LOCUS       NM_001097622             696 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens oncomodulin (OCM), transcript variant 1, mRNA.
ACCESSION   NM_001097622 XM_928782 XM_941567
VERSION     NM_001097622.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 696)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 696)
  AUTHORS   Tong,B., Hornak,A.J., Maison,S.F., Ohlemiller,K.K., Liberman,M.C.
            and Simmons,D.D.
  TITLE     Oncomodulin, an EF-Hand Ca2+ Buffer, Is Critical for Maintaining
            Cochlear Function in Mice
  JOURNAL   J Neurosci 36 (5), 1631-1635 (2016)
   PUBMED   26843644
  REMARK    GeneRIF: Deletion of oncomodulin in outer hair cells, leads to a
            progressive hearing loss in transgenic mice.
REFERENCE   3  (bases 1 to 696)
  AUTHORS   Ali,G., Lee,K., Andrade,P.B., Basit,S., Santos-Cortez,R.L.,
            Chen,L., Jelani,M., Ansar,M., Ahmad,W. and Leal,S.M.
  TITLE     Novel autosomal recessive nonsyndromic hearing impairment locus
            DFNB90 maps to 7p22.1-p15.3
  JOURNAL   Hum Hered 71 (2), 106-112 (2011)
   PUBMED   21734401
  REMARK    GeneRIF: Data indicate taht candidate genes ACTB, BZW, OCM, MACC1,
            NXPH1, PRPS1L1, RAC1 and RPA3, which lie within the DFNB90 region,
            were sequenced and no potentially causal variants were identified.
REFERENCE   4  (bases 1 to 696)
  AUTHORS   Kurimoto,T., Yin,Y., Omura,K., Gilbert,H.Y., Kim,D., Cen,L.P.,
            Moko,L., Kugler,S. and Benowitz,L.I.
  TITLE     Long-distance axon regeneration in the mature optic nerve:
            contributions of oncomodulin, cAMP, and pten gene deletion
  JOURNAL   J Neurosci 30 (46), 15654-15663 (2010)
   PUBMED   21084621
  REMARK    GeneRIF: Ocm plays a central role in inflammation-induced
            regeneration in the optic nerve.
REFERENCE   5  (bases 1 to 696)
  AUTHORS   Pauls,T.L., Cox,J.A. and Berchtold,M.W.
  TITLE     The Ca2+(-)binding proteins parvalbumin and oncomodulin and their
            genes: new structural and functional findings
  JOURNAL   Biochim Biophys Acta 1306 (1), 39-54 (1996)
   PUBMED   8611623
  REMARK    Review article
REFERENCE   6  (bases 1 to 696)
  AUTHORS   Fohr,U.G., Weber,B.R., Muntener,M., Staudenmann,W., Hughes,G.J.,
            Frutiger,S., Banville,D., Schafer,B.W. and Heizmann,C.W.
  TITLE     Human alpha and beta parvalbumins. Structure and tissue-specific
            expression
  JOURNAL   Eur J Biochem 215 (3), 719-727 (1993)
   PUBMED   8354278
REFERENCE   7  (bases 1 to 696)
  AUTHORS   Ritzler,J.M., Sawhney,R., Geurts van Kessel,A.H., Grzeschik,K.H.,
            Schinzel,A. and Berchtold,M.W.
  TITLE     The genes for the highly homologous Ca(2+)-binding proteins
            oncomodulin and parvalbumin are not linked in the human genome
  JOURNAL   Genomics 12 (3), 567-572 (1992)
   PUBMED   1559707
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC113704.1, DB339645.1 and CB045979.1.
            
            On May 17, 2019 this sequence version replaced NM_001097622.1.
            
            Summary: Oncomodulin is a high-affinity calcium ion-binding
            protein. It belongs to the superfamily of calmodulin proteins, also
            known as the EF-hand proteins. Oncomodulin is an oncodevelopmental
            protein found in early embryonic cells in the placenta and also in
            tumors. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC113706.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000242104.6/ ENSP00000242104.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-509               BC113704.1         1-509
            510-695             DB339645.1         1-186               c
            696-696             CB045979.1         66-66               c
FEATURES             Location/Qualifiers
     source          1..696
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p22.1"
     gene            1..696
                     /gene="OCM"
                     /gene_synonym="OCM1; OM; ONCM"
                     /note="oncomodulin"
                     /db_xref="GeneID:654231"
                     /db_xref="HGNC:HGNC:8105"
                     /db_xref="MIM:164795"
     exon            1..153
                     /gene="OCM"
                     /gene_synonym="OCM1; OM; ONCM"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..422
                     /gene="OCM"
                     /gene_synonym="OCM1; OM; ONCM"
                     /note="isoform a is encoded by transcript variant 1;
                     oncomodulin-1; hCG18255; parvalbumin beta; beta
                     parvalbumin"
                     /codon_start=1
                     /product="oncomodulin-1 isoform a"
                     /protein_id="NP_001091091.1"
                     /db_xref="CCDS:CCDS43548.1"
                     /db_xref="GeneID:654231"
                     /db_xref="HGNC:HGNC:8105"
                     /db_xref="MIM:164795"
                     /translation="MSITDVLSADDIAAALQECRDPDTFEPQKFFQTSGLSKMSANQV
                     KDVFRFIDNDQSGYLDEEELKFFLQKFESGARELTESETKSLMAAADNDGDGKIGAEE
                     FQEMVHS"
     exon            154..286
                     /gene="OCM"
                     /gene_synonym="OCM1; OM; ONCM"
                     /inference="alignment:Splign:2.1.0"
     exon            287..396
                     /gene="OCM"
                     /gene_synonym="OCM1; OM; ONCM"
                     /inference="alignment:Splign:2.1.0"
     exon            397..696
                     /gene="OCM"
                     /gene_synonym="OCM1; OM; ONCM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      675..680
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OCM"
                     /gene_synonym="OCM1; OM; ONCM"
                     /note="hexamer: AATAAA"
     polyA_site      696
                     /gene="OCM"
                     /gene_synonym="OCM1; OM; ONCM"
                     /note="major polyA site"
ORIGIN      
        1 cagtgggcct gggaagatgt gtttcccctg gatgtgcaca ttcctgtttg tggcttatcg
       61 cctctcattt attctgtgtg agtaggtaga aaatgagcat cacggacgtg ctcagtgctg
      121 acgacattgc agcagcgctc caggaatgcc gagacccaga cacttttgaa ccccaaaaat
      181 tcttccagac atcaggcctc tccaagatgt cagccaatca ggtgaaggat gttttccggt
      241 tcatagacaa cgaccagagc gggtacctgg atgaagaaga gcttaagttt ttcctccaga
      301 agtttgagag tggtgccaga gaactgaccg agtcagaaac caagtccttg atggctgcgg
      361 cggataatga tggagatggg aaaattggag cagaggaatt ccaggaaatg gtgcattctt
      421 aaaagcccca gtctctggag aaaagagaga aagggataat cacctggaag gattccaaag
      481 ccctgggaat ggggaacccc acatcccatc cctacctaat ttgttaattt tccctgaaaa
      541 ccttctgcag tttgctcatt gttttagtga ggtcacgagg gagtcactcc tgactttctt
      601 ggtggtgggt atatgccctg acaacttctg taagcccccc ttcccccaac aggcaatgcc
      661 tctaaaaatc acccaataaa gacaggcttc tcatca
//
