LOCUS       NM_007346               2410 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens opioid growth factor receptor (OGFR), mRNA.
ACCESSION   NM_007346
VERSION     NM_007346.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2410)
  AUTHORS   Patel,C., Thomas,G., Zomorodi,N., Zagon,I.S. and McLaughlin,P.J.
  TITLE     beta-endorphin and opioid growth factor as biomarkers of physical
            ability in multiple sclerosis
  JOURNAL   Mult Scler Relat Disord 50, 102868 (2021)
   PUBMED   33677409
  REMARK    GeneRIF: beta-endorphin and opioid growth factor as biomarkers of
            physical ability in multiple sclerosis.
REFERENCE   2  (bases 1 to 2410)
  AUTHORS   Kim,J.Y., Ahn,H.J., Kim,J.K., Kim,J., Lee,S.H. and Chae,H.B.
  TITLE     Morphine Suppresses Lung Cancer Cell Proliferation Through the
            Interaction with Opioid Growth Factor Receptor: An In Vitro and
            Human Lung Tissue Study
  JOURNAL   Anesth Analg 123 (6), 1429-1436 (2016)
   PUBMED   27167686
  REMARK    GeneRIF: Morphine interacts with OGFR and may suppress lung cancer
            proliferation and progression.
REFERENCE   3  (bases 1 to 2410)
  AUTHORS   Thakur,N.A., DeBoyace,S.D. and Margulies,B.S.
  TITLE     Antagonism of the Met5-enkephalin-opioid growth factor
            receptor-signaling axis promotes MSC to differentiate into
            osteoblasts
  JOURNAL   J Orthop Res 34 (7), 1195-1205 (2016)
   PUBMED   26687326
REFERENCE   4  (bases 1 to 2410)
  AUTHORS   Suzuki,M., Chiwaki,F., Sawada,Y., Ashikawa,M., Aoyagi,K.,
            Fujita,T., Yanagihara,K., Komatsu,M., Narita,M., Suzuki,T.,
            Nagase,H., Kushima,R., Sakamoto,H., Fukagawa,T., Katai,H.,
            Nakagama,H., Yoshida,T., Uezono,Y. and Sasaki,H.
  TITLE     Peripheral opioid antagonist enhances the effect of anti-tumor drug
            by blocking a cell growth-suppressive pathway in vivo
  JOURNAL   PLoS One 10 (4), e0123407 (2015)
   PUBMED   25853862
  REMARK    GeneRIF: The blockade of OGF signaling by MNTX releases cells from
            their arrest and boosts the effect of Doc
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2410)
  AUTHORS   Zagon,I.S., Donahue,R. and McLaughlin,P.J.
  TITLE     Targeting the opioid growth factor: opioid growth factor receptor
            axis for treatment of human ovarian cancer
  JOURNAL   Exp Biol Med (Maywood) 238 (5), 579-587 (2013)
   PUBMED   23856908
  REMARK    GeneRIF: The OGF-OGFr axis may be a feasible target for treatment
            of cancer of the ovary (i) in a prophylactic fashion, (ii)
            following cytoreduction or (iii) in conjunction with standard
            chemotherapy for additive effectiveness
REFERENCE   6  (bases 1 to 2410)
  AUTHORS   Zagon,I.S., Verderame,M.F. and McLaughlin,P.J.
  TITLE     The biology of the opioid growth factor receptor (OGFr)
  JOURNAL   Brain Res Brain Res Rev 38 (3), 351-376 (2002)
   PUBMED   11890982
  REMARK    Review article
REFERENCE   7  (bases 1 to 2410)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   8  (bases 1 to 2410)
  AUTHORS   Hattori,A., Okumura,K., Nagase,T., Kikuno,R., Hirosawa,M. and
            Ohara,O.
  TITLE     Characterization of long cDNA clones from human adult spleen
  JOURNAL   DNA Res 7 (6), 357-366 (2000)
   PUBMED   11214971
REFERENCE   9  (bases 1 to 2410)
  AUTHORS   Wu,C.J., Yang,X.F., McLaughlin,S., Neuberg,D., Canning,C.,
            Stein,B., Alyea,E.P., Soiffer,R.J., Dranoff,G. and Ritz,J.
  TITLE     Detection of a potent humoral response associated with
            immune-induced remission of chronic myelogenous leukemia
  JOURNAL   J Clin Invest 106 (5), 705-714 (2000)
   PUBMED   10974024
REFERENCE   10 (bases 1 to 2410)
  AUTHORS   Zagon,I.S., Verderame,M.F., Allen,S.S. and McLaughlin,P.J.
  TITLE     Cloning, sequencing, chromosomal location, and function of cDNAs
            encoding an opioid growth factor receptor (OGFr) in humans
  JOURNAL   Brain Res 856 (1-2), 75-83 (2000)
   PUBMED   10677613
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL035669.43 and AF172453.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_007346.3.
            
            Summary: The protein encoded by this gene is a receptor for opioid
            growth factor (OGF), also known as [Met(5)]-enkephalin. OGF is a
            negative regulator of cell proliferation and tissue organization in
            a variety of processes. The encoded unbound receptor for OGF has
            been localized to the outer nuclear envelope, where it binds OGF
            and is translocated into the nucleus. The coding sequence of this
            gene contains a polymorphic region of 60 nt tandem imperfect repeat
            units. Several transcripts containing between zero and eight repeat
            units have been reported. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK022234.1, AF172451.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000290291.10/ ENSP00000290291.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AL035669.43        54012-54030
            20-683              AF172453.2         1-664
            684-2410            AL035669.43        61451-63177
FEATURES             Location/Qualifiers
     source          1..2410
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.33"
     gene            1..2410
                     /gene="OGFR"
                     /note="opioid growth factor receptor"
                     /db_xref="GeneID:11054"
                     /db_xref="HGNC:HGNC:15768"
                     /db_xref="MIM:606459"
     exon            1..196
                     /gene="OGFR"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..2059
                     /gene="OGFR"
                     /note="zeta-type opioid receptor; protein 7-60"
                     /codon_start=1
                     /product="opioid growth factor receptor"
                     /protein_id="NP_031372.2"
                     /db_xref="CCDS:CCDS13504.1"
                     /db_xref="GeneID:11054"
                     /db_xref="HGNC:HGNC:15768"
                     /db_xref="MIM:606459"
                     /translation="MDDPDCDSTWEEDEEDAEDAEDEDCEDGEAAGARDADAGDEDEE
                     SEEPRAARPSSFQSRMTGSRNWRATRDMCRYRHNYPDLVERDCNGDTPNLSFYRNEIR
                     FLPNGCFIEDILQNWTDNYDLLEDNHSYIQWLFPLREPGVNWHAKPLTLREVEVFKSS
                     QEIQERLVRAYELMLGFYGIRLEDRGTGTVGRAQNYQKRFQNLNWRSHNNLRITRILK
                     SLGELGLEHFQAPLVRFFLEETLVRRELPGVRQSALDYFMFAVRCRHQRRQLVHFAWE
                     HFRPRCKFVWGPQDKLRRFKPSSLPHPLEGSRKVEEEGSPGDPDHEASTQGRTCGPEH
                     SKGGGRVDEGPQPRSVEPQDAGPLERSQGDEAGGHGEDRPEPLSPKESKKRKLELSRR
                     EQPPTEPGPQSASEVEKIALNLEGCALSQGSLRTGTQEVGGQDPGEAVQPCRQPLGAR
                     VADKVRKRRKVDEGAGDSAAVASGGAQTLALAGSPAPSGHPKAGHSENGVEEDTEGRT
                     GPKEGTPGSPSETPGPSPAGPAGDEPAESPSETPGPRPAGPAGDEPAESPSETPGPRP
                     AGPAGDEPAESPSETPGPSPAGPTRDEPAESPSETPGPRPAGPAGDEPAESPSETPGP
                     RPAGPAGDEPAESPSETPGPSPAGPTRDEPAKAGEAAELQDAEVESSAKSGKP"
     exon            197..265
                     /gene="OGFR"
                     /inference="alignment:Splign:2.1.0"
     exon            266..344
                     /gene="OGFR"
                     /inference="alignment:Splign:2.1.0"
     exon            345..423
                     /gene="OGFR"
                     /inference="alignment:Splign:2.1.0"
     exon            424..490
                     /gene="OGFR"
                     /inference="alignment:Splign:2.1.0"
     exon            491..639
                     /gene="OGFR"
                     /inference="alignment:Splign:2.1.0"
     exon            640..2410
                     /gene="OGFR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2390..2395
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OGFR"
                     /note="hexamer: AATAAA"
     polyA_site      2410
                     /gene="OGFR"
                     /note="major polyA site"
ORIGIN      
        1 agcgcgagcc ccgccgccgc cgagcatgga cgaccccgac tgcgactcca cctgggagga
       61 ggacgaggag gatgcggagg acgcggagga cgaggactgc gaggacggcg aggccgccgg
      121 cgcgagggac gcggacgcag gggacgagga cgaggagtcg gaggagccgc gggcggcgcg
      181 gcccagctcg ttccagtcca gaatgacagg gtccagaaac tggcgagcca cgagggacat
      241 gtgtaggtat cggcacaact atccggatct ggtggaacga gactgcaatg gggacacgcc
      301 aaacctgagt ttctacagaa atgagatccg cttcctgccc aacggctgtt tcattgagga
      361 cattcttcag aactggacgg acaactatga cctccttgag gacaatcact cctacatcca
      421 gtggctgttt cctctgcgag aaccaggagt gaactggcat gccaagcccc tcacgctcag
      481 ggaggtcgag gtgtttaaaa gctcccagga gatccaggag cggcttgtcc gggcctacga
      541 gctcatgctg ggcttctacg ggatccggct ggaggaccga ggcacgggca cggtgggccg
      601 agcacagaac taccagaagc gcttccagaa cctgaactgg cgcagccaca acaacctccg
      661 catcacacgc atcctcaagt cgctgggtga gctgggcctc gagcacttcc aggcgccgct
      721 ggtccgcttc ttcctggagg agacgctggt gcggcgggag ctgccggggg tgcggcagag
      781 tgccctggac tacttcatgt tcgccgtgcg ctgccgacac cagcgccgcc agctggtgca
      841 cttcgcctgg gagcacttcc ggccccgctg caagttcgtc tgggggcccc aagacaagct
      901 gcggaggttc aagcccagct ctctgcccca tccgctcgag ggctccagga aggtggagga
      961 ggaaggaagc cccggggacc ccgaccacga ggccagcacc cagggtcgga cctgtgggcc
     1021 agagcatagc aagggtgggg gcagggtgga cgaggggccc cagccacgga gcgtggagcc
     1081 ccaggatgcg ggacccctgg agaggagcca gggggatgag gcagggggcc acggggaaga
     1141 taggccggag cccttaagcc ccaaagagag caagaagagg aagctggagc tgagccggcg
     1201 ggagcagccg cccacagagc caggccctca gagtgcctca gaggtggaga agatcgctct
     1261 gaatttggag gggtgtgccc tcagccaggg cagcctcagg acggggaccc aggaagtggg
     1321 cggtcaggac cctggggagg cagtgcagcc ctgccgccaa cccctgggag ccagggtggc
     1381 cgacaaggtg aggaagcgga ggaaggtgga tgagggtgct ggggacagtg ctgcggtggc
     1441 cagtggtggt gcccagacct tggcccttgc cgggtcccct gccccatcgg ggcaccccaa
     1501 ggctggacac agtgagaacg gggttgagga ggacacagaa ggtcgaacgg ggcccaaaga
     1561 aggtacccct gggagcccat cggagacccc aggccccagc ccagcaggac ctgcagggga
     1621 cgagccagcc gagagcccat cggagacccc aggcccccgc ccagcaggac ctgcagggga
     1681 cgagccagcc gagagcccat cggagacccc aggcccccgc ccggcaggac ctgcagggga
     1741 cgagccagcc gagagcccat cggagacccc aggccccagc ccggcaggac ctacaaggga
     1801 tgagccagcc gagagcccat cggagacccc aggcccccgc ccggcaggac ctgcagggga
     1861 cgagccagcc gagagcccat cggagacccc aggcccccgc ccggcaggac ctgcagggga
     1921 cgagccagcc gagagcccat cggagacccc aggccccagc ccggcaggac ctacaaggga
     1981 tgagccagcc aaggcggggg aggcagcaga gttgcaggac gcagaggtgg agtcttctgc
     2041 caagtctggg aagccttaag gaaaggagtg cccgtcggcg tcttggtcct cctgtccctg
     2101 ctgcaggggc tggggcctcc ggagctgctg cgggctcccc tcaggctctg cttcgtgacc
     2161 cgtgacccat gacccacagt gctggcctcc tgtggggcca ctatagcagc caccagaagc
     2221 cgcgaggccc tcagggaagc ccaaggcctg cagaagcctc ctggcctggc tgtgtcttcc
     2281 ccacccagct ctcccctgcg cccctgtctt tgtaaattga cccttctgga gtggggggcg
     2341 gcgggcaggg ctgcttttct tagtctgata ccaagcaagg ccttttctga ataaattcat
     2401 ttgactttga
//
