LOCUS       NM_017855               1355 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens odontogenic, ameloblast associated (ODAM), transcript
            variant 1, mRNA.
ACCESSION   NM_017855
VERSION     NM_017855.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1355)
  AUTHORS   Yuan,D.F., Wang,H.R., Wang,Z.F., Liang,G.H., Xing,W.Q. and Qin,J.J.
  TITLE     CircRNA CircZMYM4 inhibits the growth and metastasis of lung
            adenocarcinoma via the miR-587/ODAM pathway
  JOURNAL   Biochem Biophys Res Commun 580, 100-106 (2021)
   PUBMED   34634673
  REMARK    GeneRIF: CircRNA CircZMYM4 inhibits the growth and metastasis of
            lung adenocarcinoma via the miR-587/ODAM pathway.
REFERENCE   2  (bases 1 to 1355)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1355)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1355)
  AUTHORS   Tremillo-Maldonado,O., Molina-Frechero,N., Gonzalez-Gonzalez,R.,
            Damian-Matsumura,P., Sanchez-Perez,L., Sicco,E., Suarez,M. and
            Bologna-Molina,R.
  TITLE     DNA sequencing reveals AMELX, ODAM and MMP20 variations in dental
            fluorosis
  JOURNAL   Arch Oral Biol 110, 104626 (2020)
   PUBMED   31838295
  REMARK    GeneRIF: AMELX and ODAM variations was not different between two
            populations of schoolchildren with respect to dental fluorosis (DF)
            severity; however, the presence of rs1784418 differed between
            phenotypes with regard to susceptibility to DF. Therefore, MMP20
            might be related to the various phenotypes of DF
REFERENCE   5  (bases 1 to 1355)
  AUTHORS   Ikeda,Y., Neshatian,M., Holcroft,J. and Ganss,B.
  TITLE     The enamel protein ODAM promotes mineralization in a collagen
            matrix
  JOURNAL   Connect Tissue Res 59 (sup1), 62-66 (2018)
   PUBMED   29745811
  REMARK    GeneRIF: Similar to AMTN, ODAM is able to promote HA nucleation in
            a dose-dependent manner in SBF, and even outside of its biological
            context in vitro.
REFERENCE   6  (bases 1 to 1355)
  AUTHORS   Kestler,D.P., Foster,J.S., Macy,S.D., Murphy,C.L., Weiss,D.T. and
            Solomon,A.
  TITLE     Expression of odontogenic ameloblast-associated protein (ODAM) in
            dental and other epithelial neoplasms
  JOURNAL   Mol Med 14 (5-6), 318-326 (2008)
   PUBMED   18472969
  REMARK    GeneRIF: Data suggest that ODAM is a developmental antigen that has
            an essential role in tooth maturation and in the pathogenesis of
            certain odontogenic and other epithelial neoplasms
REFERENCE   7  (bases 1 to 1355)
  AUTHORS   Moffatt,P., Smith,C.E., St-Arnaud,R. and Nanci,A.
  TITLE     Characterization of Apin, a secreted protein highly expressed in
            tooth-associated epithelia
  JOURNAL   J Cell Biochem 103 (3), 941-956 (2008)
   PUBMED   17647262
  REMARK    GeneRIF: The protein sequences deduced from the cloned cDNA for
            rat, mouse, pig, and human were aligned together with those
            obtained from four other mammal genomes. Apin is highly conserved
            in mammals.
REFERENCE   8  (bases 1 to 1355)
  AUTHORS   Moffatt,P., Smith,C.E., Sooknanan,R., St-Arnaud,R. and Nanci,A.
  TITLE     Identification of secreted and membrane proteins in the rat incisor
            enamel organ using a signal-trap screening approach
  JOURNAL   Eur J Oral Sci 114 Suppl 1, 139-46 (2006)
   PUBMED   16674676
REFERENCE   9  (bases 1 to 1355)
  AUTHORS   Solomon,A., Murphy,C.L., Weaver,K., Weiss,D.T., Hrncic,R.,
            Eulitz,M., Donnell,R.L., Sletten,K., Westermark,G. and
            Westermark,P.
  TITLE     Calcifying epithelial odontogenic (Pindborg) tumor-associated
            amyloid consists of a novel human protein
  JOURNAL   J Lab Clin Med 142 (5), 348-355 (2003)
   PUBMED   14647039
  REMARK    GeneRIF: Calcifying epithelial odontogenic tumor-associated amyloid
            consists of a unique and previously undescribed protein that we
            provisionally designate APin.
REFERENCE   10 (bases 1 to 1355)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC105347.4.
            
            On Jul 21, 2020 this sequence version replaced NM_017855.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.316870.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2142670
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000683306.1/
                                                ENSP00000507531.1
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                AC105347.4         3799-3867
            70-135              AC105347.4         4603-4668
            136-177             AC105347.4         4766-4807
            178-225             AC105347.4         5348-5395
            226-459             AC105347.4         5998-6231
            460-507             AC105347.4         6653-6700
            508-612             AC105347.4         8571-8675
            613-660             AC105347.4         9528-9575
            661-732             AC105347.4         10332-10403
            733-894             AC105347.4         10830-10991
            895-953             AC105347.4         11230-11288
            954-1355            AC105347.4         12249-12650
FEATURES             Location/Qualifiers
     source          1..1355
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q13.3"
     gene            1..1355
                     /gene="ODAM"
                     /gene_synonym="APIN"
                     /note="odontogenic, ameloblast associated"
                     /db_xref="GeneID:54959"
                     /db_xref="HGNC:HGNC:26043"
                     /db_xref="MIM:614843"
     exon            1..69
                     /gene="ODAM"
                     /gene_synonym="APIN"
                     /inference="alignment:Splign:2.1.0"
     exon            70..135
                     /gene="ODAM"
                     /gene_synonym="APIN"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..924
                     /gene="ODAM"
                     /gene_synonym="APIN"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; odontogenic ameloblast-associated protein;
                     odontogenic, ameloblast asssociated"
                     /codon_start=1
                     /product="odontogenic ameloblast-associated protein
                     isoform 1 precursor"
                     /protein_id="NP_060325.3"
                     /db_xref="CCDS:CCDS3536.2"
                     /db_xref="GeneID:54959"
                     /db_xref="HGNC:HGNC:26043"
                     /db_xref="MIM:614843"
                     /translation="MKIIILLGFLGATLSAPLIPQRLMSASNSNELLLNLNNGQLLPL
                     QLQGPLNSWIPPFSGILQQQQQAQIPGLSQFSLSALDQFAGLLPNQIPLTGEASFAQG
                     AQAGQVDPLQLQTPPQTQPGPSHVMPYVFSFKMPQEQGQMFQYYPVYMVLPWEQPQQT
                     VPRSPQQTRQQQYEEQIPFYAQFGYIPQLAEPAISGGQQQLAFDPQLGTAPEIAVMST
                     GEEIPYLQKEAINFRHDSAGVFMPSTSPKPSTTNVFTSAVDQTITPELPEEKDKTDSL
                     REP"
     exon            136..177
                     /gene="ODAM"
                     /gene_synonym="APIN"
                     /inference="alignment:Splign:2.1.0"
     exon            178..225
                     /gene="ODAM"
                     /gene_synonym="APIN"
                     /inference="alignment:Splign:2.1.0"
     exon            226..459
                     /gene="ODAM"
                     /gene_synonym="APIN"
                     /inference="alignment:Splign:2.1.0"
     exon            460..507
                     /gene="ODAM"
                     /gene_synonym="APIN"
                     /inference="alignment:Splign:2.1.0"
     exon            508..612
                     /gene="ODAM"
                     /gene_synonym="APIN"
                     /inference="alignment:Splign:2.1.0"
     exon            613..660
                     /gene="ODAM"
                     /gene_synonym="APIN"
                     /inference="alignment:Splign:2.1.0"
     exon            661..732
                     /gene="ODAM"
                     /gene_synonym="APIN"
                     /inference="alignment:Splign:2.1.0"
     exon            733..894
                     /gene="ODAM"
                     /gene_synonym="APIN"
                     /inference="alignment:Splign:2.1.0"
     exon            895..953
                     /gene="ODAM"
                     /gene_synonym="APIN"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1355
                     /gene="ODAM"
                     /gene_synonym="APIN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1201..1206
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ODAM"
                     /gene_synonym="APIN"
                     /note="hexamer: AATAAA"
     polyA_site      1225
                     /gene="ODAM"
                     /gene_synonym="APIN"
                     /note="major polyA site"
     regulatory      1332..1337
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ODAM"
                     /gene_synonym="APIN"
                     /note="hexamer: AGTAAA"
     polyA_site      1355
                     /gene="ODAM"
                     /gene_synonym="APIN"
                     /note="major polyA site"
ORIGIN      
        1 agagctgaga gaggaaaaga acacagatct cgcatggttc agatttttct ttttaggtcc
       61 aggagtaaga tatatcatac gaaaatgaaa attataattc ttcttggatt cctgggagcc
      121 acattgtcag ccccacttat cccacagcgt ctcatgtctg ccagcaatag caatgagtta
      181 cttcttaatc ttaataatgg tcaacttttg ccactacaac ttcagggccc acttaattca
      241 tggattccac ctttctctgg aattttacaa cagcagcagc aggctcaaat tccaggactc
      301 tcccagttct ctttatcagc tctagaccag tttgctggac tgctcccaaa tcagataccc
      361 ttaacaggag aggccagttt tgcccaagga gcccaggcag gccaagttga tcccttacag
      421 cttcaaacac cgcctcagac acaaccaggc cccagtcacg tgatgcccta tgtattctcc
      481 ttcaaaatgc ctcaagagca aggacagatg tttcaatact atccagttta catggtccta
      541 ccctgggaac aacctcagca aacagttcca aggtcacctc aacaaacaag acagcaacag
      601 tatgaggagc agataccatt ctatgctcaa tttggataca ttccacaact agcagaacct
      661 gctatatcag gaggacagca gcaactagct tttgatcccc aactaggcac agctcctgaa
      721 attgctgtga tgtcaacagg agaagagata ccatatttac aaaaagaagc gatcaacttt
      781 agacatgaca gtgcaggagt tttcatgccc tcaacttcac caaaacccag cacaaccaat
      841 gttttcactt ctgctgtaga ccaaactatt accccagagc tcccagaaga gaaggacaag
      901 actgacagcc taagggaacc ataagaagtt gccctgatca ttcagacatt ttgggaaaaa
      961 gatgtggcca tgccttggat ataattttag gctattagct tcctcaatac tagtatcagt
     1021 tctttggaat acatgaaata tcttgactct tctcctaaat ttgtttttac ttatacatgt
     1081 tattaaactc tttaaatatg tcatagaaaa taatacaatc atgtaatgag tcttgtctta
     1141 caaaattata tgtctcttca aatatcctat cattgtataa tatggaatat aataacacag
     1201 aataaagcta gtatcattaa atcaattgga taattgcatt agtaaatgat gcctctgcaa
     1261 aatggtagta cccatgaaga tatgtatatt gtcattggat gtatgatgag tgttgtgatt
     1321 ggaactgatg aagtaaaata agtatctaga tttga
//
