LOCUS       NM_006188                693 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens oncomodulin 2 (OCM2), mRNA.
ACCESSION   NM_006188
VERSION     NM_006188.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 693)
  AUTHORS   Hinova-Palova,D.V., Edelstein,L., Landzhov,B.V., Braak,E.,
            Malinova,L.G., Minkov,M., Paloff,A. and Ovtscharoff,W.
  TITLE     Parvalbumin-immunoreactive neurons in the human claustrum
  JOURNAL   Brain Struct Funct 219 (5), 1813-1830 (2014)
   PUBMED   23832597
  REMARK    GeneRIF: This study deministrated that Parvalbumin-immunoreactive
            neurons in the human claustrum.
REFERENCE   2  (bases 1 to 693)
  AUTHORS   Aouizerat,B.E., Vittinghoff,E., Musone,S.L., Pawlikowska,L.,
            Kwok,P.Y., Olgin,J.E. and Tseng,Z.H.
  TITLE     GWAS for discovery and replication of genetic loci associated with
            sudden cardiac arrest in patients with coronary artery disease
  JOURNAL   BMC Cardiovasc Disord 11, 29 (2011)
   PUBMED   21658281
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 693)
  AUTHORS   Babini,E., Bertini,I., Capozzi,F., Del Bianco,C., Hollender,D.,
            Kiss,T., Luchinat,C. and Quattrone,A.
  TITLE     Solution structure of human beta-parvalbumin and structural
            comparison with its paralog alpha-parvalbumin and with their rat
            orthologs
  JOURNAL   Biochemistry 43 (51), 16076-16085 (2004)
   PUBMED   15610002
REFERENCE   4  (bases 1 to 693)
  AUTHORS   Belkacemi,L., Simoneau,L. and Lafond,J.
  TITLE     Calcium-binding proteins: distribution and implication in mammalian
            placenta
  JOURNAL   Endocrine 19 (1), 57-64 (2002)
   PUBMED   12583602
  REMARK    Review article
REFERENCE   5  (bases 1 to 693)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
REFERENCE   6  (bases 1 to 693)
  AUTHORS   Ritzler,J.M., Sawhney,R., Geurts van Kessel,A.H., Grzeschik,K.H.,
            Schinzel,A. and Berchtold,M.W.
  TITLE     The genes for the highly homologous Ca(2+)-binding proteins
            oncomodulin and parvalbumin are not linked in the human genome
  JOURNAL   Genomics 12 (3), 567-572 (1992)
   PUBMED   1559707
REFERENCE   7  (bases 1 to 693)
  AUTHORS   Palmer,E.J., MacManus,J.P. and Mutus,B.
  TITLE     Inhibition of glutathione reductase by oncomodulin
  JOURNAL   Arch Biochem Biophys 277 (1), 149-154 (1990)
   PUBMED   2306116
REFERENCE   8  (bases 1 to 693)
  AUTHORS   Mutus,B., Palmer,E.J. and MacManus,J.P.
  TITLE     Disulfide-linked dimer of oncomodulin: comparison to calmodulin
  JOURNAL   Biochemistry 27 (15), 5615-5622 (1988)
   PUBMED   3179268
REFERENCE   9  (bases 1 to 693)
  AUTHORS   Gillen,M.F., Banville,D., Rutledge,R.G., Narang,S., Seligy,V.L.,
            Whitfield,J.F. and MacManus,J.P.
  TITLE     A complete complementary DNA for the oncodevelopmental
            calcium-binding protein, oncomodulin
  JOURNAL   J Biol Chem 262 (11), 5308-5312 (1987)
   PUBMED   3558395
REFERENCE   10 (bases 1 to 693)
  AUTHORS   MacManus,J.P., Brewer,L.M. and Whitfield,J.F.
  TITLE     The widely-distributed tumour protein, oncomodulin, is a normal
            constituent of human and rodent placentas
  JOURNAL   Cancer Lett 27 (2), 145-151 (1985)
   PUBMED   4005827
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC004967.3.
            
            On Jun 30, 2021 this sequence version replaced NM_006188.3.
            
            Summary: This gene is similar to the oncomodulin gene, a
            high-affinity calcium ion-binding protein that belongs to the
            superfamily of calmodulin proteins, also known as the EF-hand
            proteins. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA1968968, SAMEA2148874
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000257627.5/ ENSP00000257627.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               AC004967.3         47181-47333         c
            154-286             AC004967.3         45553-45685         c
            287-396             AC004967.3         44184-44293         c
            397-693             AC004967.3         41824-42120         c
FEATURES             Location/Qualifiers
     source          1..693
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q21.3"
     gene            1..693
                     /gene="OCM2"
                     /gene_synonym="OCM; OM"
                     /note="oncomodulin 2"
                     /db_xref="GeneID:4951"
                     /db_xref="HGNC:HGNC:34396"
                     /db_xref="MIM:620522"
     exon            1..153
                     /gene="OCM2"
                     /gene_synonym="OCM; OM"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..422
                     /gene="OCM2"
                     /gene_synonym="OCM; OM"
                     /note="parvalbumin beta"
                     /codon_start=1
                     /product="putative oncomodulin-2"
                     /protein_id="NP_006179.2"
                     /db_xref="CCDS:CCDS5653.1"
                     /db_xref="GeneID:4951"
                     /db_xref="HGNC:HGNC:34396"
                     /db_xref="MIM:620522"
                     /translation="MSITDVLSADDIAAALQECQDPDTFEPQKFFQTSGLSKMSASQV
                     KDVFRFIDNDQSGYLDEEELKFFLQKFESGARELTESETKSLMAAADNDGDGKIGAEE
                     FQEMVHS"
     exon            154..286
                     /gene="OCM2"
                     /gene_synonym="OCM; OM"
                     /inference="alignment:Splign:2.1.0"
     exon            287..396
                     /gene="OCM2"
                     /gene_synonym="OCM; OM"
                     /inference="alignment:Splign:2.1.0"
     exon            397..693
                     /gene="OCM2"
                     /gene_synonym="OCM; OM"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagtgggcct gggaagatgt gtttcccctg gatgtgcacg ttcctgtttg tggcttatcg
       61 cctctcgttt attctgtgtg agtaggtaga aaatgagcat cacggacgtg ctcagtgctg
      121 atgacattgc agcagcgctc caggaatgcc aagacccaga cacttttgaa ccccaaaaat
      181 tcttccagac gtcaggcctc tccaagatgt cagccagtca ggtgaaggat gttttccggt
      241 tcatagacaa cgaccagagc gggtatctgg atgaagaaga gcttaagttt ttcctccaga
      301 agtttgagag tggtgccaga gaactgaccg agtcagaaac caagtccttg atggctgcgg
      361 cggataatga tggagatggg aaaattggag cagaggaatt ccaggaaatg gtgcattctt
      421 aaaagcccca gtctctggag aaaagagaga aagggataat cacctggaag gattccaaag
      481 ccctgggaat ggggaacccc acatcccatc cctacctaat ttgttaattt tccctgaaaa
      541 ccttctgcag tttgctcatt gttttagcga ggtcacgaga gagtcactca tgactttctt
      601 ggtggtgggt atatgccctg acaacttctg taagcccccc ttcccccaac aggcaatgcc
      661 tctaaaaatc acccaataaa gacaggcttc tca
//
