LOCUS       NM_018233               4587 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens 2-oxoglutarate and iron dependent oxygenase domain
            containing 1 (OGFOD1), transcript variant 1, mRNA.
ACCESSION   NM_018233 NM_001031707
VERSION     NM_018233.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4587)
  AUTHORS   Rodriguez,R., Harris,M., Murphy,E. and Kennedy,L.M.
  TITLE     OGFOD1 modulates the transcriptional and proteomic landscapes to
            alter isoproterenol-induced hypertrophy susceptibility
  JOURNAL   J Mol Cell Cardiol 179, 42-46 (2023)
   PUBMED   37084634
  REMARK    GeneRIF: OGFOD1 modulates the transcriptional and proteomic
            landscapes to alter isoproterenol-induced hypertrophy
            susceptibility.
REFERENCE   2  (bases 1 to 4587)
  AUTHORS   Yin,D., Wang,Q., Wang,S., Zhu,G., Tang,Q. and Liu,J.
  TITLE     OGFOD1 negatively regulated by miR-1224-5p promotes proliferation
            in human papillomavirus-infected laryngeal papillomas
  JOURNAL   Mol Genet Genomics 295 (3), 675-684 (2020)
   PUBMED   32002629
  REMARK    GeneRIF: High OGFOD1 expression is associated with
            papillomavirus-infected laryngeal papillomas.
REFERENCE   3  (bases 1 to 4587)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4587)
  AUTHORS   Stoehr,A., Kennedy,L., Yang,Y., Patel,S., Lin,Y., Linask,K.L.,
            Fergusson,M., Zhu,J., Gucek,M., Zou,J. and Murphy,E.
  TITLE     The ribosomal prolyl-hydroxylase OGFOD1 decreases during cardiac
            differentiation and modulates translation and splicing
  JOURNAL   JCI Insight 5 (13), 128496 (2019)
   PUBMED   31112528
  REMARK    GeneRIF: The ribosomal prolyl-hydroxylase OGFOD1 decreases during
            cardiac differentiation and modulates translation and splicing.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4587)
  AUTHORS   Kim,J.H., Lee,S.M., Lee,J.H., Chun,S., Kang,B.H., Kwak,S.,
            Roe,J.S., Kim,T.W., Kim,H., Kim,W.H., Cho,E.J. and Youn,H.D.
  TITLE     OGFOD1 is required for breast cancer cell proliferation and is
            associated with poor prognosis in breast cancer
  JOURNAL   Oncotarget 6 (23), 19528-19541 (2015)
   PUBMED   25909288
  REMARK    GeneRIF: Propose that OGFOD1 is required for breast cancer cell
            proliferation and is associated with poor prognosis in breast
            cancer.
REFERENCE   6  (bases 1 to 4587)
  AUTHORS   Loenarz,C., Sekirnik,R., Thalhammer,A., Ge,W., Spivakovsky,E.,
            Mackeen,M.M., McDonough,M.A., Cockman,M.E., Kessler,B.M.,
            Ratcliffe,P.J., Wolf,A. and Schofield,C.J.
  TITLE     Hydroxylation of the eukaryotic ribosomal decoding center affects
            translational accuracy
  JOURNAL   Proc Natl Acad Sci U S A 111 (11), 4019-4024 (2014)
   PUBMED   24550462
REFERENCE   7  (bases 1 to 4587)
  AUTHORS   Singleton,R.S., Liu-Yi,P., Formenti,F., Ge,W., Sekirnik,R.,
            Fischer,R., Adam,J., Pollard,P.J., Wolf,A., Thalhammer,A.,
            Loenarz,C., Flashman,E., Yamamoto,A., Coleman,M.L., Kessler,B.M.,
            Wappner,P., Schofield,C.J., Ratcliffe,P.J. and Cockman,M.E.
  TITLE     OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in
            translation control and stress granule formation
  JOURNAL   Proc Natl Acad Sci U S A 111 (11), 4031-4036 (2014)
   PUBMED   24550447
  REMARK    GeneRIF: OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is
            involved in translation control and stress granule formation.
REFERENCE   8  (bases 1 to 4587)
  AUTHORS   Saito,K., Adachi,N., Koyama,H. and Matsushita,M.
  TITLE     OGFOD1, a member of the 2-oxoglutarate and iron dependent
            dioxygenase family, functions in ischemic signaling
  JOURNAL   FEBS Lett 584 (15), 3340-3347 (2010)
   PUBMED   20579638
  REMARK    GeneRIF: OGFOD1 plays an important role in ischemic cell survival
            and an OGFOD1 iron binding residue is required for ATPAF1 gene
            expression.
REFERENCE   9  (bases 1 to 4587)
  AUTHORS   Wehner,K.A., Schutz,S. and Sarnow,P.
  TITLE     OGFOD1, a novel modulator of eukaryotic translation initiation
            factor 2alpha phosphorylation and the cellular response to stress
  JOURNAL   Mol Cell Biol 30 (8), 2006-2016 (2010)
   PUBMED   20154146
  REMARK    GeneRIF: Data suggest that OGFOD1 plays important proapoptotic
            roles in the regulation of translation and HRI-mediated
            phosphorylation of eIF2alpha in cells subjected to arsenite-induced
            stress.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC032919.1 and AC092140.4.
            
            On May 17, 2019 this sequence version replaced NM_018233.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.200390.1,
                                           SRR1803617.63173.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000566157.6/ ENSP00000457258.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2281              BC032919.1         14-2294
            2282-2978           AC092140.4         170330-171026
            2979-4587           AC092140.4         171027-172635
FEATURES             Location/Qualifiers
     source          1..4587
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q13"
     gene            1..4587
                     /gene="OGFOD1"
                     /gene_synonym="TPA1"
                     /note="2-oxoglutarate and iron dependent oxygenase domain
                     containing 1"
                     /db_xref="GeneID:55239"
                     /db_xref="HGNC:HGNC:25585"
                     /db_xref="MIM:615857"
     exon            1..213
                     /gene="OGFOD1"
                     /gene_synonym="TPA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..1688
                     /gene="OGFOD1"
                     /gene_synonym="TPA1"
                     /EC_number="1.14.11.-"
                     /note="isoform 1 is encoded by transcript variant 1; TPA1,
                     termination and polyadenylation 1, homolog; 2-oxoglutarate
                     and iron-dependent oxygenase domain-containing protein 1;
                     termination and polyadenylation 1 homolog; prolyl
                     3-hydroxylase OGFOD1; uS12 prolyl 3-hydroxylase"
                     /codon_start=1
                     /product="prolyl 3-hydroxylase OGFOD1 isoform 1"
                     /protein_id="NP_060703.3"
                     /db_xref="CCDS:CCDS10761.2"
                     /db_xref="GeneID:55239"
                     /db_xref="HGNC:HGNC:25585"
                     /db_xref="MIM:615857"
                     /translation="MNGKRPAEPGPARVGKKGKKEVMAEFSDAVTEETLKKQVAEAWS
                     RRTPFSHEVIVMDMDPFLHCVIPNFIQSQDFLEGLQKELMNLDFHEKYNDLYKFQQSD
                     DLKKRREPHISTLRKILFEDFRSWLSDISKIDLESTIDMSCAKYEFTDALLCHDDELE
                     GRRIAFILYLVPPWDRSMGGTLDLYSIDEHFQPKQIVKSLIPSWNKLVFFEVSPVSFH
                     QVSEVLSEEKSRLSISGWFHGPSLTRPPNYFEPPIPRSPHIPQDHEILYDWINPTYLD
                     MDYQVQIQEEFEESSEILLKEFLKPEKFTKVCEALEHGHVEWSSRGPPNKRFYEKAEE
                     SKLPEILKECMKLFRSEALFLLLSNFTGLKLHFLAPSEEDEMNDKKEAETTDITEEGT
                     SHSPPEPENNQMAISNNSQQSNEQTDPEPEENETKKESSVPMCQGELRHWKTGHYTLI
                     HDHSKAEFALDLILYCGCEGWEPEYGGFTSYIAKGEDEELLTVNPESNSLALVYRDRE
                     TLKFVKHINHRSLEQKKTFPNRTGFWDFSFIYYE"
     exon            214..359
                     /gene="OGFOD1"
                     /gene_synonym="TPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            360..406
                     /gene="OGFOD1"
                     /gene_synonym="TPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            407..507
                     /gene="OGFOD1"
                     /gene_synonym="TPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            508..624
                     /gene="OGFOD1"
                     /gene_synonym="TPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            625..716
                     /gene="OGFOD1"
                     /gene_synonym="TPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            717..845
                     /gene="OGFOD1"
                     /gene_synonym="TPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            846..959
                     /gene="OGFOD1"
                     /gene_synonym="TPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1039
                     /gene="OGFOD1"
                     /gene_synonym="TPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1344
                     /gene="OGFOD1"
                     /gene_synonym="TPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1467
                     /gene="OGFOD1"
                     /gene_synonym="TPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1526
                     /gene="OGFOD1"
                     /gene_synonym="TPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..4587
                     /gene="OGFOD1"
                     /gene_synonym="TPA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2262..2267
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OGFOD1"
                     /gene_synonym="TPA1"
                     /note="hexamer: CATAAA"
     polyA_site      2281
                     /gene="OGFOD1"
                     /gene_synonym="TPA1"
     regulatory      2959..2964
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OGFOD1"
                     /gene_synonym="TPA1"
                     /note="hexamer: ATTAAA"
     polyA_site      2978
                     /gene="OGFOD1"
                     /gene_synonym="TPA1"
                     /note="major polyA site"
     regulatory      3962..3967
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OGFOD1"
                     /gene_synonym="TPA1"
                     /note="hexamer: ACTAAA"
     polyA_site      3981
                     /gene="OGFOD1"
                     /gene_synonym="TPA1"
     regulatory      4559..4564
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OGFOD1"
                     /gene_synonym="TPA1"
                     /note="hexamer: GATAAA"
     polyA_site      4587
                     /gene="OGFOD1"
                     /gene_synonym="TPA1"
ORIGIN      
        1 gtaccctcag gaaggtagcg tcttgatctg cgtggcgtgg ttctgtgcct tgggaagaga
       61 tgaatgggaa gcggccagcg gagcccggcc cagcccgggt gggaaaaaag ggaaagaagg
      121 aggtgatggc ggagttttcg gacgctgtta cggaagaaac cttgaaaaag caggtggctg
      181 aggcctggag ccgcaggacg ccgttcagtc acgaagtcat tgtcatggac atggaccctt
      241 ttcttcactg tgtgatccca aacttcatcc aaagccaaga cttcttagaa gggcttcaga
      301 aggaactgat gaacttggac ttccatgaga agtataatga tttatataag ttccagcagt
      361 ctgatgattt gaagaagaga agagagcctc acatctccac tttaaggaaa attctgtttg
      421 aagatttccg gtcctggctt tctgatattt ctaaaattga cctggaatca accattgaca
      481 tgtcctgtgc taaatatgaa ttcactgatg ccctgctgtg ccatgatgat gagctggaag
      541 ggcgccggat tgccttcatc ctgtacctgg ttcctccctg ggacaggagc atgggtggta
      601 ccctggacct gtacagcatt gatgaacact ttcagccgaa gcagattgtc aagtctctta
      661 tcccttcgtg gaacaaactg gttttctttg aagtatctcc tgtgtccttt caccaggtgt
      721 ctgaagtgct gtctgaagaa aagtcacgtt tgtctataag tggctggttt catggtccat
      781 cattgactcg gcctcccaac tactttgaac cccccatacc tcggagccct cacatcccac
      841 aagatcatga gattttgtat gattggatca accctactta tctggacatg gattaccaag
      901 ttcaaattca agaagagttt gaagaaagtt ctgaaattct cctgaaggag tttcttaagc
      961 ctgagaaatt cacgaaagtc tgtgaggcct tggagcatgg acatgtggaa tggagcagcc
     1021 gaggtccccc taacaaaagg ttttatgaga aagctgagga gagtaagctt cctgagatat
     1081 tgaaggagtg catgaagtta tttcgctctg aggcactatt cttgctgctc tccaacttca
     1141 caggcctgaa gcttcatttc ttggcccctt cggaagaaga tgagatgaat gataaaaaag
     1201 aggcagaaac cactgatatc actgaagaag ggactagcca tagtcctcct gagccagaga
     1261 ataatcagat ggccatcagc aacaacagcc aacagagcaa tgagcagaca gacccagagc
     1321 cagaggaaaa tgaaacaaag aaagaatcaa gtgttcccat gtgccaaggg gaactgaggc
     1381 attggaagac cggtcactac actttaattc atgaccatag caaggctgaa tttgccctag
     1441 acttaattct gtactgtggc tgtgaaggct gggagccaga atatggcggt tttacttctt
     1501 acattgccaa aggtgaagat gaagagctgc taacagtgaa tccagaaagc aattctttgg
     1561 cattggtcta cagagacaga gagactctga aatttgtcaa gcatattaac caccgaagcc
     1621 tggaacaaaa gaaaaccttc ccaaacagaa caggtttctg ggacttttca ttcatctatt
     1681 atgaatgaca gcactgggca aagctgaaca aaaatgtgac ccttcgtaat tactgggaag
     1741 tctgaaagag ctaagcatgg agtcaaggag aactacatgg tagcttgcct gacagtgttc
     1801 ttaaaactgg ttgtctttta ctaggactca taatgattgt cctcaaccga gaccttgagc
     1861 ttgcagctaa gtacttatct cttgattaaa aaaaaaaagt tggctttttt ttttttaaca
     1921 tttagtcctt tttccatatt ggcttcttca gtgaattttt aagttcaatt tgtttttatt
     1981 gaggtaaaat atttataaca taaaactgac cagcttaccc atttttaaat atgcaattca
     2041 gtggattaag tacattctca ttgttgtcca gccatcacca tcatccatct ccagaagttt
     2101 tccatcttcc caaattctgt gcccattgaa caataactcc ccacctcccc ttcccctagc
     2161 aacagccata ccttttgtct ctatcatcaa cttcactact catatttctc atgtaagtgg
     2221 aatcatacag tatttgtcct tttgtgactg gtttcactta gcataaagtc tttaagatgc
     2281 atccatgttt ccagtgtttc ggttttttta gaaaaactca tacgtgattg cagccgggca
     2341 tggtggctca cgcctgtaat cccagcactt gggaggccaa ggcaggcgga tcacctgagg
     2401 tcaggagtta aagaccagcc tgacaaacat ggagaaaccc catctctact aaaaatacaa
     2461 aattagctgg gcgtggtggc acatgcctgt aatcccagct actcaggagg ctggggcagg
     2521 agaattggtt gaacccagga ggcggaggtt gcagtgagcc gagattgtgc cactgcactc
     2581 cagcctgggc aacaagagtg aaactctgtc tcaaaaaaaa aaaagaagaa aaaaacataa
     2641 gtgattgcag aattttgttc ttctcataat ttctggttta gaaaattatg gagccttaca
     2701 tcctgatcat gctgggcctt agaattctga cacagtgagt catcacattt cctcccactg
     2761 cctgtggcct tgttccacca tgactctcac agtacagtgt aggcttagtg tagtattatt
     2821 cccttggaaa gggtctggcc taccatcaca tgccccaaga aacttctggt tggtaaagaa
     2881 gataggctgc ttattgccat gtgtagtcac ttccaagtgc ccactgcctt tccatcctgc
     2941 aattgtggcc tgtgtataat taaatgattt tagcctcacg tgttgcttct gttttcctaa
     3001 atactgtagg gtcaactata taactaattg ctttttattt taagagacgg aatgctaaaa
     3061 ccacatcaga atgccaagag gctgtgcatc ttgttaattt ttttcttgaa ctgttccagg
     3121 gagttacatc ataattacct gtgtgtgggt atgcatgggt ggatgaaaga tgctgttctc
     3181 attccatccc aatagagtct tctgtttcct ttctcttttt tacatttatt tttagctttt
     3241 gcagtagtgt ttagtgtggg ttttactaat taatagaaaa agcactgggc ctttaaactt
     3301 cttaactact cttctctttc atctcctaaa acttttgagt attcattctt ttctgaagtt
     3361 tgcatttaaa tgaaaatgac tttcgctttg gcttttaggt ttagtttcaa aaaggtttaa
     3421 ttctgcaccc tagccagtta agaaatgttt tagcaggtat gcccttgata tggatattta
     3481 tatattttac acatgtagta atattatttc tataacttac tgttataaaa cactaatttt
     3541 taaatgatga gataaaaaga aatatctaga actagttcta acattgtctt cccctatgca
     3601 tatggtaacg aaccatttta caccatacta ttttggagac cacaattttt tttgcgtttg
     3661 agatggagtc tcactctgtg gcccaggctg gagtacagtg gcatgatatc ggctcactgt
     3721 gacctctgtc tcctgggttc aagcaattct cctgcctcag cctcctaagt agctgggatt
     3781 acaggcacct gcctccatac ccagctaatt tttttatatt tttagtagag acagggtttc
     3841 accatgttgg ccaggctgga gaccacaatt ttttaaccac agtgtagcaa cactcaagtg
     3901 ggattgcgaa tactgttact aatggttaat gtcacagctt gccttttcta tattccagct
     3961 gactaaaggt catctcactc acttgccttc tgatgtgttt tcatgagttg aggggaaagg
     4021 gtgtcagtgg cataacttca ggaagaccca gggaaaagtg cttgggtagg tgaaactgtc
     4081 atgtgtgcca agcttggaaa atagtttgag actcatggct gtaggcacca tccaaggcca
     4141 attttccaat tctggaaagc caaatctgaa tcttagaata cctcacaagt gttaaaatgt
     4201 gctttttagt gtctccttta tctcagtgtg tttatgatct gtcaacacat aatcatcttt
     4261 tatacactac aaaaagggac tcgggtgtct gaggggagag aatccctagg agcccaactc
     4321 tgatgttgct gtcagttaca tcatctacag cagcacctct tagattgtga aggatggtgt
     4381 aacttaaaag attgtgtttc tgcactgaag atagatacac agtgatagtg aagtttgttt
     4441 tccttatagt acttcatttt gcatcttgat tgctttttag ggcctggggc caatgtcaac
     4501 aactcttagg tagcaaaaga agaattagaa catgggcatc ttttttatac ctctttcaga
     4561 taaaagctat gatgttcacc tgtaaaa
//
