LOCUS       NM_017847               3820 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens odr-4 GPCR localization factor homolog (ODR4),
            transcript variant 1, mRNA.
ACCESSION   NM_017847
VERSION     NM_017847.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3820)
  AUTHORS   Xu,X. and Wu,G.
  TITLE     Human C1orf27 protein interacts with alpha2A-adrenergic receptor
            and regulates its anterograde transport
  JOURNAL   J Biol Chem 298 (6), 102021 (2022)
   PUBMED   35551911
  REMARK    GeneRIF: Human C1orf27 protein interacts with alpha2A-adrenergic
            receptor and regulates its anterograde transport.
REFERENCE   2  (bases 1 to 3820)
  AUTHORS   Chen,C., Itakura,E., Weber,K.P., Hegde,R.S. and de Bono,M.
  TITLE     An ER complex of ODR-4 and ODR-8/Ufm1 specific protease 2 promotes
            GPCR maturation by a Ufm1-independent mechanism
  JOURNAL   PLoS Genet 10 (3), e1004082 (2014)
   PUBMED   24603482
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3820)
  AUTHORS   Zhang,M. and Swanson,P.C.
  TITLE     V(D)J recombinase binding and cleavage of cryptic recombination
            signal sequences identified from lymphoid malignancies
  JOURNAL   J Biol Chem 283 (11), 6717-6727 (2008)
   PUBMED   18187418
  REMARK    GeneRIF: LMO2, TAL1, Ttg-1, and SIL support levels of V(D)J
            recombination above background levels in cell culture and are also
            cleaved by the RAG proteins, while Hox11 and SCL are nicked but not
            cleaved efficiently in vitro
REFERENCE   4  (bases 1 to 3820)
  AUTHORS   Lehman,C.W., Lee,J.D. and Komives,C.F.
  TITLE     Ubiquitously expressed GPCR membrane-trafficking orthologs
  JOURNAL   Genomics 85 (3), 386-391 (2005)
   PUBMED   15718105
REFERENCE   5  (bases 1 to 3820)
  AUTHORS   Fujiwara,N., Matsuo,T. and Ohtsuki,H.
  TITLE     Protein expression, genomic structure, and polymorphisms of
            oculomedin
  JOURNAL   Ophthalmic Genet 24 (3), 141-151 (2003)
   PUBMED   12868032
REFERENCE   6  (bases 1 to 3820)
  AUTHORS   Sood,R., Bonner,T.I., Makalowska,I., Stephan,D.A., Robbins,C.M.,
            Connors,T.D., Morgenbesser,S.D., Su,K., Faruque,M.U., Pinkett,H.,
            Graham,C., Baxevanis,A.D., Klinger,K.W., Landes,G.M., Trent,J.M.
            and Carpten,J.D.
  TITLE     Cloning and characterization of 13 novel transcripts and the human
            RGS8 gene from the 1q25 region encompassing the hereditary prostate
            cancer (HPC1) locus
  JOURNAL   Genomics 73 (2), 211-222 (2001)
   PUBMED   11318611
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB116803.1, BC003397.1, AL596220.9 and AY854248.1.
            
            On Nov 23, 2018 this sequence version replaced NM_017847.5.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.78010.1,
                                           SRR1803617.167120.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000287859.11/ ENSP00000287859.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                DB116803.1         82-168
            88-2008             BC003397.1         1-1921
            2009-3616           AL596220.9         91664-93271
            3617-3816           AY854248.1         3587-3786
            3817-3820           AL596220.9         93472-93475
FEATURES             Location/Qualifiers
     source          1..3820
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q31.1"
     gene            1..3820
                     /gene="ODR4"
                     /gene_synonym="C1orf27; odr-4; TTG1"
                     /note="odr-4 GPCR localization factor homolog"
                     /db_xref="GeneID:54953"
                     /db_xref="HGNC:HGNC:24299"
                     /db_xref="MIM:609335"
     exon            1..137
                     /gene="ODR4"
                     /gene_synonym="C1orf27; odr-4; TTG1"
                     /inference="alignment:Splign:2.1.0"
     exon            138..255
                     /gene="ODR4"
                     /gene_synonym="C1orf27; odr-4; TTG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..1521
                     /gene="ODR4"
                     /gene_synonym="C1orf27; odr-4; TTG1"
                     /EC_number="1.1.1.14"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein odr-4 homolog; odorant response abnormal 4;
                     LAG1-interacting protein; transactivated by transforming
                     growth factor beta protein 1; transactivated by
                     recombinant transforming growth factor beta 1"
                     /codon_start=1
                     /product="protein odr-4 homolog isoform 1"
                     /protein_id="NP_060317.3"
                     /db_xref="CCDS:CCDS53448.1"
                     /db_xref="GeneID:54953"
                     /db_xref="HGNC:HGNC:24299"
                     /db_xref="MIM:609335"
                     /translation="MGRTYIVEETVGQYLSNINLQGKAFVSGLLIGQCSSQKDYVILA
                     TRTPPKEEQSENLKHPKAKLDNLDEEWATEHACQVSRMLPGGLLVLGVFIITTLELAN
                     DFQNALRRLMFAVEKSINRKRLWNFTEEEVSERVTLHICASTKKIFCRTYDIHDPKSS
                     ARPADWKYQSGLSSSWLSLECTVHINIHIPLSATSVSYTLEKNTKNGLTRWAKEIENG
                     VYLINGQVKDEDCDLLEGQKKSSRGNTQATSHSFDVRVLTQLLLNSDHRSTATVQICS
                     GSVNLKGAVKCRAYIHSSKPKVKDAVQAVKRDILNTVADRCEMLFEDLLLNEIPEKKD
                     SEKEFHVLPYRVFVPLPGSTVMLCDYKFDDESAEEIRDHFMEMLDHTIQIEDLEIAEE
                     TNTACMSSSMNSQASLDNTDDEQPKQPIKTTMLLKIQQNIGVIAAFTVAVLAAGISFH
                     YFSD"
     exon            256..390
                     /gene="ODR4"
                     /gene_synonym="C1orf27; odr-4; TTG1"
                     /inference="alignment:Splign:2.1.0"
     exon            391..486
                     /gene="ODR4"
                     /gene_synonym="C1orf27; odr-4; TTG1"
                     /inference="alignment:Splign:2.1.0"
     exon            487..593
                     /gene="ODR4"
                     /gene_synonym="C1orf27; odr-4; TTG1"
                     /inference="alignment:Splign:2.1.0"
     exon            594..630
                     /gene="ODR4"
                     /gene_synonym="C1orf27; odr-4; TTG1"
                     /inference="alignment:Splign:2.1.0"
     exon            631..771
                     /gene="ODR4"
                     /gene_synonym="C1orf27; odr-4; TTG1"
                     /inference="alignment:Splign:2.1.0"
     exon            772..867
                     /gene="ODR4"
                     /gene_synonym="C1orf27; odr-4; TTG1"
                     /inference="alignment:Splign:2.1.0"
     exon            868..936
                     /gene="ODR4"
                     /gene_synonym="C1orf27; odr-4; TTG1"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1065
                     /gene="ODR4"
                     /gene_synonym="C1orf27; odr-4; TTG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1156
                     /gene="ODR4"
                     /gene_synonym="C1orf27; odr-4; TTG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1342
                     /gene="ODR4"
                     /gene_synonym="C1orf27; odr-4; TTG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1453
                     /gene="ODR4"
                     /gene_synonym="C1orf27; odr-4; TTG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..3820
                     /gene="ODR4"
                     /gene_synonym="C1orf27; odr-4; TTG1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1661..1666
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ODR4"
                     /gene_synonym="C1orf27; odr-4; TTG1"
                     /note="hexamer: ATTAAA"
     polyA_site      1678
                     /gene="ODR4"
                     /gene_synonym="C1orf27; odr-4; TTG1"
                     /note="major polyA site"
     regulatory      2921..2926
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ODR4"
                     /gene_synonym="C1orf27; odr-4; TTG1"
                     /note="hexamer: AAGAAA"
     polyA_site      2939
                     /gene="ODR4"
                     /gene_synonym="C1orf27; odr-4; TTG1"
     polyA_site      3703
                     /gene="ODR4"
                     /gene_synonym="C1orf27; odr-4; TTG1"
     regulatory      3796..3801
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ODR4"
                     /gene_synonym="C1orf27; odr-4; TTG1"
                     /note="hexamer: AATAAA"
     polyA_site      3820
                     /gene="ODR4"
                     /gene_synonym="C1orf27; odr-4; TTG1"
ORIGIN      
        1 gatgaattca gtggcagtga attgagaccg gagggaatct ggcccctaga ggctggtact
       61 tgggcccgaa acccccatct ccggcggaga gaccgtccga ggtaattgtc tgccacgagt
      121 gcacattctg aaaacaggag attttagttc ctaaaaatgg gaagaaccta cattgtagaa
      181 gagactgttg gccagtatct ttcaaacata aatctccaag gaaaggcttt tgtctctggc
      241 cttttaatag gacagtgttc gtcacaaaag gattatgtga ttcttgccac tagaacgcca
      301 cccaaagagg agcaaagtga gaacctcaaa catcccaaag ctaagttgga taacttggat
      361 gaagaatggg ccacagaaca tgcctgccag gtatccagaa tgctaccagg gggactttta
      421 gttcttggag tatttattat tactacttta gaactggcaa atgattttca aaatgccctg
      481 cgtagactaa tgtttgctgt ggaaaagtct ataaatagaa agagattgtg gaatttcaca
      541 gaggaggaag tctcagaacg agtgacactt cacatttgtg cttctacaaa aaaaatattt
      601 tgtcgaactt atgatatcca tgatccaaag agttcagcaa gaccagcaga ttggaagtat
      661 caaagtggat tatcatcctc atggctttct ttagagtgta cagttcacat taatattcac
      721 atcccacttt ctgctacttc tgtcagctat actctggaga aaaatacaaa gaatggactt
      781 acacgctggg ccaaggaaat agaaaatggt gtttatttga ttaatggaca agttaaagat
      841 gaagattgtg acctattaga aggacagaaa aaatcttcta gaggaaatac tcaagcaact
      901 agtcattctt ttgatgtcag agtgctaacg cagttgctcc tgaattcaga ccacagatcc
      961 acagccacag tccagatatg tagcggttct gtaaacctta agggtgctgt gaaatgcaga
     1021 gcttatatcc acagcagtaa acccaaagtt aaagatgctg tgcaggcagt aaagagggat
     1081 atattgaaca cagttgctga tcgttgtgaa atgctatttg aggatctgct tttgaatgaa
     1141 attccagaaa aaaaagattc tgaaaaagag ttccacgtcc tcccttatcg agtctttgtt
     1201 ccccttcctg gatccactgt aatgttgtgt gattataaat ttgacgatga gtcagctgaa
     1261 gaaatcaggg accattttat ggagatgttg gatcacacaa ttcaaataga agatttggaa
     1321 attgcagagg aaacaaacac agcttgtatg agttcttcta tgaatagtca agcttcattg
     1381 gacaacacag atgatgaaca accaaaacaa ccaattaaaa ctacaatgtt attgaaaatt
     1441 cagcaaaaca taggtgtgat tgcagcattt acagttgcag tccttgctgc gggtatctcc
     1501 tttcattact tcagtgatta gggtgaggca caaagagttt cttgatcatc cagagaacat
     1561 tgacagacaa ttatgaataa taaagatgtt aacaatccat ctgtatttaa aacactagca
     1621 gccagatctg ctgccatgat gcctatttgg tgtgtttctg attaaaatga aatcacaagc
     1681 tgccttgttt agcctgcttt acattgtagg tggcccgcat ttccagaaat aacgttatgc
     1741 atctagatgg aagctgcatg taacaaatca ttattatcta tttttaaaag cttcaaaatg
     1801 atgggatatg atcatagatt ttagtcttac taatctgaat cacatattaa tcaggacatt
     1861 aaaaacttta acagaggcat gatggctcac acgtataatc ctaatgcttt gagaggctga
     1921 ggtaggagca tcacctgggg ctgggaggga gttggagacc agcctggatg acataatgag
     1981 attctgtctc tactggaaaa aaaaaaaatt agctggacat ggtggcaatc agctctagtc
     2041 ccaactactt ggaggctgaa gcaggaagat cacgtgagcc caggagtttg aggctgcagc
     2101 gagctatgat cacatcactg tactccagcc tgggtgacaa aatgagacat tgtctctaaa
     2161 atacataagt aaatttaaaa aaaaaagaat aataatttga acagtgaatg ttgatgtaac
     2221 atcttaataa tagagcacca gaaaaatttc taccaaatga gacaacaact ttaggataag
     2281 ttcatcctct aggagctttc taatgtgcac tcagttcctg tatactgtgt gttttgttct
     2341 gatcaagggg tagggaacct ttccagagaa gtcccattag taagaaatga cataaaatac
     2401 gtgctttctc aggttactgt ataactgtta taatatattt aatatataaa attaagactt
     2461 ttgcttccag caagtatgtt agactagata ttataaaaca actagatcct gaataaaatc
     2521 tgcttttaat aggttcactg gaagtaggag aattttcaag aaccatactt cgacatttcc
     2581 tctgccacaa aaaatgaacg cattttaagt taggagtcat gaatactgta ttgaccatac
     2641 aagtggatta tggttgtctg gatggcagat accaatagca acattgtcat atgcagtttg
     2701 cctcaaatca gaaacaagaa gacatcggaa tctgagatgc tgccctagag aggacagtta
     2761 aagaaggttc agtggtcctc agtttgcagt gctctagctc ctggcagaag caagagggaa
     2821 acattcctaa tttagttcca agattcctac agattattat caagtagtag tattttatga
     2881 ctagagatca caggcacaag ttgaaacaaa ctaacatgac aagaaagcta tagaaaaaat
     2941 aaacattgaa ctcagttctt caaggtttca tcaccaacat aaggaatgaa gttggaacca
     3001 caggcagatc tgaaaaagaa ccaaatagag ctcctaaaaa tgagaaatat ttattgaaat
     3061 aagaaaaaag ccctcagaca tgttgaatat tttattagac tcagctgaag agacaagtga
     3121 actaaactat aagctggatc taaagaaatt acccagtgag cagtgaggag aaacaaggag
     3181 ctagaaaaca ttggaaagtt aagagagttc gagggaagaa ttataaagac taggagtcct
     3241 agaaagagaa aatttagaga ataaaggaga ggcagtactt gaaagataac acaattttac
     3301 aaatttgttg gaaaaacatg aattcataaa ttcaggaagc acaatatata ccaaacatat
     3361 atttaaataa aatccaggcc tagactcaag gtattgtaaa tgacaagata ccaaatacaa
     3421 gattttaaaa gcaaccatgg ggagaaaaag atcagtgaaa gcaagacagt caaatactta
     3481 gtaggcttcc taacagcaac aatgtaccca aaagagggta gaattctgag aaaaactatt
     3541 agcttagaat ttgcaacaag cgaaactgaa acaaacagat gctcagatga aaaacagatg
     3601 ttatcctcag cacaaattca gtaaagagac tacaaaagga tgatcttcaa gaagggaaat
     3661 gattctaaaa ggattatctg aaattgaaaa actagtaagc aaataaatga taaacataag
     3721 taaatttaaa ctgttgtttg tataaaacaa ttataatgaa gtgtttataa gaaattgtaa
     3781 acaaatgtaa aactaaataa acattgttat gcaacattaa
//
