LOCUS       NM_001366781            4198 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens outer dense fiber of sperm tails 2 like (ODF2L),
            transcript variant 6, mRNA.
ACCESSION   NM_001366781 XM_005271054
VERSION     NM_001366781.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4198)
  AUTHORS   Li,J., Lu,J., Xu,M., Yang,S., Yu,T., Zheng,C., Huang,X., Pan,Y.,
            Chen,Y., Long,J., Zhang,C., Huang,H., Dai,Q., Li,B., Wang,W.,
            Yao,S. and Pan,C.
  TITLE     ODF2L acts as a synthetic lethal partner with WEE1 inhibition in
            epithelial ovarian cancer models
  JOURNAL   J Clin Invest 133 (2), e161544 (2023)
   PUBMED   36378528
  REMARK    GeneRIF: ODF2L acts as a synthetic lethal partner with WEE1
            inhibition in epithelial ovarian cancer models.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4198)
  AUTHORS   de Saram,P., Iqbal,A., Murdoch,J.N. and Wilkinson,C.J.
  TITLE     BCAP is a centriolar satellite protein and inhibitor of
            ciliogenesis
  JOURNAL   J Cell Sci 130 (19), 3360-3373 (2017)
   PUBMED   28775150
REFERENCE   3  (bases 1 to 4198)
  AUTHORS   Ponsard,C., Seltzer,V., Perret,E., Tournier,F. and Middendorp,S.
  TITLE     Identification of BCAP, a new protein associated with basal bodies
            and centrioles
  JOURNAL   Front Biosci 12, 3683-3693 (2007)
   PUBMED   17485331
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC119749.2 and AL136382.6.
            
            On Oct 19, 2018 this sequence version replaced XM_005271054.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.68507.1,
                                           SRR1660805.149150.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000460698.7/ ENSP00000433092.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-291               AC119749.2         11700-11990         c
            292-463             AC119749.2         2582-2753           c
            464-596             AC119749.2         1125-1257           c
            597-722             AC119749.2         343-468             c
            723-785             AL136382.6         126544-126606       c
            786-857             AL136382.6         126341-126412       c
            858-974             AL136382.6         125652-125768       c
            975-1160            AL136382.6         119643-119828       c
            1161-1270           AL136382.6         115841-115950       c
            1271-1406           AL136382.6         114428-114563       c
            1407-1517           AL136382.6         103836-103946       c
            1518-1622           AL136382.6         102197-102301       c
            1623-1781           AL136382.6         99854-100012        c
            1782-1867           AL136382.6         98184-98269         c
            1868-2030           AL136382.6         97940-98102         c
            2031-2156           AL136382.6         96269-96394         c
            2157-4198           AL136382.6         90247-92288         c
FEATURES             Location/Qualifiers
     source          1..4198
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p22.3"
     gene            1..4198
                     /gene="ODF2L"
                     /note="outer dense fiber of sperm tails 2 like"
                     /db_xref="GeneID:57489"
                     /db_xref="HGNC:HGNC:29225"
                     /db_xref="MIM:620130"
     exon            1..291
                     /gene="ODF2L"
                     /inference="alignment:Splign:2.1.0"
     exon            292..463
                     /gene="ODF2L"
                     /inference="alignment:Splign:2.1.0"
     CDS             351..2285
                     /gene="ODF2L"
                     /note="isoform f is encoded by transcript variant 6; basal
                     body centriole-associated protein; protein BCAP; ODF2-like
                     protein"
                     /codon_start=1
                     /product="protein BCAP isoform f"
                     /protein_id="NP_001353710.1"
                     /db_xref="CCDS:CCDS90997.1"
                     /db_xref="GeneID:57489"
                     /db_xref="HGNC:HGNC:29225"
                     /db_xref="MIM:620130"
                     /translation="MEKAVNDGSHSEELFCHLKTISEKEDLPRCTSESHLSCLKQDIL
                     NEKTELEATLKEAELVTHSVELLLPLFKDTIEKINFENANLSALNLKISEQKEILIKE
                     LDTFKSVKLALEHLLRKRDYKQTGDNLSSMLLENLTDNESENTNLKKKVFEKEAHIQE
                     LSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAENDKLKEYVKSLETKIAKWN
                     LQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTGAIEKLTSQIRDQEAKLSE
                     TISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMEDHGKNSCEEILRKV
                     HSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQEVEKKQKTLIEMYKTQVQK
                     LQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELERVCDSLTAAERRL
                     HECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQQKL
                     EQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEGRQKVAEEIE
                     KMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKSENQ
                     NESIKNYLQFLKTSYVTMFE"
     exon            464..596
                     /gene="ODF2L"
                     /inference="alignment:Splign:2.1.0"
     exon            597..722
                     /gene="ODF2L"
                     /inference="alignment:Splign:2.1.0"
     exon            723..785
                     /gene="ODF2L"
                     /inference="alignment:Splign:2.1.0"
     exon            786..857
                     /gene="ODF2L"
                     /inference="alignment:Splign:2.1.0"
     exon            858..974
                     /gene="ODF2L"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1160
                     /gene="ODF2L"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1270
                     /gene="ODF2L"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1406
                     /gene="ODF2L"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1517
                     /gene="ODF2L"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1622
                     /gene="ODF2L"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..1781
                     /gene="ODF2L"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..1867
                     /gene="ODF2L"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..2030
                     /gene="ODF2L"
                     /inference="alignment:Splign:2.1.0"
     exon            2031..2156
                     /gene="ODF2L"
                     /inference="alignment:Splign:2.1.0"
     exon            2157..4198
                     /gene="ODF2L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2281..2286
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ODF2L"
                     /note="hexamer: AATAAA"
     polyA_site      2298
                     /gene="ODF2L"
                     /note="major polyA site"
     regulatory      2899..2904
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ODF2L"
                     /note="hexamer: TATAAA"
     regulatory      2906..2911
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ODF2L"
                     /note="hexamer: AATAGA"
     polyA_site      2924
                     /gene="ODF2L"
                     /note="major polyA site"
     polyA_site      2929
                     /gene="ODF2L"
                     /note="major polyA site"
     regulatory      4169..4174
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ODF2L"
                     /note="hexamer: AATAAA"
     polyA_site      4198
                     /gene="ODF2L"
ORIGIN      
        1 agagaagcca ctagccggtt actagctgcg cttttgttcc acttgagcgg gcactcttct
       61 gcggcaagca ggtctaggaa ttcgcctggt tcccacctcg cgtcccttgc cttccttcct
      121 agtctaccca ctgtagtgcc ccctgcgtcc cgctccctcc tagccgactc agagcacaag
      181 aaggattgcc acggtttcca ttgcagcagc cgtggcgcct ctgacccttt ttttatatcg
      241 cggcgacggc gggctgtcgt cacgacgacg tgcggacgca gcggcggggg cctttcagct
      301 tatgtggaga agtcgctgtg aagccaccta taaatccatt tactgaattt atggagaagg
      361 ctgtaaatga tggaagtcat tcagaagaac tcttttgcca tcttaaaact atatcagaga
      421 aagaagattt accacggtgt accagtgaaa gtcatctcag ctgcctgaag caggacattc
      481 taaatgaaaa gactgaattg gaagcaacac ttaaggaagc ggagttggta actcattctg
      541 tagaattgct tttgccacta tttaaggaca ccattgaaaa gattaatttt gaaaatgcga
      601 atctttctgc attgaatttg aagatttctg aacagaagga aatattaata aaagaattag
      661 acaccttcaa aagtgtaaaa ctagctttag aacatcttct tagaaagaga gactacaaac
      721 aaacaggaga caatttatcc agcatgttgc tagaaaatct aactgataat gaaagtgaaa
      781 atactaatct taagaagaag gtatttgaaa aggaggccca tatccaagaa ctttcttgtt
      841 tgtttcagag tgaaaaggca aatactttga aagcaaaccg tttttcccaa tcagtaaaag
      901 tagtacatga acgactacag atccaaattc ataaaaggga agccgagaac gataagttga
      961 aagaatatgt aaagagctta gaaaccaaga tagccaagtg gaacctgcaa tcaagaatga
     1021 ataagaatga ggctatagtg atgaaagaag caagtaggca aaaaactgta gctttaaaaa
     1081 aggcatctaa agtttacaaa caaaggcttg accattttac aggagctatt gaaaagctta
     1141 cttcccaaat tagagatcag gaagccaagt tgtctgaaac aatttcagct tccaatgcct
     1201 ggaaaagtca ttatgagaaa attgtgatag aaaaaaccga attggaagta cagattgaaa
     1261 caatgaaaaa gcaaatcatt aatcttttgg aagatctgaa gaaaatggaa gaccatggaa
     1321 aaaattcatg tgaagaaatt cttagaaaag ttcactcaat tgaatatgaa aatgaaactc
     1381 tgaatcttga gaatacaaaa ttaaagacta cacttgctgc tttgaaggat gaagttgtat
     1441 ctgttgaaaa tgaactctca gaattgcaag aagtagaaaa aaaacagaaa acccttattg
     1501 aaatgtataa aactcaggta caaaagttgc aagaagcagc tgaaatagta aaaagcagat
     1561 gtgaaaattt gctacataaa aataaccaaa taacaaaaac caaaaataaa aatgtagaga
     1621 agatgagagg ccagatggag tctcatctga aggagttaga gcgtgtctgc gattccttga
     1681 cggcggcgga acggaggctt cacgagtgtc aggagagtct gcagtgctgc aaggggaagt
     1741 gtgcagacca ggaacacacc attagggagc ttcagggcca ggttgatgga aatcacaatc
     1801 ttctgacaaa gctttctctg gaagaggaaa actgtcttat tcagctgaag tgtgaaaacc
     1861 ttcaacaaaa attagaacag atggacgcag aaaataaaga gcttgagaag aagctggcaa
     1921 accaagaaga atgtcttaag cacagcaatc ttaagtttaa agagaaatct gcagagtata
     1981 cagcattggc cagacaactg gaagctgctt tagaagaagg aagacaaaag gttgctgaag
     2041 aaatagagaa aatgtcatct agagagagtg ctttacaaat taaaatatta gatctggaaa
     2101 ctgagcttag aaagaaaaat gaagaacaaa atcaacttgt ttgcaaaatg aacagtaaag
     2161 cacaacatca ggaagtgtgt ttgaaagaag tacaaaatag tcttgagaag tcggaaaatc
     2221 aaaatgagag tattaagaat tatttacagt ttcttaaaac ttcttatgta acaatgtttg
     2281 aataaattgt caaatttatt ttctctaagt agtagatttt tattatgagt ctaaaatgtg
     2341 attgggtaaa aaaataaata tactaccagt tacattttat gatttatgag tggtagtatt
     2401 agaggttttt atgtaaagat ttttgaaaca taatttatct aactgaaact ttaaaatagg
     2461 atagttgtta ctattcctgt ttgctggata attcttattt atctttggtt taatttcttt
     2521 taaaattaaa ttggttgtta gaatattttt ctcacacata gacatggaag tcagattcat
     2581 tctttgtgat gtttgtagcc accattcaag tgaatttgta gtaagtcttg gtcaatatga
     2641 ttttaaataa tatatataat tgttttatat tatgatatat aaatgtaaaa tattctgaat
     2701 tttaattttt aataatggtg taattacata ctttctaaag ctactaaatg tctcaatata
     2761 ctacacttaa tattgtttca agtatatgct gagttgccat tataatttct gttaggtttt
     2821 aagtatacaa ttttaaatca tcgctattaa gtaccaactg ctaatgacag atgaaaacgt
     2881 ggtcatgcat tatttcttta taaagaatag atattcaggc tgtcttcaat ttgtactctc
     2941 ttttattcgt tttatactaa tgattatctg atattattat tattttagac attctagagc
     3001 cccttagtta aataaaagat taaaggggaa cagcttatcc caccctttcc atggccaact
     3061 catggggatg atcaaaataa gcactcttaa catcaagaag ctttaaaata aggtctttag
     3121 tattgggata aagttgtcca agttgaaaaa gaacttgttt gctataatct cccactgtgt
     3181 gtgccaaggc aggatactct aaaaggggat gacgtggttt acaaaggatc aagtaatagt
     3241 gactcctctt ggacaatgac ttgagagctg ttaattcaga ggaacactca ggtcttaaaa
     3301 gatcactaaa aaaggcaggt tgtgaactac acagttccag cctatgaaca gaaatatctc
     3361 tttaagatgt tttatgcttt ttttctgatc agagatgggg gcctggtccc ctctgatccc
     3421 ctcactttta agactgtcat atcattcaca gatgcttact ttctagtgat ccagttggtt
     3481 cgtagtattt ttcttaaaat agcaaaatac agagtgtcag aactggccac attttttacc
     3541 caacaattgc taacaagatt agtgtcattt taaaaaaaat cttagtactc atcatactaa
     3601 aaacatgctt gacccttgca gccctttctt tacctcctaa tgcaaaggga gccttaaatg
     3661 cccacatgaa aggaaagcaa agctcttgag ttttactcac taaactgtaa gctccttaag
     3721 ggccgaaatg tatcttagtc atataaatat ctgggcactc agttgatgtt tgtggataga
     3781 tggacagatg ttgaaagagg caggtattcg tactcctgtt ttagatatga aaaatgtaag
     3841 caaaaaggat taattaccat ggctgtggta tgaaacttgt ttaaagttgg catttaaatt
     3901 caagtctgca acattaaagt tctgtgtaca gagccgtttt cccactgtag cagcagcgca
     3961 gcagcagcgc tgctatgatt gattaagcac ttgctatgtg ccagagttaa taattgtgat
     4021 aatatattaa ctcatttaat tttcaggaaa ctaagacatg gaaaggttag gtaacttgcc
     4081 caaggtcgca cagctagtaa gtggcagaca tccagagtct ctgctctgct cttaactctc
     4141 accatactac ctctgtatcc atttcataaa taaagatagt agtttcttat aacagtaa
//
