LOCUS       NM_024578               1111 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens occludin/ELL domain containing 1 (OCEL1), mRNA.
ACCESSION   NM_024578
VERSION     NM_024578.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1111)
  AUTHORS   Deng,M., Zhang,Z., Liu,B., Lv,Q., Hou,K., Che,X., Qu,X., Liu,Y.,
            Zhang,Y. and Hu,X.
  TITLE     Low OCEL1 expression is associated with poor prognosis in human
            non-small cell lung cancer
  JOURNAL   Cancer Biomark 27 (4), 519-524 (2020)
   PUBMED   32083572
  REMARK    GeneRIF: Low OCEL1 expression is associated with poor prognosis in
            human non-small cell lung cancer.
REFERENCE   2  (bases 1 to 1111)
  AUTHORS   Wong,B.K., Sutton,V.R., Lewis,R.A. and Van den Veyver,I.B.
  TITLE     Independent variant analysis of TEAD1 and OCEL1 in 38 Aicardi
            syndrome patients
  JOURNAL   Mol Genet Genomic Med 5 (2), 117-121 (2017)
   PUBMED   28361097
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC029361.1 and AK026362.1.
            
            On Nov 22, 2018 this sequence version replaced NM_024578.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK026362.1, BC029361.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000215061.9/ ENSP00000215061.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1104              BC029361.1         23-1126
            1105-1111           AK026362.1         1085-1091
FEATURES             Location/Qualifiers
     source          1..1111
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..1111
                     /gene="OCEL1"
                     /gene_synonym="FWP009; S863-9"
                     /note="occludin/ELL domain containing 1"
                     /db_xref="GeneID:79629"
                     /db_xref="HGNC:HGNC:26221"
     exon            1..91
                     /gene="OCEL1"
                     /gene_synonym="FWP009; S863-9"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..817
                     /gene="OCEL1"
                     /gene_synonym="FWP009; S863-9"
                     /codon_start=1
                     /product="occludin/ELL domain-containing protein 1"
                     /protein_id="NP_078854.1"
                     /db_xref="CCDS:CCDS12351.1"
                     /db_xref="GeneID:79629"
                     /db_xref="HGNC:HGNC:26221"
                     /translation="MHNPDGSASPTADPGSELQTLGQAARRPPPPRAGHDAPRRTRPS
                     ARKPLSCFSRRPMPTREPPKTRGSRGHLHTHPPGPGPPLQGLAPRGLKTSAPRPPCQP
                     QPGPHKAKTKKIVFEDELLSQALLGAKKPIGAIPKGHKPRPHPVPDYELKYPPVSSER
                     ERSRYVAVFQDQYGEFLELQHEVGCAQAKLRQLEALLSSLPPPQSQKEAQVAARVWRE
                     FEMKRMDPGFLDKQARCHYLKGKLRHLKTQIQKFDDQGDSEGSVYF"
     exon            92..268
                     /gene="OCEL1"
                     /gene_synonym="FWP009; S863-9"
                     /inference="alignment:Splign:2.1.0"
     exon            269..474
                     /gene="OCEL1"
                     /gene_synonym="FWP009; S863-9"
                     /inference="alignment:Splign:2.1.0"
     exon            475..640
                     /gene="OCEL1"
                     /gene_synonym="FWP009; S863-9"
                     /inference="alignment:Splign:2.1.0"
     exon            641..694
                     /gene="OCEL1"
                     /gene_synonym="FWP009; S863-9"
                     /inference="alignment:Splign:2.1.0"
     exon            695..1111
                     /gene="OCEL1"
                     /gene_synonym="FWP009; S863-9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1089..1094
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OCEL1"
                     /gene_synonym="FWP009; S863-9"
                     /note="hexamer: AATAAA"
     polyA_site      1111
                     /gene="OCEL1"
                     /gene_synonym="FWP009; S863-9"
                     /note="major polyA site"
ORIGIN      
        1 agtcgggtcc atcctgcagt aaatgcacaa cccggacgga agtgcctctc cgacagcaga
       61 tccaggctcg gagctccaga cgctgggaca ggccgcccgc agaccacccc cgccgcgcgc
      121 gggacacgac gccccccgca ggacccgccc atcagcccgg aaacccctga gctgcttctc
      181 ccggaggccg atgcccaccc gggagccccc aaagactcgc ggctcccggg ggcacctgca
      241 tactcacccg cctgggcctg ggcccccgct gcagggactg gcgccccgag gcctcaaaac
      301 cagcgccccc cgccctccgt gccagcccca gccgggaccc cacaaggcaa agaccaagaa
      361 gattgtgttt gaggatgagt tgctctccca ggccctcctg ggcgccaaga agcctattgg
      421 agccatccct aaggggcata agcctaggcc ccacccagtg cccgactatg agcttaagta
      481 cccgccagtg agcagtgaga gggaacggag ccgctatgtc gcagtgttcc aggaccagta
      541 cggagagttc ttggagctcc agcacgaggt ggggtgtgca caggcaaagc tcaggcagct
      601 ggaggccctg ctgagctccc tgcccccacc ccaaagccag aaggaggccc aagttgcagc
      661 ccgggtttgg agggagtttg agatgaagcg aatggatcct ggcttcctgg acaagcaggc
      721 tcgctgccac tacctgaagg gtaaactgag gcatctcaag actcagatcc agaaattcga
      781 tgaccaagga gacagcgagg gctccgtgta cttctaagtg cccctgcaga tgggcagagg
      841 gatgcatggg gatgcaggtc ccttgcattt cttggtatct ctcagctttt cctcttgcag
      901 ctccccctac caggggtcgc tttctcctgg attgcaaatg cctcttcagt ttggactcag
      961 ctctgacagc ccctcctcca ggaaggcctt ccaggacttc ctcctctggg tcctctagct
     1021 ctgaccctac agggactcca gatctcaacc tgttccctgg aagtagggcc tgctctccat
     1081 cccagtgaaa taaacatgta ttagacacct a
//
