LOCUS       NM_017830               1958 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens OCIA domain containing 1 (OCIAD1), transcript variant
            1, mRNA.
ACCESSION   NM_017830
VERSION     NM_017830.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1958)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1958)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1958)
  AUTHORS   Le Vasseur,M., Friedman,J., Jost,M., Xu,J., Yamada,J., Kampmann,M.,
            Horlbeck,M.A., Salemi,M.R., Phinney,B.S., Weissman,J.S. and
            Nunnari,J.
  TITLE     Genome-wide CRISPRi screening identifies OCIAD1 as a prohibitin
            client and regulatory determinant of mitochondrial Complex III
            assembly in human cells
  JOURNAL   Elife 10, e67624 (2021)
   PUBMED   34034859
  REMARK    GeneRIF: Genome-wide CRISPRi screening identifies OCIAD1 as a
            prohibitin client and regulatory determinant of mitochondrial
            Complex III assembly in human cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1958)
  AUTHORS   Tran,H.T.L., Morikawa,K., Anggakusuma, Zibi,R., Thi,V.L.D.,
            Penin,F., Heim,M.H., Quadroni,M., Pietschmann,T., Gouttenoire,J.
            and Moradpour,D.
  TITLE     OCIAD1 is a host mitochondrial substrate of the hepatitis C virus
            NS3-4A protease
  JOURNAL   PLoS One 15 (7), e0236447 (2020)
   PUBMED   32697788
  REMARK    GeneRIF: OCIAD1 is a host mitochondrial substrate of the hepatitis
            C virus NS3-4A protease.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1958)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1958)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   7  (bases 1 to 1958)
  AUTHORS   Sengupta,S., Michener,C.M., Escobar,P., Belinson,J. and
            Ganapathi,R.
  TITLE     Ovarian cancer immuno-reactive antigen domain containing 1
            (OCIAD1), a key player in ovarian cancer cell adhesion
  JOURNAL   Gynecol Oncol 109 (2), 226-233 (2008)
   PUBMED   18328549
  REMARK    GeneRIF: Over-expressed in metastatic ovarian cancer. Effect of
            OCIAD1 on cell adhesion may be related to its function in ovarian
            cancer. Possibility of OCIAD1's role in tumor metastasis.
REFERENCE   8  (bases 1 to 1958)
  AUTHORS   Kim,J.M., Lee,K.H., Jeon,Y.J., Oh,J.H., Jeong,S.Y., Song,I.S.,
            Kim,J.M., Lee,D.S. and Kim,N.S.
  TITLE     Identification of genes related to Parkinson's disease using
            expressed sequence tags
  JOURNAL   DNA Res 13 (6), 275-286 (2006)
   PUBMED   17213182
REFERENCE   9  (bases 1 to 1958)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   10 (bases 1 to 1958)
  AUTHORS   Luo,L.Y., Soosaipillai,A. and Diamandis,E.P.
  TITLE     Molecular cloning of a novel human gene on chromosome 4p11 by
            immunoscreening of an ovarian carcinoma cDNA library
  JOURNAL   Biochem Biophys Res Commun 280 (1), 401-406 (2001)
   PUBMED   11162530
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA037995.1, AF251296.1, BM999322.1 and AI038315.1.
            
            On May 21, 2020 this sequence version replaced NM_017830.3.
            
            Transcript Variant: This variant (1) encodes isoform 1. Both
            variants 1 and 2 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK000462.1, SRR14038191.1126054.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264312.12/ ENSP00000264312.7
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-105               DA037995.1         46-150
            106-1387            AF251296.1         119-1400
            1388-1956           BM999322.1         17-585              c
            1957-1958           AI038315.1         5-6                 c
FEATURES             Location/Qualifiers
     source          1..1958
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p11"
     gene            1..1958
                     /gene="OCIAD1"
                     /gene_synonym="ASRIJ; OCIA; TPA018"
                     /note="OCIA domain containing 1"
                     /db_xref="GeneID:54940"
                     /db_xref="HGNC:HGNC:16074"
                     /db_xref="MIM:619596"
     exon            1..162
                     /gene="OCIAD1"
                     /gene_synonym="ASRIJ; OCIA; TPA018"
                     /inference="alignment:Splign:2.1.0"
     exon            163..225
                     /gene="OCIAD1"
                     /gene_synonym="ASRIJ; OCIA; TPA018"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..905
                     /gene="OCIAD1"
                     /gene_synonym="ASRIJ; OCIA; TPA018"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ovarian carcinoma immunoreactive antigen; ovarian cancer
                     immunoreactive antigen domain containing 1; OCIA
                     domain-containing protein 1; ovarian cancer immunoreactive
                     antigen domain containing 1A"
                     /codon_start=1
                     /product="OCIA domain-containing protein 1 isoform 1"
                     /protein_id="NP_060300.1"
                     /db_xref="CCDS:CCDS3484.1"
                     /db_xref="GeneID:54940"
                     /db_xref="HGNC:HGNC:16074"
                     /db_xref="MIM:619596"
                     /translation="MNGRADFREPNAEVPRPIPHIGPDYIPTEEERRVFAECNDESFW
                     FRSVPLAATSMLITQGLISKGILSSHPKYGSIPKLILACIMGYFAGKLSYVKTCQEKF
                     KKLENSPLGEALRSGQARRSSPPGHYYQKSKYDSSVSGQSSFVTSPAADNIEMLPHYE
                     PIPFSSSMNESAPTGITDHIVQGPDPNLEESPKRKNITYEELRNKNRESYEVSLTQKT
                     DPSVRPMHERVPKKEVKVNKYGDTWDE"
     exon            226..306
                     /gene="OCIAD1"
                     /gene_synonym="ASRIJ; OCIA; TPA018"
                     /inference="alignment:Splign:2.1.0"
     exon            307..360
                     /gene="OCIAD1"
                     /gene_synonym="ASRIJ; OCIA; TPA018"
                     /inference="alignment:Splign:2.1.0"
     exon            361..408
                     /gene="OCIAD1"
                     /gene_synonym="ASRIJ; OCIA; TPA018"
                     /inference="alignment:Splign:2.1.0"
     exon            409..544
                     /gene="OCIAD1"
                     /gene_synonym="ASRIJ; OCIA; TPA018"
                     /inference="alignment:Splign:2.1.0"
     exon            545..714
                     /gene="OCIAD1"
                     /gene_synonym="ASRIJ; OCIA; TPA018"
                     /inference="alignment:Splign:2.1.0"
     exon            715..867
                     /gene="OCIAD1"
                     /gene_synonym="ASRIJ; OCIA; TPA018"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1958
                     /gene="OCIAD1"
                     /gene_synonym="ASRIJ; OCIA; TPA018"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1368..1373
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OCIAD1"
                     /gene_synonym="ASRIJ; OCIA; TPA018"
                     /note="hexamer: AATAAA"
     polyA_site      1391
                     /gene="OCIAD1"
                     /gene_synonym="ASRIJ; OCIA; TPA018"
                     /note="major polyA site"
     regulatory      1937..1942
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OCIAD1"
                     /gene_synonym="ASRIJ; OCIA; TPA018"
                     /note="hexamer: AATAAA"
     polyA_site      1958
                     /gene="OCIAD1"
                     /gene_synonym="ASRIJ; OCIA; TPA018"
ORIGIN      
        1 gagcccctgt ctggatgact tcttgcggct gttctacccc tccccctccc cgcggtacct
       61 tgcacttttc tccctccctg ccccctctcg agtccaccct ccgggccttc tgcccctgat
      121 cgcttggttt tccttgcagt cgcctgctgc tgtcgtcggg aggaaagatg aatgggaggg
      181 ctgattttcg agagccgaat gcagaggttc caagaccaat tccccacata gggcctgatt
      241 acattccaac agaggaagaa aggagagtct tcgcagaatg caatgatgaa agcttctggt
      301 tcagatctgt gcctttggct gcaacaagta tgttgattac tcaaggatta attagtaaag
      361 gaatactttc aagtcatccc aaatatggtt ccatccctaa acttatactt gcttgtatca
      421 tgggatactt tgctggaaaa ctttcttatg tgaaaacttg ccaagagaaa ttcaagaaac
      481 ttgaaaattc cccccttgga gaagctttac gatcaggaca agcacgacga tcttcaccac
      541 ctgggcacta ttatcaaaag tcaaaatatg actcaagtgt gagtggtcaa tcatcttttg
      601 tgacatcccc agcagcagac aacatagaaa tgcttcctca ttatgagcca attccattca
      661 gttcttctat gaatgaatct gctcccactg gtattactga tcatattgtc caaggacctg
      721 atcccaacct tgaagaaagt cctaaaagaa aaaatattac atatgaggaa ttaaggaata
      781 agaacagaga gtcatatgaa gtatctttaa cacaaaagac tgacccctca gtcaggccta
      841 tgcatgaaag agtgccaaaa aaagaagtca aagtaaacaa gtatggagat acttgggatg
      901 agtgaaaaat tacatcattg gacatgaagg agtttcaaca tccagcttca tctaggtggt
      961 catgattacc tgcatgcttt gagctcagca gcagtcttca taaacacatt taaaacaaga
     1021 tcctgggttt ttgtggtttg acttctatgg tgttttaaaa aaacacagat ttttagtgtt
     1081 aatattgtgt aaatgtactc accttaggga ttcatttgaa tgatggtatt ataccatgat
     1141 tgtatacagt ttgtgaaatt gttgcaaggg caaagataac tcttaaaaaa ccgtcgagat
     1201 tacaatgctc tagaatcagc atataagaaa ataaatgata tctgcatgtt gaattggggt
     1261 ggatgggggg agcaagcata atttttaagt gtgaagcttt gcatcaagaa attattaaaa
     1321 agcttttttt ctccagtatt ttctgtatta tcttaatgtt tatggcaaat aaaatgtaaa
     1381 ggaacatgca acagccctca tcttccttga ttttatggtt ttattgtttg taatttattg
     1441 atttattttt aagctagtta taatcatgta ggtataggaa ataaagtcat ctataatatt
     1501 tctataatat ggctataata tggctataaa tctataatat ggctggaggc agtgggcagt
     1561 ggttcatgcc tgtaatccca gcactttggg aggccgaagt gggaggattg catgagtcca
     1621 ggagtttgag accagcctgg gcaacaaagc gagaccctgt ctttacaaaa aaataaaaat
     1681 tagctggcga tggtgtcgtg tgcctgtagt cctagttact taagaggctg agttgggagg
     1741 atcagttgaa cccagtggtt ctgggttgca gtgagctgtg gtcacaccac tgaactccag
     1801 cctgtgcgac tgagtgagac cctgtgtcta aaaaaataaa aatataatga atgtgattta
     1861 tgtagataaa ttgataatat agtaaatagg taaatgcctt aaaaagcatt tttaaagaat
     1921 ttgtaaattc taaaacaata aaaatttggt atacatca
//
