattat
     7861 gtcattttgg aaactattgt gtcccttgta ttttaaatat ttcaggaaaa tgcctacgat
     7921 tgttacaaag atgtgtgttt tacttataac ataagctctg attctccagt ggccactggg
     7981 ccttctctgt gctctgtatt caactgcagt atgaattaca gaatgctgtg catgttcgtt
     8041 agtaccaata ccatgtgtat gtggtagaag ttgtaaccag tttctggatc tgtatggtac
     8101 tataaaatac ttattttata attctgtaac cgtatggcag tgttatgcca aaaatgtata
     8161 aagagcaata gtttttgttg cttactgctg tattttaaaa tattgtttct aaaataatag
     8221 agttagagtt ccttttgagt aattattttt aagaactatt gccaaatata catcctgtaa
     8281 aactaataaa agccactcca tcttagataa cattttagca ttgtgctaga gtacattatg
     8341 gtgattttgc acgattaaaa tatttttaaa gaactagaaa aaatgacttg ctgttttcct
     8401 gtcattaagc atgtattttt tatgattaac acataagact aacattattt tcttttatcc
     8461 tcaaaaataa atattgtgaa gggtgaatca ta
//
