LOCUS       NM_002539               2476 bp    mRNA    linear   PRI 04-OCT-2024
DEFINITION  Homo sapiens ornithine decarboxylase 1 (ODC1), transcript variant
            1, mRNA.
ACCESSION   NM_002539
VERSION     NM_002539.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2476)
  AUTHORS   Jin,R., Li,H., Nan,S. and Wang,H.
  TITLE     FOXA1 co-activates circODC1 and ODC1 in HPV-positive cervical
            cancer cell growth
  JOURNAL   Syst Biol Reprod Med 70 (1), 113-123 (2024)
   PUBMED   38743820
  REMARK    GeneRIF: FOXA1 co-activates circODC1 and ODC1 in HPV-positive
            cervical cancer cell growth.
REFERENCE   2  (bases 1 to 2476)
  AUTHORS   Li,Y.P., Huang,Z.J., He,Q.K., Li,Y.X., Zhao,X.P., Ma,Z.Q.,
            Qin,M.J., Chen,A.W., Wei,Q., Wang,Y. and Lu,C.H.
  TITLE     Pirin Promotes the Progression of Non-Small-Cell Lung Cancer by
            Increasing ODC1 to Suppress Autophagy
  JOURNAL   J Proteome Res 23 (5), 1713-1724 (2024)
   PUBMED   38648079
  REMARK    GeneRIF: Pirin Promotes the Progression of Non-Small-Cell Lung
            Cancer by Increasing ODC1 to Suppress Autophagy.
REFERENCE   3  (bases 1 to 2476)
  AUTHORS   Cressman,A., Morales,D., Zhang,Z., Le,B., Foley,J.,
            Murray-Stewart,T., Genetos,D.C. and Fierro,F.A.
  TITLE     Effects of Spermine Synthase Deficiency in Mesenchymal Stromal
            Cells Are Rescued by Upstream Inhibition of Ornithine Decarboxylase
  JOURNAL   Int J Mol Sci 25 (5), 2463 (2024)
   PUBMED   38473716
  REMARK    GeneRIF: Effects of Spermine Synthase Deficiency in Mesenchymal
            Stromal Cells Are Rescued by Upstream Inhibition of Ornithine
            Decarboxylase.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2476)
  AUTHORS   Keller,T., Koepsell,H. and Groll,J.
  TITLE     Evaluation of the Influence of Biosurface Design on the Interaction
            between the Regulatory Peptide RS1-reg and ODC1 Reveals a
            Membrane-Dependent Affinity Increase
  JOURNAL   Adv Biol (Weinh) 6 (10), e2101108 (2022)
   PUBMED   35735188
  REMARK    GeneRIF: Evaluation of the Influence of Biosurface Design on the
            Interaction between the Regulatory Peptide RS1-reg and ODC1 Reveals
            a Membrane-Dependent Affinity Increase.
REFERENCE   5  (bases 1 to 2476)
  AUTHORS   Zhou,X.E., Suino-Powell,K., Schultz,C.R., Aleiwi,B.,
            Brunzelle,J.S., Lamp,J., Vega,I.E., Ellsworth,E., Bachmann,A.S. and
            Melcher,K.
  TITLE     Structural basis of binding and inhibition of ornithine
            decarboxylase by 1-amino-oxy-3-aminopropane
  JOURNAL   Biochem J 478 (23), 4137-4149 (2021)
   PUBMED   34796899
  REMARK    GeneRIF: Structural basis of binding and inhibition of ornithine
            decarboxylase by 1-amino-oxy-3-aminopropane.
REFERENCE   6  (bases 1 to 2476)
  AUTHORS   Bupp,C., Michael,J., VanSickle,E., Rajasekaran,S. and Bachmann,A.S.
  TITLE     Bachmann-Bupp Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   36007106
REFERENCE   7  (bases 1 to 2476)
  AUTHORS   Yoshida,M., Hayashi,H., Taira,M. and Isono,K.
  TITLE     Elevated expression of the ornithine decarboxylase gene in human
            esophageal cancer
  JOURNAL   Cancer Res 52 (23), 6671-6675 (1992)
   PUBMED   1423312
REFERENCE   8  (bases 1 to 2476)
  AUTHORS   Moshier,J.A., Osborne,D.L., Skunca,M., Dosescu,J., Gilbert,J.D.,
            Fitzgerald,M.C., Polidori,G., Wagner,R.L., Friezner Degen,S.J.,
            Luk,G.D. et al.
  TITLE     Multiple promoter elements govern expression of the human ornithine
            decarboxylase gene in colon carcinoma cells
  JOURNAL   Nucleic Acids Res 20 (10), 2581-2590 (1992)
   PUBMED   1598217
REFERENCE   9  (bases 1 to 2476)
  AUTHORS   Hickok,N.J., Wahlfors,J., Crozat,A., Halmekyto,M., Alhonen,L.,
            Janne,J. and Janne,O.A.
  TITLE     Human ornithine decarboxylase-encoding loci: nucleotide sequence of
            the expressed gene and characterization of a pseudogene
  JOURNAL   Gene 93 (2), 257-263 (1990)
   PUBMED   2227439
REFERENCE   10 (bases 1 to 2476)
  AUTHORS   Hsieh,J.T., Denning,M.F., Heidel,S.M. and Verma,A.K.
  TITLE     Expression of human chromosome 2 ornithine decarboxylase gene in
            ornithine decarboxylase-deficient Chinese hamster ovary cells
  JOURNAL   Cancer Res 50 (8), 2239-2244 (1990)
   PUBMED   2317811
  REMARK    Erratum:[Cancer Res 1990 Jul 1;50(13):4174]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC007249.5, BC014562.2,
            BC025296.1 and AI277727.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002539.2.
            
            Summary: This gene encodes the rate-limiting enzyme of the
            polyamine biosynthesis pathway which catalyzes ornithine to
            putrescine. The activity level for the enzyme varies in response to
            growth-promoting stimuli and exhibits a high turnover rate in
            comparison to other mammalian proteins. Originally localized to
            both chromosomes 2 and 7, the gene encoding this enzyme has been
            determined to be located on 2p25, with a pseudogene located on
            7q31-qter. Multiple alternatively spliced transcript variants
            encoding distinct isoforms have been identified. [provided by
            RefSeq, Dec 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1). Variants 1, 3, and 4
            encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.551440.1,
                                           SRR1163657.208736.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000234111.9/ ENSP00000234111.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                AC007249.5         112862-112909       c
            49-295              BC014562.2         1-247
            296-2056            BC025296.1         263-2023
            2057-2073           AI277727.1         8-24                c
            2074-2476           AC007249.5         104550-104952       c
FEATURES             Location/Qualifiers
     source          1..2476
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p25.1"
     gene            1..2476
                     /gene="ODC1"
                     /gene_synonym="BABS; NEDBA; NEDBIA; ODC"
                     /note="ornithine decarboxylase 1"
                     /db_xref="GeneID:4953"
                     /db_xref="HGNC:HGNC:8109"
                     /db_xref="MIM:165640"
     exon            1..207
                     /gene="ODC1"
                     /gene_synonym="BABS; NEDBA; NEDBIA; ODC"
                     /inference="alignment:Splign:2.1.0"
     exon            208..317
                     /gene="ODC1"
                     /gene_synonym="BABS; NEDBA; NEDBIA; ODC"
                     /inference="alignment:Splign:2.1.0"
     exon            318..436
                     /gene="ODC1"
                     /gene_synonym="BABS; NEDBA; NEDBIA; ODC"
                     /inference="alignment:Splign:2.1.0"
     CDS             335..1720
                     /gene="ODC1"
                     /gene_synonym="BABS; NEDBA; NEDBIA; ODC"
                     /EC_number="4.1.1.17"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="ornithine decarboxylase isoform 1"
                     /protein_id="NP_002530.1"
                     /db_xref="CCDS:CCDS1672.1"
                     /db_xref="GeneID:4953"
                     /db_xref="HGNC:HGNC:8109"
                     /db_xref="MIM:165640"
                     /translation="MNNFGNEEFDCHFLDEGFTAKDILDQKINEVSSSDDKDAFYVAD
                     LGDILKKHLRWLKALPRVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLG
                     VPPERIIYANPCKQVSQIKYAANNGVQMMTFDSEVELMKVARAHPKAKLVLRIATDDS
                     KAVCRLSVKFGATLRTSRLLLERAKELNIDVVGVSFHVGSGCTDPETFVQAISDARCV
                     FDMGAEVGFSMYLLDIGGGFPGSEDVKLKFEEITGVINPALDKYFPSDSGVRIIAEPG
                     RYYVASAFTLAVNIIAKKIVLKEQTGSDDEDESSEQTFMYYVNDGVYGSFNCILYDHA
                     HVKPLLQKRPKPDEKYYSSSIWGPTCDGLDRIVERCDLPEMHVGDWMLFENMGAYTVA
                     AASTFNGFQRPTIYYVMSGPAWQLMQQFQNPDFPPEVEEQDASTLPVSCAWESGMKRH
                     RAACASASINV"
     exon            437..610
                     /gene="ODC1"
                     /gene_synonym="BABS; NEDBA; NEDBIA; ODC"
                     /inference="alignment:Splign:2.1.0"
     exon            611..783
                     /gene="ODC1"
                     /gene_synonym="BABS; NEDBA; NEDBIA; ODC"
                     /inference="alignment:Splign:2.1.0"
     exon            784..918
                     /gene="ODC1"
                     /gene_synonym="BABS; NEDBA; NEDBIA; ODC"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1000
                     /gene="ODC1"
                     /gene_synonym="BABS; NEDBA; NEDBIA; ODC"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1084
                     /gene="ODC1"
                     /gene_synonym="BABS; NEDBA; NEDBIA; ODC"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1247
                     /gene="ODC1"
                     /gene_synonym="BABS; NEDBA; NEDBIA; ODC"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1360
                     /gene="ODC1"
                     /gene_synonym="BABS; NEDBA; NEDBIA; ODC"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1575
                     /gene="ODC1"
                     /gene_synonym="BABS; NEDBA; NEDBIA; ODC"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..2476
                     /gene="ODC1"
                     /gene_synonym="BABS; NEDBA; NEDBIA; ODC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2037..2042
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ODC1"
                     /gene_synonym="BABS; NEDBA; NEDBIA; ODC"
                     /note="hexamer: AATAAA"
     polyA_site      2056
                     /gene="ODC1"
                     /gene_synonym="BABS; NEDBA; NEDBIA; ODC"
                     /note="major polyA site"
     regulatory      2450..2455
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ODC1"
                     /gene_synonym="BABS; NEDBA; NEDBIA; ODC"
                     /note="hexamer: AATAAA"
     polyA_site      2476
                     /gene="ODC1"
                     /gene_synonym="BABS; NEDBA; NEDBIA; ODC"
ORIGIN      
        1 gtcagtccct cctgtagccg ccgccgccgc cgcccgccgc ccctctgcca gcagctccgg
       61 cgccacctcg ggccggcgtc tccggcgggc gggagccagg cgctgacggg cgcggcgggg
      121 gcggccgagc gctcctgcgg ctgcgactca ggctccggcg tctgcgcttc cccatggggc
      181 tggcctgcgg cgcctgggcg ctctgagatt gtcactgctg ttccaagggc acacgcagag
      241 ggatttggaa ttcctggaga gttgcctttg tgagaagctg gaaatatttc tttcaattcc
      301 atctcttagt tttccatagg aacatcaaga aatcatgaac aactttggta atgaagagtt
      361 tgactgccac ttcctcgatg aaggttttac tgccaaggac attctggacc agaaaattaa
      421 tgaagtttct tcttctgatg ataaggatgc cttctatgtg gcagacctgg gagacattct
      481 aaagaaacat ctgaggtggt taaaagctct ccctcgtgtc accccctttt atgcagtcaa
      541 atgtaatgat agcaaagcca tcgtgaagac ccttgctgct accgggacag gatttgactg
      601 tgctagcaag actgaaatac agttggtgca gagtctgggg gtgcctccag agaggattat
      661 ctatgcaaat ccttgtaaac aagtatctca aattaagtat gctgctaata atggagtcca
      721 gatgatgact tttgatagtg aagttgagtt gatgaaagtt gccagagcac atcccaaagc
      781 aaagttggtt ttgcggattg ccactgatga ttccaaagca gtctgtcgtc tcagtgtgaa
      841 attcggtgcc acgctcagaa ccagcaggct ccttttggaa cgggcgaaag agctaaatat
      901 cgatgttgtt ggtgtcagct tccatgtagg aagcggctgt accgatcctg agaccttcgt
      961 gcaggcaatc tctgatgccc gctgtgtttt tgacatgggg gctgaggttg gtttcagcat
     1021 gtatctgctt gatattggcg gtggctttcc tggatctgag gatgtgaaac ttaaatttga
     1081 agagatcacc ggcgtaatca acccagcgtt ggacaaatac tttccgtcag actctggagt
     1141 gagaatcata gctgagcccg gcagatacta tgttgcatca gctttcacgc ttgcagttaa
     1201 tatcattgcc aagaaaattg tattaaagga acagacgggc tctgatgacg aagatgagtc
     1261 gagtgagcag acctttatgt attatgtgaa tgatggcgtc tatggatcat ttaattgcat
     1321 actctatgac cacgcacatg taaagcccct tctgcaaaag agacctaaac cagatgagaa
     1381 gtattattca tccagcatat ggggaccaac atgtgatggc ctcgatcgga ttgttgagcg
     1441 ctgtgacctg cctgaaatgc atgtgggtga ttggatgctc tttgaaaaca tgggcgctta
     1501 cactgttgct gctgcctcta cgttcaatgg cttccagagg ccgacgatct actatgtgat
     1561 gtcagggcct gcgtggcaac tcatgcagca attccagaac cccgacttcc cacccgaagt
     1621 agaggaacag gatgccagca ccctgcctgt gtcttgtgcc tgggagagtg ggatgaaacg
     1681 ccacagagca gcctgtgctt cggctagtat taatgtgtag atagcactct ggtagctgtt
     1741 aactgcaagt ttagcttgaa ttaagggatt tggggggacc atgtaactta attactgcta
     1801 gttttgaaat gtctttgtaa gagtagggtc gccatgatgc agccatatgg aagactagga
     1861 tatgggtcac acttatctgt gttcctatgg aaactatttg aatatttgtt ttatatggat
     1921 ttttattcac tcttcagaca cgctactcaa gagtgcccct cagctgctga acaagcattt
     1981 gtagcttgta caatggcaga atgggccaaa agcttagtgt tgtgacctgt ttttaaaata
     2041 aagtatcttg aaataattag gcattgggac gtttttatgg tgtgttcatt ccagacagtt
     2101 cacgaatccc gtatagctcg ctctgattct cagagaacaa tgagtgggtc cacccacaca
     2161 caggtaggag gacaggtgag acggaagccc catcctccca tgtggacggt gcacatctgc
     2221 tcagcccacc ccacatgtcc agagttggct gcaaactcct tgtccagagc ctctggtggt
     2281 gggacctact taagtctgac ggacctgtcc tgtccaggcc agtgcccagg gaaggtgtgg
     2341 gaggcccttt gagcctggcc tgcagagacc atccgtgtcc cctcccacct tcatgcctgt
     2401 gagaagttag gaatgtatac ggtaccacat ttggcagtca gcttatttta ataaattcag
     2461 caacagcaag tcccta
//
