LOCUS       NM_080721               2123 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens osteoclast stimulatory transmembrane protein
            (OCSTAMP), mRNA.
ACCESSION   NM_080721 XM_001722538 XM_496476 XM_938433
VERSION     NM_080721.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2123)
  AUTHORS   Wang,Z.L., Liu,Y., Zhou,Y.L., Li,J.L., Sun,Q.Y., Wu,L.X., Wen,L.,
            Lai,Y.Y., Liu,Y.R., Chang,Y.J., Shi,H.X., Liu,K.Y., Huang,X.J.,
            Lu,J. and Ruan,G.R.
  TITLE     Osteoclast stimulatory transmembrane protein (OC-STAMP) is a
            promising molecular prognostic indicator for multiple myeloma
  JOURNAL   Eur J Haematol 105 (2), 185-195 (2020)
   PUBMED   32282962
  REMARK    GeneRIF: Osteoclast stimulatory transmembrane protein (OC-STAMP) is
            a promising molecular prognostic indicator for multiple myeloma.
REFERENCE   2  (bases 1 to 2123)
  AUTHORS   Yuan,H., He,J., Zhang,G., Zhang,D., Kong,X. and Chen,F.
  TITLE     Osteoclast stimulatory transmembrane protein induces a phenotypic
            switch in macrophage polarization suppressing an M1
            pro-inflammatory state
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 49 (10), 935-944 (2017)
   PUBMED   28981605
  REMARK    GeneRIF: Results indicte that oc-stamp may play an important role
            in macrophage polarization and inhibit the M1 pro-inflammatory
            state.
REFERENCE   3  (bases 1 to 2123)
  AUTHORS   Yang,M., Birnbaum,M.J., MacKay,C.A., Mason-Savas,A., Thompson,B.
            and Odgren,P.R.
  TITLE     Osteoclast stimulatory transmembrane protein (OC-STAMP), a novel
            protein induced by RANKL that promotes osteoclast differentiation
  JOURNAL   J Cell Physiol 215 (2), 497-505 (2008)
   PUBMED   18064667
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL034424.9.
            
            On May 17, 2019 this sequence version replaced NM_080721.2.
            
            Summary: The protein encoded by this gene is orthologous to the
            mouse osteoclast stimulatory transmembrane protein (OCSTAMP), which
            is a membrane-anchored cell surface receptor that promotes
            nucleation of osteoclasts. The mouse protein is also involved in
            bone resorption and osteoclast differentiation. [provided by
            RefSeq, Feb 2017].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.1233594.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1968968,
                                           SAMEA2148874 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000279028.3/ ENSP00000279028.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-138               AL034424.9         38708-38845         c
            139-1141            AL034424.9         33518-34520         c
            1142-2123           AL034424.9         29137-30118         c
FEATURES             Location/Qualifiers
     source          1..2123
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.12"
     gene            1..2123
                     /gene="OCSTAMP"
                     /gene_synonym="C20orf123; dJ257E24.3; OC-STAMP"
                     /note="osteoclast stimulatory transmembrane protein"
                     /db_xref="GeneID:128506"
                     /db_xref="HGNC:HGNC:16116"
                     /db_xref="MIM:620432"
     exon            1..138
                     /gene="OCSTAMP"
                     /gene_synonym="C20orf123; dJ257E24.3; OC-STAMP"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..1795
                     /gene="OCSTAMP"
                     /gene_synonym="C20orf123; dJ257E24.3; OC-STAMP"
                     /note="transmembrane protein C20orf123"
                     /codon_start=1
                     /product="osteoclast stimulatory transmembrane protein"
                     /protein_id="NP_542452.1"
                     /db_xref="CCDS:CCDS54468.1"
                     /db_xref="GeneID:128506"
                     /db_xref="HGNC:HGNC:16116"
                     /db_xref="MIM:620432"
                     /translation="MPGHPGAAEQLVKTGWRSWHLGFWKALAPLQAAWDAFSQPVPAS
                     CGQLLTQLLLCASLAAAAAGLVYHWLASLLLYPPGPSAMVATVCGLLVFLSLGLVPPV
                     RCLFALSVPTLGMEQGRRLLLSYSTATLAIAVVPNVLANVGAAGQVLRCVTEGSLESL
                     LNTTHQLHAASRALGPTGQAGSRGLTFEAQDNGSAFYLHMLRVTQQVLEDFSGLESLA
                     RAAALGTQRVVTGLFMLGLLVESAWYLHCYLTDLRFDNIYATQQLTQRLAQAQATHLL
                     APPPTWLLQAAQLRLSQEELLSCLLRLGLLALLLVATAVAVATDHVAFLLAQATVDWA
                     QKLPTVPITLTVKYDVAYTVLGFIPFLFNQLAPESPFLSVHSSYQWELRLTSARCPLL
                     PARRPRAAAPLAAGALQLLAGSTVLLEAYARRLRHAIAASFFTAQEARRVRHLHARLQ
                     RRHDRHQGQQLPLGDPSCVPTPRPACKPPAWIDYRLDALRTESSEGEGKELWSCRDLS
                     CNLGPVPPPCVTLGKSLHLSEPRFLHLHNDSIFTIDVTYFPRRDVVRMEGNTGHDRPG
                     "
     exon            139..1141
                     /gene="OCSTAMP"
                     /gene_synonym="C20orf123; dJ257E24.3; OC-STAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..2123
                     /gene="OCSTAMP"
                     /gene_synonym="C20orf123; dJ257E24.3; OC-STAMP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2015..2020
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OCSTAMP"
                     /gene_synonym="C20orf123; dJ257E24.3; OC-STAMP"
                     /note="hexamer: AATAAA"
     polyA_site      2038
                     /gene="OCSTAMP"
                     /gene_synonym="C20orf123; dJ257E24.3; OC-STAMP"
                     /note="major polyA site"
ORIGIN      
        1 agggattccc aagtcccagc gattccccca cttcctctcc acctgccaca gctgccagcg
       61 accgcccgcc tgaaaccact gccatttgga cagcatgcca ggccacccag gagcagctga
      121 gcaacttgtc aagaccgggt ggaggtcctg gcacttgggg ttctggaagg cccttgcccc
      181 actgcaggct gcctgggacg ccttctccca gcctgttcca gccagctgtg gccagctgct
      241 gacccagctc ctcctgtgtg cctccctggc tgctgctgct gcaggtctgg tttatcactg
      301 gctggcatcc ttgctgcttt atcctcctgg accttcagcc atggttgcca ctgtctgtgg
      361 cctcctggtc ttcctgagcc tgggcctggt acccccagtc cgctgcctgt ttgcactcag
      421 cgtgcccacc ctgggtatgg agcagggccg ccggctgctc ctgtcctaca gcactgccac
      481 cctggccatt gctgtggtgc ccaacgtcct ggccaacgtg ggtgcggccg ggcaggtgct
      541 gaggtgtgtc accgagggct ccctggagag tctcctcaat accactcacc agctgcatgc
      601 agcatccagg gctctgggcc ccacaggcca ggcaggcagc cggggcctga catttgaggc
      661 ccaggacaat ggctctgcct tctaccttca catgctcagg gtcactcagc aggtcctgga
      721 ggatttctct ggcctggagt ccctggcccg ggcagcagcg ctagggaccc agcgagtggt
      781 cacagggctg tttatgttgg gcctcctggt ggagtcggca tggtacctcc attgctacct
      841 gacagacctg cggtttgaca atatctacgc cactcaacag ctgacccagc ggttggcaca
      901 ggcccaggct acacacctcc tggcccctcc acccacctgg ctgctccagg cggctcagct
      961 gaggctgtca caggaggagc tgttgagttg tcttctaagg ctggggctgc ttgccctgct
     1021 cctcgtggcc acggctgtgg cggtggccac agaccatgta gccttcctcc tggcacaggc
     1081 tactgtggac tgggctcaga agttgccaac tgtgcccatc acgctcacgg tcaagtatga
     1141 tgtggcatac actgtcctgg gcttcatccc tttcctcttc aaccagctgg ctccggagag
     1201 ccccttcctc tccgtccaca gctcctacca atgggagctc cgcctcacct ccgcccgctg
     1261 cccactgcta cccgcccggc gtccccgcgc agctgccccg ctggccgcgg gggccctgca
     1321 gctcctggcg ggctccacgg tgctcctgga ggcctacgcc cgccgcctgc ggcatgccat
     1381 cgccgcttcc ttcttcacag cccaggaggc gaggagggtc cgccacctgc acgcccggct
     1441 ccagcgaaga cacgacaggc accaaggcca gcagctgccc ctaggggatc cttcttgcgt
     1501 ccccacaccc agacctgcct gcaagcctcc ggcatggata gactacaggc tggatgcctt
     1561 aagaaccgag agcagtgagg gagaagggaa agagctttgg agttgcagag acctgagttg
     1621 taaccttggt cctgtgccgc ctccctgtgt gaccttgggt aagtcacttc acctctctga
     1681 gcctcggttt ctacatctgc ataacgacag catatttacc attgatgtga cctacttccc
     1741 acgcagggat gtggtcagga tggaaggaaa tactgggcat gataggcctg gataaccggt
     1801 aaagaaccat gcaaaggcga agacaaggag tgcagagaga gctcatggtt cctccaggct
     1861 ggttggcgat caggctcatc tcatctgcac caactgctct acttgttaga tggagacctt
     1921 gcatcatgaa tttctcgaaa tgctcctgga acttatttat atgcctcaaa atcctctaaa
     1981 ctcatttata gtaacccata gttttaattt tataaataaa cgtatttatt aaatcttaga
     2041 ttacgttatt cctctgcctc aaattccttc agggcctttc cattgccagg attagatttt
     2101 gccaaattaa aatataggac act
//
