LOCUS       NM_000276               5173 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens OCRL inositol polyphosphate-5-phosphatase (OCRL),
            transcript variant a, mRNA.
ACCESSION   NM_000276
VERSION     NM_000276.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5173)
  AUTHORS   Li,Q., Yang,Z., Zang,R., Liu,S., Yu,L., Wang,J., Wang,C., Wang,X.
            and Sun,S.
  TITLE     Clinical features and genetic analysis of 15 Chinese children with
            dent disease
  JOURNAL   Ren Fail 46 (1), 2349133 (2024)
   PUBMED   38726999
  REMARK    GeneRIF: Clinical features and genetic analysis of 15 Chinese
            children with dent disease.
REFERENCE   2  (bases 1 to 5173)
  AUTHORS   Du,R., Zhou,C., Chen,S., Li,T., Lin,Y., Xu,A., Huang,Y., Mei,H.,
            Huang,X., Tan,D., Zheng,R., Liang,C., Cai,Y., Shao,Y., Zhang,W.,
            Liu,L. and Zeng,C.
  TITLE     Atypical phenotypes and novel OCRL variations in southern Chinese
            patients with Lowe syndrome
  JOURNAL   Pediatr Nephrol 39 (8), 2377-2391 (2024)
   PUBMED   38589698
  REMARK    GeneRIF: Atypical phenotypes and novel OCRL variations in southern
            Chinese patients with Lowe syndrome.
REFERENCE   3  (bases 1 to 5173)
  AUTHORS   Fuentealba,L.M., Pizarro,H. and Marzolo,M.P.
  TITLE     OCRL1 Deficiency Affects the Intracellular Traffic of ApoER2 and
            Impairs Reelin-Induced Responses
  JOURNAL   Biomolecules 14 (7), 799 (2024)
   PUBMED   39062513
  REMARK    GeneRIF: OCRL1 Deficiency Affects the Intracellular Traffic of
            ApoER2 and Impairs Reelin-Induced Responses.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5173)
  AUTHORS   Nussbaum,R.L., Orrison,B.M., Janne,P.A., Charnas,L. and
            Chinault,A.C.
  TITLE     Physical mapping and genomic structure of the Lowe syndrome gene
            OCRL1
  JOURNAL   Hum Genet 99 (2), 145-150 (1997)
   PUBMED   9048911
REFERENCE   5  (bases 1 to 5173)
  AUTHORS   Zhang,X., Jefferson,A.B., Auethavekiat,V. and Majerus,P.W.
  TITLE     The protein deficient in Lowe syndrome is a
            phosphatidylinositol-4,5-bisphosphate 5-phosphatase
  JOURNAL   Proc Natl Acad Sci U S A 92 (11), 4853-4856 (1995)
   PUBMED   7761412
REFERENCE   6  (bases 1 to 5173)
  AUTHORS   Lieske,J.C., Milliner,D.S., Beara-Lasic,L., Harris,P., Cogal,A. and
            Abrash,E.
  TITLE     Dent Disease
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   22876375
REFERENCE   7  (bases 1 to 5173)
  AUTHORS   Lewis,R.A., Nussbaum,R.L. and Brewer,E.D.
  TITLE     Lowe Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301653
REFERENCE   8  (bases 1 to 5173)
  AUTHORS   Attree,O., Olivos,I.M., Okabe,I., Bailey,L.C., Nelson,D.L.,
            Lewis,R.A., McInnes,R.R. and Nussbaum,R.L.
  TITLE     The Lowe's oculocerebrorenal syndrome gene encodes a protein highly
            homologous to inositol polyphosphate-5-phosphatase
  JOURNAL   Nature 358 (6383), 239-242 (1992)
   PUBMED   1321346
REFERENCE   9  (bases 1 to 5173)
  AUTHORS   Mueller,O.T., Hartsfield,J.K. Jr., Gallardo,L.A., Essig,Y.P.,
            Miller,K.L., Papenhausen,P.R. and Tedesco,T.A.
  TITLE     Lowe oculocerebrorenal syndrome in a female with a balanced X;20
            translocation: mapping of the X chromosome breakpoint
  JOURNAL   Am J Hum Genet 49 (4), 804-810 (1991)
   PUBMED   1897526
REFERENCE   10 (bases 1 to 5173)
  AUTHORS   Duden,R., Griffiths,G., Frank,R., Argos,P. and Kreis,T.E.
  TITLE     Beta-COP, a 110 kd protein associated with non-clathrin-coated
            vesicles and the Golgi complex, shows homology to beta-adaptin
  JOURNAL   Cell 64 (3), 649-665 (1991)
   PUBMED   1840503
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL138745.19, AL662877.5 and
            AL022162.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 26, 2018 this sequence version replaced NM_000276.3.
            
            Summary: This gene encodes an inositol polyphosphate 5-phosphatase.
            This protein is involved in regulating membrane trafficking and is
            located in numerous subcellular locations including the trans-Golgi
            network, clathrin-coated vesicles and, endosomes and the plasma
            membrane. This protein may also play a role in primary cilium
            formation. Mutations in this gene cause oculocerebrorenal syndrome
            of Lowe and also Dent disease. Alternate splicing results in
            multiple transcript variants. [provided by RefSeq, Jan 2016].
            
            Transcript Variant: This variant (a) encodes isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U57627.2, SRR1803616.230978.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467146, SAMN03267753
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371113.9/ ENSP00000360154.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-220               AL138745.19        59656-59875
            221-300             AL138745.19        60141-60220
            301-380             AL138745.19        64355-64434
            381-419             AL138745.19        67960-67998
            420-530             AL662877.5         9085-9195
            531-620             AL662877.5         9621-9710
            621-741             AL022162.1         2075-2195
            742-903             AL022162.1         2282-2443
            904-1005            AL022162.1         3992-4093
            1006-1120           AL022162.1         4621-4735
            1121-1237           AL022162.1         5826-5942
            1238-1425           AL022162.1         6041-6228
            1426-1537           AL022162.1         9214-9325
            1538-1647           AL022162.1         10696-10805
            1648-1783           AL022162.1         12706-12841
            1784-1894           AL022162.1         18582-18692
            1895-2060           AL022162.1         19339-19504
            2061-2296           AL022162.1         19759-19994
            2297-2320           AL022162.1         27786-27809
            2321-2437           AL022162.1         30444-30560
            2438-2522           AL022162.1         31621-31705
            2523-2650           AL022162.1         32328-32455
            2651-2762           AL022162.1         33287-33398
            2763-5173           AL022162.1         33588-35998
FEATURES             Location/Qualifiers
     source          1..5173
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq26.1"
     gene            1..5173
                     /gene="OCRL"
                     /gene_synonym="Dent-2; DENT2; INPP5F; LOCR; NPHL2; OCRL-1;
                     OCRL1"
                     /note="OCRL inositol polyphosphate-5-phosphatase"
                     /db_xref="GeneID:4952"
                     /db_xref="HGNC:HGNC:8108"
                     /db_xref="MIM:300535"
     exon            1..220
                     /gene="OCRL"
                     /gene_synonym="Dent-2; DENT2; INPP5F; LOCR; NPHL2; OCRL-1;
                     OCRL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             182..2887
                     /gene="OCRL"
                     /gene_synonym="Dent-2; DENT2; INPP5F; LOCR; NPHL2; OCRL-1;
                     OCRL1"
                     /EC_number="3.1.3.56"
                     /EC_number="3.1.3.36"
                     /EC_number="3.1.3.86"
                     /note="oculocerebrorenal syndrome of Lowe protein; isoform
                     a is encoded by transcript variant a; phosphatidylinositol
                     polyphosphate 5-phosphatase; inositol polyphosphate
                     5-phosphatase OCRL-1; Lowe oculocerebrorenal syndrome
                     protein; phosphatidylinositol 3,4,5-triphosphate
                     5-phosphatase"
                     /codon_start=1
                     /product="inositol polyphosphate 5-phosphatase OCRL
                     isoform a"
                     /protein_id="NP_000267.2"
                     /db_xref="CCDS:CCDS35393.1"
                     /db_xref="GeneID:4952"
                     /db_xref="HGNC:HGNC:8108"
                     /db_xref="MIM:300535"
                     /translation="MEPPLPVGAQPLATVEGMEMKGPLREPCALTLAQRNGQYELIIQ
                     LHEKEQHVQDIIPINSHFRCVQEAEETLLIDIASNSGCKIRVQGDWIRERRFEIPDEE
                     HCLKFLSAVLAAQKAQSQLLVPEQKDSSSWYQKLDTKDKPSVFSGLLGFEDNFSSMNL
                     DKKINSQNQPTGIHREPPPPPFSVNKMLPREKEASNKEQPKVTNTMRKLFVPNTQSGQ
                     REGLIKHILAKREKEYVNIQTFRFFVGTWNVNGQSPDSGLEPWLNCDPNPPDIYCIGF
                     QELDLSTEAFFYFESVKEQEWSMAVERGLHSKAKYKKVQLVRLVGMMLLIFARKDQCR
                     YIRDIATETVGTGIMGKMGNKGGVAVRFVFHNTTFCIVNSHLAAHVEDFERRNQDYKD
                     ICARMSFVVPNQTLPQLNIMKHEVVIWLGDLNYRLCMPDANEVKSLINKKDLQRLLKF
                     DQLNIQRTQKKAFVDFNEGEIKFIPTYKYDSKTDRWDSSGKCRVPAWCDRILWRGTNV
                     NQLNYRSHMELKTSDHKPVSALFHIGVKVVDERRYRKVFEDSVRIMDRMENDFLPSLE
                     LSRREFVFENVKFRQLQKEKFQISNNGQVPCHFSFIPKLNDSQYCKPWLRAEPFEGYL
                     EPNETVDISLDVYVSKDSVTILNSGEDKIEDILVLHLDRGKDYFLTISGNYLPSCFGT
                     SLEALCRMKRPIREVPVTKLIDLEEDSFLEKEKSLLQMVPLDEGASERPLQVPKEIWL
                     LVDHLFKYACHQEDLFQTPGMQEELQQIIDCLDTSIPETIPGSNHSVAEALLIFLEAL
                     PEPVICYELYQRCLDSAYDPRICRQVISQLPRCHRNVFRYLMAFLRELLKFSEYNSVN
                     ANMIATLFTSLLLRPPPNLMARQTPSDRQRAIQFLLGFLLGSEED"
     exon            221..300
                     /gene="OCRL"
                     /gene_synonym="Dent-2; DENT2; INPP5F; LOCR; NPHL2; OCRL-1;
                     OCRL1"
                     /inference="alignment:Splign:2.1.0"
     exon            301..380
                     /gene="OCRL"
                     /gene_synonym="Dent-2; DENT2; INPP5F; LOCR; NPHL2; OCRL-1;
                     OCRL1"
                     /inference="alignment:Splign:2.1.0"
     exon            381..419
                     /gene="OCRL"
                     /gene_synonym="Dent-2; DENT2; INPP5F; LOCR; NPHL2; OCRL-1;
                     OCRL1"
                     /inference="alignment:Splign:2.1.0"
     exon            420..530
                     /gene="OCRL"
                     /gene_synonym="Dent-2; DENT2; INPP5F; LOCR; NPHL2; OCRL-1;
                     OCRL1"
                     /inference="alignment:Splign:2.1.0"
     exon            531..620
                     /gene="OCRL"
                     /gene_synonym="Dent-2; DENT2; INPP5F; LOCR; NPHL2; OCRL-1;
                     OCRL1"
                     /inference="alignment:Splign:2.1.0"
     exon            621..741
                     /gene="OCRL"
                     /gene_synonym="Dent-2; DENT2; INPP5F; LOCR; NPHL2; OCRL-1;
                     OCRL1"
                     /inference="alignment:Splign:2.1.0"
     exon            742..903
                     /gene="OCRL"
                     /gene_synonym="Dent-2; DENT2; INPP5F; LOCR; NPHL2; OCRL-1;
                     OCRL1"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1005
                     /gene="OCRL"
                     /gene_synonym="Dent-2; DENT2; INPP5F; LOCR; NPHL2; OCRL-1;
                     OCRL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1120
                     /gene="OCRL"
                     /gene_synonym="Dent-2; DENT2; INPP5F; LOCR; NPHL2; OCRL-1;
                     OCRL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1237
                     /gene="OCRL"
                     /gene_synonym="Dent-2; DENT2; INPP5F; LOCR; NPHL2; OCRL-1;
                     OCRL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1425
                     /gene="OCRL"
                     /gene_synonym="Dent-2; DENT2; INPP5F; LOCR; NPHL2; OCRL-1;
                     OCRL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1537
                     /gene="OCRL"
                     /gene_synonym="Dent-2; DENT2; INPP5F; LOCR; NPHL2; OCRL-1;
                     OCRL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1647
                     /gene="OCRL"
                     /gene_synonym="Dent-2; DENT2; INPP5F; LOCR; NPHL2; OCRL-1;
                     OCRL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1783
                     /gene="OCRL"
                     /gene_synonym="Dent-2; DENT2; INPP5F; LOCR; NPHL2; OCRL-1;
                     OCRL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1894
                     /gene="OCRL"
                     /gene_synonym="Dent-2; DENT2; INPP5F; LOCR; NPHL2; OCRL-1;
                     OCRL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..2060
                     /gene="OCRL"
                     /gene_synonym="Dent-2; DENT2; INPP5F; LOCR; NPHL2; OCRL-1;
                     OCRL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..2296
                     /gene="OCRL"
                     /gene_synonym="Dent-2; DENT2; INPP5F; LOCR; NPHL2; OCRL-1;
                     OCRL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2297..2320
                     /gene="OCRL"
                     /gene_synonym="Dent-2; DENT2; INPP5F; LOCR; NPHL2; OCRL-1;
                     OCRL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2321..2437
                     /gene="OCRL"
                     /gene_synonym="Dent-2; DENT2; INPP5F; LOCR; NPHL2; OCRL-1;
                     OCRL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2438..2522
                     /gene="OCRL"
                     /gene_synonym="Dent-2; DENT2; INPP5F; LOCR; NPHL2; OCRL-1;
                     OCRL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2523..2650
                     /gene="OCRL"
                     /gene_synonym="Dent-2; DENT2; INPP5F; LOCR; NPHL2; OCRL-1;
                     OCRL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2651..2762
                     /gene="OCRL"
                     /gene_synonym="Dent-2; DENT2; INPP5F; LOCR; NPHL2; OCRL-1;
                     OCRL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2763..5173
                     /gene="OCRL"
                     /gene_synonym="Dent-2; DENT2; INPP5F; LOCR; NPHL2; OCRL-1;
                     OCRL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5154..5159
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OCRL"
                     /gene_synonym="Dent-2; DENT2; INPP5F; LOCR; NPHL2; OCRL-1;
                     OCRL1"
                     /note="hexamer: AATATA"
     polyA_site      5173
                     /gene="OCRL"
                     /gene_synonym="Dent-2; DENT2; INPP5F; LOCR; NPHL2; OCRL-1;
                     OCRL1"
                     /note="major polyA site"
ORIGIN      
        1 ctctcttggg tcagattctc agctcccagc tccccgctcc cggctcccgg cgcccggcgc
       61 ccggcgcgga gctgttcctc aaacgacacg cagccgaggt gggtgggtgt ggggacgcgg
      121 gagccagtgt cgtcggatcg gcccgcagtc cgctgtcctg ctgagcccgg aggccgcctg
      181 gatggagccg ccgctcccgg tcggagccca gccgcttgcc actgtcgagg gtatggagat
      241 gaagggtcct ctccgggagc cctgcgccct gaccctagcc cagaggaacg ggcaatatga
      301 gttaataatc cagttgcatg agaaggaaca gcatgttcaa gatatcattc ctataaatag
      361 ccacttcaga tgtgttcaag aagcagaaga aactcttttg attgacatag cttctaacag
      421 tggctgcaaa attcgggttc agggggactg gatcagagag cgccgctttg aaatccctga
      481 tgaggaacac tgtttgaagt tcctctcagc tgtccttgct gctcagaaag ctcagtcaca
      541 gcttcttgtt ccagagcaaa aggactcatc tagctggtac cagaaattag acactaagga
      601 caaaccttct gttttttcag ggcttcttgg atttgaagac aatttttctt ctatgaattt
      661 ggacaagaaa ataaattcac aaaatcagcc tactgggatt catcgggaac ccccacctcc
      721 acccttttca gtgaataaaa tgcttccacg tgaaaaagaa gcttctaaca aggagcagcc
      781 caaagtgacc aacaccatgc ggaagctctt tgtaccaaat acccaatctg ggcagcggga
      841 gggtctcatc aaacatatcc tggcaaagcg agagaaagaa tatgtcaaca ttcagacttt
      901 cagatttttt gttggaactt ggaatgtgaa tggccagtct ccagatagcg ggttagaacc
      961 ttggctgaac tgtgatccca atcctcctga tatctactgc attggattcc aagaactgga
     1021 cttgagcaca gaagccttct tctactttga atctgtgaag gaacaagaat ggtccatggc
     1081 tgtagagaga ggtttgcatt ccaaagccaa gtataagaaa gttcaactgg tgcgccttgt
     1141 tgggatgatg cttcttatat ttgccagaaa ggatcagtgt cgatacattc gtgatattgc
     1201 tacagaaaca gttggaactg gaatcatggg gaaaatggga aacaaaggtg gggtagctgt
     1261 gagatttgta tttcacaaca ccaccttttg cattgtcaat tcccatctgg ctgcacacgt
     1321 ggaggacttt gagagaagga atcaagatta taaggacatt tgtgcgagaa tgagttttgt
     1381 ggtcccaaat cagaccctcc cgcagttgaa catcatgaaa catgaggttg tcatttggtt
     1441 gggagatttg aattatagac tttgcatgcc tgatgccaat gaggtgaaaa gtcttattaa
     1501 taagaaagac cttcagagac tcttgaaatt cgaccagcta aatattcagc gcacacagaa
     1561 aaaagctttt gttgacttca atgaagggga aatcaagttc atccccactt ataagtatga
     1621 ctctaaaaca gaccggtggg attccagtgg gaaatgccgg gttccagcct ggtgtgaccg
     1681 aattctttgg agaggaacaa atgttaatca gcttaattat cggagtcaca tggaactgaa
     1741 aaccagcgac cacaagcctg ttagcgccct cttccatatt ggggtgaagg ttgtggatga
     1801 acgaaggtac cggaaagtct ttgaagatag tgtacgcatc atggacagaa tggaaaatga
     1861 cttccttcct tccttagaac tcagcaggag ggagtttgtg tttgaaaatg tgaagtttcg
     1921 gcaactacaa aaggagaagt tccagatcag caacaatgga caggttccct gccatttttc
     1981 tttcatccct aaacttaatg acagccagta ctgcaagcca tggcttcggg ctgaaccttt
     2041 tgagggctac ttggagccaa atgagacagt ggacatttct cttgatgtgt atgtcagcaa
     2101 agactctgta accatcctga actcgggaga agataagatt gaagatattc tcgtccttca
     2161 cctggatcga ggcaaagatt acttcttgac tatcagtgga aattacctcc caagttgttt
     2221 tggcacatcc ttagaggctc tgtgccgtat gaaaagacca atccgagaag ttcctgttac
     2281 caaactcata gacttggaag aagacagctt cctagaaaag gagaaatccc ttctgcaaat
     2341 ggttcctttg gatgaaggtg ccagtgagag accccttcag gttcccaagg agatctggct
     2401 tctagtagat cacctattca aatacgcctg tcaccaggag gacctgttcc agacccctgg
     2461 aatgcaggaa gagctccagc agatcattga ttgtctggat accagcattc ctgagacaat
     2521 ccctggcagc aaccactctg tggctgaagc actgctcatt ttcttggaag ccctgccaga
     2581 gccagtcatc tgttacgagc tgtatcagcg atgtcttgac tctgcttatg atccccggat
     2641 ctgccgacag gtgatctccc agcttccgag atgccataga aatgttttcc gttacttgat
     2701 ggcattcctt cgagaactct taaaattctc tgaatacaat agcgtcaatg ccaacatgat
     2761 cgctactctc ttcactagtc ttctcctgag gcctccaccc aaccttatgg caagacagac
     2821 tccaagtgac cgccagcgtg ctattcagtt ccttctgggc tttctgcttg ggagcgaaga
     2881 agactaaggc ttttactgtt ctctgatatt ctagaagcag acgatctcgg gctccaagta
     2941 tttcagaatg atttaaaaag tcatgccaca ggaagggtct attgcagaat ttcaagttct
     3001 gtttatagta aaaaggaaga gcgtttccta atccctcctt taccatatcc tacacagaaa
     3061 aatactttta gacttatatt gccaagccaa agttaccata ttttggtgtt tttgtgtttt
     3121 ctctttataa ggcaaaaaga tctgtattta cactccttca cctagggatg tgtttgttgc
     3181 cctcctaccc aattgtcatg attgtcctta gtaccctagg cctagattct gagatcttcc
     3241 cattctaggc ctacaagcac tacttgctgt agctgagact tgtctagagt cctttgtttt
     3301 gcacttttga cccacccctt cctggatcac tcctttgcac tccactcccc tcgttctgtc
     3361 actttgaacg aagtctgagt gaggctagtg actccttggg tgtcctcaac agtgaattca
     3421 ctgtctgcgt gcagttatta catgcatttg tgcatttcta ctacaatggc atctttatgt
     3481 ctctgtaaca ttggcctttt catggctcca cactgggtgg aaccatattc tcttagatca
     3541 catttagtag cataactgta gggactatta gagatggcat ctcatcgatg agagagaatc
     3601 acaatcagaa tggaagcact ttgagtatct gaagagtgag agcattcatg tttgacaggt
     3661 cctgcttccc actatccttt tcctgttatt attcaaattt tacacaagga ctaatcctgg
     3721 gtgtctctga gacccatctc ctgcctagac atccacctcc agagcaacac tggccccaca
     3781 gtaaaagagg aagtcttgta cctcaggcag gcccatctag agctattgct ccttcccaca
     3841 gcaaaggtat tgtggatgac ccttagaatc cattctctgg tcttctgaaa taccaagggc
     3901 agatgtcacc tccttcctca gcaggactga ctctgggctc tacaaccagc tccttcacat
     3961 aaagggttta gagactcccc ttggctccca gtcaccatat ccagtgttgt gtaaagagac
     4021 tggccaacag gaccaaccaa gcaccttacc tctcccatac aagatgaccc tctgagcttt
     4081 tcatttattc aagctctgtg gtacagcctt tttttaaaat aaattaatct atattggttg
     4141 acaaacaagc caccaaccac tgactgcaaa actgcctgat gcagttgggt tcctcctggt
     4201 tttcttttgt tacaaccacc cttgcctgtt tacattaatt gcaaggagca taacgtacag
     4261 gctgtatgta caatcctggg cattgactct gtgacatttc tagcatatcc aaggcaccac
     4321 cagtgatttc tcctgtttct tggtgggggt gggggggaag gtacgtattc tgcaatatgg
     4381 ctaaaccctt tcctgattga gagttaaagc aataggagtc aagttactgg tgccacagat
     4441 ctggaggtat gataggtcag gggctaggtg ttgaacttag ttaatggaag actgagagca
     4501 gaacaggttt gtcatctccg caaggccaga aagtgatcac aaaaagaggc agatgataga
     4561 cactggggta gggtcatacc acagggaaat acctttcctg ggcttgtttt ctagcatatc
     4621 actgacctgg gatctttggg tgatcaaggg tgtggttagt ggaggctctg tgctgcacgt
     4681 atgcagtatc ctatctcttt ctacatcaga tcaaaacact aagttggtgt actgcctcga
     4741 ccttttttca gctcatcctg gaacatatac agagttgaga gttttagaca atctctaggt
     4801 agaggagaca agatgtagac ccagacagaa gaaatctgct tccctaccat ggctattcca
     4861 gcaccccaac ctgtaattgc caagtcctct aaggtactaa tttgtagctg ctctgaagta
     4921 aggatttcgg attcagctgg tagggaaaga ctctgcacct gctgtcttag ggaagaaatg
     4981 gttcaaatcc atgtggtgac attgcattag tctccctttc actgttttct tattctgtaa
     5041 ttgtttgtta tatttcccaa aaacgtcttg atcactaagc aaagctgcta gtgggattct
     5101 atatttcgtg tcatcttttt tattataatt tattgcaaat ttttttctga ataaatatat
     5161 gttgtgtgaa aaa
//
