LOCUS       NM_001351578            3862 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens outer dense fiber of sperm tails 2 (ODF2), transcript
            variant 13, mRNA.
ACCESSION   NM_001351578 XM_011518730
VERSION     NM_001351578.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3862)
  AUTHORS   Kiani,A., Dogus,Y., Saadatnia,S., Yazdani,Y., Asadi,F.,
            Al-Naqeeb,B.Z.T., Masouleh,S.S., Merza,M.S., Daemi,A. and Rahimi,A.
  TITLE     Sperm DNA fragmentation and apoptosis in the sperm of men with
            oligozoospermia are closely related to anti-ODF2 autoantibodies
  JOURNAL   Pathol Res Pract 245, 154434 (2023)
   PUBMED   37086632
  REMARK    GeneRIF: Sperm DNA fragmentation and apoptosis in the sperm of men
            with oligozoospermia are closely related to anti-ODF2
            autoantibodies.
REFERENCE   2  (bases 1 to 3862)
  AUTHORS   Aljiboury,A., Mujcic,A., Curtis,E., Cammerino,T., Magny,D., Lan,Y.,
            Bates,M., Freshour,J., Ahmed-Braimeh,Y.H. and Hehnly,H.
  TITLE     Pericentriolar matrix (PCM) integrity relies on cenexin and
            polo-like kinase (PLK)1
  JOURNAL   Mol Biol Cell 33 (9), br14 (2022)
   PUBMED   35609215
  REMARK    GeneRIF: Pericentriolar matrix (PCM) integrity relies on cenexin
            and polo-like kinase (PLK)1.
REFERENCE   3  (bases 1 to 3862)
  AUTHORS   O'Neill,A.C., Uzbas,F., Antognolli,G., Merino,F., Draganova,K.,
            Jack,A., Zhang,S., Pedini,G., Schessner,J.P., Cramer,K.,
            Schepers,A., Metzger,F., Esgleas,M., Smialowski,P., Guerrini,R.,
            Falk,S., Feederle,R., Freytag,S., Wang,Z., Bahlo,M., Jungmann,R.,
            Bagni,C., Borner,G.H.H., Robertson,S.P., Hauck,S.M. and Gotz,M.
  TITLE     Spatial centrosome proteome of human neural cells uncovers
            disease-relevant heterogeneity
  JOURNAL   Science 376 (6599), eabf9088 (2022)
   PUBMED   35709258
REFERENCE   4  (bases 1 to 3862)
  AUTHORS   Ma,D., Wang,F., Wang,R., Hu,Y., Chen,Z., Huang,N., Tian,Y., Xia,Y.,
            Teng,J. and Chen,J.
  TITLE     alpha-/gamma-Taxilin are required for centriolar subdistal
            appendage assembly and microtubule organization
  JOURNAL   Elife 11, e73252 (2022)
   PUBMED   35119360
  REMARK    GeneRIF: alpha-/gamma-Taxilin are required for centriolar subdistal
            appendage assembly and microtubule organization.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3862)
  AUTHORS   Abu-Halima,M., Belkacemi,A., Ayesh,B.M., Simone Becker,L.,
            Sindiani,A.M., Fischer,U., Hammadeh,M., Keller,A. and Meese,E.
  TITLE     MicroRNA-targeting in spermatogenesis: Over-expressions of
            microRNA-23a/b-3p and its affected targeting of the genes ODF2 and
            UBQLN3 in spermatozoa of patients with oligoasthenozoospermia
  JOURNAL   Andrology 9 (4), 1137-1144 (2021)
   PUBMED   33784796
  REMARK    GeneRIF: MicroRNA-targeting in spermatogenesis: Over-expressions of
            microRNA-23a/b-3p and its affected targeting of the genes ODF2 and
            UBQLN3 in spermatozoa of patients with oligoasthenozoospermia.
REFERENCE   6  (bases 1 to 3862)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   7  (bases 1 to 3862)
  AUTHORS   Kierszenbaum,A.L.
  TITLE     Keratins: unraveling the coordinated construction of scaffolds in
            spermatogenic cells
  JOURNAL   Mol Reprod Dev 61 (1), 1-2 (2002)
   PUBMED   11774369
  REMARK    Review article
REFERENCE   8  (bases 1 to 3862)
  AUTHORS   Petersen,C., Fuzesi,L. and Hoyer-Fender,S.
  TITLE     Outer dense fibre proteins from human sperm tail: molecular cloning
            and expression analyses of two cDNA transcripts encoding proteins
            of approximately 70 kDa
  JOURNAL   Mol Hum Reprod 5 (7), 627-635 (1999)
   PUBMED   10381817
REFERENCE   9  (bases 1 to 3862)
  AUTHORS   Hoyer-Fender,S., Petersen,C., Brohmann,H., Rhee,K. and
            Wolgemuth,D.J.
  TITLE     Mouse Odf2 cDNAs consist of evolutionary conserved as well as
            highly variable sequences and encode outer dense fiber proteins of
            the sperm tail
  JOURNAL   Mol Reprod Dev 51 (2), 167-175 (1998)
   PUBMED   9740324
  REMARK    GeneRIF: Mouse and rat ODF2 protein homolog sequences and
            expression are compared.
REFERENCE   10 (bases 1 to 3862)
  AUTHORS   Shao,X., Murthy,S., Demetrick,D.J. and van der Hoorn,F.A.
  TITLE     Human outer dense fiber gene, ODF2, localizes to chromosome 9q34
  JOURNAL   Cytogenet Cell Genet 83 (3-4), 221-223 (1998)
   PUBMED   10072582
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL359091.10 and AL445287.16.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 23, 2020 this sequence version replaced NM_001351578.1.
            
            Summary: The outer dense fibers are cytoskeletal structures that
            surround the axoneme in the middle piece and principal piece of the
            sperm tail. The fibers function in maintaining the elastic
            structure and recoil of the sperm tail as well as in protecting the
            tail from shear forces during epididymal transport and ejaculation.
            Defects in the outer dense fibers lead to abnormal sperm morphology
            and infertility. This gene encodes one of the major outer dense
            fiber proteins. Alternative splicing results in multiple transcript
            variants. The longer transcripts, also known as 'Cenexins', encode
            proteins with a C-terminal extension that are differentially
            targeted to somatic centrioles and thought to be crucial for the
            formation of microtubule organizing centers. [provided by RefSeq,
            Oct 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.1693086.1,
                                           SRR14038191.2398491.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000351030.8/ ENSP00000342581.4
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-250               AL359091.10        155202-155451
            251-341             AL359091.10        158763-158853
            342-458             AL359091.10        159746-159862
            459-584             AL359091.10        160138-160263
            585-755             AL359091.10        168379-168549
            756-916             AL359091.10        170504-170664
            917-1046            AL359091.10        172109-172238
            1047-1178           AL359091.10        172806-172937
            1179-1250           AL359091.10        180776-180847
            1251-1322           AL359091.10        182012-182083
            1323-1439           AL359091.10        183134-183250
            1440-1625           AL359091.10        183897-184082
            1626-1735           AL445287.16        2117-2226
            1736-1871           AL445287.16        4642-4777
            1872-1982           AL445287.16        9178-9288
            1983-2087           AL445287.16        9453-9557
            2088-2246           AL445287.16        11262-11420
            2247-2347           AL445287.16        12793-12893
            2348-2510           AL445287.16        15165-15327
            2511-2636           AL445287.16        15753-15878
            2637-3862           AL445287.16        16819-18044
FEATURES             Location/Qualifiers
     source          1..3862
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.11"
     gene            1..3862
                     /gene="ODF2"
                     /gene_synonym="CT134; ODF2/1; ODF2/2; ODF84"
                     /note="outer dense fiber of sperm tails 2"
                     /db_xref="GeneID:4957"
                     /db_xref="HGNC:HGNC:8114"
                     /db_xref="MIM:602015"
     exon            1..250
                     /gene="ODF2"
                     /gene_synonym="CT134; ODF2/1; ODF2/2; ODF84"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..2825
                     /gene="ODF2"
                     /gene_synonym="CT134; ODF2/1; ODF2/2; ODF84"
                     /note="isoform 13 is encoded by transcript variant 13;
                     cancer/testis antigen 134; outer dense fiber of sperm
                     tails, 84-kD; cenexin 1; sperm tail structural protein;
                     testis tissue sperm-binding protein Li 51e"
                     /codon_start=1
                     /product="outer dense fiber protein 2 isoform 13"
                     /protein_id="NP_001338507.1"
                     /db_xref="CCDS:CCDS94498.1"
                     /db_xref="GeneID:4957"
                     /db_xref="HGNC:HGNC:8114"
                     /db_xref="MIM:602015"
                     /translation="MGELPTGCRKRRRKRGGAAARARLHPPRRLHGTTLASDFNDFIR
                     RRFWAQPCRSWFPSCGKNGVTSLTQKKVLRAPCGAPSVTVTKPTMKDRSSTPPLHVHV
                     DENTPVHVHIKKLPKPSATSSQKSHKRGMKGDTVNVRRSVRVKTKVPWMPPGKSSARP
                     VGCKWENPPHCLEITPPSSEKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVG
                     CLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFT
                     ILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTR
                     QKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLL
                     LLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQI
                     KNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHV
                     QLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKM
                     REDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEG
                     MIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQQL
                     PDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQASQK
                     ENKQLSLKVDELERKLEATSAQNIEFLQVIAKREEAIHQSQLRLEEKTRECGTLARQL
                     ESAIEDARRQVEQTKEHALSKERAAQNKILDLETQLSRTKTELSQLRRSRDDADRRYQ
                     SRLQDLKDRLEQSESTNRSMQNYVQFLKSSYANVFGDGPYSTFLTSSPIRSRSPPA"
     exon            251..341
                     /gene="ODF2"
                     /gene_synonym="CT134; ODF2/1; ODF2/2; ODF84"
                     /inference="alignment:Splign:2.1.0"
     exon            342..458
                     /gene="ODF2"
                     /gene_synonym="CT134; ODF2/1; ODF2/2; ODF84"
                     /inference="alignment:Splign:2.1.0"
     exon            459..584
                     /gene="ODF2"
                     /gene_synonym="CT134; ODF2/1; ODF2/2; ODF84"
                     /inference="alignment:Splign:2.1.0"
     exon            585..755
                     /gene="ODF2"
                     /gene_synonym="CT134; ODF2/1; ODF2/2; ODF84"
                     /inference="alignment:Splign:2.1.0"
     exon            756..916
                     /gene="ODF2"
                     /gene_synonym="CT134; ODF2/1; ODF2/2; ODF84"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1046
                     /gene="ODF2"
                     /gene_synonym="CT134; ODF2/1; ODF2/2; ODF84"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1178
                     /gene="ODF2"
                     /gene_synonym="CT134; ODF2/1; ODF2/2; ODF84"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1250
                     /gene="ODF2"
                     /gene_synonym="CT134; ODF2/1; ODF2/2; ODF84"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1322
                     /gene="ODF2"
                     /gene_synonym="CT134; ODF2/1; ODF2/2; ODF84"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1439
                     /gene="ODF2"
                     /gene_synonym="CT134; ODF2/1; ODF2/2; ODF84"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1625
                     /gene="ODF2"
                     /gene_synonym="CT134; ODF2/1; ODF2/2; ODF84"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1735
                     /gene="ODF2"
                     /gene_synonym="CT134; ODF2/1; ODF2/2; ODF84"
                     /inference="alignment:Splign:2.1.0"
     exon            1736..1871
                     /gene="ODF2"
                     /gene_synonym="CT134; ODF2/1; ODF2/2; ODF84"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..1982
                     /gene="ODF2"
                     /gene_synonym="CT134; ODF2/1; ODF2/2; ODF84"
                     /inference="alignment:Splign:2.1.0"
     exon            1983..2087
                     /gene="ODF2"
                     /gene_synonym="CT134; ODF2/1; ODF2/2; ODF84"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2246
                     /gene="ODF2"
                     /gene_synonym="CT134; ODF2/1; ODF2/2; ODF84"
                     /inference="alignment:Splign:2.1.0"
     exon            2247..2347
                     /gene="ODF2"
                     /gene_synonym="CT134; ODF2/1; ODF2/2; ODF84"
                     /inference="alignment:Splign:2.1.0"
     exon            2348..2510
                     /gene="ODF2"
                     /gene_synonym="CT134; ODF2/1; ODF2/2; ODF84"
                     /inference="alignment:Splign:2.1.0"
     exon            2511..2636
                     /gene="ODF2"
                     /gene_synonym="CT134; ODF2/1; ODF2/2; ODF84"
                     /inference="alignment:Splign:2.1.0"
     exon            2637..3862
                     /gene="ODF2"
                     /gene_synonym="CT134; ODF2/1; ODF2/2; ODF84"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3513
                     /gene="ODF2"
                     /gene_synonym="CT134; ODF2/1; ODF2/2; ODF84"
                     /note="major polyA site"
     polyA_site      3530
                     /gene="ODF2"
                     /gene_synonym="CT134; ODF2/1; ODF2/2; ODF84"
                     /note="major polyA site"
     regulatory      3833..3838
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ODF2"
                     /gene_synonym="CT134; ODF2/1; ODF2/2; ODF84"
                     /note="hexamer: AATAAG"
     polyA_site      3840
                     /gene="ODF2"
                     /gene_synonym="CT134; ODF2/1; ODF2/2; ODF84"
     polyA_site      3862
                     /gene="ODF2"
                     /gene_synonym="CT134; ODF2/1; ODF2/2; ODF84"
ORIGIN      
        1 tggcggggcg gggcatctct gtgacgctag gggctgggcc tcgatggcga aacccaagcg
       61 gctcccgggg gggtttgaac tggccaatgg gcgagctgcc gaccgggtgt cggaaaagga
      121 ggcggaagcg gggaggagcc gctgccagag ccagactgca tccgccgcgg cgtctccatg
      181 gcacgaccct ggcctccgac ttcaacgact tcataaggcg gcgtttctgg gcgcagccgt
      241 gtcgctcctg gtttccatcg tgtgggaaga acggagtaac gagtctcacg cagaaaaagg
      301 tcttgagagc accttgtggc gcacccagtg taactgtgac gaagccaacc atgaaggacc
      361 gctcttcaac tcccccctta catgttcacg tggatgagaa cacccctgtc cacgtccaca
      421 taaaaaaact cccgaaacca tcagcgacca gcagccagaa atctcacaag cgaggaatga
      481 aaggggacac tgtgaatgtg cggcggagtg tccgggtgaa aaccaaggta ccttggatgc
      541 cccctggaaa atcatctgcc cggcctgtgg gatgcaagtg ggagaatcca cctcattgcc
      601 tggagatcac gccaccatct tcagaaaagc tggtctcagt gatgcggtta agtgacctct
      661 ctacagaaga tgatgactca ggtcactgta aaatgaaccg ttatgataag aagattgata
      721 gtctaatgaa tgcggttggt tgtctgaagt ctgaggtcaa gatgcaaaaa ggtgagcgcc
      781 agatggccaa aaggttcctg gaggaacgga aggaagagct ggaggaggtg gcccacgaac
      841 tggctgagac tgagcacgag aacacggtgt tgaggcacaa catcgagcgc atgaaggagg
      901 agaaggactt caccatactt cagaagaaac acctacaaca ggagaaggag tgcctcatgt
      961 ccaagctggt ggaggcggaa atggatgggg ctgcggctgc caagcaggtc atggccttga
     1021 aggataccat cgggaagctg aaaacagaga aacaaatgac ctgcacggac atcaacaccc
     1081 tgacaaggca gaaggaactt ctcctgcaga agctgagcac atttgaggag accaaccgca
     1141 ccctccgaga cctcctgagg gaacagcact gcaaagagga ttctgaaaga ctaatggagc
     1201 aacaaggagc actgctgaaa cggctggcgg aggccgactc agagaaagcg cgcctgctgt
     1261 tactgctgca agacaaggac aaggaggtgg aagagctcct tcaggaaata caatgtgaga
     1321 aggctcaagc aaagacagcc tctgagcttt ctaaatccat ggagtccatg cgtgggcatt
     1381 tgcaggcaca gcttcggtcc aaagaggctg agaacagtcg cctgtgcatg cagattaaga
     1441 atctggagcg cagcgggaat cagcataagg cagaagtgga ggccatcatg gagcagctga
     1501 aggagttgaa gcagaaggga gaccgagaca aagagagctt gaagaaggcc atccgagccc
     1561 agaaggagcg agccgagaag agcgaggagt atgctgagca gctacacgtg caactcgctg
     1621 acaaggatct ttatgtcgct gaagctttat ccactctgga atcctggagg agccgctaca
     1681 accaagttgt aaaagaaaag ggagaccttg agctggaaat tattgtcctg aatgaccggg
     1741 taacagatct tgtaaaccaa caacaaaccc tggaggagaa gatgcgggaa gaccgggata
     1801 gcctggtgga gagactacac cgtcagactg ctgagtattc cgcattcaag ctggagaatg
     1861 agaggctgaa ggccagcttt gctccaatgg aggacaaact caaccaggca cacctcgagg
     1921 tccagcagct gaaggcctca gtgaagaact atgaggggat gattgacaac tataagagtc
     1981 aggtgatgaa gaccagattg gaggctgatg aagtagctgc ccagctagaa cgctgtgaca
     2041 aagagaacaa gatccttaaa gatgagatga acaaagagat tgaggcggca cgaaggcagt
     2101 tccagtctca gctggctgac ctgcagcagc tccctgacat cctgaagatc acggaggcga
     2161 agctggctga gtgccaagac caactgcagg gctatgagcg gaagaacatc gacctcacag
     2221 ccatcatatc agacctgcgc agccggatcg aacaccaggg ggacaagctg gagatggcga
     2281 gagagaaaca tcaggcttcc cagaaggaaa ataaacagct gagtctgaag gtggatgaac
     2341 tggagaggaa actggaggcg accagtgccc agaatatcga gttcctacag gtgattgcca
     2401 agagggagga ggcaatccac cagtcccagc tgcggctgga ggagaaaaca cgggaatgtg
     2461 ggaccctggc aaggcagttg gagagtgcca ttgaagatgc gaggaggcag gtggaacaaa
     2521 ccaaggagca cgcactctcc aaggagcgag cagcccagaa caaaatcctg gaccttgaga
     2581 cccagctgag cagaaccaaa acggaattga gccagctgcg gcggagccgt gatgatgcgg
     2641 accgccgcta ccagagccgg ctgcaagacc tgaaagatcg cctggagcag tccgagagca
     2701 ccaaccgcag catgcagaac tacgtccagt tcctcaaatc atcatacgcc aacgtgtttg
     2761 gggatggtcc ctattccacc ttcctgacta gctctcccat ccgctcccga tctcctcctg
     2821 cctgaggcca cttatcaggg cctggagccc tgatggaagc cataggaact ccagagttgc
     2881 caagccatag ctgagaagcc tggtggtttt cctctcccag tgaaaaaatg ggttcagggt
     2941 cttgtcctta gctactagct ctagaaaagt cccaaaagca gcagaaggtg aagcaggaag
     3001 cacttggttt tctccttcct gatatagtca cctgttggaa gtgttaaaat ttcctcgaca
     3061 ggccttaaat ttactactac attagggtac cacattttaa cttaccatga ctttgctcct
     3121 tcctttcctg agaaaatatt tccactggat tttttccacc agtcccctta cagccctcat
     3181 tgttttagga atctctctca ggttttttct gacctaaacc agcaggaagt cgtcctgggc
     3241 tgtaagcacc atcacttgct tttttttttt ttctgatttc acaagtgtgg tgttttccca
     3301 aggctccctt cccaagctca gtgcaaacct ctcactccca agtttctttg aggccacttg
     3361 cccccaagca cttcacaata gaccctcgag ggcttgtgtc catttggcct tttacaagtg
     3421 taatgccaat ttcattgatt tttgtttctt ttggcctgat ttgtatctct ggaatgcatt
     3481 tattcttgaa atatttgtgt gattttacaa aaagcttttg taatcagtta tttaaggctc
     3541 catttgatga tttcctttac ccaaccagtc ctcatccctc ctctaaaaaa tgattaagta
     3601 aaatgctgca ggacagccag tagacatttt taaagtactt ggtgcctgaa acatcaggct
     3661 tctcatttca ttttagctca ggttggtgct ttcacattgt aatcaatgaa ctgtcaggag
     3721 ggaacaaact gtaagaagga ttgcttggtg ttttagggta gatcacttta gctattagga
     3781 agaggatggg gtagtgtaca gtatatattt ttaaaatgtg aattggtttc tgaataagaa
     3841 tctgggccat ttttgttcac ca
//
