LOCUS       NM_145045               2123 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens outer dynein arm docking complex subunit 3 (ODAD3),
            transcript variant 1, mRNA.
ACCESSION   NM_145045
VERSION     NM_145045.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2123)
  AUTHORS   Braschi,B., Omran,H., Witman,G.B., Pazour,G.J., Pfister,K.K.,
            Bruford,E.A. and King,S.M.
  TITLE     Consensus nomenclature for dyneins and associated assembly factors
  JOURNAL   J Cell Biol 221 (2) (2022)
   PUBMED   35006274
REFERENCE   2  (bases 1 to 2123)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 2123)
  AUTHORS   Deng,S., Wu,S., Xia,H., Xiong,W., Deng,X., Liao,J., Deng,H. and
            Yuan,L.
  TITLE     Identification of a frame shift mutation in the CCDC151 gene in a
            Han-Chinese family with Kartagener syndrome
  JOURNAL   Biosci Rep 40 (6) (2020)
   PUBMED   32490514
  REMARK    GeneRIF: Identification of a frame shift mutation in the CCDC151
            gene in a Han-Chinese family with Kartagener syndrome.
REFERENCE   4  (bases 1 to 2123)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2123)
  AUTHORS   Zhang,W., Li,D., Wei,S., Guo,T., Wang,J., Luo,H., Yang,Y. and
            Tan,Z.
  TITLE     Whole-exome sequencing identifies a novel CCDC151 mutation,
            c.325G>T (p.E109X), in a patient with primary ciliary dyskinesia
            and situs inversus
  JOURNAL   J Hum Genet 64 (3), 249-252 (2019)
   PUBMED   30504913
  REMARK    GeneRIF: CCDC151 mutation is associated with primary ciliary
            dyskinesia and situs inversus.
            Erratum:[J Hum Genet. 2019 Aug;64(8):829. doi:
            10.1038/s10038-019-0624-2.. PMID: 31178588]
REFERENCE   6  (bases 1 to 2123)
  AUTHORS   Hjeij,R., Onoufriadis,A., Watson,C.M., Slagle,C.E., Klena,N.T.,
            Dougherty,G.W., Kurkowiak,M., Loges,N.T., Diggle,C.P.,
            Morante,N.F., Gabriel,G.C., Lemke,K.L., Li,Y., Pennekamp,P.,
            Menchen,T., Konert,F., Marthin,J.K., Mans,D.A., Letteboer,S.J.,
            Werner,C., Burgoyne,T., Westermann,C., Rutman,A., Carr,I.M.,
            O'Callaghan,C., Moya,E., Chung,E.M., Sheridan,E., Nielsen,K.G.,
            Roepman,R., Bartscherer,K., Burdine,R.D., Lo,C.W., Omran,H. and
            Mitchison,H.M.
  CONSRTM   UK10K Consortium
  TITLE     CCDC151 mutations cause primary ciliary dyskinesia by disruption of
            the outer dynein arm docking complex formation
  JOURNAL   Am J Hum Genet 95 (3), 257-274 (2014)
   PUBMED   25192045
  REMARK    GeneRIF: CCDC151 mutations cause primary ciliary dyskinesia by
            disruption of the outer dynein arm docking complex formation.
REFERENCE   7  (bases 1 to 2123)
  AUTHORS   Jerber,J., Baas,D., Soulavie,F., Chhin,B., Cortier,E., Vesque,C.,
            Thomas,J. and Durand,B.
  TITLE     The coiled-coil domain containing protein CCDC151 is required for
            the function of IFT-dependent motile cilia in animals
  JOURNAL   Hum Mol Genet 23 (3), 563-577 (2014)
   PUBMED   24067530
REFERENCE   8  (bases 1 to 2123)
  AUTHORS   Dean,A.B. and Mitchell,D.R.
  TITLE     Chlamydomonas ODA10 is a conserved axonemal protein that plays a
            unique role in outer dynein arm assembly
  JOURNAL   Mol Biol Cell 24 (23), 3689-3696 (2013)
   PUBMED   24088566
REFERENCE   9  (bases 1 to 2123)
  AUTHORS   Weimann,M., Grossmann,A., Woodsmith,J., Ozkan,Z., Birth,P.,
            Meierhofer,D., Benlasfer,N., Valovka,T., Timmermann,B.,
            Wanker,E.E., Sauer,S. and Stelzl,U.
  TITLE     A Y2H-seq approach defines the human protein methyltransferase
            interactome
  JOURNAL   Nat Methods 10 (4), 339-342 (2013)
   PUBMED   23455924
REFERENCE   10 (bases 1 to 2123)
  AUTHORS   Zariwala,M.A., Knowles,M.R. and Leigh,M.W.
  TITLE     Primary Ciliary Dyskinesia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301301
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB040667.1, AK056363.1 and
            BC036041.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_145045.4.
            
            Summary: This gene encodes a protein containing coiled-coil
            domains. The encoded protein functions in outer dynein arm assembly
            and is required for motile cilia function. Mutations in this gene
            result in primary ciliary dyskinesia. Alternative splicing results
            in multiple transcript variants encoding different isoforms.
            [provided by RefSeq, Oct 2014].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.254774.1,
                                           SRR3476690.1116476.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968540,
                                           SAMEA1968832 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356392.9/ ENSP00000348757.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                DB040667.1         39-79
            42-548              AK056363.1         1-507
            549-2123            BC036041.1         874-2448
FEATURES             Location/Qualifiers
     source          1..2123
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..2123
                     /gene="ODAD3"
                     /gene_synonym="CCDC151; CILD30; ODA10"
                     /note="outer dynein arm docking complex subunit 3"
                     /db_xref="GeneID:115948"
                     /db_xref="HGNC:HGNC:28303"
                     /db_xref="MIM:615956"
     exon            1..349
                     /gene="ODAD3"
                     /gene_synonym="CCDC151; CILD30; ODA10"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..1893
                     /gene="ODAD3"
                     /gene_synonym="CCDC151; CILD30; ODA10"
                     /note="isoform 1 is encoded by transcript variant 1;
                     coiled-coil domain-containing protein 151; coiled-coil
                     domain containing 151"
                     /codon_start=1
                     /product="outer dynein arm-docking complex subunit 3
                     isoform 1"
                     /protein_id="NP_659482.3"
                     /db_xref="CCDS:CCDS42501.1"
                     /db_xref="GeneID:115948"
                     /db_xref="HGNC:HGNC:28303"
                     /db_xref="MIM:615956"
                     /translation="MTSPLCRAASANALPPQDQASTPSSRVKGREASGKPSHLRGKGT
                     AQAWTPGRSKGGSFHRGAGKPSVHSQVAELHKKIQLLEGDRKAFFESSQWNIKKNQET
                     ISQLRKETKALELKLLDLLKGDEKVVQAVIREWKWEKPYLKNRTGQALEHLDHRLREK
                     VKQQNALRHQVVLRQRRLEELQLQHSLRLLEMAEAQNRHTEVAKTMRNLENRLEKAQM
                     KAQEAEHITSVYLQLKAYLMDESLNLENRLDSMEAEVVRTKHELEALHVVNQEALNAR
                     DIAKNQLQYLEETLVRERKKRERYISECKKRAEEKKLENERMERKTHREHLLLQSDDT
                     IQDSLHAKEEELRQRWSMYQMEVIFGKVKDATGTDETHSLVRRFLAQGDTFAQLETLK
                     SENEQTLVRLKQEKQQLQRELEDLKYSGEATLVSQQKLQAEAQERLKKEERRHAEAKD
                     QLERALRAMQVAKDSLEHLASKLIHITVEDGRFAGKELDPQADNYVPNLLGLVEEKLL
                     KLQAQLQGHDVQEMLCHIANREFLASLEGRLPEYNTRIALPLATSKDKFFDEESEEED
                     NEVVTRASLKIRSQKLIESHKKHRRSRRS"
     exon            350..471
                     /gene="ODAD3"
                     /gene_synonym="CCDC151; CILD30; ODA10"
                     /inference="alignment:Splign:2.1.0"
     exon            472..549
                     /gene="ODAD3"
                     /gene_synonym="CCDC151; CILD30; ODA10"
                     /inference="alignment:Splign:2.1.0"
     exon            550..717
                     /gene="ODAD3"
                     /gene_synonym="CCDC151; CILD30; ODA10"
                     /inference="alignment:Splign:2.1.0"
     exon            718..819
                     /gene="ODAD3"
                     /gene_synonym="CCDC151; CILD30; ODA10"
                     /inference="alignment:Splign:2.1.0"
     exon            820..945
                     /gene="ODAD3"
                     /gene_synonym="CCDC151; CILD30; ODA10"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1068
                     /gene="ODAD3"
                     /gene_synonym="CCDC151; CILD30; ODA10"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1221
                     /gene="ODAD3"
                     /gene_synonym="CCDC151; CILD30; ODA10"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1382
                     /gene="ODAD3"
                     /gene_synonym="CCDC151; CILD30; ODA10"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1539
                     /gene="ODAD3"
                     /gene_synonym="CCDC151; CILD30; ODA10"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1695
                     /gene="ODAD3"
                     /gene_synonym="CCDC151; CILD30; ODA10"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1780
                     /gene="ODAD3"
                     /gene_synonym="CCDC151; CILD30; ODA10"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..2123
                     /gene="ODAD3"
                     /gene_synonym="CCDC151; CILD30; ODA10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2104..2109
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ODAD3"
                     /gene_synonym="CCDC151; CILD30; ODA10"
                     /note="hexamer: AATAAA"
     polyA_site      2123
                     /gene="ODAD3"
                     /gene_synonym="CCDC151; CILD30; ODA10"
                     /note="major polyA site"
ORIGIN      
        1 gcatttttca gagccctagg aatccgagct gacggatccc tgacaggggc gactgactcc
       61 tagttatccc cctaacccct aggggccttc agccccaacc ccatcatgac atctcctctg
      121 tgcagggcgg cctccgccaa cgccctgcct cctcaggacc aggcttcgac gccctcttcc
      181 agggtcaagg gcagggaggc ttcgggcaaa cccagccacc tccgaggcaa gggcacagcc
      241 caggcgtgga ccccaggccg ttccaaggga ggatccttcc acagaggtgc agggaagccc
      301 tctgtgcact ctcaggtggc tgagttacat aaaaagatac aactgttaga gggtgaccgg
      361 aaggcttttt ttgagagctc tcagtggaac atcaagaaga accaggagac catcagtcag
      421 ctccgcaagg agactaaggc actggaacta aagctgctgg acctgctcaa gggagatgag
      481 aaagtggtcc aggcagtgat tcgcgaatgg aagtgggaga agccatacct gaagaacagg
      541 acaggacagg ccctggagca cctagaccac cggctgaggg agaaggtgaa gcagcagaac
      601 gccctgcggc accaggtggt gttgcggcag aggcggctgg aggagctcca gctgcagcac
      661 agcctgcgcc ttctggagat ggcggaggcg caaaacagac acacggaggt ggccaagacc
      721 atgcggaacc tggagaaccg cctggagaag gcccagatga aggcgcagga ggccgagcac
      781 attaccagcg tgtacctgca gctcaaggcc tatctaatgg acgagagcct caacttggag
      841 aaccggctgg actccatgga ggctgaggtg gtgaggacca aacatgagct ggaggcactg
      901 cacgtggtga accaagaggc cctcaatgcc cgggacattg ccaagaacca gctgcagtac
      961 ctagaggaga ccttggttcg agagcgcaag aagcgggaac gctacataag tgagtgcaag
     1021 aagcgcgccg aggagaagaa actggagaac gagcgcatgg agcgcaagac ccaccgcgag
     1081 cacctgctgc tacagtccga cgacaccatc caggacagcc tgcatgccaa ggaggaggag
     1141 ctgcggcagc gctggagcat gtaccagatg gaggtgatct ttggcaaggt caaggacgcc
     1201 actggcactg acgagacgca ctcgttggtg cggcggttcc tggcccaggg cgacaccttc
     1261 gcgcagttgg agacgctcaa gagcgagaac gagcagacgt tggtgaggct gaagcaggag
     1321 aagcaacaac tgcagcggga gctggaagac ctcaagtact cgggggaggc cacgctggtg
     1381 agccagcaga aactgcaagc cgaggcgcag gagcgtctca agaaggagga gcggcggcac
     1441 gccgaggcca aggaccagct ggagcgcgcc ttgcgggcga tgcaagtggc caaggacagc
     1501 ctggagcacc tggccagcaa gctgatccac atcactgtgg aggacggccg cttcgcggga
     1561 aaggagctgg atccccaggc agataactat gtgccaaacc tgctgggcct cgtggaggaa
     1621 aagctgctga aactgcaggc gcagctccag ggccacgacg tgcaggagat gctgtgccac
     1681 atcgctaacc gcgagttcct cgccagctta gagggaaggc tgcccgaata caacacccgc
     1741 atcgccctgc cccttgccac ttccaaggac aagttttttg acgaagagag tgaggaggag
     1801 gacaacgagg tagtgacccg cgcatcactc aagatccgtt cccagaaatt aatcgaaagt
     1861 cacaagaagc accgtcgctc tcggaggtcc tagactcgtc ctgacaccca ccaggcggcc
     1921 cccttcggag cccccgatcc ctccgggtct agcgcaggcc ccacggggcc ccttcagggg
     1981 ctgaacgcgg cccggaccgg gaacggaggc ggccagcggc gcccggaggg gaggaagggg
     2041 ccgggccaga cgttcccaca gtaaatctcc ccagctgggt ccgccccggc ctcagagttg
     2101 cgcaataaat gttaccgacc atg
//
