LOCUS       NM_153007               1180 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens outer dense fiber of sperm tails 4 (ODF4), transcript
            variant 1, mRNA.
ACCESSION   NM_153007
VERSION     NM_153007.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1180)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1180)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1180)
  AUTHORS   Afsharpad,M., Nowroozi,M.R., Mobasheri,M.B., Ayati,M.,
            Nekoohesh,L., Saffari,M., Zendehdel,K. and Modarressi,M.H.
  TITLE     Cancer-Testis Antigens as New Candidate Diagnostic Biomarkers for
            Transitional Cell Carcinoma of Bladder
  JOURNAL   Pathol Oncol Res 25 (1), 191-199 (2019)
   PUBMED   29058301
  REMARK    GeneRIF: High ODF4 expression is associated with Transitional Cell
            Carcinoma of Bladder.
REFERENCE   4  (bases 1 to 1180)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 1180)
  AUTHORS   Petit,F.M., Serres,C., Bourgeon,F., Pineau,C. and Auer,J.
  TITLE     Identification of sperm head proteins involved in zona pellucida
            binding
  JOURNAL   Hum Reprod 28 (4), 852-865 (2013)
   PUBMED   23355646
REFERENCE   6  (bases 1 to 1180)
  AUTHORS   Ghafouri-Fard,S., Ghafouri-Fard,S. and Modarressi,M.H.
  TITLE     Expression of splice variants of cancer-testis genes ODF3 and ODF4
            in the testis of a prostate cancer patient
  JOURNAL   Genet Mol Res 11 (4), 3642-3648 (2012)
   PUBMED   23096689
  REMARK    GeneRIF: Two alternative splice variants of ODF3 and ODF4, were
            found.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1180)
  AUTHORS   Ghafouri-Fard,S., Modarressi,M.H. and Yazarloo,F.
  TITLE     Expression of testis-specific genes, TEX101 and ODF4, in chronic
            myeloid leukemia and evaluation of TEX101 immunogenicity
  JOURNAL   Ann Saudi Med 32 (3), 256-261 (2012)
   PUBMED   22588436
  REMARK    GeneRIF: ODF4 is a cancer-testis (CT) gene useful for detection of
            CML. It was expressed in 30% of CML patients but not in any of the
            healthy donors.
REFERENCE   8  (bases 1 to 1180)
  AUTHORS   Miyamoto,T., Sengoku,K., Hayashi,H., Sasaki,Y., Takuma,N.,
            Yamashita,T. and Ishikawa,M.
  TITLE     Isolation and expression analysis of the testis-specific gene,
            human OPPO1
  JOURNAL   J Assist Reprod Genet 21 (4), 129-134 (2004)
   PUBMED   15270212
REFERENCE   9  (bases 1 to 1180)
  AUTHORS   Kitamura,K., Miyagawa,Y., Iguchi,N., Nishimura,H., Tanaka,H. and
            Nishimune,Y.
  TITLE     Molecular cloning and characterization of the human orthologue of
            the oppo 1 gene encoding a sperm tail protein
  JOURNAL   Mol Hum Reprod 9 (5), 237-243 (2003)
   PUBMED   12728016
  REMARK    GeneRIF: Genomic structure has evolved independently of mouse,
            whereas functional structure is well-conserved
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC135178.13 and AB081120.1.
            
            On May 17, 2019 this sequence version replaced NM_153007.4.
            
            Summary: This gene encodes a protein that is localized in the outer
            dense fibers of the tails of mature sperm. This protein is thought
            to have some important role in the sperm tail. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Feb
            2016].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: The RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.209949.1,
                                           SRR5189667.330850.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000328248.7/ ENSP00000331086.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                AC135178.13        44714-44743         c
            31-503              AB081120.1         1-473
            504-628             AC135178.13        44116-44240         c
            629-1179            AB081120.1         599-1149
            1180-1180           AC135178.13        38537-38537         c
FEATURES             Location/Qualifiers
     source          1..1180
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..1180
                     /gene="ODF4"
                     /gene_synonym="CT134; CT136; OPPO1"
                     /note="outer dense fiber of sperm tails 4"
                     /db_xref="GeneID:146852"
                     /db_xref="HGNC:HGNC:19056"
                     /db_xref="MIM:610097"
     exon            1..666
                     /gene="ODF4"
                     /gene_synonym="CT134; CT136; OPPO1"
                     /inference="alignment:Splign:2.1.0"
     CDS             213..986
                     /gene="ODF4"
                     /gene_synonym="CT134; CT136; OPPO1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cancer/testis antigen 134; cancer/testis antigen 136;
                     testis-specific protein oppo 1; outer dense fiber protein
                     4; outer dense fiber 4; hOPPO1; outer dense fiber of sperm
                     tails protein 4"
                     /codon_start=1
                     /product="outer dense fiber protein 4 isoform 1"
                     /protein_id="NP_694552.2"
                     /db_xref="CCDS:CCDS11140.1"
                     /db_xref="GeneID:146852"
                     /db_xref="HGNC:HGNC:19056"
                     /db_xref="MIM:610097"
                     /translation="MDAEYSGNEFPRSEGERDQHQRPGKERKSGEAGWGTGELGQDGR
                     LLSSTLSLSSNRSLGQRQNSPLPFQWRITHSFRWMAQVLASELSLVAFILLLVVAFSK
                     KWLDLSRSLFYQRWPVDVSNRIHTSAHVMSMGLLHFYKSRSCSDLENGKVTFIFSTLM
                     LFPINIWIFELERNVSIPIGWSYFIGWLVLILYFTCAILCYFNHKSFWSLILSHPSGA
                     VSCSSSFGSVEESPRAQTITDTPITQEGVLDPEQKDTHV"
     exon            667..801
                     /gene="ODF4"
                     /gene_synonym="CT134; CT136; OPPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            802..1180
                     /gene="ODF4"
                     /gene_synonym="CT134; CT136; OPPO1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1154..1159
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ODF4"
                     /gene_synonym="CT134; CT136; OPPO1"
                     /note="hexamer: AATAAA"
     polyA_site      1180
                     /gene="ODF4"
                     /gene_synonym="CT134; CT136; OPPO1"
                     /note="major polyA site"
ORIGIN      
        1 gtggcagtta ggggacctgg cctgctgaat gggttggggc cttctcttgg atcaagagtc
       61 tcttatttga tcgaggtctg ttattagact tcctcattct ttctcagacc tcaggctgca
      121 tggtggcagc tgatgaaaat atccaaaaga tgagaagaga caattgagtc tggtgaggga
      181 aaggggagac agagggtgaa gtggtgctca agatggatgc agagtactct gggaatgagt
      241 tccccaggtc agaaggagaa agagaccaac atcagagacc tggaaaggaa aggaagagtg
      301 gggaggcagg atggggcaca ggtgagctgg gacaagatgg gagactgctg tcctccaccc
      361 tctccctcag tagtaacagg tccttgggcc agcgccagaa ctctccgctg ccctttcaat
      421 ggagaatcac acacagcttc cgctggatgg cccaggtgtt ggcctctgag ctcagcctgg
      481 ttgcctttat cctactattg gtcgtggcct tctccaagaa atggctggac ctctctagga
      541 gcctcttcta ccagcgctgg cccgtggatg tcagcaacag aatccacaca tcagcccacg
      601 ttatgtccat ggggctcctg cacttttaca aatccaggag ctgttctgac ttagagaatg
      661 ggaaagtcac cttcatcttc tccaccctca tgctattccc cattaacatc tggatcttcg
      721 agttggaaag gaatgtatcc atccccatag gctggagcta tttcattggt tggctggtgc
      781 ttatcctata cttcacctgc gcgatccttt gctacttcaa ccataaaagt ttctggagtc
      841 tgattctgag ccaccccagt ggtgccgtgt cctgcagcag cagtttcggc tcagtagaag
      901 aatctccaag ggcacagacg atcacagaca cccccatcac ccaggaggga gtcctggatc
      961 ctgagcagaa ggatacacat gtgtaatctt ttctgaactc ctggcaccaa gttctgtcca
     1021 ttcatctgac cccatctcct catcctcccc cagcccttga ataggttggt cctcatcatt
     1081 gcaaggaatg agaaagggag gattttgcac tcctctgctt tctccctgcc ttgattgagc
     1141 ttgagtgatg tggaataaat tgtccgtctc ttctttctca
//
