LOCUS       NM_001014446            1109 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens OCIA domain containing 2 (OCIAD2), transcript variant
            1, mRNA.
ACCESSION   NM_001014446
VERSION     NM_001014446.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1109)
  AUTHORS   Yin,Y.F., Jia,Q.Y., Yao,H.F., Zhu,Y.H., Zheng,J.H., Duan,Z.H.,
            Hu,C.Y., Sun,Y.W., Liu,D.J., Huo,Y.M. and Liu,W.
  TITLE     OCIAD2 promotes pancreatic cancer progression through the AKT
            signaling pathway
  JOURNAL   Gene 927, 148735 (2024)
   PUBMED   38944166
  REMARK    GeneRIF: OCIAD2 promotes pancreatic cancer progression through the
            AKT signaling pathway.
REFERENCE   2  (bases 1 to 1109)
  AUTHORS   Maki,M., JeongMin,H., Nakagawa,T., Kawai,H., Sakamoto,N., Sato,Y.
            and Noguchi,M.
  TITLE     Aberrant OCIAD2 demethylation in lung adenocarcinoma is associated
            with outcome
  JOURNAL   Pathol Int 72 (10), 496-505 (2022)
   PUBMED   35920378
  REMARK    GeneRIF: Aberrant OCIAD2 demethylation in lung adenocarcinoma is
            associated with outcome.
REFERENCE   3  (bases 1 to 1109)
  AUTHORS   Chojnacka,K.J., Elancheliyan,P., Mussulini,B.H.M., Mohanraj,K.,
            Callegari,S., Gosk,A., Banach,T., Goral,T., Szczepanowska,K.,
            Rehling,P., Serwa,R.A. and Chacinska,A.
  TITLE     Ovarian carcinoma immunoreactive antigen-like protein 2 (OCIAD2) is
            a novel complex III-specific assembly factor in mitochondria
  JOURNAL   Mol Biol Cell 33 (4), ar29 (2022)
   PUBMED   35080992
  REMARK    GeneRIF: Ovarian carcinoma immunoreactive antigen-like protein 2
            (OCIAD2) is a novel complex III-specific assembly factor in
            mitochondria.
REFERENCE   4  (bases 1 to 1109)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   5  (bases 1 to 1109)
  AUTHORS   Hong,J., Shiba-Ishii,A., Kim,Y., Noguchi,M. and Sakamoto,N.
  TITLE     Ovarian carcinoma immunoreactive antigen domain 2 controls
            mitochondrial apoptosis in lung adenocarcinoma
  JOURNAL   Cancer Sci 112 (12), 5114-5126 (2021)
   PUBMED   34628698
  REMARK    GeneRIF: Ovarian carcinoma immunoreactive antigen domain 2 controls
            mitochondrial apoptosis in lung adenocarcinoma.
REFERENCE   6  (bases 1 to 1109)
  AUTHORS   Han,J., Jung,S., Jang,J., Kam,T.I., Choi,H., Kim,B.J., Nah,J.,
            Jo,D.G., Nakagawa,T., Nishimura,M. and Jung,Y.K.
  TITLE     OCIAD2 activates gamma-secretase to enhance amyloid beta production
            by interacting with nicastrin
  JOURNAL   Cell Mol Life Sci 71 (13), 2561-2576 (2014)
   PUBMED   24270855
  REMARK    GeneRIF: OCIAD2 also increased the interaction of nicastrin with
            C99 and stimulated APP processing via gamma-secretase activation,
            but did not affect Notch processing
REFERENCE   7  (bases 1 to 1109)
  AUTHORS   Zhang,R., Zhao,C., Xiong,Z. and Zhou,X.
  TITLE     Pathway bridge based multiobjective optimization approach for
            lurking pathway prediction
  JOURNAL   Biomed Res Int 2014, 351095 (2014)
   PUBMED   24949437
  REMARK    GeneRIF: it well explained the mechanism of TGFbeta induced OCIAD2
            expression in cancer microenvironment, therefore providing an
            important clue for the future functional analysis of OCIAD2 in
            tumor pathogenesis.
REFERENCE   8  (bases 1 to 1109)
  AUTHORS   Nagata,C., Kobayashi,H., Sakata,A., Satomi,K., Minami,Y.,
            Morishita,Y., Ohara,R., Yoshikawa,H., Arai,Y., Nishida,M. and
            Noguchi,M.
  TITLE     Increased expression of OCIA domain containing 2 during stepwise
            progression of ovarian mucinous tumor
  JOURNAL   Pathol Int 62 (7), 471-476 (2012)
   PUBMED   22726067
  REMARK    GeneRIF: Like OCIAD1, OCIAD2 is a cancer-related protein and its
            expression level increases during the course of malignant
            progression and is thought to be a very useful marker for
            evaluating the malignancy of ovarian mucinous tumors.
REFERENCE   9  (bases 1 to 1109)
  AUTHORS   Ishiyama,T., Kano,J., Anami,Y., Onuki,T., Iijima,T., Morisita,Y.,
            Yokota,J. and Noguchi,M.
  TITLE     OCIA domain containing 2 is highly expressed in adenocarcinoma
            mixed subtype with bronchioloalveolar carcinoma component and is
            associated with better prognosis
  JOURNAL   Cancer Sci 98 (1), 50-57 (2007)
   PUBMED   17054434
REFERENCE   10 (bases 1 to 1109)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK298305.1 and AC105444.2.
            
            On May 17, 2019 this sequence version replaced NM_001014446.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK298305.1, AW248322.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000508632.6/ ENSP00000423014.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-748               AK298305.1         24-771
            749-1109            AC105444.2         16505-16865         c
FEATURES             Location/Qualifiers
     source          1..1109
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p11"
     gene            1..1109
                     /gene="OCIAD2"
                     /note="OCIA domain containing 2"
                     /db_xref="GeneID:132299"
                     /db_xref="HGNC:HGNC:28685"
                     /db_xref="MIM:619633"
     exon            1..117
                     /gene="OCIAD2"
                     /inference="alignment:Splign:2.1.0"
     exon            118..245
                     /gene="OCIAD2"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..644
                     /gene="OCIAD2"
                     /note="isoform 1 is encoded by transcript variant 1; OCIA
                     domain-containing protein 2; ovarian carcinoma
                     immunoreactive antigen-like protein; ovarian cancer
                     immunoreactive antigen domain containing 2"
                     /codon_start=1
                     /product="OCIA domain-containing protein 2 isoform 1"
                     /protein_id="NP_001014446.1"
                     /db_xref="CCDS:CCDS33981.1"
                     /db_xref="GeneID:132299"
                     /db_xref="HGNC:HGNC:28685"
                     /db_xref="MIM:619633"
                     /translation="MASASARGNQDKDAHFPPPSKQSLLFCPKSKLHIHRAEISKIMR
                     ECQEESFWKRALPFSLVSMLVTQGLVYQGYLAANSRFGSLPKVALAGLLGFGLGKVSY
                     IGVCQSKFHFFEDQLRGAGFGPQHNRHCLLTCEECKIKHGLSEKGDSQPSAS"
     exon            246..342
                     /gene="OCIAD2"
                     /inference="alignment:Splign:2.1.0"
     exon            343..396
                     /gene="OCIAD2"
                     /inference="alignment:Splign:2.1.0"
     exon            397..444
                     /gene="OCIAD2"
                     /inference="alignment:Splign:2.1.0"
     exon            445..562
                     /gene="OCIAD2"
                     /inference="alignment:Splign:2.1.0"
     exon            563..1109
                     /gene="OCIAD2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      720..725
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OCIAD2"
                     /note="hexamer: AATAAA"
     polyA_site      746
                     /gene="OCIAD2"
                     /note="major polyA site"
ORIGIN      
        1 gagacaggtg gggtactcgg gaagctggag cgggccggcg gtgcagtcac gggggagcga
       61 ggcctgctgg gcttggcaac gagggactcg gcctcggagg cgacccagac cacacagaca
      121 ctgggtcaag gagtaagcag aggataaaca actggaagga gagcaagcac aaagtcatca
      181 tggcttcagc gtctgctcgt ggaaaccaag ataaagatgc ccattttcca ccaccaagca
      241 agcagagcct gttgttttgt ccaaaatcaa aactgcacat ccacagagca gagatctcaa
      301 agattatgcg agaatgtcag gaagaaagtt tctggaagag agctctgcct ttttctcttg
      361 taagcatgct tgtcacccag ggactagtct accaaggtta tttggcagct aattctagat
      421 ttggatcatt gcccaaagtt gcacttgctg gtctcttggg atttggcctt ggaaaggtat
      481 catacatagg agtatgccag agtaaattcc atttttttga agatcagctc cgtggggctg
      541 gttttggtcc acagcataac aggcactgcc tccttacctg tgaggaatgc aaaataaagc
      601 atggattaag tgagaaggga gactctcagc cttcagcttc ctaaattctg tgtctgtgac
      661 tttcgaagtt ttttaaacct ctgaatttgt acacatttaa aatttcaagt gtactttaaa
      721 ataaaatact tctaatggaa caaaaacatt gtgtctgtca ctcactgaaa tgtattccgt
      781 ggaaggcttt caagtgaact aagcgttaca tgtttttctg ctctttaaga acatgtcggg
      841 gcatggcgca gtggctcatg cctgtaatcc cagtactttg ggaggccgag gcaggcagat
      901 catttgaggt caggagttca tgaccagctt ggccaacatg gtgaaacccc atctctgcta
      961 aaaatataaa aattagccag gcgtggtggc acatgcctgt aatcccagct actgagaggg
     1021 aggctgaggc aggagaatca cttgaaccca ggaggcgaaa gttgcagcga gcagagattg
     1081 tgccactgca ctccagcctg ggtgccaga
//
