LOCUS       NM_001287190            2654 bp    mRNA    linear   PRI 05-OCT-2024
DEFINITION  Homo sapiens ornithine decarboxylase 1 (ODC1), transcript variant
            4, mRNA.
ACCESSION   NM_001287190 XM_005246165
VERSION     NM_001287190.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2654)
  AUTHORS   Jin,R., Li,H., Nan,S. and Wang,H.
  TITLE     FOXA1 co-activates circODC1 and ODC1 in HPV-positive cervical
            cancer cell growth
  JOURNAL   Syst Biol Reprod Med 70 (1), 113-123 (2024)
   PUBMED   38743820
  REMARK    GeneRIF: FOXA1 co-activates circODC1 and ODC1 in HPV-positive
            cervical cancer cell growth.
REFERENCE   2  (bases 1 to 2654)
  AUTHORS   Li,Y.P., Huang,Z.J., He,Q.K., Li,Y.X., Zhao,X.P., Ma,Z.Q.,
            Qin,M.J., Chen,A.W., Wei,Q., Wang,Y. and Lu,C.H.
  TITLE     Pirin Promotes the Progression of Non-Small-Cell Lung Cancer by
            Increasing ODC1 to Suppress Autophagy
  JOURNAL   J Proteome Res 23 (5), 1713-1724 (2024)
   PUBMED   38648079
  REMARK    GeneRIF: Pirin Promotes the Progression of Non-Small-Cell Lung
            Cancer by Increasing ODC1 to Suppress Autophagy.
REFERENCE   3  (bases 1 to 2654)
  AUTHORS   Cressman,A., Morales,D., Zhang,Z., Le,B., Foley,J.,
            Murray-Stewart,T., Genetos,D.C. and Fierro,F.A.
  TITLE     Effects of Spermine Synthase Deficiency in Mesenchymal Stromal
            Cells Are Rescued by Upstream Inhibition of Ornithine Decarboxylase
  JOURNAL   Int J Mol Sci 25 (5), 2463 (2024)
   PUBMED   38473716
  REMARK    GeneRIF: Effects of Spermine Synthase Deficiency in Mesenchymal
            Stromal Cells Are Rescued by Upstream Inhibition of Ornithine
            Decarboxylase.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2654)
  AUTHORS   Keller,T., Koepsell,H. and Groll,J.
  TITLE     Evaluation of the Influence of Biosurface Design on the Interaction
            between the Regulatory Peptide RS1-reg and ODC1 Reveals a
            Membrane-Dependent Affinity Increase
  JOURNAL   Adv Biol (Weinh) 6 (10), e2101108 (2022)
   PUBMED   35735188
  REMARK    GeneRIF: Evaluation of the Influence of Biosurface Design on the
            Interaction between the Regulatory Peptide RS1-reg and ODC1 Reveals
            a Membrane-Dependent Affinity Increase.
REFERENCE   5  (bases 1 to 2654)
  AUTHORS   Zhou,X.E., Suino-Powell,K., Schultz,C.R., Aleiwi,B.,
            Brunzelle,J.S., Lamp,J., Vega,I.E., Ellsworth,E., Bachmann,A.S. and
            Melcher,K.
  TITLE     Structural basis of binding and inhibition of ornithine
            decarboxylase by 1-amino-oxy-3-aminopropane
  JOURNAL   Biochem J 478 (23), 4137-4149 (2021)
   PUBMED   34796899
  REMARK    GeneRIF: Structural basis of binding and inhibition of ornithine
            decarboxylase by 1-amino-oxy-3-aminopropane.
REFERENCE   6  (bases 1 to 2654)
  AUTHORS   Bupp,C., Michael,J., VanSickle,E., Rajasekaran,S. and Bachmann,A.S.
  TITLE     Bachmann-Bupp Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   36007106
REFERENCE   7  (bases 1 to 2654)
  AUTHORS   Yoshida,M., Hayashi,H., Taira,M. and Isono,K.
  TITLE     Elevated expression of the ornithine decarboxylase gene in human
            esophageal cancer
  JOURNAL   Cancer Res 52 (23), 6671-6675 (1992)
   PUBMED   1423312
REFERENCE   8  (bases 1 to 2654)
  AUTHORS   Moshier,J.A., Osborne,D.L., Skunca,M., Dosescu,J., Gilbert,J.D.,
            Fitzgerald,M.C., Polidori,G., Wagner,R.L., Friezner Degen,S.J.,
            Luk,G.D. et al.
  TITLE     Multiple promoter elements govern expression of the human ornithine
            decarboxylase gene in colon carcinoma cells
  JOURNAL   Nucleic Acids Res 20 (10), 2581-2590 (1992)
   PUBMED   1598217
REFERENCE   9  (bases 1 to 2654)
  AUTHORS   Hickok,N.J., Wahlfors,J., Crozat,A., Halmekyto,M., Alhonen,L.,
            Janne,J. and Janne,O.A.
  TITLE     Human ornithine decarboxylase-encoding loci: nucleotide sequence of
            the expressed gene and characterization of a pseudogene
  JOURNAL   Gene 93 (2), 257-263 (1990)
   PUBMED   2227439
REFERENCE   10 (bases 1 to 2654)
  AUTHORS   Hsieh,J.T., Denning,M.F., Heidel,S.M. and Verma,A.K.
  TITLE     Expression of human chromosome 2 ornithine decarboxylase gene in
            ornithine decarboxylase-deficient Chinese hamster ovary cells
  JOURNAL   Cancer Res 50 (8), 2239-2244 (1990)
   PUBMED   2317811
  REMARK    Erratum:[Cancer Res 1990 Jul 1;50(13):4174]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC007249.5, HY044065.1,
            BI463057.1, BC014562.2 and AI277727.1.
            
            On May 31, 2019 this sequence version replaced NM_001287190.1.
            
            Summary: This gene encodes the rate-limiting enzyme of the
            polyamine biosynthesis pathway which catalyzes ornithine to
            putrescine. The activity level for the enzyme varies in response to
            growth-promoting stimuli and exhibits a high turnover rate in
            comparison to other mammalian proteins. Originally localized to
            both chromosomes 2 and 7, the gene encoding this enzyme has been
            determined to be located on 2p25, with a pseudogene located on
            7q31-qter. Multiple alternatively spliced transcript variants
            encoding distinct isoforms have been identified. [provided by
            RefSeq, Dec 2013].
            
            Transcript Variant: This variant (4) has an alternate 5' UTR exon,
            compared to variant 1. Variants 1, 3 and 4 encode the same isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.138048.1,
                                           SRR1803615.144145.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-213               AC007249.5         112382-112594       c
            214-270             HY044065.1         2-58
            271-925             BI463057.1         58-712
            926-2234            BC014562.2         703-2011
            2235-2251           AI277727.1         8-24                c
            2252-2654           AC007249.5         104550-104952       c
FEATURES             Location/Qualifiers
     source          1..2654
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p25.1"
     gene            1..2654
                     /gene="ODC1"
                     /gene_synonym="BABS; NEDBA; NEDBIA; ODC"
                     /note="ornithine decarboxylase 1"
                     /db_xref="GeneID:4953"
                     /db_xref="HGNC:HGNC:8109"
                     /db_xref="MIM:165640"
     exon            1..385
                     /gene="ODC1"
                     /gene_synonym="BABS; NEDBA; NEDBIA; ODC"
                     /inference="alignment:Splign:2.1.0"
     exon            386..495
                     /gene="ODC1"
                     /gene_synonym="BABS; NEDBA; NEDBIA; ODC"
                     /inference="alignment:Splign:2.1.0"
     exon            496..614
                     /gene="ODC1"
                     /gene_synonym="BABS; NEDBA; NEDBIA; ODC"
                     /inference="alignment:Splign:2.1.0"
     CDS             513..1898
                     /gene="ODC1"
                     /gene_synonym="BABS; NEDBA; NEDBIA; ODC"
                     /EC_number="4.1.1.17"
                     /note="isoform 1 is encoded by transcript variant 4"
                     /codon_start=1
                     /product="ornithine decarboxylase isoform 1"
                     /protein_id="NP_001274119.1"
                     /db_xref="CCDS:CCDS1672.1"
                     /db_xref="GeneID:4953"
                     /db_xref="HGNC:HGNC:8109"
                     /db_xref="MIM:165640"
                     /translation="MNNFGNEEFDCHFLDEGFTAKDILDQKINEVSSSDDKDAFYVAD
                     LGDILKKHLRWLKALPRVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLG
                     VPPERIIYANPCKQVSQIKYAANNGVQMMTFDSEVELMKVARAHPKAKLVLRIATDDS
                     KAVCRLSVKFGATLRTSRLLLERAKELNIDVVGVSFHVGSGCTDPETFVQAISDARCV
                     FDMGAEVGFSMYLLDIGGGFPGSEDVKLKFEEITGVINPALDKYFPSDSGVRIIAEPG
                     RYYVASAFTLAVNIIAKKIVLKEQTGSDDEDESSEQTFMYYVNDGVYGSFNCILYDHA
                     HVKPLLQKRPKPDEKYYSSSIWGPTCDGLDRIVERCDLPEMHVGDWMLFENMGAYTVA
                     AASTFNGFQRPTIYYVMSGPAWQLMQQFQNPDFPPEVEEQDASTLPVSCAWESGMKRH
                     RAACASASINV"
     exon            615..788
                     /gene="ODC1"
                     /gene_synonym="BABS; NEDBA; NEDBIA; ODC"
                     /inference="alignment:Splign:2.1.0"
     exon            789..961
                     /gene="ODC1"
                     /gene_synonym="BABS; NEDBA; NEDBIA; ODC"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1096
                     /gene="ODC1"
                     /gene_synonym="BABS; NEDBA; NEDBIA; ODC"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1178
                     /gene="ODC1"
                     /gene_synonym="BABS; NEDBA; NEDBIA; ODC"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1262
                     /gene="ODC1"
                     /gene_synonym="BABS; NEDBA; NEDBIA; ODC"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1425
                     /gene="ODC1"
                     /gene_synonym="BABS; NEDBA; NEDBIA; ODC"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1538
                     /gene="ODC1"
                     /gene_synonym="BABS; NEDBA; NEDBIA; ODC"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1753
                     /gene="ODC1"
                     /gene_synonym="BABS; NEDBA; NEDBIA; ODC"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..2654
                     /gene="ODC1"
                     /gene_synonym="BABS; NEDBA; NEDBIA; ODC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2215..2220
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ODC1"
                     /gene_synonym="BABS; NEDBA; NEDBIA; ODC"
                     /note="hexamer: AATAAA"
     polyA_site      2234
                     /gene="ODC1"
                     /gene_synonym="BABS; NEDBA; NEDBIA; ODC"
                     /note="major polyA site"
     regulatory      2628..2633
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ODC1"
                     /gene_synonym="BABS; NEDBA; NEDBIA; ODC"
                     /note="hexamer: AATAAA"
     polyA_site      2654
                     /gene="ODC1"
                     /gene_synonym="BABS; NEDBA; NEDBIA; ODC"
ORIGIN      
        1 ggagacacgt ggtcgccgag cgggccacga ccttgaggcg ccgcttcctc ccggcccggg
       61 gttctcccgc ggctggataa gggtgatccg ggcgcctcgt tctgcccccg tcttcacagc
      121 tcggggctgg aggggcctag gggagaccca cccggagacc ctgcggcccc gcgccggcct
      181 ctttcccaac ccttcggcgg ccgcgcgctg gccggggagc cgttggggag gccctggcgg
      241 ccgcgcagca ggtgcagggg cgcagagccc gggctcgcct tggtacagac gagcgggccc
      301 cggccttggc gccttcagtt tccttccagt ttttattttc gctgtgtcta cagagcagat
      361 gacaccaatt tggaaacccg cgagaattgt cactgctgtt ccaagggcac acgcagaggg
      421 atttggaatt cctggagagt tgcctttgtg agaagctgga aatatttctt tcaattccat
      481 ctcttagttt tccataggaa catcaagaaa tcatgaacaa ctttggtaat gaagagtttg
      541 actgccactt cctcgatgaa ggttttactg ccaaggacat tctggaccag aaaattaatg
      601 aagtttcttc ttctgatgat aaggatgcct tctatgtggc agacctggga gacattctaa
      661 agaaacatct gaggtggtta aaagctctcc ctcgtgtcac ccccttttat gcagtcaaat
      721 gtaatgatag caaagccatc gtgaagaccc ttgctgctac cgggacagga tttgactgtg
      781 ctagcaagac tgaaatacag ttggtgcaga gtctgggggt gcctccagag aggattatct
      841 atgcaaatcc ttgtaaacaa gtatctcaaa ttaagtatgc tgctaataat ggagtccaga
      901 tgatgacttt tgatagtgaa gttgagttga tgaaagttgc cagagcacat cccaaagcaa
      961 agttggtttt gcggattgcc actgatgatt ccaaagcagt ctgtcgtctc agtgtgaaat
     1021 tcggtgccac gctcagaacc agcaggctcc ttttggaacg ggcgaaagag ctaaatatcg
     1081 atgttgttgg tgtcagcttc catgtaggaa gcggctgtac cgatcctgag accttcgtgc
     1141 aggcaatctc tgatgcccgc tgtgtttttg acatgggggc tgaggttggt ttcagcatgt
     1201 atctgcttga tattggcggt ggctttcctg gatctgagga tgtgaaactt aaatttgaag
     1261 agatcaccgg cgtaatcaac ccagcgttgg acaaatactt tccgtcagac tctggagtga
     1321 gaatcatagc tgagcccggc agatactatg ttgcatcagc tttcacgctt gcagttaata
     1381 tcattgccaa gaaaattgta ttaaaggaac agacgggctc tgatgacgaa gatgagtcga
     1441 gtgagcagac ctttatgtat tatgtgaatg atggcgtcta tggatcattt aattgcatac
     1501 tctatgacca cgcacatgta aagccccttc tgcaaaagag acctaaacca gatgagaagt
     1561 attattcatc cagcatatgg ggaccaacat gtgatggcct cgatcggatt gttgagcgct
     1621 gtgacctgcc tgaaatgcat gtgggtgatt ggatgctctt tgaaaacatg ggcgcttaca
     1681 ctgttgctgc tgcctctacg ttcaatggct tccagaggcc gacgatctac tatgtgatgt
     1741 cagggcctgc gtggcaactc atgcagcaat tccagaaccc cgacttccca cccgaagtag
     1801 aggaacagga tgccagcacc ctgcctgtgt cttgtgcctg ggagagtggg atgaaacgcc
     1861 acagagcagc ctgtgcttcg gctagtatta atgtgtagat agcactctgg tagctgttaa
     1921 ctgcaagttt agcttgaatt aagggatttg gggggaccat gtaacttaat tactgctagt
     1981 tttgaaatgt ctttgtaaga gtagggtcgc catgatgcag ccatatggaa gactaggata
     2041 tgggtcacac ttatctgtgt tcctatggaa actatttgaa tatttgtttt atatggattt
     2101 ttattcactc ttcagacacg ctactcaaga gtgcccctca gctgctgaac aagcatttgt
     2161 agcttgtaca atggcagaat gggccaaaag cttagtgttg tgacctgttt ttaaaataaa
     2221 gtatcttgaa ataattaggc attgggacgt ttttatggtg tgttcattcc agacagttca
     2281 cgaatcccgt atagctcgct ctgattctca gagaacaatg agtgggtcca cccacacaca
     2341 ggtaggagga caggtgagac ggaagcccca tcctcccatg tggacggtgc acatctgctc
     2401 agcccacccc acatgtccag agttggctgc aaactccttg tccagagcct ctggtggtgg
     2461 gacctactta agtctgacgg acctgtcctg tccaggccag tgcccaggga aggtgtggga
     2521 ggccctttga gcctggcctg cagagaccat ccgtgtcccc tcccaccttc atgcctgtga
     2581 gaagttagga atgtatacgg taccacattt ggcagtcagc ttattttaat aaattcagca
     2641 acagcaagtc ccta
//
