LOCUS       NM_024410               1026 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens outer dense fiber of sperm tails 1 (ODF1), mRNA.
ACCESSION   NM_024410
VERSION     NM_024410.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1026)
  AUTHORS   Li,B., Li,X., Mao,R., Liu,M., Fu,L., Shi,L., Zhao,S. and Fu,M.
  TITLE     Overexpression of ODF1 in Gastrointestinal Tract Neuroendocrine
            Neoplasms: a Novel Potential Immunohistochemical Biomarker for
            Well-differentiated Neuroendocrine Tumors
  JOURNAL   Endocr Pathol 32 (2), 301-308 (2021)
   PUBMED   32869188
  REMARK    GeneRIF: Overexpression of ODF1 in Gastrointestinal Tract
            Neuroendocrine Neoplasms: a Novel Potential Immunohistochemical
            Biomarker for Well-differentiated Neuroendocrine Tumors.
REFERENCE   2  (bases 1 to 1026)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1026)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1026)
  AUTHORS   Cabrillana,M.E., Monclus,M.L.A., Lancellotti,T.E.S., Boarelli,P.V.,
            Vincenti,A.E., Fornes,M.M., Sanabria,E.A. and Fornes,M.W.
  TITLE     Thiols of flagellar proteins are essential for progressive motility
            in human spermatozoa
  JOURNAL   Reprod Fertil Dev 29 (7), 1435-1446 (2017)
   PUBMED   27363428
  REMARK    GeneRIF: Thiols of flagellar proteins, such as outer dense fibre
            protein 1 (ODF1), are oxidised to form disulfides during epididymal
            transit and the spermatozoa become motile. This study was designed
            to determine how oxidative changes in protein thiol status affect
            progressive motility in spermatozoa.
REFERENCE   5  (bases 1 to 1026)
  AUTHORS   Hetherington,L., Schneider,E.K., Scott,C., DeKretser,D.,
            Muller,C.H., Hondermarck,H., Velkov,T. and Baker,M.A.
  TITLE     Deficiency in Outer Dense Fiber 1 Is a Marker and Potential Driver
            of Idiopathic Male Infertility
  JOURNAL   Mol Cell Proteomics 15 (12), 3685-3693 (2016)
   PUBMED   27770032
  REMARK    GeneRIF: Study provides evidence that ODF1 down regulation is
            responsible for male infertility.
            Erratum:[Mol Cell Proteomics. 2017 Jun;16(6):1172. doi:
            10.1074/mcp.A116.060343.. PMID: 28572402]
REFERENCE   6  (bases 1 to 1026)
  AUTHORS   Shao,X. and van der Hoorn,F.A.
  TITLE     Self-interaction of the major 27-kilodalton outer dense fiber
            protein is in part mediated by a leucine zipper domain in the rat
  JOURNAL   Biol Reprod 55 (6), 1343-1350 (1996)
   PUBMED   8949892
REFERENCE   7  (bases 1 to 1026)
  AUTHORS   Burmester,S. and Hoyer-Fender,S.
  TITLE     Transcription and translation of the outer dense fiber gene (Odf1)
            during spermiogenesis in the rat. A study by in situ analyses and
            polysome fractionation
  JOURNAL   Mol Reprod Dev 45 (1), 10-20 (1996)
   PUBMED   8873064
REFERENCE   8  (bases 1 to 1026)
  AUTHORS   Gastmann,O., Burfeind,P., Gunther,E., Hameister,H., Szpirer,C. and
            Hoyer-Fender,S.
  TITLE     Sequence, expression, and chromosomal assignment of a human sperm
            outer dense fiber gene
  JOURNAL   Mol Reprod Dev 36 (4), 407-418 (1993)
   PUBMED   8305202
REFERENCE   9  (bases 1 to 1026)
  AUTHORS   Hofferbert,S., Burfeind,P., Hoyer-Fender,S., Lange,R., Haidl,G. and
            Engel,W.
  TITLE     A homozygous deletion of 27 basepairs in the coding region of the
            human outer dense fiber protein gene does not result in a
            pathologic phenotype
  JOURNAL   Hum Mol Genet 2 (12), 2167-2170 (1993)
   PUBMED   8111388
REFERENCE   10 (bases 1 to 1026)
  AUTHORS   Henkel,R., Stalf,T. and Miska,W.
  TITLE     Isolation and partial characterization of the outer dense fiber
            proteins from human spermatozoa
  JOURNAL   Biol Chem Hoppe Seyler 373 (8), 685-689 (1992)
   PUBMED   1418683
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP002852.3, DB457574.1,
            AP002851.2 and BG214987.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_024410.3.
            
            Summary: The outer dense fibers are cytoskeletal structures that
            surround the axoneme in the middle piece and principal piece of the
            sperm tail. The fibers function in maintaining the elastic
            structure and recoil of the sperm tail as well as in protecting the
            tail from shear forces during epididymal transport and ejaculation.
            Defects in the outer dense fibers lead to abnormal sperm morphology
            and infertility. The human outer dense fibers contains at least 10
            major proteins and this gene encodes the main protein. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189652.98276.1, ERR279841.4494.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000285402.4/ ENSP00000285402.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                AP002852.3         150297-150327
            32-498              DB457574.1         1-467
            499-994             AP002851.2         37632-38127
            995-1025            BG214987.1         538-568
            1026-1026           AP002851.2         38159-38159
FEATURES             Location/Qualifiers
     source          1..1026
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q22.3"
     gene            1..1026
                     /gene="ODF1"
                     /gene_synonym="CT133; HSPB10; ODF; ODF2; ODF27; ODFP;
                     ODFPG; ODFPGA; ODFPGB; RT7; SODF"
                     /note="outer dense fiber of sperm tails 1"
                     /db_xref="GeneID:4956"
                     /db_xref="HGNC:HGNC:8113"
                     /db_xref="MIM:182878"
     exon            1..459
                     /gene="ODF1"
                     /gene_synonym="CT133; HSPB10; ODF; ODF2; ODF27; ODFP;
                     ODFPG; ODFPGA; ODFPGB; RT7; SODF"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..892
                     /gene="ODF1"
                     /gene_synonym="CT133; HSPB10; ODF; ODF2; ODF27; ODFP;
                     ODFPG; ODFPGA; ODFPGB; RT7; SODF"
                     /note="cancer/testis antigen 133; outer dense fiber of
                     sperm tails, 27-kD; heat shock protein beta-10; heat shock
                     protein family B member 10"
                     /codon_start=1
                     /product="outer dense fiber protein 1"
                     /protein_id="NP_077721.2"
                     /db_xref="CCDS:CCDS6293.1"
                     /db_xref="GeneID:4956"
                     /db_xref="HGNC:HGNC:8113"
                     /db_xref="MIM:182878"
                     /translation="MAALSCLLDSVRRDIKKVDRELRQLRCIDEFSTRCLCDLYMHPY
                     CCCDLHPYPYCLCYSKRSRSCGLCDLYPCCLCDYKLYCLRPSLRSLERKAIRAIEDEK
                     RELAKLRRTTNRILASSCCSSNILGSVNVCGFEPDQVKVRVKDGKVCVSAERENRYDC
                     LGSKKYSYMNICKEFSLPPCVDEKDVTYSYGLGSCVKIESPCYPCTSPCSPCSPCSPC
                     NPCSPCNPCSPYDPCNPCYPCGSRFSCRKMIL"
     exon            460..1026
                     /gene="ODF1"
                     /gene_synonym="CT133; HSPB10; ODF; ODF2; ODF27; ODFP;
                     ODFPG; ODFPGA; ODFPGB; RT7; SODF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1007..1012
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ODF1"
                     /gene_synonym="CT133; HSPB10; ODF; ODF2; ODF27; ODFP;
                     ODFPG; ODFPGA; ODFPGB; RT7; SODF"
                     /note="hexamer: AATACA"
     polyA_site      1026
                     /gene="ODF1"
                     /gene_synonym="CT133; HSPB10; ODF; ODF2; ODF27; ODFP;
                     ODFPG; ODFPGA; ODFPGB; RT7; SODF"
                     /note="major polyA site"
ORIGIN      
        1 agaacacaag ctttaaagta agtgaatcat gtgtgcctca tttattttta aaagcaactt
       61 ctgagaaggg cttagaacaa attttttccc ggagtgccat ttcccaaagg tactcacaga
      121 acaatcaggt gtgaccataa tggctgcact gagttgtctc ttggacagtg tcagaaggga
      181 cataaagaag gtggacagag aactaaggca actgagatgc atcgacgaat ttagcacacg
      241 gtgcctgtgc gacttgtata tgcaccccta ttgctgctgt gacttgcacc catatccgta
      301 ctgcttgtgc tattccaagc gatcacgctc ttgcggcctg tgtgatctct acccatgttg
      361 cctgtgtgat tataagcttt actgtctgcg accatctctc agaagtttgg agaggaaagc
      421 catcagagcc atagaagatg agaagcgaga gcttgccaaa ctgagaagaa caacaaatag
      481 aattctggct tcctcctgct gtagcagtaa cattttagga tcggtgaatg tatgcggttt
      541 tgaacccgat caagtcaaag ttcgagtgaa ggatggaaag gtatgtgtgt cggctgagcg
      601 ggagaacagg tacgactgcc ttggatcgaa aaagtacagc tacatgaaca tctgcaaaga
      661 gttcagcttg ccgccctgtg tggatgagaa ggatgtaaca tactcctatg ggctcggcag
      721 ctgtgtcaag atcgagtctc cttgctaccc ttgcacttct ccttgcagcc cctgcagccc
      781 ctgcagcccc tgcaacccct gcagcccctg caacccgtgc agcccatatg atccttgcaa
      841 cccgtgttat ccctgtggaa gccgattttc ctgtaggaag atgattttgt aaagtgcgca
      901 taggaaccca ttacttaata gaagtcagtt actccagcca ggcagctctc ccaatgtttc
      961 tcctctcctt cccatggccc ctgttgttga agtacgtagg aaactgaata cataactgca
     1021 atctgc
//
