LOCUS       NM_001304833            1757 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens 2-oxoglutarate and iron dependent oxygenase domain
            containing 2 (OGFOD2), transcript variant 1, mRNA.
ACCESSION   NM_001304833
VERSION     NM_001304833.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1757)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1757)
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Biological insights from 108 schizophrenia-associated genetic loci
  JOURNAL   Nature 511 (7510), 421-427 (2014)
   PUBMED   25056061
REFERENCE   3  (bases 1 to 1757)
  AUTHORS   Ripke,S., O'Dushlaine,C., Chambert,K., Moran,J.L., Kahler,A.K.,
            Akterin,S., Bergen,S.E., Collins,A.L., Crowley,J.J., Fromer,M.,
            Kim,Y., Lee,S.H., Magnusson,P.K., Sanchez,N., Stahl,E.A.,
            Williams,S., Wray,N.R., Xia,K., Bettella,F., Borglum,A.D.,
            Bulik-Sullivan,B.K., Cormican,P., Craddock,N., de Leeuw,C.,
            Durmishi,N., Gill,M., Golimbet,V., Hamshere,M.L., Holmans,P.,
            Hougaard,D.M., Kendler,K.S., Lin,K., Morris,D.W., Mors,O.,
            Mortensen,P.B., Neale,B.M., O'Neill,F.A., Owen,M.J.,
            Milovancevic,M.P., Posthuma,D., Powell,J., Richards,A.L.,
            Riley,B.P., Ruderfer,D., Rujescu,D., Sigurdsson,E., Silagadze,T.,
            Smit,A.B., Stefansson,H., Steinberg,S., Suvisaari,J., Tosato,S.,
            Verhage,M., Walters,J.T., Levinson,D.F., Gejman,P.V., Kendler,K.S.,
            Laurent,C., Mowry,B.J., O'Donovan,M.C., Owen,M.J., Pulver,A.E.,
            Riley,B.P., Schwab,S.G., Wildenauer,D.B., Dudbridge,F., Holmans,P.,
            Shi,J., Albus,M., Alexander,M., Campion,D., Cohen,D., Dikeos,D.,
            Duan,J., Eichhammer,P., Godard,S., Hansen,M., Lerer,F.B.,
            Liang,K.Y., Maier,W., Mallet,J., Nertney,D.A., Nestadt,G.,
            Norton,N., O'Neill,F.A., Papadimitriou,G.N., Ribble,R.,
            Sanders,A.R., Silverman,J.M., Walsh,D., Williams,N.M., Wormley,B.,
            Arranz,M.J., Bakker,S., Bender,S., Bramon,E., Collier,D.,
            Crespo-Facorro,B., Hall,J., Iyegbe,C., Jablensky,A., Kahn,R.S.,
            Kalaydjieva,L., Lawrie,S., Lewis,C.M., Lin,K., Linszen,D.H.,
            Mata,I., McIntosh,A., Murray,R.M., Ophoff,R.A., Powell,J.,
            Rujescu,D., Van Os,J., Walshe,M., Weisbrod,M., Wiersma,D.,
            Donnelly,P., Barroso,I., Blackwell,J.M., Bramon,E., Brown,M.A.,
            Casas,J.P., Corvin,A.P., Deloukas,P., Duncanson,A., Jankowski,J.,
            Markus,H.S., Mathew,C.G., Palmer,C.N., Plomin,R., Rautanen,A.,
            Sawcer,S.J., Trembath,R.C., Viswanathan,A.C., Wood,N.W.,
            Spencer,C.C., Band,G., Bellenguez,C., Freeman,C., Hellenthal,G.,
            Giannoulatou,E., Pirinen,M., Pearson,R.D., Strange,A., Su,Z.,
            Vukcevic,D., Donnelly,P., Langford,C., Hunt,S.E., Edkins,S.,
            Gwilliam,R., Blackburn,H., Bumpstead,S.J., Dronov,S., Gillman,M.,
            Gray,E., Hammond,N., Jayakumar,A., McCann,O.T., Liddle,J.,
            Potter,S.C., Ravindrarajah,R., Ricketts,M.,
            Tashakkori-Ghanbaria,A., Waller,M.J., Weston,P., Widaa,S.,
            Whittaker,P., Barroso,I., Deloukas,P., Mathew,C.G., Blackwell,J.M.,
            Brown,M.A., Corvin,A.P., McCarthy,M.I., Spencer,C.C., Bramon,E.,
            Corvin,A.P., O'Donovan,M.C., Stefansson,K., Scolnick,E.,
            Purcell,S., McCarroll,S.A., Sklar,P., Hultman,C.M. and
            Sullivan,P.F.
  CONSRTM   Multicenter Genetic Studies of Schizophrenia Consortium; Psychosis
            Endophenotypes International Consortium; Wellcome Trust Case
            Control Consortium 2
  TITLE     Genome-wide association analysis identifies 13 new risk loci for
            schizophrenia
  JOURNAL   Nat Genet 45 (10), 1150-1159 (2013)
   PUBMED   23974872
REFERENCE   4  (bases 1 to 1757)
  AUTHORS   Ramsuran,V., Kulkarni,H., He,W., Mlisana,K., Wright,E.J.,
            Werner,L., Castiblanco,J., Dhanda,R., Le,T., Dolan,M.J., Guan,W.,
            Weiss,R.A., Clark,R.A., Karim,S.S., Ahuja,S.K. and Ndung'u,T.
  TITLE     Duffy-null-associated low neutrophil counts influence HIV-1
            susceptibility in high-risk South African black women
  JOURNAL   Clin Infect Dis 52 (10), 1248-1256 (2011)
   PUBMED   21507922
REFERENCE   5  (bases 1 to 1757)
  AUTHORS   Stelzl,U., Worm,U., Lalowski,M., Haenig,C., Brembeck,F.H.,
            Goehler,H., Stroedicke,M., Zenkner,M., Schoenherr,A., Koeppen,S.,
            Timm,J., Mintzlaff,S., Abraham,C., Bock,N., Kietzmann,S.,
            Goedde,A., Toksoz,E., Droege,A., Krobitsch,S., Korn,B.,
            Birchmeier,W., Lehrach,H. and Wanker,E.E.
  TITLE     A human protein-protein interaction network: a resource for
            annotating the proteome
  JOURNAL   Cell 122 (6), 957-968 (2005)
   PUBMED   16169070
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC026362.38.
            
            On Jul 15, 2021 this sequence version replaced NM_001304833.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK094820.1, SRR18074967.2312396.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000228922.12/ ENSP00000228922.7
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-140               AC026362.38        47620-47759
            141-197             AC026362.38        48187-48243
            198-311             AC026362.38        49030-49143
            312-411             AC026362.38        49247-49346
            412-539             AC026362.38        50818-50945
            540-797             AC026362.38        51129-51386
            798-1757            AC026362.38        51459-52418
FEATURES             Location/Qualifiers
     source          1..1757
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.31"
     gene            1..1757
                     /gene="OGFOD2"
                     /note="2-oxoglutarate and iron dependent oxygenase domain
                     containing 2"
                     /db_xref="GeneID:79676"
                     /db_xref="HGNC:HGNC:25823"
     exon            1..140
                     /gene="OGFOD2"
                     /inference="alignment:Splign:2.1.0"
     CDS             9..1061
                     /gene="OGFOD2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     2-oxoglutarate and iron-dependent oxygenase
                     domain-containing protein 2"
                     /codon_start=1
                     /product="2-oxoglutarate and iron-dependent oxygenase
                     domain-containing protein 2 isoform 1"
                     /protein_id="NP_001291762.1"
                     /db_xref="CCDS:CCDS76617.1"
                     /db_xref="GeneID:79676"
                     /db_xref="HGNC:HGNC:25823"
                     /translation="MATVGAPRHFCRCACFCTDNLYVARYGLHVRFRGEQQLRRDYGP
                     ILRSRGCVSAKDFQQLLAELEQEVERRQRLGQESAARKALIASSYHPARPEVYDSLQD
                     AALAPEFLAVTEYSVSPDADLKGLLQRLETVSEEKRIYRVPVFTAPFCQALLEELEHF
                     EQSDMPKGRPNTMNNYGVLLHELGLDEPLMTPLRERFLQPLMALLYPDCGGGRLDSHR
                     AFVVKYAPGQDLELGCHYDNAELTLNVALGKVFTGGALYFGGLFQAPTALTEPLEVEH
                     VVGQGVLHRGGQLHGARPLGTGERWNLVVWLRASAVRNSLCPMCCREPDLVDDEGFGD
                     GFTREEPATVDVCALT"
     exon            141..197
                     /gene="OGFOD2"
                     /inference="alignment:Splign:2.1.0"
     exon            198..311
                     /gene="OGFOD2"
                     /inference="alignment:Splign:2.1.0"
     exon            312..411
                     /gene="OGFOD2"
                     /inference="alignment:Splign:2.1.0"
     exon            412..539
                     /gene="OGFOD2"
                     /inference="alignment:Splign:2.1.0"
     exon            540..797
                     /gene="OGFOD2"
                     /inference="alignment:Splign:2.1.0"
     exon            798..1757
                     /gene="OGFOD2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1129..1134
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OGFOD2"
                     /note="hexamer: AATAAA"
     polyA_site      1166
                     /gene="OGFOD2"
     regulatory      1739..1744
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OGFOD2"
                     /note="hexamer: TATAAA"
     polyA_site      1757
                     /gene="OGFOD2"
                     /note="major polyA site"
ORIGIN      
        1 gcttcactat ggcgacggtg ggggctccgc ggcacttctg ccgctgcgcc tgcttctgca
       61 ccgataactt gtacgtggcg cgctatgggc tgcacgtgcg cttccgaggc gagcagcagc
      121 tgcgccggga ctacggcccg atcctgcgca gccgaggctg tgttagcgcc aaggacttcc
      181 agcagctgtt agcagagctt gagcaggagg tggagcggcg gcagcggctg gggcaggagt
      241 cagcagctag gaaagccctc atcgcgagtt cctaccaccc ggcacggcct gaggtctacg
      301 actcactgca ggatgcagct ctggcccccg agttcctggc cgtgactgag tacagcgtgt
      361 ccccagacgc agacctcaag ggccttctcc agcggctgga gacagtatcg gaggagaagc
      421 gcatctaccg ggtgcctgtt ttcacagcgc ccttctgcca ggccctgctg gaagagctgg
      481 agcacttcga gcaatcggac atgcctaagg ggaggcccaa caccatgaac aactacgggg
      541 tgctgctgca cgagctcggg ctggacgagc cgctgatgac accactgcgg gagcgcttcc
      601 tgcagccgct gatggccctg ctgtaccctg actgtggcgg gggccggctc gacagccacc
      661 gggcctttgt ggtcaaatac gcaccgggcc aggacctgga gctgggctgc cactatgata
      721 atgccgagct caccctcaat gtggccttgg gcaaggtctt cacagggggc gccctgtatt
      781 ttgggggcct cttccaggca cccacagccc tgacggagcc cctggaggtg gagcacgtgg
      841 tgggccaggg tgtcctccac cgtggcggcc agctgcatgg agcccggccc ttgggcactg
      901 gtgagcgttg gaaccttgtc gtctggctcc gagcctctgc tgtgcgcaac agcctctgtc
      961 ccatgtgctg ccgtgagccc gacctggtgg acgatgaggg cttcggtgat ggcttcaccc
     1021 gagaggagcc cgccacggtg gatgtatgtg cgctcacctg agcttgcttg ggcccagtgt
     1081 gggggtggca ggcaggtgag ggctccgttg ccttggtctg ggggcagaaa taaaatcccc
     1141 gcagcctact gcacttcttg gctcaacggt gtgccagctt ctgggtcatt ctatgggcaa
     1201 agatgctgcc ttagttcagg tttgtcagaa gcagggtctg gaatggggct tcagcgaggg
     1261 agtcagggaa gcaggggagg ggagggagca gctgggcaag gaagtggctt cagaggacgt
     1321 ccagcctcag ctggccccac ggagagctcc aggcagagcc cacagtacca cagtgtgccc
     1381 acaccaccgg ttactggctc ctggatgagg gggccagaga ggagtgaata acttcccaga
     1441 cacttatctc cagggcaggg tgccttccag tagccaaggg aagcctccag agagcacaga
     1501 tgtgaaccct cagcagcagg catcaccccc cagtggactc gggtgggcca ccagtagcat
     1561 cttctagatg gcagaggggt gaatggcagg gccaggaacc aggctgcccg ggttcccatt
     1621 ctgcttctgc cacttccagc tgtgtggctt taggtgagcc ttcacctttt ggtgccttcg
     1681 tttcctcatt tagcacctac ctcctagagc tgttttggga gtcaaatgcg ctgacgtata
     1741 taaagtgctt tgcaaga
//
