LOCUS       NM_031421               3146 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens outer dynein arm docking complex subunit 4 (ODAD4),
            transcript variant 1, mRNA.
ACCESSION   NM_031421
VERSION     NM_031421.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3146)
  AUTHORS   De Ita,M., Gaytan-Cervantes,J., Cisneros,B., Araujo,M.A.,
            Huicochea-Montiel,J.C., Cardenas-Conejo,A., Lazo-Cardenas,C.C.,
            Ramirez-Portillo,C.I., Feria-Kaiser,C., Peregrino-Bejarano,L.,
            Yanez-Gutierrez,L., Gonzalez-Torres,C. and Rosas-Vargas,H.
  TITLE     Clustering of Genetic Anomalies of Cilia Outer Dynein Arm and
            Central Apparatus in Patients with Transposition of the Great
            Arteries
  JOURNAL   Genes (Basel) 13 (9), 1662 (2022)
   PUBMED   36140829
  REMARK    GeneRIF: Clustering of Genetic Anomalies of Cilia Outer Dynein Arm
            and Central Apparatus in Patients with Transposition of the Great
            Arteries.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3146)
  AUTHORS   Braschi,B., Omran,H., Witman,G.B., Pazour,G.J., Pfister,K.K.,
            Bruford,E.A. and King,S.M.
  TITLE     Consensus nomenclature for dyneins and associated assembly factors
  JOURNAL   J Cell Biol 221 (2) (2022)
   PUBMED   35006274
REFERENCE   3  (bases 1 to 3146)
  AUTHORS   Vojinovic,D., Brison,N., Ahmad,S., Noens,I., Pappa,I.,
            Karssen,L.C., Tiemeier,H., van Duijn,C.M., Peeters,H. and Amin,N.
  TITLE     Variants in TTC25 affect autistic trait in patients with autism
            spectrum disorder and general population
  JOURNAL   Eur J Hum Genet 25 (8), 982-987 (2017)
   PUBMED   28513607
  REMARK    GeneRIF: TTC25 variants are associated with quantitative autistic
            trait in patients with autism spectrum disorder.  Variants in TTC25
            may also be relevant for broader ASD phenotype in the general
            population.
REFERENCE   4  (bases 1 to 3146)
  AUTHORS   Wallmeier,J., Shiratori,H., Dougherty,G.W., Edelbusch,C., Hjeij,R.,
            Loges,N.T., Menchen,T., Olbrich,H., Pennekamp,P., Raidt,J.,
            Werner,C., Minegishi,K., Shinohara,K., Asai,Y., Takaoka,K., Lee,C.,
            Griese,M., Memari,Y., Durbin,R., Kolb-Kokocinski,A., Sauer,S.,
            Wallingford,J.B., Hamada,H. and Omran,H.
  TITLE     TTC25 Deficiency Results in Defects of the Outer Dynein Arm Docking
            Machinery and Primary Ciliary Dyskinesia with Left-Right Body
            Asymmetry Randomization
  JOURNAL   Am J Hum Genet 99 (2), 460-469 (2016)
   PUBMED   27486780
  REMARK    GeneRIF: report of TTC25 as a new member of the outer dynein arms
            docking machinery in humans and mice
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC125257.4, AL136760.1 and
            CB242540.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_031421.4.
            
            Summary: This gene encodes a tetratricopeptide repeat
            domain-containing protein that localizes to ciliary axonmenes and
            plays a role in the docking of the outer dynein arm to cilia.
            Mutations in this gene cause severely reduced ciliary motility and
            the disorder CILD35 (ciliary dyskinesia,primary, 35). Primary
            ciliary dyskinesia is often associated with recurrent respiratory
            infections, immotile spermatozoa, and situs inversus; an inversion
            in left-right body symmetry. Alternative splicing results in
            multiple transcript variants encoding distinct isoforms. [provided
            by RefSeq, Apr 2017].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.239710.1,
                                           SRR1803612.162805.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377540.6/ ENSP00000478589.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                AC125257.4         95306-95344
            40-2294             AL136760.1         1-2255
            2295-2518           AC125257.4         130341-130564
            2519-3146           CB242540.1         32-659              c
FEATURES             Location/Qualifiers
     source          1..3146
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..3146
                     /gene="ODAD4"
                     /gene_synonym="TTC25"
                     /note="outer dynein arm docking complex subunit 4"
                     /db_xref="GeneID:83538"
                     /db_xref="HGNC:HGNC:25280"
                     /db_xref="MIM:617095"
     exon            1..221
                     /gene="ODAD4"
                     /gene_synonym="TTC25"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..2126
                     /gene="ODAD4"
                     /gene_synonym="TTC25"
                     /note="isoform 1 is encoded by transcript variant 1;
                     tetratricopeptide repeat protein 25; TPR repeat protein
                     25; tetratricopeptide repeat domain 25"
                     /codon_start=1
                     /product="outer dynein arm-docking complex subunit 4
                     isoform 1"
                     /protein_id="NP_113609.1"
                     /db_xref="CCDS:CCDS74063.1"
                     /db_xref="GeneID:83538"
                     /db_xref="HGNC:HGNC:25280"
                     /db_xref="MIM:617095"
                     /translation="MSDPEGETLRSTFPSYMAEGERLYLCGEFSKAAQSFSNALYLQD
                     GDKNCLVARSKCFLKMGDLERSLKDAEASLQSDPAFCKGILQKAETLYTMGDFEFALV
                     FYHRGYKLRPDREFRVGIQKAQEAINNSVGSPSSIKLENKGDLSFLSKQAENIKAQQK
                     PQPMKHLLHPTKGEPKWKASLKSEKTVRQLLGELYVDKEYLEKLLLDEDLIKGTMKGG
                     LTVEDLIMTGINYLDTHSNFWRQQKPIYARERDRKLMQEKWLRDHKRRPSQTAHYILK
                     SLEDIDMLLTSGSAEGSLQKAEKVLKKVLEWNKEEVPNKDELVGNLYSCIGNAQIELG
                     QMEAALQSHRKDLEIAKEYDLPDAKSRALDNIGRVFARVGKFQQAIDTWEEKIPLAKT
                     TLEKTWLFHEIGRCYLELDQAWQAQNYGEKSQQCAEEEGDIEWQLNASVLVAQAQVKL
                     RDFESAVNNFEKALERAKLVHNNEAQQAIISALDDANKGIIRELRKTNYVENLKEKSE
                     GEASLYEDRIITREKDMRRVRDEPEKVVKQWDHSEDEKETDEDDEAFGEALQSPASGK
                     QSVEAGKARSDLGAVAKGLSGELGTRSGETGRKLLEAGRRESREIYRRPSGELEQRLS
                     GEFSRQEPEELKKLSEVGRREPEELGKTQFGEIGETKKTGNEMEKEYE"
     exon            222..353
                     /gene="ODAD4"
                     /gene_synonym="TTC25"
                     /inference="alignment:Splign:2.1.0"
     exon            354..504
                     /gene="ODAD4"
                     /gene_synonym="TTC25"
                     /inference="alignment:Splign:2.1.0"
     exon            505..566
                     /gene="ODAD4"
                     /gene_synonym="TTC25"
                     /inference="alignment:Splign:2.1.0"
     exon            567..732
                     /gene="ODAD4"
                     /gene_synonym="TTC25"
                     /inference="alignment:Splign:2.1.0"
     exon            733..957
                     /gene="ODAD4"
                     /gene_synonym="TTC25"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1165
                     /gene="ODAD4"
                     /gene_synonym="TTC25"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1252
                     /gene="ODAD4"
                     /gene_synonym="TTC25"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1449
                     /gene="ODAD4"
                     /gene_synonym="TTC25"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1550
                     /gene="ODAD4"
                     /gene_synonym="TTC25"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1635
                     /gene="ODAD4"
                     /gene_synonym="TTC25"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..3146
                     /gene="ODAD4"
                     /gene_synonym="TTC25"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2266..2271
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ODAD4"
                     /gene_synonym="TTC25"
                     /note="hexamer: ATTAAA"
     polyA_site      2294
                     /gene="ODAD4"
                     /gene_synonym="TTC25"
                     /note="major polyA site"
     regulatory      3104..3109
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ODAD4"
                     /gene_synonym="TTC25"
                     /note="hexamer: AATAAA"
     regulatory      3119..3124
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ODAD4"
                     /gene_synonym="TTC25"
                     /note="hexamer: ATTAAA"
     polyA_site      3128
                     /gene="ODAD4"
                     /gene_synonym="TTC25"
     polyA_site      3143
                     /gene="ODAD4"
                     /gene_synonym="TTC25"
ORIGIN      
        1 gctgtacatc tcatggttgc taagaaacgg agcttccaca aaccagatag aggttctcca
       61 gcttttcttt gattgtctct gctttagcgt ctctaaatcc ggtcaccatg tcggaccccg
      121 aaggcgagac cttgcgaagc acctttccct cttatatggc cgaaggcgag cggctctacc
      181 tgtgcgggga attttctaaa gccgcgcaga gcttcagcaa cgctctttac cttcaggatg
      241 gagacaagaa ctgcctggtt gctcgctcaa agtgcttcct gaagatggga gacttggaga
      301 gatccctgaa ggatgctgag gcttcgctcc agagtgaccc agctttctgt aaggggattt
      361 tgcaaaaggc tgagacactg tacaccatgg gagactttga gtttgccttg gtattctatc
      421 atcgaggcta caagctgagg cctgatcggg aattcagagt tggcattcag aaagcccagg
      481 aagccatcaa caactcagtg ggaagtcctt cttccattaa gctggagaac aaaggggacc
      541 tctccttctt aagcaagcag gctgagaata taaaagccca gcagaagcct cagcccatga
      601 aacacctctt acaccccacc aagggagagc ccaagtggaa ggcctcgctc aagagtgaga
      661 agactgtccg ccagcttctg ggggagctct acgtggacaa agagtatttg gagaagctcc
      721 tattggatga agacctgatc aaaggcacca tgaagggcgg cctgactgtg gaggacctca
      781 tcatgacggg catcaactac ctggatactc acagcaactt ctggaggcag cagaagccga
      841 tctacgccag ggagcgggac cggaagctga tgcaagagaa atggctgcgg gaccacaaac
      901 gccgtccctc acagacagcc cattacatcc tcaagagcct ggaggacatt gatatgttgc
      961 tcacaagtgg cagtgctgaa gggagtcttc agaaagctga gaaagtgctg aagaaggtac
     1021 tggaatggaa caaggaagag gtacccaaca aggatgaact ggttggaaac ttgtatagct
     1081 gcatagggaa tgcccagatt gagctggggc agatggaggc agccctgcag agccacagaa
     1141 aggacctgga gatcgccaag gaatatgacc ttcctgatgc aaaatcgaga gcccttgaca
     1201 acattggcag agtttttgcc agagttggga aattccagca agccattgac acgtgggaag
     1261 aaaagatccc tctggcaaaa accaccctgg agaagacctg gctgttccac gagatcggcc
     1321 gctgctactt ggagctggac caggcctggc aggcccagaa ttatggcgag aagtcccagc
     1381 agtgtgccga ggaggaaggg gacattgagt ggcaactgaa tgccagtgtt ctggtggccc
     1441 aggcacaagt gaagctgaga gacttcgagt cagccgtgaa caattttgag aaggccctgg
     1501 agagagcaaa gcttgtgcat aacaacgagg cgcagcaggc catcatcagt gccttggacg
     1561 atgccaacaa gggtatcatc agagaactga ggaaaaccaa ctacgtggag aatctcaaag
     1621 aaaaaagcga gggagaagct tcactgtatg aagatagaat aataacaaga gagaaggaca
     1681 tgaggagagt gagagatgag cccgagaagg tggtgaagca gtgggaccat agtgaggatg
     1741 agaaagagac agatgaggac gatgaggctt ttggggaagc tctgcagagc ccagcaagcg
     1801 gaaagcagag tgtggaagca ggaaaagcca gaagcgattt gggagcagtt gccaagggcc
     1861 tgtcaggaga attaggcaca agatcaggag aaacaggcag gaagctacta gaagctggca
     1921 gaagagagtc aagagaaatt tataggaggc cttcgggaga attagagcaa agactctcag
     1981 gagaattcag cagacaggaa ccagaagaac taaagaaact ttcagaagtg ggcagaagag
     2041 agccagaaga actgggaaaa acacaatttg gagaaatagg agaaacgaaa aaaacaggaa
     2101 atgagatgga aaaggaatat gaatgaagcc atcggtagag atgaggatca ggaagctggt
     2161 gttcagaggg atcatgggat tttattaaac tggattttca agcgatttgt ctgttatagg
     2221 aaaaatgagg gttttacttc tgctgctttc catcactatt ttgccattaa ataggtgtct
     2281 ttcactcttg caaaccctga gtctgtcact ttgcctcttc acccctgccc attcttggaa
     2341 gagcatcgtg gaagaaatga gaaaggtgcc aagaagaaag ggtttcagga gggtgaagat
     2401 acgggcgcta cagggaacaa gaagtcacag ggaggagagg ggaaggcctg ggaggagagg
     2461 tgcttcccac acaccggtga ctgactgagt ccctccagtg cgcaggacag cggggaggct
     2521 ttatggatgg aacagtggtg gggcggcccc agctgtcaca ggtaggagaa tgccgcaagc
     2581 cagaaccaag cgaatgctgg gagtgaggcc aaagataggg gagtggcctg ggagtcggga
     2641 gggcagacag actccgcctc tgacacctct gggtggcata atcaggtaaa tcaggctctc
     2701 caagctggct tctcctctga acaatgggat acctgcctca ggggttgctg cgaggactga
     2761 gtgcttagca cagcacttgg acaggaaact caaaaatcca acggagctct cagtggtttc
     2821 acagaggagg tggcagctga ggatctggcc tcagaggatg ttaggatttc actccgttac
     2881 tcatctgtcc ctttggccat tgccatcctg gtctgtctcc acagctccta gaaggaaagg
     2941 tcggggctga gactgacttt cggctggcac agggcctgga cgaatgaggc cagtgaggca
     3001 tttcagatgc agagtttacc ggaatgccag caaattgcat gataatattt taatccaatg
     3061 tggtaaaaaa aaaagttttt aattaatgca aaagtccatg atgaataaaa tatcaaaaat
     3121 taaagacagg atccgacttt gcacga
//
